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ES2113606T3 - Cetonas peptidicas como inhibidores de la enzima convertidora de la interleuquina-1beta. - Google Patents

Cetonas peptidicas como inhibidores de la enzima convertidora de la interleuquina-1beta.

Info

Publication number
ES2113606T3
ES2113606T3 ES94201192T ES94201192T ES2113606T3 ES 2113606 T3 ES2113606 T3 ES 2113606T3 ES 94201192 T ES94201192 T ES 94201192T ES 94201192 T ES94201192 T ES 94201192T ES 2113606 T3 ES2113606 T3 ES 2113606T3
Authority
ES
Spain
Prior art keywords
interleukin
cr5r6
lysine
components
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94201192T
Other languages
English (en)
Inventor
Roland E Dolle
Todd L Graybill
Gary J Speier
Catherine P Prouty
Stanley J Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2113606T3 publication Critical patent/ES2113606T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE DESCRIBEN COMPONENTES DE LA FORMULA (I) Y SALES CONSIGUIENTES FARMACEUTICAMENTE ACEPTABLES:;DONDE R1 ES (CR5R6)N RILO, (CR5R6)N LO O X SER OPCIONALMENTE SUSTITUIDOS; X ES O O NR5; R5 Y R6 SON INDEPENDIENTEMENTE H O ALQUIL INFERIOR; R2 ES H, HALO, ALQUILO INFERIOR O (CR5R6)N QUILO; A ES UN ISOMERO D O L DE UN AMINOACIDO SELECCIONADO DEL GRUPO QUE CONSISTE EN ALANINA, VALINA, LEUCINA, ISOLEUCINA, PROLINA, FENILANINA, GLICINA, TIROSINA, MECIONINA, ASPARAGINA, GLUTAMINA, ACIDO ASPARTICO, ACIDO GLUTAMICO, LISINA, ARGININA, HISTIDINA Y BETA-TIENILALANINA; Z ES CH2 U O; Y N ES 0-4; COMPUESTOS FARMACEUTICOS QUE CONTIENEN LOS COMPONENTES; Y UN METODO PARA INHIBIR LA ACTIVIDAD DE LA PROTEASA INTERLEUCINA-1BETA EN UN MAMIFERO QUE UTILIZA LOS COMPONENTES Y LAS COMPOSICIONES.
ES94201192T 1993-05-07 1994-04-29 Cetonas peptidicas como inhibidores de la enzima convertidora de la interleuquina-1beta. Expired - Lifetime ES2113606T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/060,197 US5462939A (en) 1993-05-07 1993-05-07 Peptidic ketones as interleukin-1β-converting enzyme inhibitors

Publications (1)

Publication Number Publication Date
ES2113606T3 true ES2113606T3 (es) 1998-05-01

Family

ID=22027975

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94201192T Expired - Lifetime ES2113606T3 (es) 1993-05-07 1994-04-29 Cetonas peptidicas como inhibidores de la enzima convertidora de la interleuquina-1beta.

Country Status (21)

Country Link
US (2) US5462939A (es)
EP (1) EP0623606B1 (es)
JP (1) JPH0725839A (es)
AT (1) ATE161849T1 (es)
AU (1) AU668465B2 (es)
CA (1) CA2123055A1 (es)
CZ (1) CZ108394A3 (es)
DE (1) DE69407654T2 (es)
DK (1) DK0623606T3 (es)
ES (1) ES2113606T3 (es)
FI (1) FI942107A7 (es)
GR (1) GR3026556T3 (es)
HK (1) HK1008146A1 (es)
HU (1) HU217070B (es)
IL (1) IL109585A0 (es)
NO (1) NO941675L (es)
NZ (1) NZ260477A (es)
PH (1) PH30362A (es)
RU (1) RU2133251C1 (es)
SK (1) SK282270B6 (es)
TW (1) TW377350B (es)

