DK1040119T3 - Hemiasterlinanaloger - Google Patents
HemiasterlinanalogerInfo
- Publication number
- DK1040119T3 DK1040119T3 DK98962157T DK98962157T DK1040119T3 DK 1040119 T3 DK1040119 T3 DK 1040119T3 DK 98962157 T DK98962157 T DK 98962157T DK 98962157 T DK98962157 T DK 98962157T DK 1040119 T3 DK1040119 T3 DK 1040119T3
- Authority
- DK
- Denmark
- Prior art keywords
- hemiasterline
- analogues
- analogs
- hemiasterlin
- synthesis
- Prior art date
Links
- KQODQNJLJQHFQV-UHFFFAOYSA-N (-)-hemiasterlin Natural products C1=CC=C2C(C(C)(C)C(C(=O)NC(C(=O)N(C)C(C=C(C)C(O)=O)C(C)C)C(C)(C)C)NC)=CN(C)C2=C1 KQODQNJLJQHFQV-UHFFFAOYSA-N 0.000 abstract 1
- KQODQNJLJQHFQV-MKWZWQCGSA-N (e,4s)-4-[[(2s)-3,3-dimethyl-2-[[(2s)-3-methyl-2-(methylamino)-3-(1-methylindol-3-yl)butanoyl]amino]butanoyl]-methylamino]-2,5-dimethylhex-2-enoic acid Chemical compound C1=CC=C2C(C(C)(C)[C@@H](C(=O)N[C@H](C(=O)N(C)[C@H](\C=C(/C)C(O)=O)C(C)C)C(C)(C)C)NC)=CN(C)C2=C1 KQODQNJLJQHFQV-MKWZWQCGSA-N 0.000 abstract 1
- 239000003080 antimitotic agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 229930187626 hemiasterlin Natural products 0.000 abstract 1
- 108010057806 hemiasterlin Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Junction Field-Effect Transistors (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Amplifiers (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002225325A CA2225325A1 (fr) | 1997-12-19 | 1997-12-19 | Substances hemiasterlines analogues |
| PCT/CA1998/001184 WO1999032509A2 (fr) | 1997-12-19 | 1998-12-18 | Analogues d'hemiasterline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1040119T3 true DK1040119T3 (da) | 2009-04-14 |
Family
ID=4161925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98962157T DK1040119T3 (da) | 1997-12-19 | 1998-12-18 | Hemiasterlinanaloger |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7579323B1 (fr) |
| EP (1) | EP1040119B1 (fr) |
| JP (1) | JP4417551B2 (fr) |
| KR (1) | KR100937756B1 (fr) |
| CN (1) | CN100422208C (fr) |
| AT (1) | ATE419268T1 (fr) |
| AU (1) | AU762691C (fr) |
| BR (1) | BR9813817A (fr) |
| CA (2) | CA2225325A1 (fr) |
| DE (1) | DE69840415D1 (fr) |
| DK (1) | DK1040119T3 (fr) |
| ES (1) | ES2320499T3 (fr) |
| HK (1) | HK1034523A1 (fr) |
| HU (1) | HUP0105460A3 (fr) |
| IL (1) | IL136654A0 (fr) |
| NZ (1) | NZ505086A (fr) |
| WO (1) | WO1999032509A2 (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003072754A2 (fr) * | 2002-02-27 | 2003-09-04 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Conjugues de ligand, adaptateur et agent cytotoxique, compositions associees et procedes d'utilisation relatifs |
| MXPA04009209A (es) * | 2002-03-22 | 2004-11-26 | Eisai Co Ltd | Derivados de hemiasterlina y usos de los mismos. |
| US7064211B2 (en) | 2002-03-22 | 2006-06-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
| WO2004026814A2 (fr) * | 2002-09-20 | 2004-04-01 | Wyeth Holdings Corporation | Procede de synthese d'intermediaires utiles dans la synthese d'inhibiteurs de tubuline |
