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ES321631A1 - Procedure for the preparation of 5,6-dihydro-6-oxormorphantridines 5-basically replaced. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of 5,6-dihydro-6-oxormorphantridines 5-basically replaced. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES321631A1
ES321631A1 ES0321631A ES321631A ES321631A1 ES 321631 A1 ES321631 A1 ES 321631A1 ES 0321631 A ES0321631 A ES 0321631A ES 321631 A ES321631 A ES 321631A ES 321631 A1 ES321631 A1 ES 321631A1
Authority
ES
Spain
Prior art keywords
formula
lower alkyl
hydrogen
dihydro
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0321631A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wander AG
Original Assignee
Wander AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wander AG filed Critical Wander AG
Publication of ES321631A1 publication Critical patent/ES321631A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Process for the preparation of 5-basicly substituted 5,6-dihydro-6-oxomorfantridines of the formula: ** (See formula) ** wherein R means a straight or branched alkylene group with 2 to 4 C atoms; R1 and R2 are the same or different and mean hydrogen or lower alkyl, one of both R3 being hydrogen, and the other halogen or lower alkyl, and R4 represents a lower alkyl moiety, as well as acid addition salts thereof, characterized by that either: a) Amines of the formula XH are reacted, optionally after the preceding or simultaneous action of a condensation medium, with reactable esters of alcohols of the formula YR-OH, with X and Y being interchangeable with each other, and, on the one hand, they represent a residue of 11-R4-5,6-dihydro-6-oxo-5-morfantridinyl, halogenated in one of both nuclei of benzol or inferiorly alkylated, on the other hand, the basic rest (see formula), while R, R1, R2 and R4 have the meaning quoted above, or because b) They are cyclized, with the release of water, respectively of an alcohol, an acid or an ester, o-amino-o'-carboxy (respectively, carbalkoxy) -1,1-diphenylalkanes n-aminoalkylated of the formula: ** (See formula) ** wherein R, R1, R2, R3 and R4 have the meaning indicated above, meaning R5 hydrogen or an acyl group, and R6 hydrogen or a lower alkyl group, or because c) For the preparation of compounds according to formula I, in which R 1 and/or R 2 represent lower alkyl, primary or secondary secondary amines of the formula are ** (See formula) ** wherein R, R1, R3 and R4 have the meaning indicated above, after which the reaction product is isolated in the form of the free base or of an acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES0321631A 1965-01-11 1966-01-11 Procedure for the preparation of 5,6-dihydro-6-oxormorphantridines 5-basically replaced. (Machine-translation by Google Translate, not legally binding) Expired ES321631A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH32765A CH464930A (en) 1965-01-11 1965-01-11 Process for the preparation of 5-basic substituted 5,6-dihydro-6-oxomorphanthridines

Publications (1)

Publication Number Publication Date
ES321631A1 true ES321631A1 (en) 1966-09-01

Family

ID=4184485

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0321631A Expired ES321631A1 (en) 1965-01-11 1966-01-11 Procedure for the preparation of 5,6-dihydro-6-oxormorphantridines 5-basically replaced. (Machine-translation by Google Translate, not legally binding)

Country Status (9)

Country Link
AT (3) AT260270B (en)
BE (1) BE674950A (en)
BR (1) BR6676352D0 (en)
CH (1) CH464930A (en)
DE (1) DE1620722A1 (en)
ES (1) ES321631A1 (en)
FR (1) FR5915M (en)
GB (1) GB1078266A (en)
IL (1) IL24925A (en)

Also Published As

Publication number Publication date
IL24925A (en) 1969-04-30
DE1620722A1 (en) 1970-08-27
BR6676352D0 (en) 1973-09-06
CH464930A (en) 1968-11-15
GB1078266A (en) 1967-08-09
BE674950A (en) 1966-07-11
AT260269B (en) 1968-02-26
AT260259B (en) 1968-02-26
FR5915M (en) 1968-04-01
AT260270B (en) 1968-02-26

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