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GR3002317T3 - Aqueous steroid formulations for nasal administration - Google Patents

Aqueous steroid formulations for nasal administration

Info

Publication number
GR3002317T3
GR3002317T3 GR91400394T GR910400394T GR3002317T3 GR 3002317 T3 GR3002317 T3 GR 3002317T3 GR 91400394 T GR91400394 T GR 91400394T GR 910400394 T GR910400394 T GR 910400394T GR 3002317 T3 GR3002317 T3 GR 3002317T3
Authority
GR
Greece
Prior art keywords
amount
nasal administration
effective amount
steroid formulations
aqueous
Prior art date
Application number
GR91400394T
Other languages
English (en)
Inventor
Eric Joel Benjamin
Shabbir Tyabji Anik
Ya-Yin Tracy Lin
Original Assignee
Syntex Pharma Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Pharma Int filed Critical Syntex Pharma Int
Publication of GR3002317T3 publication Critical patent/GR3002317T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GR91400394T 1986-05-22 1991-07-18 Aqueous steroid formulations for nasal administration GR3002317T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/866,171 US4782047A (en) 1986-05-22 1986-05-22 Aqueous steroid formulations for nasal administration

Publications (1)

Publication Number Publication Date
GR3002317T3 true GR3002317T3 (en) 1992-12-30

Family

ID=25347059

Family Applications (1)

Application Number Title Priority Date Filing Date
GR91400394T GR3002317T3 (en) 1986-05-22 1991-07-18 Aqueous steroid formulations for nasal administration

Country Status (19)

Country Link
US (1) US4782047A (el)
EP (1) EP0246652B1 (el)
JP (1) JP2521291B2 (el)
KR (1) KR950008308B1 (el)
AT (1) ATE65183T1 (el)
AU (1) AU609718B2 (el)
CA (1) CA1288048C (el)
DE (1) DE3771389D1 (el)
DK (1) DK175238B1 (el)
ES (1) ES2031467T3 (el)
FI (1) FI88459C (el)
GR (1) GR3002317T3 (el)
HK (1) HK39094A (el)
IE (1) IE60259B1 (el)
IL (1) IL82615A (el)
IT (1) IT1205667B (el)
NO (1) NO173365C (el)
NZ (1) NZ220394A (el)
ZA (1) ZA873663B (el)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4983595A (en) * 1986-05-22 1991-01-08 Syntex (U.S.A.) Inc. Aqueous steroid formulations for nasal administration
JPH0311016A (ja) * 1989-06-09 1991-01-18 Tokyo Tanabe Co Ltd ピリド［１，２―ａ］ピリミジン誘導体の水性製剤
GB9103824D0 (en) * 1991-02-23 1991-04-10 Fisons Ag Formulation
US5338732A (en) * 1991-06-18 1994-08-16 Bristol-Myers Squibb Company Megestrol acetate formulation
AU681452B2 (en) * 1993-10-21 1997-08-28 Hisamitsu Pharmaceutical Co., Inc. Pernasal composition and pernasal preparation containing thesame
US5762917A (en) * 1994-09-27 1998-06-09 Virotex Corporation Method and composition for cleansing wounds with minimal cytotoxicity for minimal scarring
US5976573A (en) * 1996-07-03 1999-11-02 Rorer Pharmaceutical Products Inc. Aqueous-based pharmaceutical composition
US6241969B1 (en) * 1998-06-26 2001-06-05 Elan Corporation Plc Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
US8466134B1 (en) 1998-06-26 2013-06-18 Athena Neurosciences, Inc. Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
GB9918559D0 (en) * 1999-08-07 1999-10-06 Glaxo Wellcome Kk Novel pharmaceutical formulation
US20040115133A1 (en) * 2000-05-10 2004-06-17 Wermeling Daniel P. Intranasal opioid compositions
US20060083691A1 (en) * 2000-05-10 2006-04-20 Wermeling Daniel P Intranasal opioid compositions, delivery devices and methods of using same
US6610271B2 (en) * 2000-05-10 2003-08-26 University Of Kentucky Research Foundation System and method for intranasal administration of lorazepam
US6948492B2 (en) 2000-08-15 2005-09-27 University Of Kentucky Research Foundation Programmable multi-dose intranasal drug delivery device
US20040176359A1 (en) * 2001-02-20 2004-09-09 University Of Kentucky Research Foundation Intranasal Benzodiazepine compositions
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
CA2493764C (en) 2002-08-01 2011-05-24 Aesgen, Inc. Improved treatment of cancer with glutamine
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US7404489B1 (en) 2003-03-04 2008-07-29 Qol Medical, Llc Cyanocobalamin low viscosity aqueous formulations for intranasal delivery
JP5238779B2 (ja) * 2003-04-25 2013-07-17 ロート製薬株式会社 点鼻剤
JP4632687B2 (ja) * 2003-04-25 2011-02-16 ロート製薬株式会社 点鼻剤
CA2550811C (en) * 2003-12-24 2012-05-01 Jane Hirsh Temperature-stable formulations, and methods of development thereof
GB0400804D0 (en) 2004-01-14 2004-02-18 Innoscience Technology Bv Pharmaceutical compositions
US20060045850A1 (en) * 2004-08-30 2006-03-02 Qpharma, Llc Nasal delivery of cyclodextrin complexes of anti-inflammatory steroids
BRPI0517891A (pt) 2004-11-24 2008-10-21 Medpointe Healthcare Inc composições compreendendo azelastina e métodos de uso das mesmas
JP2009504767A (ja) 2005-08-17 2009-02-05 フレミング・アンド・カンパニー・ファーマシューティカルズ ビタミンｂ１２鼻用スプレーおよび使用方法
KR100767976B1 (ko) 2006-08-25 2007-10-18 한국유나이티드제약 주식회사 비내 건조증에 효과적인 약제학적 조성물
CN101678112B (zh) 2007-01-19 2016-08-31 哈南亚有限公司 用于递送治疗剂的方法和组合物
US20080275030A1 (en) 2007-01-19 2008-11-06 Sveinbjorn Gizurarson Methods and Compositions for the Delivery of a Therapeutic Agent
JP2011001317A (ja) * 2009-06-19 2011-01-06 Fumakilla Ltd 鼻用洗浄剤
CA2905587A1 (en) 2013-03-15 2014-09-18 Medicis Pharmaceutical Corporation Topical compositions of flunisolide and methods of treatment
US11135155B2 (en) 2014-07-08 2021-10-05 Hikma Pharmaceuticals Usa Inc. Liquid naloxone spray
JP6097787B2 (ja) * 2015-06-09 2017-03-15 パル ファーマシューティカル， インコーポレーテッド 鼻内送達用シアノコバラミン低粘度水性製剤
EA036233B1 (ru) 2015-07-16 2020-10-16 Мариномед Биотек Аг Способ улучшения растворимости в воде лекарственных средств, нерастворимых или слаборастворимых в воде
US11510859B2 (en) 2015-07-16 2022-11-29 Marinomed Biotech Ag Method for improving aqueous solubility of water-insoluble or slightly water-soluble drugs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2989437A (en) * 1955-06-08 1961-06-20 Upjohn Co Anti-inflammatory and anti-bacterial decongestant nasal spray compositions
MX3864E (es) * 1975-05-27 1981-08-26 Syntex Corp Un proceso para prepara el compuesto cristalino 6-fluiro-11b 21-dihiroxi-16 17-isopropilidendioxipregna-1 4-dien-3 20-diona
DE2750090A1 (de) * 1976-11-19 1978-06-01 Sandoz Ag Neue verabreichungsformen fuer organische verbindungen
US4444762A (en) * 1980-04-04 1984-04-24 Nelson Research & Development Company Vehicle composition containing 1-substituted azacyclopentan-2-ones
US4344940A (en) * 1981-11-30 1982-08-17 E. R. Squibb & Sons, Inc. Steroid formulation containing dipotassium EDTA
US4603131A (en) * 1982-04-26 1986-07-29 Bernstein Joel E Method and composition for treating and preventing irritation of the mucous membranes of the nose

