[go: up one dir, main page]

HK1018464A1 - Improved process for obtaining insulin precursors having correctly bonded cystine bridges. - Google Patents

Improved process for obtaining insulin precursors having correctly bonded cystine bridges.

Info

Publication number
HK1018464A1
HK1018464A1 HK99103399A HK99103399A HK1018464A1 HK 1018464 A1 HK1018464 A1 HK 1018464A1 HK 99103399 A HK99103399 A HK 99103399A HK 99103399 A HK99103399 A HK 99103399A HK 1018464 A1 HK1018464 A1 HK 1018464A1
Authority
HK
Hong Kong
Prior art keywords
improved process
insulin precursors
cystine bridges
correctly bonded
obtaining insulin
Prior art date
Application number
HK99103399A
Other languages
English (en)
Inventor
Franz-Josef Rubroeder
Reinhold Keller
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of HK1018464A1 publication Critical patent/HK1018464A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK99103399A 1997-08-18 1999-08-06 Improved process for obtaining insulin precursors having correctly bonded cystine bridges. HK1018464A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19735711A DE19735711C2 (de) 1997-08-18 1997-08-18 Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken

Publications (1)

Publication Number Publication Date
HK1018464A1 true HK1018464A1 (en) 1999-12-24

Family

ID=7839275

Family Applications (3)

Application Number Title Priority Date Filing Date
HK99103399A HK1018464A1 (en) 1997-08-18 1999-08-06 Improved process for obtaining insulin precursors having correctly bonded cystine bridges.
HK04104835.7A HK1061870A1 (en) 1997-08-18 2004-07-06 Improved process for obtaining insulin precursors having correctly bonded cystine bridges
HK08107963.0A HK1119449A1 (en) 1997-08-18 2008-07-18 Process for obtaining insulin or insulin derivatives having correctly bonded cystine bridges

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK04104835.7A HK1061870A1 (en) 1997-08-18 2004-07-06 Improved process for obtaining insulin precursors having correctly bonded cystine bridges
HK08107963.0A HK1119449A1 (en) 1997-08-18 2008-07-18 Process for obtaining insulin or insulin derivatives having correctly bonded cystine bridges

Country Status (21)

