HK1008146A1 - Peptidic ketones as interleukin-1beta-converting enzyme inhibitors - Google Patents

Peptidic ketones as interleukin-1beta-converting enzyme inhibitors Download PDF

Info

Publication number: HK1008146A1
Authority: HK; Hong Kong
Prior art keywords: ketone; benzyloxycarbonyl; aspartic acid; tetronoyloxymethyl; aryl
Prior art date: 1993-05-07

Application number

HK98109010A

Other languages

German (de)

English (en)

French (fr)

Chinese (zh)

Other versions

HK1008146B (en

Inventor

E. Dolle Roland

L. Graybill Todd

J. Speier Gray

P. Prouty Catherine

J. Schmidt Stanley

Original Assignee

Vertex Pharmaceuticals Incorporated

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-07

Filing date

1998-07-07

Publication date

1999-04-30

1998-07-07 Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated

1999-04-30 Publication of HK1008146B publication Critical patent/HK1008146B/en

1999-04-30 Publication of HK1008146A1 publication Critical patent/HK1008146A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Crystallography & Structural Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Rheumatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Enzymes And Modification Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

HK98109010A 1993-05-07 1998-07-07 Peptidic ketones as interleukin-1beta-converting enzyme inhibitors HK1008146A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/060,197 US5462939A (en)	1993-05-07	1993-05-07	Peptidic ketones as interleukin-1β-converting enzyme inhibitors
US60197		1993-05-07

Publications (2)

Publication Number	Publication Date
HK1008146B HK1008146B (en)	1999-04-30
HK1008146A1 true HK1008146A1 (en)	1999-04-30

Family

ID=22027975

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK98109010A HK1008146A1 (en)	1993-05-07	1998-07-07	Peptidic ketones as interleukin-1beta-converting enzyme inhibitors

Country Status (21)

Country	Link
US (2)	US5462939A (xx)
EP (1)	EP0623606B1 (xx)
JP (1)	JPH0725839A (xx)
AT (1)	ATE161849T1 (xx)
AU (1)	AU668465B2 (xx)
CA (1)	CA2123055A1 (xx)
CZ (1)	CZ108394A3 (xx)
DE (1)	DE69407654T2 (xx)
DK (1)	DK0623606T3 (xx)
ES (1)	ES2113606T3 (xx)
FI (1)	FI942107A7 (xx)
GR (1)	GR3026556T3 (xx)
HK (1)	HK1008146A1 (xx)
HU (1)	HU217070B (xx)
IL (1)	IL109585A0 (xx)
NO (1)	NO941675L (xx)
NZ (1)	NZ260477A (xx)
PH (1)	PH30362A (xx)
RU (1)	RU2133251C1 (xx)
SK (1)	SK282270B6 (xx)
TW (1)	TW377350B (xx)

