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HK1005740A1 - Acylated uridine and cytidine and uses thereof - Google Patents

Acylated uridine and cytidine and uses thereof Download PDF

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Publication number
HK1005740A1
HK1005740A1 HK98104859A HK98104859A HK1005740A1 HK 1005740 A1 HK1005740 A1 HK 1005740A1 HK 98104859 A HK98104859 A HK 98104859A HK 98104859 A HK98104859 A HK 98104859A HK 1005740 A1 HK1005740 A1 HK 1005740A1
Authority
HK
Hong Kong
Prior art keywords
acid
uridine
cytidine
acyl
tri
Prior art date
Application number
HK98104859A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1005740B (en
Inventor
Warren Von Borstel Reid
Kevin Bamat Michael
Original Assignee
Wellstat Therapeutics Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellstat Therapeutics Corporation filed Critical Wellstat Therapeutics Corporation
Publication of HK1005740B publication Critical patent/HK1005740B/en
Publication of HK1005740A1 publication Critical patent/HK1005740A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
HK98104859A 1987-10-28 1988-10-27 Acylated uridine and cytidine and uses thereof HK1005740A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11592987A 1987-10-28 1987-10-28
US115929 1987-10-28
PCT/US1988/003823 WO1989003837A1 (en) 1987-10-28 1988-10-27 Acylated uridine and cytidine and uses thereof

Publications (2)

Publication Number Publication Date
HK1005740B HK1005740B (en) 1999-01-22
HK1005740A1 true HK1005740A1 (en) 1999-01-22

Family

ID=22364208

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98104859A HK1005740A1 (en) 1987-10-28 1988-10-27 Acylated uridine and cytidine and uses thereof

Country Status (12)