Country Link
US (3) US5986048A (zh)
EP (2) EP0906918B1 (zh)
JP (1) JP4291900B2 (zh)
KR (2) KR100537842B1 (zh)
CN (3) CN101186940B (zh)
AR (1) AR016821A1 (zh)
AT (2) ATE217636T1 (zh)
AU (1) AU744824B2 (zh)
BR (2) BRPI9816233B8 (zh)
CA (1) CA2245151C (zh)
CZ (1) CZ295679B6 (zh)
DE (3) DE19735711C2 (zh)
DK (2) DK0906918T3 (zh)
ES (2) ES2177178T3 (zh)
HK (3) HK1018464A1 (zh)
HU (2) HU228161B1 (zh)
ID (1) ID20717A (zh)
PL (1) PL191901B1 (zh)
PT (2) PT980874E (zh)
RU (2) RU2205836C2 (zh)
TR (1) TR199801587A3 (zh)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19735711C2 (de) 1997-08-18 2001-04-26 Aventis Pharma Gmbh Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken
DE19930676B4 (de) 1999-07-02 2006-01-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
AU2151401A (en) 1999-12-22 2001-07-03 Novo Nordisk A/S Method for extractive refolding of scrambled single-chain polypeptides
WO2002004481A2 (en) * 2000-07-12 2002-01-17 Eli Lilly And Company Process to increase protein stability
DE10235168A1 (de) * 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
DE102004015965A1 (de) * 2004-04-01 2005-10-20 Aventis Pharma Gmbh Verfahren zur Gewinnung von Insulinen durch verbesserte Luftbegasung der Faltung
CA2633554C (en) 2005-12-22 2012-11-13 Genetech, Inc. Recombinant production of heparin binding proteins
AR062069A1 (es) * 2006-07-14 2008-10-15 Genentech Inc Replegado de proteinas recombinantes
RU2468373C2 (ru) * 2007-07-03 2012-11-27 Эмджен Инк. Количественное определение белков с использованием сухого веса внутриклеточных телец
RU2451750C2 (ru) * 2007-09-24 2012-05-27 Общество С Ограниченной Ответственностью "Герофарм" Способ получения рекомбинантного с-пептида проинсулина человека
CN102007143B (zh) 2008-01-09 2015-08-26 塞诺菲-安万特德国有限公司 具有超延迟时效特征的新型胰岛素衍生物
JP5677938B2 (ja) * 2008-04-30 2015-02-25 ウォックハート リサーチ センター インシュリンの再折りたたみ方法
US9526764B2 (en) 2008-10-17 2016-12-27 Sanofi-Aventis Deutschland Gmbh Combination of an insulin and a GLP-1-agonist
WO2011058082A1 (de) 2009-11-13 2011-05-19 Sanofi-Aventis Deutschland Gmbh Pharmazeutische zusammensetzung umfassend einen glp-1-agonisten und methionin
HUE038147T2 (hu) 2009-11-13 2018-09-28 Sanofi Aventis Deutschland GLP-1 agonistát, inzulint és metionint tartalmazó gyógyászati készítmény
WO2012028172A1 (en) 2010-08-30 2012-03-08 Sanofi-Aventis Deutschland Gmbh Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
US12157766B2 (en) * 2012-08-05 2024-12-03 Absci Corporation Cytoplasmic expression system
EP2931301B2 (en) 2012-12-17 2021-09-15 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
TWI755579B (zh) * 2013-02-26 2022-02-21 南韓商韓美藥品股份有限公司 新穎胰島素類似物及其用途
CN103694339B (zh) * 2013-12-04 2017-10-13 珠海联邦制药股份有限公司 一种甘精胰岛素前体的复性方法
US10407483B2 (en) 2014-03-14 2019-09-10 Merck Sharp & Dohme Corp. Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature
HRP20230470T1 (hr) 2014-12-12 2023-07-21 Sanofi-Aventis Deutschland Gmbh Formulacija fiksnog omjera inzulin glargin/liksisenatid
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
CN104911203A (zh) * 2015-06-30 2015-09-16 成都易胜科生物科技有限公司 一种重组人胰岛素的工业制备方法
WO2017040363A1 (en) 2015-09-02 2017-03-09 Merck Sharp & Dohme Corp. A process for obtaining insulin with correctly formed disulfide bonds
WO2017205309A1 (en) * 2016-05-25 2017-11-30 Merck Sharp & Dohme Corp. Insulin receptor partial agonists
WO2018018613A1 (zh) 2016-07-29 2018-02-01 广东东阳光药业有限公司 一种提高抗体纯度的细胞培养基和培养方法
CN113773391B (zh) * 2020-06-09 2023-10-20 宁波鲲鹏生物科技有限公司 一种门冬胰岛素的制备方法
CN113773400B (zh) * 2020-06-09 2023-08-18 宁波鲲鹏生物科技有限公司 一种门冬胰岛素衍生物及其应用
CN113773396A (zh) * 2020-06-10 2021-12-10 宁波鲲鹏生物科技有限公司 一种地特胰岛素衍生物及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
DE3501641A1 (de) * 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
GR1005153B (el) * 1989-08-29 2006-03-13 The General Hospital Corporation Πρωτεινες συντηξεως, παρασκευη τους και χρηση τους.
EP0600372B1 (de) * 1992-12-02 1997-02-05 Hoechst Aktiengesellschaft Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
ATE350053T1 (de) * 1994-12-29 2007-01-15 Ferring Int Ct Sa Herstellung von humaninsulin
DE19735711C2 (de) * 1997-08-18 2001-04-26 Aventis Pharma Gmbh Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken

