GR3034462T3 - Preparation of diagnostic agents. - Google Patents
Preparation of diagnostic agents.Info
- Publication number
- GR3034462T3 GR3034462T3 GR20000402151T GR20000402151T GR3034462T3 GR 3034462 T3 GR3034462 T3 GR 3034462T3 GR 20000402151 T GR20000402151 T GR 20000402151T GR 20000402151 T GR20000402151 T GR 20000402151T GR 3034462 T3 GR3034462 T3 GR 3034462T3
- Authority
- GR
- Greece
- Prior art keywords
- microcapsules
- wall
- preparation
- forming material
- diagnostic agents
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229940039227 diagnostic agent Drugs 0.000 title 1
- 239000000032 diagnostic agent Substances 0.000 title 1
- 239000003094 microcapsule Substances 0.000 abstract 4
- 239000000463 material Substances 0.000 abstract 3
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000004005 microsphere Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/225—Microparticles, microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
- B01J13/043—Drying and spraying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/14—Polymerisation; cross-linking
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
- Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system
- Y10S516/928—Mixing combined with non-mixing operation or step, successively or simultaneously, e.g. heating, cooling, ph change, ageing, milling
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dispersion Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Compounds Of Unknown Constitution (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Ink Jet Recording Methods And Recording Media Thereof (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919107628A GB9107628D0 (en) | 1991-04-10 | 1991-04-10 | Preparation of diagnostic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
GR3034462T3 true GR3034462T3 (en) | 2000-12-29 |
Family
ID=10693031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR20000402151T GR3034462T3 (en) | 1991-04-10 | 2000-09-21 | Preparation of diagnostic agents. |
Country Status (24)
Country | Link |
---|---|
US (3) | US5518709A (el) |
EP (6) | EP0512693B1 (el) |
JP (2) | JP2865866B2 (el) |
KR (1) | KR0129861B1 (el) |
CN (1) | CN1066977A (el) |
AT (3) | ATE246519T1 (el) |
AU (2) | AU655016B2 (el) |
CA (1) | CA2083260A1 (el) |
DE (3) | DE69231195T2 (el) |
DK (3) | DK0972526T3 (el) |
ES (3) | ES2242355T3 (el) |
FI (1) | FI925600A0 (el) |
GB (2) | GB9107628D0 (el) |
GR (1) | GR3034462T3 (el) |
HK (1) | HK1006538A1 (el) |
HU (1) | HUT62805A (el) |
IE (1) | IE921140A1 (el) |
IL (2) | IL101564A (el) |
MX (1) | MX9201694A (el) |
NZ (1) | NZ242328A (el) |
PT (2) | PT512693E (el) |
RU (1) | RU2109521C1 (el) |
WO (1) | WO1992018164A1 (el) |
ZA (1) | ZA922636B (el) |
Families Citing this family (196)
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---|---|---|---|---|
US6613306B1 (en) | 1990-04-02 | 2003-09-02 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
US6989141B2 (en) | 1990-05-18 | 2006-01-24 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
US5445813A (en) | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
USRE39146E1 (en) | 1990-04-02 | 2006-06-27 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
US7083778B2 (en) | 1991-05-03 | 2006-08-01 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
IN172208B (el) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
US6391343B1 (en) | 1991-01-15 | 2002-05-21 | Hemosphere, Inc. | Fibrinogen-coated particles for therapeutic use |
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US5993805A (en) * | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
IL104084A (en) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them |
US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
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DE69434119T3 (de) † | 1993-07-30 | 2011-05-05 | Imcor Pharmaceutical Co., San Diego | Stabilisierte mikrogasbläschen-zusammensetzungen für echographie |
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- 1992-04-10 EP EP92303236A patent/EP0512693B1/en not_active Expired - Lifetime
- 1992-04-10 PT PT92303236T patent/PT512693E/pt unknown
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- 1992-04-10 DE DE69231195T patent/DE69231195T2/de not_active Expired - Fee Related
- 1992-04-10 WO PCT/GB1992/000643 patent/WO1992018164A1/en not_active Application Discontinuation
- 1992-04-10 EP EP92908598A patent/EP0533886A1/en active Pending
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- 1992-04-10 DK DK99203198T patent/DK0972526T3/da active
- 1992-04-10 EP EP07075443A patent/EP1829557A3/en not_active Withdrawn
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- 1992-04-10 DK DK95110723T patent/DK0681843T3/da active
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- 1992-04-10 US US07/956,875 patent/US5518709A/en not_active Expired - Lifetime
- 1992-04-10 ES ES92303236T patent/ES2150908T3/es not_active Expired - Lifetime
- 1992-04-10 DK DK92303236T patent/DK0512693T3/da active
- 1992-04-10 JP JP4508032A patent/JP2865866B2/ja not_active Expired - Fee Related
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- 1992-04-10 HU HU9203891A patent/HUT62805A/hu unknown
- 1992-04-10 EP EP05075544A patent/EP1547619A3/en not_active Withdrawn
- 1992-04-10 EP EP99203198A patent/EP0972526B1/en not_active Revoked
- 1992-04-10 ZA ZA922636A patent/ZA922636B/xx unknown
- 1992-04-10 ES ES95110723T patent/ES2203626T3/es not_active Expired - Lifetime
- 1992-10-29 RU RU92016571A patent/RU2109521C1/ru active
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1994
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1995
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1998
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- 1998-08-19 JP JP10233181A patent/JPH11128232A/ja active Pending
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1999
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2000
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