Country Link
US (1) US5583117A (ja)
EP (1) EP0339075B1 (ja)
JP (6) JP2894610B2 (ja)
AT (1) ATE93236T1 (ja)
AU (1) AU2789989A (ja)
CA (1) CA1321994C (ja)
DE (1) DE3883374T2 (ja)
HK (1) HK1005740A1 (ja)
IL (1) IL88208A (ja)
IN (1) IN167680B (ja)
WO (1) WO1989003837A1 (ja)
ZA (1) ZA89232B (ja)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
US7776838B1 (en) 1987-10-28 2010-08-17 Wellstat Therapeutics Corporation Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US6329350B1 (en) 1987-10-28 2001-12-11 Pro-Neuron, Inc. Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
US5968914A (en) 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US5736531A (en) 1987-10-28 1998-04-07 Pro-Neuron, Inc. Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
US5470838A (en) 1987-10-28 1995-11-28 Pro-Neuron, Inc. Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine
US6060459A (en) * 1987-10-28 2000-05-09 Pro-Neuron, Inc. Enhancing blood cell count with oxypurine nucleosides
US7173017B1 (en) * 1987-10-28 2007-02-06 Wellstat Therapeutics Corporation Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
IT1219667B (it) * 1988-06-21 1990-05-24 Polifarma Spa Impiego di uridina nel trattamento farmacologico di disturbi dovuti ad alterato equilibrio dopaminergico
US5216142A (en) * 1989-04-17 1993-06-01 Efamol Holdings Plc Anti-virals
US4964959A (en) * 1990-04-12 1990-10-23 Olin Hunt Specialty Products Inc. Process for preparing a nonconductive substrate for electroplating
IT1241984B (it) * 1990-06-13 1994-02-02 Polifarma Spa Impiego di uridina nel trattamento farmacologico delle complicazioni periferiche del diabete
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
RU2158269C2 (ru) * 1991-02-08 2000-10-27 Про-Ньюрон, Инк. Ацильные производные гуанозина, инозина, ксантозина, дезоксиинозина, дезоксигуанозина, инозин-2',3'-(ациклического)диалкоголя или их фармацевтически приемлемые соли, фармацевтическая композиция, стимулирующая гемопоэз, способ лечения цитопении
WO1993001202A1 (en) * 1991-07-05 1993-01-21 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
KR100315890B1 (ko) * 1992-12-08 2002-06-27 마이클 바마트 전신염증및염증성간염치료용피리미딘누클레오티드전구체
DK0661051T3 (da) * 1993-10-11 2006-05-22 Viatris Gmbh Medikament til behandling af hypertension
US5641758A (en) * 1993-11-10 1997-06-24 Kluge; Michael Cytarabine derivatives, the preparation and use thereof
EP0768883A4 (en) * 1994-07-01 2004-09-15 Wellstat Therapeutics Corp PYRIMIDINE NUCLEOTIDE PRECURSORS FOR THE TREATMENT OF SYSTEMIC INFLAMMATION AND INFLAMMATORY HEPATITIS
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
KR20000053226A (ko) * 1996-11-12 2000-08-25 요나스 프릭 뉴클레오사이드
AU728892B2 (en) * 1997-08-15 2001-01-18 Medivir Ab Nucleosides analogues, such as antivirals including inhibitors of retroviral reverse transcriptase and the DNA polymerase of hepatitis B virus (HBV)
US8314064B2 (en) * 1998-07-31 2012-11-20 Massachusetts Institute Of Technology Uridine administration stimulates membrane production
US20070004670A1 (en) * 1998-07-31 2007-01-04 Richard Wurtman Compositions containing citicoline, and methods of use thereof
US20060069061A1 (en) * 1998-07-31 2006-03-30 Dick Wurtman Compositions containing uridine and choline, and methods utilizing same
PT2145627E (pt) * 1998-07-31 2014-07-24 Massachusetts Inst Technology Utilização de uridina em combinação com colina para o tratamento de disfunções de humor e emocionais
US8518882B2 (en) * 1998-07-31 2013-08-27 Massachusetts Institute Of Technology Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same
US20050203053A1 (en) * 1999-07-30 2005-09-15 Wurtman Richard J. Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function
US8143234B2 (en) 1998-07-31 2012-03-27 Massachusetts Institute Of Technology Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function
US6136339A (en) * 1998-08-21 2000-10-24 Gardiner; Paul T. Food supplements and methods comprising lipoic acid and creatine
US7915233B1 (en) 1998-08-31 2011-03-29 Wellstat Therapeutics Corporation Compositions and methods for treatment of mitochondrial diseases
US7807654B2 (en) * 1998-08-31 2010-10-05 Wellstat Therapeutics Corporation Compositions and methods for treatment of mitochondrial diseases
US6472378B2 (en) * 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
DK1171137T3 (da) 1999-02-23 2008-03-31 Univ California Anvendelse af triacetyluridin til behandling af mitochondriale lidelser
SE521031C2 (sv) * 1999-05-05 2003-09-23 Srinivas Uppugunduri Nya specifika inhibitorer av akut och kronisk inflammation
ES2425114T3 (es) 2000-03-16 2013-10-11 The Mclean Hospital Corporation CDP-colina y uridina para el tratamiento del abuso del acohol
US7560442B2 (en) * 2001-04-30 2009-07-14 Trommsdorff Gmbh & Co. Kg Arzneimittel Pharmaceutically active uridine esters
CN1551778A (zh) 2001-09-05 2004-12-01 ɽ����ʽ���� 用于糖尿病神经病变的药物组合物
AUPR951101A0 (en) * 2001-12-13 2002-01-24 Centre For Molecular Biology And Medicine Method of treatment
ES2427347T3 (es) * 2002-11-08 2013-10-30 The Mclean Hospital Corporation Compuestos para el tratamiento de la dependencia y la abstinencia de tabaco
CA2535013C (en) 2003-08-13 2013-02-12 Nobex Corporation Micro-particle fatty acid salt solid dosage formulations for therapeutic agents
