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GT201300121A - Derivados de 2,3-dihidroimidazo(1,2-c)quinazolina sustituidos con aminoalcoholes que son de utilidad para tratar trastornos hiperproliferativos y enfermedades asociadas a la angiogénesis - Google Patents

Derivados de 2,3-dihidroimidazo(1,2-c)quinazolina sustituidos con aminoalcoholes que son de utilidad para tratar trastornos hiperproliferativos y enfermedades asociadas a la angiogénesis

Info

Publication number
GT201300121A
GT201300121A GT201300121A GT201300121A GT201300121A GT 201300121 A GT201300121 A GT 201300121A GT 201300121 A GT201300121 A GT 201300121A GT 201300121 A GT201300121 A GT 201300121A GT 201300121 A GT201300121 A GT 201300121A
Authority
GT
Guatemala
Prior art keywords
dihydroimidazo
angiogenesis
diseases associated
derivatives
hyperproliferative disorders
Prior art date
Application number
GT201300121A
Other languages
English (en)
Inventor
Scott William Johnston
Liu Ningshu
Möwes Manfred
Hägebarth Andrea
Mönning Ursula
Bömer Ulf
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44999756&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT201300121(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of GT201300121A publication Critical patent/GT201300121A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A NUEVOS DERIVADOS DE 2,3-DIHIDROIMIDAZO [1,2-C] QUINAZOLINA COMPUESTOS, COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN TALES COMPUESTOS Y EL USO DE AQUELLOS COMPUESTOS O COMPOSICIONES PARA LA FOSFATIDILINOSITOL-3-QUINASA (PI3K) Y EN EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS A LA FOSFATIDILINOSITOL- 3-QUINASA (PI3K) LA ACTIVIDAD, PARTICULARMENTE, EN EL TRATAMIENTO DE TRASTORNOS HIPERPROLIFERATIVOS Y/O RELACIONADOS CON LA ANGIOGÉNESIS, SOLOS O EN COMBINACIÓN CON OTROS INGREDIENTES ACTIVOS.
GT201300121A 2010-11-11 2013-05-10 Derivados de 2,3-dihidroimidazo(1,2-c)quinazolina sustituidos con aminoalcoholes que son de utilidad para tratar trastornos hiperproliferativos y enfermedades asociadas a la angiogénesis GT201300121A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41255610P 2010-11-11 2010-11-11

Publications (1)

Publication Number Publication Date
GT201300121A true GT201300121A (es) 2014-12-22

Family

ID=44999756

Family Applications (1)

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GT201300121A GT201300121A (es) 2010-11-11 2013-05-10 Derivados de 2,3-dihidroimidazo(1,2-c)quinazolina sustituidos con aminoalcoholes que son de utilidad para tratar trastornos hiperproliferativos y enfermedades asociadas a la angiogénesis

Country Status (32)

Country Link
US (2) US8895549B2 (es)
EP (1) EP2638045B1 (es)
JP (1) JP6196156B2 (es)
KR (1) KR20140003436A (es)
CN (1) CN102906094B (es)
AP (1) AP3337A (es)
AR (1) AR083842A1 (es)
AU (1) AU2011328192B2 (es)
BR (1) BR112013011634A2 (es)
CA (1) CA2817317C (es)
CL (1) CL2013001295A1 (es)
CO (1) CO6761350A2 (es)
CR (1) CR20130213A (es)
CU (1) CU20130069A7 (es)
DO (1) DOP2013000105A (es)
EA (1) EA024406B1 (es)
EC (1) ECSP13012618A (es)
GT (1) GT201300121A (es)
HK (1) HK1180685A1 (es)
IL (1) IL226066A0 (es)
MA (1) MA34655B1 (es)
MX (1) MX2013005305A (es)
MY (1) MY164730A (es)
NZ (1) NZ610018A (es)
PE (1) PE20140411A1 (es)
PH (1) PH12013500938A1 (es)
SG (1) SG190100A1 (es)
TW (1) TW201305170A (es)
UA (1) UA113280C2 (es)
UY (1) UY33719A (es)
WO (1) WO2012062748A1 (es)
ZA (1) ZA201304244B (es)

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MY164730A (en) 2018-01-30
AU2011328192A1 (en) 2013-05-02
US20150080374A1 (en) 2015-03-19
EA201300556A1 (ru) 2013-10-30
AP2013006921A0 (en) 2013-06-30
PE20140411A1 (es) 2014-04-13
CN102906094A (zh) 2013-01-30
CL2013001295A1 (es) 2013-10-04
AP3337A (en) 2015-07-31
HK1180685A1 (zh) 2013-10-25
JP6196156B2 (ja) 2017-09-13
IL226066A0 (en) 2013-06-27
AU2011328192B2 (en) 2016-09-01
JP2013542238A (ja) 2013-11-21
ZA201304244B (en) 2014-12-23
US9902727B2 (en) 2018-02-27
EP2638045B1 (en) 2022-08-31
MX2013005305A (es) 2013-06-13
NZ610018A (en) 2016-03-31
AR083842A1 (es) 2013-03-27
UA113280C2 (xx) 2017-01-10
EP2638045A1 (en) 2013-09-18
MA34655B1 (fr) 2013-11-02
ECSP13012618A (es) 2013-07-31
CO6761350A2 (es) 2013-09-30
DOP2013000105A (es) 2013-09-30
PH12013500938A1 (en) 2013-07-08
KR20140003436A (ko) 2014-01-09
CA2817317C (en) 2020-07-14
BR112013011634A2 (pt) 2018-12-11
SG190100A1 (en) 2013-07-31
US8895549B2 (en) 2014-11-25
CU20130069A7 (es) 2013-09-27
WO2012062748A1 (en) 2012-05-18
CR20130213A (es) 2013-07-01
EA024406B1 (ru) 2016-09-30
CA2817317A1 (en) 2012-05-18
CN102906094B (zh) 2016-06-22
UY33719A (es) 2012-06-29
US20130317004A1 (en) 2013-11-28
TW201305170A (zh) 2013-02-01

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