Also Published As

Publication number Publication date
ES2176870T3 (es) 2002-12-01
DE59804121D1 (de) 2002-06-20
EP0906918A2 (de) 1999-04-07
AU8076398A (en) 1999-02-25
EP0906918B1 (de) 2002-05-15
TR199801587A2 (xx) 1999-03-22
KR20050067371A (ko) 2005-07-01
HU228203B1 (en) 2013-01-28
CN1483831A (zh) 2004-03-24
KR100574580B1 (ko) 2006-04-28
HK1061870A1 (en) 2004-10-08
CA2245151C (en) 2009-10-06
ID20717A (id) 1999-02-18
DK0906918T3 (da) 2002-09-09
KR100537842B1 (ko) 2006-03-23
RU2205836C2 (ru) 2003-06-10
ES2177178T3 (es) 2002-12-01
PT980874E (pt) 2002-10-31
JPH11130798A (ja) 1999-05-18
EP0906918A3 (de) 1999-08-11
US6727346B2 (en) 2004-04-27
DE19735711C2 (de) 2001-04-26
CN1483831B (zh) 2012-06-13
CZ295679B6 (cs) 2005-09-14
CA2245151A1 (en) 1999-02-18
KR19990023651A (ko) 1999-03-25
ATE217012T1 (de) 2002-05-15
RU2302882C2 (ru) 2007-07-20
HUP9801886A2 (hu) 1999-01-28
CN101186940B (zh) 2012-02-08
HU228161B1 (en) 2013-01-28
BRPI9816233B1 (pt) 2016-09-27
AR016821A1 (es) 2001-08-01
CZ259898A3 (cs) 1999-03-17
DE59803985D1 (de) 2002-06-06
HK1119449A1 (en) 2009-03-06
ATE217636T1 (de) 2002-06-15
EP0980874B1 (de) 2002-05-02
PT906918E (pt) 2002-10-31
TR199801587A3 (tr) 1999-03-22
PL191901B1 (pl) 2006-07-31
BR9803755A (pt) 2000-03-28
DK0980874T3 (da) 2002-08-19
DE19735711A1 (de) 1999-02-25
EP0980874A1 (de) 2000-02-23
US6380355B1 (en) 2002-04-30
CN1132845C (zh) 2003-12-31
CN1209437A (zh) 1999-03-03
HU9801886D0 (en) 1998-10-28
BRPI9816233B8 (pt) 2021-05-25
PL328108A1 (en) 1999-03-01
HU0600287D0 (en) 2006-05-29
AU744824B2 (en) 2002-03-07
CN101186940A (zh) 2008-05-28
HUP9801886A3 (en) 1999-06-28
JP4291900B2 (ja) 2009-07-08
US5986048A (en) 1999-11-16
US20020156234A1 (en) 2002-10-24

Similar Documents

Publication Publication Date Title
HK1018464A1 (en) Improved process for obtaining insulin precursors having correctly bonded cystine bridges.
ZA99104B (en) Method for administering ASPB28-human insulin.
ZA989767B (en) Novel compounds.
ZA9811911B (en) Aryl fused azapolycyclic compounds.
EP0670413A3 (en) Quick connector for cementing head.
ZA983695B (en) Adhesive composition.
HK1025746A1 (en) Syringe.
EP0987332A4 (en) METHOD FOR PRODUCING OPTICALLY ACTIVE AMINO COMPOUNDS
ZA985374B (en) Specific C-peptide determination method.
HUP0001136A3 (en) Remedies for lymphocytic tumors
GB9711124D0 (en) Novel cyanoguanidines
EP1026255A4 (en) PROCESS FOR THE PREPARATION OF XYLITOL
HK1056360A1 (en) Process for preparing pesticidal intermediates.
ZA9811572B (en) Novel anti-diabetic composition.
GB9711119D0 (en) Novel cyanoguanidines
ZA9811758B (en) Novel compounds.
EP0999848A4 (en) CHIMEAN PROTEINS FOR TREATING DIABETES
EP1019359A4 (en) TECHNIQUE FOR THE PREPARATION OF AMINOARYLACETYLENES
ZA9811503B (en) Novel compounds.
EG23935A (en) Process for preparing eprosartin
GB9711127D0 (en) Novel cyanoguanidines
HUP0003452A3 (en) Process for the preparation of 1-aryl-3-cyclopropyl-1,3-propanediones
EG22077A (en) Process for preparing 4-substituted-ih-indole-3 glyoxamides
EP1026254A4 (en) METHOD FOR PRODUCING XYLITOL
ZA982255B (en) Process for the preparation of arylmalonates.

Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20180816