US20070160554A1 (en) * 2003-11-03 2007-07-12 Cognis Ip Management Gmbh Acyl ribonucleosides and acyl deoxyribonucleosides, compositions of, and methods of making same
ATE402185T1 (de) * 2003-12-22 2008-08-15 Hoffmann La Roche Verfahren für fluorcytidinderivate
BRPI0510857A (pt) * 2004-05-13 2007-12-26 Massachusetts Inst Technology efeitos da uridina na liberação de dopamina
JP4656859B2 (ja) * 2004-05-19 2011-03-23 明治飼糧株式会社 酸化ストレス抑制剤
US7947661B2 (en) 2004-08-11 2011-05-24 The Mclean Hospital Corporation Compounds for the treatment of marihuana dependence, withdrawal, and usage
US8658622B2 (en) * 2005-01-14 2014-02-25 Regents Of The University Of California Methods and compositions for preventing and treating a disease related to glycan dysregulation
US20070114476A1 (en) * 2005-11-04 2007-05-24 Williams Christopher P Low radiocarbon nucleotide and amino acid dietary supplements
EP2158462A4 (en) 2007-05-03 2010-05-05 Radiocarb Genetics Inc FOOD SUPPLEMENTS WITH LITTLE RADIO CARBON AND MANUFACTURING METHOD THEREFOR
CN101896119A (zh) 2007-11-02 2010-11-24 麻省理工学院 尿苷饮食添加顺应性方法及其用途
WO2011133580A1 (en) 2010-04-19 2011-10-27 Back Bay Scientific Llc Use of drugs that activate p2y receptors to enhance synaptogenesis
WO2012125020A1 (en) * 2011-03-14 2012-09-20 N.V. Nutricia Method for treating neurotrauma
JP5788715B2 (ja) * 2011-05-31 2015-10-07 キリンホールディングス株式会社 酸素消費量及びエネルギー消費量の低減剤
US9331955B2 (en) 2011-06-29 2016-05-03 Microsoft Technology Licensing, Llc Transporting operations of arbitrary size over remote direct memory access
EP2556832B1 (en) * 2011-08-12 2017-07-19 Universitätsklinikum Freiburg Uridine and uridine analogues for use in the treatment of chronic obstructive pulmonary disease
US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof
DE202015105351U1 (de) 2015-10-09 2016-01-07 Apotheke am Schlossplatz Inh. Mario Ganster e.K. Diätetische Zusammensetzung
AU2017289278A1 (en) * 2016-06-27 2019-01-17 Ohio State Innovation Foundation Liponucleotide-based therapy for ARDS
CN114469981A (zh) * 2021-12-16 2022-05-13 中国科学院动物研究所 尿苷在促进组织器官再生或治疗和/或预防和/或缓解和/或改善组织器官损伤中的应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3847898A (en) * 1969-05-27 1974-11-12 Upjohn Co N4-trihaloethoxy carbonyl arabino-furanosyl cytosine 5'-esters
US3585188A (en) 1969-06-16 1971-06-15 Takeda Chemical Industries Ltd Process for producing 2'-deoxyuridine
GB1297398A (ja) * 1969-08-06 1972-11-22
US3894000A (en) * 1971-01-27 1975-07-08 Upjohn Co Ara-cytidine derivatives and process of preparation
US3868451A (en) * 1971-03-30 1975-02-25 Abbott Lab Adenosine-5{40 -esters in treating angina pectoris
US3975367A (en) * 1971-06-08 1976-08-17 The Upjohn Company Arabinofuranosyl N4 -aminoacyl cytosine containing compounds
DE2147094A1 (de) * 1971-09-21 1973-04-05 Robugen Gmbh Virostatisch wirksames arzneimittel
US4022963A (en) * 1972-06-08 1977-05-10 Deutsch Daniel Harold Acetylation process for nucleoside compounds
US3991045A (en) * 1973-05-30 1976-11-09 Asahi Kasei Kogyo Kabushiki Kaisha N4 -acylarabinonucleosides
JPS5119779A (en) * 1974-08-12 1976-02-17 Asahi Chemical Ind N44 ashiru shichijinno seizoho
JPS5223085A (en) * 1975-08-12 1977-02-21 Ajinomoto Co Inc Selective n-deacylation of n4- - acylcytidine derivatives
JPS5524150A (en) * 1978-08-09 1980-02-21 Taiho Yakuhin Kogyo Kk Anti-malignant-tumor agent
JPS5635196A (en) * 1979-08-29 1981-04-07 Sanyo Electric Co Sound identification system
JPS5791994A (en) * 1980-11-26 1982-06-08 Fuji Kagaku Kogyo Kk 5'-o-(n-alkylcarbamoylalanyl)-5-fluorouridine and its preparation
DE3100478A1 (de) * 1981-01-09 1982-08-12 Dr. Thilo & Co GmbH, 8021 Sauerlach 5'ester von pyrimidinnucleosiden mit antiviraler wirksamkeit, verfahren zur herstellung und daraus hergestellte arzneimittel
JPS5849315A (ja) * 1981-09-18 1983-03-23 Mitsui Pharmaceut Inc 抗腫瘍剤
JPS60174797A (ja) * 1984-02-21 1985-09-09 Funai Corp Ν−アロイルチミジン誘導体ならびに抗腫瘍活性物質の毒性低下剤
FR2571201B1 (fr) * 1984-10-02 1987-01-02 Valeo Procede de chauffage dans la masse d'une substance par exemple en vue d'une vulcanisation ou d'une polymerisation
IT1178044B (it) * 1984-10-09 1987-09-03 Polifarma Spa Agente attivo farmaceutico per il trattamento di patologie cerebrali a base di uridina
DE3685315D1 (de) * 1985-07-22 1992-06-17 Teijin Ltd Antivirus-heilmittel.
US4762823A (en) * 1985-10-16 1988-08-09 Sloan-Kettering Institute For Cancer Research Nucleosides of 5-monofluoromethyluracil and 5-difluoromethyluracil
FR2594022B1 (fr) * 1986-02-07 1988-05-27 Cousin Cie Ets A & M Freres Articulation pour dossier de siege a grain composite.
JPH05223085A (ja) * 1992-02-07 1993-08-31 Daikin Ind Ltd 密閉形圧縮機

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JP2894610B2 (ja) 1999-05-24
EP0339075A4 (en) 1990-04-10
IN167680B (ja) 1990-12-08
JPH02500372A (ja) 1990-02-08
IL88208A0 (en) 1989-06-30
EP0339075A1 (en) 1989-11-02
JP2001192335A (ja) 2001-07-17
JPH07228535A (ja) 1995-08-29
WO1989003837A1 (en) 1989-05-05
CA1321994C (en) 1993-09-07
ZA89232B (en) 1990-06-27
JP3474073B2 (ja) 2003-12-08
US5583117A (en) 1996-12-10
IL88208A (en) 1996-10-16
EP0339075B1 (en) 1993-08-18
DE3883374D1 (de) 1993-09-23
JP2006137772A (ja) 2006-06-01
AU2789989A (en) 1989-05-23
JP2008019268A (ja) 2008-01-31
DE3883374T2 (de) 1993-12-09
JPH101436A (ja) 1998-01-06
ATE93236T1 (de) 1993-09-15

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