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US6008217A (en) * 1995-12-20 1999-12-28 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US5874424A (en) * 1995-12-20 1999-02-23 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US6204261B1 (en) 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5462939A (en) * 1993-05-07 1995-10-31 Sterling Winthrop Inc. Peptidic ketones as interleukin-1β-converting enzyme inhibitors
JPH0789951A (ja) * 1993-06-03 1995-04-04 Sterling Winthrop Inc インターロイキン−１β転換酵素阻害剤
US5843905A (en) * 1993-06-04 1998-12-01 Vertex Pharmaceuticals, Incorporated Peptidic phosphinyloxymethyl ketones as interleukin-1β-converting enzyme inhibitors
US5714484A (en) * 1993-12-08 1998-02-03 Prototek, Inc. α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors
US5486623A (en) 1993-12-08 1996-01-23 Prototek, Inc. Cysteine protease inhibitors containing heterocyclic leaving groups
US5798247A (en) * 1994-05-06 1998-08-25 Basf Aktiengesellschaft Organic-chemical compound with ice-inhibitory action
US6420522B1 (en) 1995-06-05 2002-07-16 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5756466A (en) * 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5847135A (en) * 1994-06-17 1998-12-08 Vertex Pharmaceuticals, Incorporated Inhibitors of interleukin-1β converting enzyme
US5585504A (en) * 1994-09-16 1996-12-17 Merck & Co., Inc. Process of making cox-2 inhibitors having a lactone bridge
WO1996029088A1 (en) * 1995-03-23 1996-09-26 Affymax Technologies N.V. Novel piperazine derivatives as type il-1 receptor antagonists
US6162828A (en) * 1995-03-31 2000-12-19 Takeda Chemical Industries, Ltd. Cysteine protease inhibitor
CN1221514C (zh) * 1995-05-09 2005-10-05 拜尔公司 制备烷基－二卤代苯基取代的酮烯醇的中间体
US5843904A (en) * 1995-12-20 1998-12-01 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1βconverting enzyme
US5869519A (en) * 1996-12-16 1999-02-09 Idun Pharmaceuticals, Inc. C-terminal modified (n-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US5968927A (en) * 1996-09-20 1999-10-19 Idun Pharmaceuticals, Inc. Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes
US5877197A (en) * 1996-12-16 1999-03-02 Karanewsky; Donald S. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6184244B1 (en) 1996-12-16 2001-02-06 Idun Pharmaceuticals, Inc. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6184210B1 (en) 1997-10-10 2001-02-06 Cytovia, Inc. Dipeptide apoptosis inhibitors and the use thereof
BR9814817A (pt) * 1997-10-10 2002-01-08 Cytovia Inc Inibidores de apoptose de dipeptìdio e o uso dos mesmos
CN1278243A (zh) * 1997-11-06 2000-12-27 西巴特殊化学品控股有限公司 二酯胺加合物
ATE296812T1 (de) 1998-03-09 2005-06-15 Vertex Pharma 1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms
KR20010041905A (ko) * 1998-03-16 2001-05-25 시토비아 인크. 디펩티드 카스파제 억제제 및 이의 용도
HU227920B1 (en) * 1998-03-19 2012-06-28 Vertex Pharma Inhibitors of caspases, pharmaceutical compositions comprising thereof and their use
US6242422B1 (en) 1998-10-22 2001-06-05 Idun Pharmacueticals, Inc. (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
US7157430B2 (en) 1998-10-22 2007-01-02 Idun Pharmaceuticals, Inc. (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases
WO2000055114A1 (en) * 1999-03-16 2000-09-21 Cytovia, Inc. Substituted 2-aminobenzamide caspase inhibitors and the use thereof
ATE363465T1 (de) * 1999-04-09 2007-06-15 Cytovia Inc Caspase inhibitoren und ihre verwendung
JP2003508379A (ja) 1999-08-27 2003-03-04 サイトビア インコーポレイテッド 置換α−ヒドロキシ酸カスパーゼインヒビターおよびその使用
US6566338B1 (en) 1999-10-12 2003-05-20 Cytovia, Inc. Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death
US6525024B1 (en) 2000-04-17 2003-02-25 Idun Pharmaceuticals, Inc. Inhibitors of the ICE/ced-3 family of cysteine proteases
PE20011350A1 (es) * 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
CA2421172A1 (en) 2000-09-08 2002-03-14 Merck Frosst Canada & Co. Gamma-ketoacid dipeptides as inhibitors of caspase-3
US6699866B2 (en) * 2001-04-17 2004-03-02 Sepracor Inc. Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof
DE10150203A1 (de) * 2001-10-12 2003-04-17 Probiodrug Ag Peptidylketone als Inhibitoren der DPIV
WO2003068242A1 (en) * 2002-02-11 2003-08-21 Vertex Pharmaceuticals Incorporated Phospholipids as caspase inhibitor prodrugs
US20060128696A1 (en) * 2004-05-15 2006-06-15 Annamaria Vezzani Treating seizures using ice inhibitors
CN1980658A (zh) * 2004-05-27 2007-06-13 沃泰克斯药物股份有限公司 治疗自身炎性疾病的ice抑制剂
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS

