GR22670B - METHOD FOR THE MANUFACTURE OF BASIC PRODUCTS OF SALIKYLAMIDE FORMING SALTS EASILY DISSOLVED IN WATER. - Google Patents
METHOD FOR THE MANUFACTURE OF BASIC PRODUCTS OF SALIKYLAMIDE FORMING SALTS EASILY DISSOLVED IN WATER.Info
- Publication number
- GR22670B GR22670B GR580122670A GR580122670A GR22670B GR 22670 B GR22670 B GR 22670B GR 580122670 A GR580122670 A GR 580122670A GR 580122670 A GR580122670 A GR 580122670A GR 22670 B GR22670 B GR 22670B
- Authority
- GR
- Greece
- Prior art keywords
- group
- water
- forming salts
- salikylamide
- manufacture
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
έθοδος διά την παρασκευήν βασικών παραγωγων του σαλικυλαμιδίου σχηματιζόντων άλατα ευκόλως διαλυόμενα είς το ύδωρ του γενικού τύπου (Ι) είς τον οποίον το R1 δηλοί υδρογόνον ή κατώτερον αλκύλιον τα R2και R3 δηλούν κατώτερον αλκάλιον περιέχον μέχρι 4ατόμων άνθρακος ή αραλκύλιον ή ομού μετά του αζωτου, έν ετεροκυκλικόν υπόλοιπον, ώς το πιπεριδινικόν πυρρολιδινικόν, Ν-μεθυλοπιπεραζινικο ή μορφολινικόν υπόλοιπον, τα δέ Χ δηλοί μίαν αλκαλενικήν ομάδα μετά 2 έως 3 ατόμων άνθρακος, χαρακτηριζομένη εκτούτου, ότι το σαλικυλικόν οξύ τους εστέαρς τούτου, το χλωρίδιον του οξέος ή αμίδιον του οξέος, ενδεχομένως μετά κάλυψιν της ΟΗ-ομάδος, συμπυκνούμενμετά διαμινών του τύπου (I) είς τον οποιον το R2 και R3 έχουν την ανωτέρω δοθείσαν σημασίαν, και έναναγκη ελευθερούμεν εκ νέου την ομαδα ΟΗ ή το σαλικυλαμίδιον, είς τον οποίον έν άτομον αμιδικου υδρογόνου δύναται να είναι υποκατεστημένον διά του υπολοίπου R1, και ένθα η ομάς ΟΗ προστατεύεται εκ των προτέρων, συμπυκνούμεν με μίαν αλογοναμίνην τουτύπου (ΙΙ) έν συνεχεία δε ελευθρερούμεν πάλιν την ομάδα ΟΗ. A process for the preparation of basic derivatives of salicylamide forming salts readily soluble in water of general formula (I) in which R1 denotes hydrogen or lower alkyl; R2 and R3 denote lower alkali or alkali containing up to 4% heterocyclic residue, such as piperidine pyrrolidine, N-methylpiperazine or morpholinate residue, and X denotes an alkaline group consisting of 2 to 3 carbon atoms, characterized in that their salicylic acid is an ester of this acid or its acid after coverage of the OH group, concentrates with diamines of formula (I) in which R2 and R3 have the above significance, and need to re-release the OH group or salicylamide, in which an atomic hydrogen with the residue R1, and in which the OH group is protected in advance, is concentrated with a halogenamine of the type ( II) then we do not release the OH group again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR580122670A GR22670B (en) | 1958-09-10 | 1958-09-10 | METHOD FOR THE MANUFACTURE OF BASIC PRODUCTS OF SALIKYLAMIDE FORMING SALTS EASILY DISSOLVED IN WATER. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR580122670A GR22670B (en) | 1958-09-10 | 1958-09-10 | METHOD FOR THE MANUFACTURE OF BASIC PRODUCTS OF SALIKYLAMIDE FORMING SALTS EASILY DISSOLVED IN WATER. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR22670B true GR22670B (en) | 1961-12-28 |
Family
ID=36864712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR580122670A GR22670B (en) | 1958-09-10 | 1958-09-10 | METHOD FOR THE MANUFACTURE OF BASIC PRODUCTS OF SALIKYLAMIDE FORMING SALTS EASILY DISSOLVED IN WATER. |
Country Status (1)
| Country | Link |
|---|---|
| GR (1) | GR22670B (en) |
-
1958
- 1958-09-10 GR GR580122670A patent/GR22670B/en unknown
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