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HK1017361A1 - Colchicine derivatives and the therapeutical use thereof - Google Patents

Colchicine derivatives and the therapeutical use thereof Download PDF

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Publication number
HK1017361A1
HK1017361A1 HK99102643A HK99102643A HK1017361A1 HK 1017361 A1 HK1017361 A1 HK 1017361A1 HK 99102643 A HK99102643 A HK 99102643A HK 99102643 A HK99102643 A HK 99102643A HK 1017361 A1 HK1017361 A1 HK 1017361A1
Authority
HK
Hong Kong
Prior art keywords
compounds
glucose
residue
carbon atoms
groups
Prior art date
Application number
HK99102643A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1017361B (en
Inventor
Bombardelli Ezio
Gabetta Bruno
Original Assignee
Indena S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena S.P.A. filed Critical Indena S.P.A.
Publication of HK1017361A1 publication Critical patent/HK1017361A1/en
Publication of HK1017361B publication Critical patent/HK1017361B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40Y being a hydrogen or a carbon atom
    • C07C323/41Y being a hydrogen or an acyclic carbon atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/248Colchicine radicals, e.g. colchicosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
HK99102643.9A 1994-10-05 1998-01-16 Colchicine derivatives and the therapeutical use thereof HK1017361B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI942026A IT1270124B (it) 1994-10-05 1994-10-05 Derivati della colchicina e loro impiego terapeutico
ITMI942026 1994-10-05

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
HK98100368.7A Addition HK1001394B (en) 1994-10-05 1995-09-27 Colchicine derivatives and the therapeutical use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
HK98100368.7A Division HK1001394B (en) 1994-10-05 1995-09-27 Colchicine derivatives and the therapeutical use thereof

Publications (2)

Publication Number Publication Date
HK1017361A1 true HK1017361A1 (en) 1999-11-19
HK1017361B HK1017361B (en) 2004-10-29

Family

ID=

Also Published As

Publication number Publication date
ATE271061T1 (de) 2004-07-15
FI120452B (fi) 2009-10-30
CZ101597A3 (en) 1997-10-15
CN1308059A (zh) 2001-08-15
WO1996011184A1 (en) 1996-04-18
JP2921990B2 (ja) 1999-07-19
SK281831B6 (sk) 2001-08-06
PL182204B1 (en) 2001-11-30
DK0784613T3 (da) 1999-11-15
ATE181060T1 (de) 1999-06-15
CA2201723C (en) 2003-03-25
FI971364A0 (fi) 1997-04-03
IT1270124B (it) 1997-04-28
JPH10507169A (ja) 1998-07-14
NO308030B1 (no) 2000-07-10
CZ290309B6 (cs) 2002-07-17
ES2131863T3 (es) 1999-08-01
GR3030449T3 (en) 1999-09-30
CN1075059C (zh) 2001-11-21
FI971364L (fi) 1997-05-30
AU3743295A (en) 1996-05-02
CA2201723A1 (en) 1996-04-18
CN1127480C (zh) 2003-11-12
NO971503D0 (no) 1997-04-03
HK1001394A1 (en) 1998-06-19
US5843910A (en) 1998-12-01
DE69533267D1 (de) 2004-08-19
EP0784613B1 (en) 1999-06-09
PT909763E (pt) 2004-10-29
EP0909763A2 (en) 1999-04-21
DE69510212D1 (de) 1999-07-15
CN1159801A (zh) 1997-09-17
HU223779B1 (hu) 2005-01-28
PL319455A1 (en) 1997-08-04
ES2224322T3 (es) 2005-03-01
ITMI942026A1 (it) 1996-04-05
EP0909763B1 (en) 2004-07-14
DE69510212T2 (de) 1999-11-11
KR100255074B1 (ko) 2000-05-01
RU2145598C1 (ru) 2000-02-20
EP0784613A1 (en) 1997-07-23
DE69533267T2 (de) 2005-08-04
DK0909763T3 (da) 2004-11-22
HUT77223A (hu) 1998-03-02
ITMI942026A0 (it) 1994-10-05
AU692624B2 (en) 1998-06-11
EP0909763A3 (en) 2003-01-22
SK42497A3 (en) 1997-11-05
NO971503L (no) 1997-05-14

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100927