| US20040121965A1 (en) * | 2002-09-20 | 2004-06-24 | Wyeth Holdings Corporation | Method of treating resistant tumors |
| AU2003295808A1 (en) * | 2002-11-21 | 2004-06-18 | Wyeth | Hemiasterlin affinity probes and their uses |
| US7390910B2 (en) | 2003-08-08 | 2008-06-24 | Wyeth | Compounds for treating tumors |
| GB201001070D0 (en) | 2010-01-22 | 2010-03-10 | St George's Hospital Medical School | Theraputic compounds and their use |
| TR201911139T4 (tr) | 2013-03-15 | 2019-08-21 | Zymeworks Inc | Sitotoksik ve anti-mitotik bileşikler ve bunları kullanmanın yöntemleri. |
| KR20160125361A (ko) * | 2013-12-27 | 2016-10-31 | 자임워크스 인코포레이티드 | Ｖａｒ２ｃｓａ－약물 접합체 |
| KR102384740B1 (ko) * | 2013-12-27 | 2022-04-07 | 자임워크스 인코포레이티드 | 약물 접합체를 위한 설폰아마이드-함유 연결 시스템 |
| CN113416229B (zh) | 2014-09-17 | 2024-12-13 | 酵活英属哥伦比亚有限公司 | 细胞毒性和抗有丝分裂化合物、及其使用方法 |
| SG11201704976VA (en) * | 2015-01-30 | 2017-07-28 | Sutro Biopharma Inc | Hemiasterlin derivatives for conjugation and therapy |
| RS63143B1 (sr) | 2016-06-01 | 2022-05-31 | Athira Pharma Inc | Jedinjenja |
| US10517958B2 (en) | 2016-10-04 | 2019-12-31 | Zymeworks Inc. | Compositions and methods for the treatment of platinum-drug resistant cancer |
| WO2018128745A1 (fr) | 2017-01-06 | 2018-07-12 | The Board Of Trustees Of The Leland Stanford Junior University | Ligands du récepteur du facteur neurotrophique ciliaire et leurs méthodes d'utilisation |
| EP4321523A3 (fr) | 2017-08-10 | 2024-04-24 | Sumitomo Pharma Co., Ltd. | Dérivés d'hémiasterline et conjugués anticorps-médicament les comprenant |
| DK3666787T3 (da) | 2017-08-10 | 2024-03-11 | Sumitomo Pharma Co Ltd | Antistoflægemiddelkonjugater som inkluderer hemiasterlinderivat |
| US20220144889A1 (en) | 2019-02-13 | 2022-05-12 | Sumitomo Dainippon Pharma Co., Ltd. | Hemiasterlin Derivative Having Cysteine Residue |
| WO2020166592A1 (fr) | 2019-02-13 | 2020-08-20 | 大日本住友製薬株式会社 | Dérivé d'hémiastérline et conjugué anticorps-médicament associé |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1049404B (it) | 1975-04-09 | 1981-01-20 | Zambeletti Spa L | Tripeptidi loro esteri ed amidi ad attivita antiulcera |
| EP0150227A1 (fr) | 1983-12-23 | 1985-08-07 | FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. | Dérivés de dipeptides et leur utilisation pour déterminer l'activité de la carboxypeptidase A |
| IT1209644B (it) * | 1985-06-21 | 1989-08-30 | Isf Spa | Composti farmacologicamente attivi. |
| US4820691A (en) * | 1987-06-24 | 1989-04-11 | E. R. Squibb & Sons, Inc. | Amino acid 1,2-diketo derivatives as renin inhibitors |
| CA2042027A1 (fr) | 1989-09-15 | 1991-03-16 | Arthur E. Bogden | Traitemenet du cancer du colon |
| GB9508195D0 (en) | 1995-04-20 | 1995-06-07 | Univ British Columbia | Novel biologically active compounds and compositions,their use and derivation |
| US5811515A (en) * | 1995-06-12 | 1998-09-22 | California Institute Of Technology | Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis |
| US5661175A (en) | 1995-06-20 | 1997-08-26 | Kashman; Yoel | Hemiasterlin and geodiamolide TA |