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US4582821A (en) * 1983-11-16 1986-04-15 E. I. Du Pont De Nemours And Company Inhibition of cyclic nucleotide independent protein kinases
US5055451A (en) * 1986-12-22 1991-10-08 Syntex Inc. Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
DE3737399A1 (de) * 1987-11-04 1989-05-18 Schwabe Willmar Gmbh & Co Aminosaeureester, verfahren zu ihrer herstellung und ihre verwendung
AU7775991A (en) * 1990-04-04 1991-10-30 Immunex Corporation Interleukin 1beta protease
EP0519748B1 (en) * 1991-06-21 1998-09-02 Merck & Co. Inc. Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme
DK0600880T3 (da) * 1991-08-30 2004-04-13 Vertex Pharma Interleukin 1-beta-protease og interleukin 1-beta-proteasehæmmere
GB9123326D0 (en) * 1991-11-04 1991-12-18 Sandoz Ltd Improvements in or relating to organic compounds
JP3386125B2 (ja) * 1992-02-21 2003-03-17 メルク エンド カンパニー インコーポレーテッド インターロイキン−１β変換酵素阻害剤としてのペプチジル誘導体
US5462939A (en) * 1993-05-07 1995-10-31 Sterling Winthrop Inc. Peptidic ketones as interleukin-1β-converting enzyme inhibitors

Also Published As

Publication number Publication date
AU6190694A (en) 1994-11-10
HU217070B (hu) 1999-11-29
SK50994A3 (en) 1995-02-08
CA2123055A1 (en) 1994-11-08
DK0623606T3 (da) 1998-09-07
US5462939A (en) 1995-10-31
FI942107L (fi) 1994-11-08
US5585486A (en) 1996-12-17
NO941675D0 (no) 1994-05-06
FI942107A0 (fi) 1994-05-06
NO941675L (no) 1994-11-08
HK1008146A1 (en) 1999-04-30
PH30362A (en) 1997-04-02
EP0623606A3 (en) 1994-12-07
HUT68791A (en) 1995-07-28
JPH0725839A (ja) 1995-01-27
DE69407654T2 (de) 1999-01-21
TW377350B (en) 1999-12-21
HU9401423D0 (en) 1994-08-29
EP0623606A2 (en) 1994-11-09
CZ108394A3 (en) 1994-12-15
EP0623606B1 (en) 1998-01-07
DE69407654D1 (de) 1998-02-12
SK282270B6 (sk) 2001-12-03
AU668465B2 (en) 1996-05-02
ATE161849T1 (de) 1998-01-15
RU2133251C1 (ru) 1999-07-20
GR3026556T3 (en) 1998-07-31
NZ260477A (en) 1995-12-21
FI942107A7 (fi) 1994-11-08
IL109585A0 (en) 1994-08-26

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