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US6008217A (en) *	1995-12-20	1999-12-28	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US5874424A (en) *	1995-12-20	1999-02-23	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US6204261B1 (en)	1995-12-20	2001-03-20	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β Converting enzyme inhibitors
US5462939A (en) *	1993-05-07	1995-10-31	Sterling Winthrop Inc.	Peptidic ketones as interleukin-1β-converting enzyme inhibitors
JPH0789951A (ja) *	1993-06-03	1995-04-04	Sterling Winthrop Inc	インターロイキン−１β転換酵素阻害剤
US5843905A (en) *	1993-06-04	1998-12-01	Vertex Pharmaceuticals, Incorporated	Peptidic phosphinyloxymethyl ketones as interleukin-1β-converting enzyme inhibitors
US5714484A (en) *	1993-12-08	1998-02-03	Prototek, Inc.	α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors
US5486623A (en)	1993-12-08	1996-01-23	Prototek, Inc.	Cysteine protease inhibitors containing heterocyclic leaving groups
US5798247A (en) *	1994-05-06	1998-08-25	Basf Aktiengesellschaft	Organic-chemical compound with ice-inhibitory action
US6420522B1 (en)	1995-06-05	2002-07-16	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US5716929A (en) *	1994-06-17	1998-02-10	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US5756466A (en) *	1994-06-17	1998-05-26	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US5847135A (en) *	1994-06-17	1998-12-08	Vertex Pharmaceuticals, Incorporated	Inhibitors of interleukin-1β converting enzyme
US5585504A (en) *	1994-09-16	1996-12-17	Merck & Co., Inc.	Process of making cox-2 inhibitors having a lactone bridge
WO1996029088A1 (en) *	1995-03-23	1996-09-26	Affymax Technologies N.V.	Novel piperazine derivatives as type il-1 receptor antagonists
US6162828A (en) *	1995-03-31	2000-12-19	Takeda Chemical Industries, Ltd.	Cysteine protease inhibitor
CN1221514C (zh) *	1995-05-09	2005-10-05	拜尔公司	制备烷基－二卤代苯基取代的酮烯醇的中间体
US5843904A (en) *	1995-12-20	1998-12-01	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1βconverting enzyme
US5869519A (en) *	1996-12-16	1999-02-09	Idun Pharmaceuticals, Inc.	C-terminal modified (n-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US5968927A (en) *	1996-09-20	1999-10-19	Idun Pharmaceuticals, Inc.	Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes
US5877197A (en) *	1996-12-16	1999-03-02	Karanewsky; Donald S.	C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6184244B1 (en)	1996-12-16	2001-02-06	Idun Pharmaceuticals, Inc.	C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6184210B1 (en)	1997-10-10	2001-02-06	Cytovia, Inc.	Dipeptide apoptosis inhibitors and the use thereof
BR9814817A (pt) *	1997-10-10	2002-01-08	Cytovia Inc	Inibidores de apoptose de dipeptìdio e o uso dos mesmos
CN1278243A (zh) *	1997-11-06	2000-12-27	西巴特殊化学品控股有限公司	二酯胺加合物
ATE296812T1 (de)	1998-03-09	2005-06-15	Vertex Pharma	1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms
KR20010041905A (ko) *	1998-03-16	2001-05-25	시토비아 인크.	디펩티드 카스파제 억제제 및 이의 용도
HU227920B1 (en) *	1998-03-19	2012-06-28	Vertex Pharma	Inhibitors of caspases, pharmaceutical compositions comprising thereof and their use
US6242422B1 (en)	1998-10-22	2001-06-05	Idun Pharmacueticals, Inc.	(Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
US7157430B2 (en)	1998-10-22	2007-01-02	Idun Pharmaceuticals, Inc.	(Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases
WO2000055114A1 (en) *	1999-03-16	2000-09-21	Cytovia, Inc.	Substituted 2-aminobenzamide caspase inhibitors and the use thereof
ATE363465T1 (de) *	1999-04-09	2007-06-15	Cytovia Inc	Caspase inhibitoren und ihre verwendung
JP2003508379A (ja)	1999-08-27	2003-03-04	サイトビアインコーポレイテッド	置換α−ヒドロキシ酸カスパーゼインヒビターおよびその使用
US6566338B1 (en)	1999-10-12	2003-05-20	Cytovia, Inc.	Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death
US6525024B1 (en)	2000-04-17	2003-02-25	Idun Pharmaceuticals, Inc.	Inhibitors of the ICE/ced-3 family of cysteine proteases
PE20011350A1 (es) *	2000-05-19	2002-01-15	Vertex Pharma	PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
CA2421172A1 (en)	2000-09-08	2002-03-14	Merck Frosst Canada & Co.	Gamma-ketoacid dipeptides as inhibitors of caspase-3
US6699866B2 (en) *	2001-04-17	2004-03-02	Sepracor Inc.	Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof
DE10150203A1 (de) *	2001-10-12	2003-04-17	Probiodrug Ag	Peptidylketone als Inhibitoren der DPIV
WO2003068242A1 (en) *	2002-02-11	2003-08-21	Vertex Pharmaceuticals Incorporated	Phospholipids as caspase inhibitor prodrugs
US20060128696A1 (en) *	2004-05-15	2006-06-15	Annamaria Vezzani	Treating seizures using ice inhibitors
CN1980658A (zh) *	2004-05-27	2007-06-13	沃泰克斯药物股份有限公司	治疗自身炎性疾病的ice抑制剂
US9956260B1 (en)	2011-07-22	2018-05-01	The J. David Gladstone Institutes	Treatment of HIV-1 infection and AIDS

Family Cites Families (9)

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Publication number	Priority date	Publication date	Assignee	Title
US4582821A (en) *	1983-11-16	1986-04-15	E. I. Du Pont De Nemours And Company	Inhibition of cyclic nucleotide independent protein kinases
US5055451A (en) *	1986-12-22	1991-10-08	Syntex Inc.	Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
DE3737399A1 (de) *	1987-11-04	1989-05-18	Schwabe Willmar Gmbh & Co	Aminosaeureester, verfahren zu ihrer herstellung und ihre verwendung
AU7775991A (en) *	1990-04-04	1991-10-30	Immunex Corporation	Interleukin 1beta protease
EP0519748B1 (en) *	1991-06-21	1998-09-02	Merck & Co. Inc.	Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme
DK0600880T3 (da) *	1991-08-30	2004-04-13	Vertex Pharma	Interleukin 1-beta-protease og interleukin 1-beta-proteasehæmmere
GB9123326D0 (en) *	1991-11-04	1991-12-18	Sandoz Ltd	Improvements in or relating to organic compounds
JP3386125B2 (ja) *	1992-02-21	2003-03-17	メルクエンドカンパニーインコーポレーテッド	インターロイキン−１β変換酵素阻害剤としてのペプチジル誘導体
US5462939A (en) *	1993-05-07	1995-10-31	Sterling Winthrop Inc.	Peptidic ketones as interleukin-1β-converting enzyme inhibitors