| AU716716B2 (en) * | 1995-07-17 | 2000-03-02 | Medivir Uk Ltd | Cysteine protease inhibitors for use in treatment of IgE mediated allergic diseases |
| US6214799B1 (en) * | 1996-05-14 | 2001-04-10 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and methods for their use and preparation |
| US6126939A (en) * | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| US6331554B1 (en) * | 1997-03-28 | 2001-12-18 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds, compositions containing them, and methods for their use |
| US6194578B1 (en) | 1998-11-20 | 2001-02-27 | Pfizer Inc. | Dipeptide derivatives |
-
1997
- 1997-12-19 CA CA002225325A patent/CA2225325A1/fr not_active Abandoned
-
1998
- 1998-12-13 US US09/581,511 patent/US7579323B1/en not_active Expired - Fee Related
- 1998-12-18 NZ NZ505086A patent/NZ505086A/en unknown
- 1998-12-18 JP JP2000525446A patent/JP4417551B2/ja not_active Expired - Fee Related
- 1998-12-18 CN CNB988124343A patent/CN100422208C/zh not_active Expired - Fee Related
- 1998-12-18 ES ES98962157T patent/ES2320499T3/es not_active Expired - Lifetime
- 1998-12-18 DK DK98962157T patent/DK1040119T3/da active
- 1998-12-18 WO PCT/CA1998/001184 patent/WO1999032509A2/fr active IP Right Grant
- 1998-12-18 AU AU17459/99A patent/AU762691C/en not_active Ceased
- 1998-12-18 KR KR1020007006814A patent/KR100937756B1/ko not_active IP Right Cessation
- 1998-12-18 EP EP98962157A patent/EP1040119B1/fr not_active Expired - Lifetime
- 1998-12-18 BR BR9813817-0A patent/BR9813817A/pt not_active Application Discontinuation
- 1998-12-18 AT AT98962157T patent/ATE419268T1/de not_active IP Right Cessation
- 1998-12-18 DE DE69840415T patent/DE69840415D1/de not_active Expired - Lifetime
- 1998-12-18 HU HU0105460A patent/HUP0105460A3/hu unknown
- 1998-12-18 CA CA2312826A patent/CA2312826C/fr not_active Expired - Fee Related
- 1998-12-18 IL IL13665498A patent/IL136654A0/xx unknown
-
2001
- 2001-07-31 HK HK01105313.8A patent/HK1034523A1/xx not_active IP Right Cessation
-
2009
- 2009-06-25 US US12/491,839 patent/US20090264487A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0105460A3 (en) | 2002-08-28 |
| AU762691B2 (en) | 2003-07-03 |
| BR9813817A (pt) | 2000-10-10 |
| EP1040119B1 (fr) | 2008-12-31 |
| CA2312826A1 (fr) | 1999-07-01 |
| CN100422208C (zh) | 2008-10-01 |
| KR100937756B1 (ko) | 2010-01-20 |
| ATE419268T1 (de) | 2009-01-15 |
| JP2001526294A (ja) | 2001-12-18 |
| WO1999032509A2 (fr) | 1999-07-01 |
| CA2225325A1 (fr) | 1999-06-19 |
| HK1034523A1 (en) | 2001-10-26 |
| NZ505086A (en) | 2003-05-30 |
| HUP0105460A2 (en) | 2002-06-29 |
| DE69840415D1 (de) | 2009-02-12 |
| US20090264487A1 (en) | 2009-10-22 |
| CA2312826C (fr) | 2013-06-11 |
| IL136654A0 (en) | 2001-06-14 |
| AU1745999A (en) | 1999-07-12 |
| EP1040119A2 (fr) | 2000-10-04 |
| US7579323B1 (en) | 2009-08-25 |
| ES2320499T3 (es) | 2009-05-22 |
| WO1999032509A3 (fr) | 1999-10-07 |
| KR20010024783A (ko) | 2001-03-26 |
| AU762691C (en) | 2004-07-08 |
| CN1282336A (zh) | 2001-01-31 |
| JP4417551B2 (ja) | 2010-02-17 |
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