Also Published As

Publication number Publication date
IT1205667B (it) 1989-03-31
DK258687A (da) 1987-11-23
CA1288048C (en) 1991-08-27
IT8720621A0 (it) 1987-05-21
AU7327387A (en) 1987-11-26
JP2521291B2 (ja) 1996-08-07
ZA873663B (en) 1988-12-28
FI88459C (fi) 1993-05-25
EP0246652A2 (en) 1987-11-25
KR870010862A (ko) 1987-12-18
KR950008308B1 (ko) 1995-07-27
IL82615A0 (en) 1987-11-30
NZ220394A (en) 1990-04-26
NO173365C (no) 1993-12-08
DK175238B1 (da) 2004-07-19
FI872231A0 (fi) 1987-05-21
NO872127D0 (no) 1987-05-21
JPS62283927A (ja) 1987-12-09
EP0246652B1 (en) 1991-07-17
DE3771389D1 (de) 1991-08-22
NO173365B (no) 1993-08-30
US4782047A (en) 1988-11-01
NO872127L (no) 1987-11-23
AU609718B2 (en) 1991-05-09
IE60259B1 (en) 1994-06-29
IL82615A (en) 1991-11-21
DK258687D0 (da) 1987-05-21
FI872231L (fi) 1987-11-23
EP0246652A3 (en) 1988-02-03
ES2031467T3 (es) 1992-12-16
HK39094A (en) 1994-04-29
FI88459B (fi) 1993-02-15
ATE65183T1 (de) 1991-08-15
IE871335L (en) 1987-11-22

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