1993
- 1993-05-07 US US08/060,197 patent/US5462939A/en not_active Expired - Lifetime
1994
- 1994-04-12 TW TW083103254A patent/TW377350B/zh active
- 1994-04-28 JP JP6091021A patent/JPH0725839A/ja active Pending
- 1994-04-29 DK DK94201192T patent/DK0623606T3/da active
- 1994-04-29 AT AT94201192T patent/ATE161849T1/de not_active IP Right Cessation
- 1994-04-29 EP EP94201192A patent/EP0623606B1/en not_active Expired - Lifetime
- 1994-04-29 ES ES94201192T patent/ES2113606T3/es not_active Expired - Lifetime
- 1994-04-29 DE DE69407654T patent/DE69407654T2/de not_active Expired - Lifetime
- 1994-05-02 SK SK509-94A patent/SK282270B6/sk unknown
- 1994-05-03 CZ CZ941083A patent/CZ108394A3/cs unknown
- 1994-05-06 RU RU94015842A patent/RU2133251C1/ru not_active IP Right Cessation
- 1994-05-06 HU HU9401423A patent/HU217070B/hu not_active IP Right Cessation
- 1994-05-06 FI FI942107A patent/FI942107A7/fi unknown
- 1994-05-06 IL IL10958594A patent/IL109585A0/xx unknown
- 1994-05-06 AU AU61906/94A patent/AU668465B2/en not_active Ceased
- 1994-05-06 NZ NZ260477A patent/NZ260477A/en not_active IP Right Cessation
- 1994-05-06 CA CA002123055A patent/CA2123055A1/en not_active Abandoned
- 1994-05-06 NO NO941675A patent/NO941675L/no unknown
- 1994-05-06 PH PH48226A patent/PH30362A/en unknown
1995
- 1995-05-12 US US08/440,166 patent/US5585486A/en not_active Expired - Lifetime
1998
- 1998-04-06 GR GR980400743T patent/GR3026556T3/el unknown
- 1998-07-07 HK HK98109010A patent/HK1008146A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU6190694A (en)	1994-11-10
HU217070B (hu)	1999-11-29
SK50994A3 (en)	1995-02-08
CA2123055A1 (en)	1994-11-08
DK0623606T3 (da)	1998-09-07
US5462939A (en)	1995-10-31
FI942107L (fi)	1994-11-08
US5585486A (en)	1996-12-17
NO941675D0 (no)	1994-05-06
FI942107A0 (fi)	1994-05-06
NO941675L (no)	1994-11-08
PH30362A (en)	1997-04-02
EP0623606A3 (en)	1994-12-07
HUT68791A (en)	1995-07-28
JPH0725839A (ja)	1995-01-27
DE69407654T2 (de)	1999-01-21
TW377350B (en)	1999-12-21
HU9401423D0 (en)	1994-08-29
EP0623606A2 (en)	1994-11-09
CZ108394A3 (en)	1994-12-15
EP0623606B1 (en)	1998-01-07
DE69407654D1 (de)	1998-02-12
SK282270B6 (sk)	2001-12-03
AU668465B2 (en)	1996-05-02
ATE161849T1 (de)	1998-01-15
RU2133251C1 (ru)	1999-07-20
GR3026556T3 (en)	1998-07-31
NZ260477A (en)	1995-12-21
ES2113606T3 (es)	1998-05-01
FI942107A7 (fi)	1994-11-08
IL109585A0 (en)	1994-08-26

Publication	Publication Date	Title
EP0623606B1 (en)	1998-01-07	Peptidic ketones as interleukin-1beta-converting enzyme inhibitors
HK1008146B (en)	1999-04-30	Peptidic ketones as interleukin-1beta-converting enzyme inhibitors
US5677283A (en)	1997-10-14	α-heteroaryloxymethyl ketones as interleukin - 1 β converting enzyme inhibitors
EP0644197B1 (en)	1998-09-09	Peptidic phosphinyloxymethyl ketones as interleukin-1beta-converting enzyme inhibitors
EP0623592B1 (en)	2001-06-27	Peptide analogs as irreversible interleukin-1beta protease inhibitors
AU703451B2 (en)	1999-03-25	N-(pyrimidinyl)-aspartic acid analogs as interleukin-1beta converting enzyme inhibitors
AU705882B2 (en)	1999-06-03	Bicyclic lactam inhibitors of interleukin-1-beta converting enzyme
EP0434365A2 (en)	1991-06-26	HIV protease inhibitors useful for the treatment of aids
EP0356223A2 (en)	1990-02-28	HIV protease inhibitors useful for the treatment of aids
EP0331921A1 (en)	1989-09-13	Renin inhibitors containing alpha-heteroatom amino acids
US5843905A (en)	1998-12-01	Peptidic phosphinyloxymethyl ketones as interleukin-1β-converting enzyme inhibitors
US20040009923A1 (en)	2004-01-15	Peptide analogs as irreversible interleukin-1beta protease inhibitors
EP0158947B1 (en)	1991-02-06	Amino thiol dipeptides
JPH04275263A (ja)	1992-09-30	キラルα−アミノアルデヒドからの、ヒドロキシエステル、ヒドロキシアミド及びラクトン化合物の立体制御された製造法
HK1013982A (en)	1999-09-17	Peptide analogs as irreversible interleukin-1 beta protease inhibitors

Legal Events

Date	Code	Title	Description
2004-12-15	PF	Patent in force
2006-12-08	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20060429