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GR1000263B - Μεθοδος παρασκευης αλατος της πενταμιδινης. - Google Patents

Μεθοδος παρασκευης αλατος της πενταμιδινης.

Info

Publication number
GR1000263B
GR1000263B GR880100751A GR880100751A GR1000263B GR 1000263 B GR1000263 B GR 1000263B GR 880100751 A GR880100751 A GR 880100751A GR 880100751 A GR880100751 A GR 880100751A GR 1000263 B GR1000263 B GR 1000263B
Authority
GR
Greece
Prior art keywords
pentamidine
salts
aids
preparating
pentamidine salt
Prior art date
Application number
GR880100751A
Other languages
English (en)
Inventor
S Alam Abu
N John Kapoor
Sadanand Pai
Original Assignee
Lyphomed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lyphomed Inc filed Critical Lyphomed Inc
Publication of GR1000263B publication Critical patent/GR1000263B/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/08—Acetic acid
    • C07C53/10—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/08—Lactic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/10—Polyhydroxy carboxylic acids
    • C07C59/105—Polyhydroxy carboxylic acids having five or more carbon atoms, e.g. aldonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/265—Citric acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

'Αλατα της πενταμιδίνης, διαμορφώσεις που περιέχουν τέτοια άλατα και η χρήση τέτοιων αλάτων για την θεραπευτική ή προφυλακτική αγωγή του PNEUMOCYSTIS CARINII. Η γλυκονική και γαλακτική πενταμιδίνη ανεκαλύφθησαν και ευρέθησαν ότι έχουν μεγάλη διαλυτότητα εις ύδωρ ενώ παρέχουν δυναμικώς ολιγώτερο τοξικές εναλλακτικές λύσεις της ισεθειονικής πενταμιδίνης, ιδίως για χορήγηση υπό μορφή αερολύματος σε ασθενείς πάσχοντες από σύνδρομο επίκτητης ανοσολογικής ανεπάρκειας, AIDS ή σύνδρομο σχετιζόμενο με το AIDS, ARC. ω
GR880100751A 1987-11-06 1988-11-04 Μεθοδος παρασκευης αλατος της πενταμιδινης. GR1000263B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11828487A 1987-11-06 1987-11-06

Publications (1)

Publication Number Publication Date
GR1000263B true GR1000263B (el) 1992-05-12

Family

ID=22377637

Family Applications (1)

Application Number Title Priority Date Filing Date
GR880100751A GR1000263B (el) 1987-11-06 1988-11-04 Μεθοδος παρασκευης αλατος της πενταμιδινης.

Country Status (14)

Country Link
EP (1) EP0315467A3 (el)
JP (1) JPH02150A (el)
KR (1) KR970008156B1 (el)
CN (1) CN1020897C (el)
AU (1) AU618762B2 (el)
BR (1) BR8805759A (el)
CA (1) CA1336003C (el)
DK (1) DK616088A (el)
FI (1) FI885020A (el)
GR (1) GR1000263B (el)
IL (1) IL88159A (el)
IN (1) IN168530B (el)
MX (1) MX13665A (el)
NO (1) NO171723C (el)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2770970B2 (ja) * 1987-04-09 1998-07-02 フアイソンズ・ピーエルシー ペンタミジンを含有する医薬組成物
US5364615A (en) * 1987-12-23 1994-11-15 Regents Of The University Of California Prophylaxis of pneumocystis carinii with aerosilized pentamidine
US5366726A (en) * 1987-12-23 1994-11-22 The Regents Of The University Of California Suppression of Pneumocystis carinii using aerosolized pentamidine treatment
US5807572A (en) * 1988-02-18 1998-09-15 Depotech Corporation Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
EP0335055B1 (en) * 1988-03-31 1994-10-26 ORBISPHERE LABORATORIES (INC.), Wilmington, Succursale de Collonge-Bellerive Amperometric method
GB8903438D0 (en) * 1989-02-15 1989-04-05 May & Baker Ltd New compositions of matter
DE4122744C2 (de) * 1990-08-06 1994-02-03 Nattermann A & Cie Wäßriges Liposomensystem und Verfahren zu seiner Herstellung
US5556637A (en) * 1990-08-06 1996-09-17 A. Nattermann & Cie. Gmbh Water containing liposome system
DE4122661C2 (de) * 1990-08-06 1996-07-11 Nattermann A & Cie Pharmazeutisches Produkt zur Behandlung von Pneumocystis-carinii-Pneumonie
DE4108902A1 (de) * 1990-08-06 1992-02-13 Nattermann A & Cie Wasserhaltiges liposomensystem
US6663885B1 (en) 1993-03-15 2003-12-16 A. Natterman & Cie Gmbh Aqueous liposome system and a method for the preparation of such a liposome system
RU2160093C2 (ru) * 1993-11-16 2000-12-10 Скайефарма Инк. Везикулы с регулируемым высвобождением активных ингредиентов
MX9703653A (es) * 1995-09-19 1998-07-31 Cellular Sciences Inc Composicion y metodo para tratar enfermedades mamiferas ocasionadas por la respuesta inflamatoria.
KR100219601B1 (ko) * 1996-05-15 1999-09-01 윤종용 인쇄면 판별영역을 갖는 ohp 및 승화형 열전사 프린터의 ohp 인쇄면 판별 방법 및 이에 적합한 장치
DE10149919A1 (de) 2001-10-10 2003-04-24 Biosphings Ag Neue Salze von Guanidinderivaten und pharmazeutische Zubereitungen daraus
JP3972876B2 (ja) * 2003-09-03 2007-09-05 日産自動車株式会社 エンジンの燃料カット制御装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB575145A (en) * 1944-02-23 1946-02-05 May & Baker Ltd Improvements in or relating to the preparation of amidine salts
US2410796A (en) * 1942-04-11 1946-11-05 May & Baker Ltd Soluble amidine salts
US2425221A (en) * 1942-07-27 1947-08-05 May & Baker Ltd Production of amidine salts

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU620025B2 (en) * 1987-03-26 1992-02-13 Sloan-Kettering Institute For Cancer Research Method of preventing pneumocystis carinii pneumonia using pentamidine in an aerosol form

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2410796A (en) * 1942-04-11 1946-11-05 May & Baker Ltd Soluble amidine salts
US2425221A (en) * 1942-07-27 1947-08-05 May & Baker Ltd Production of amidine salts
GB575145A (en) * 1944-02-23 1946-02-05 May & Baker Ltd Improvements in or relating to the preparation of amidine salts

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CLAIMS SEARCHED: ALL *

Also Published As

Publication number Publication date
EP0315467A3 (en) 1990-09-26
FI885020A (fi) 1989-05-07
NO171723B (no) 1993-01-18
NO884881D0 (no) 1988-11-02
NO171723C (no) 1993-04-28
AU618762B2 (en) 1992-01-09
AU2447688A (en) 1989-05-11
CN1033046A (zh) 1989-05-24
KR890007723A (ko) 1989-07-05
IL88159A (en) 1994-04-12
DK616088D0 (da) 1988-11-04
CN1020897C (zh) 1993-05-26
CA1336003C (en) 1995-06-20
MX13665A (es) 1993-12-01
BR8805759A (pt) 1989-07-25
NO884881L (no) 1989-05-08
IL88159A0 (en) 1989-06-30
KR970008156B1 (ko) 1997-05-21
DK616088A (da) 1989-05-07
IN168530B (el) 1991-04-20
FI885020A0 (fi) 1988-11-01
JPH02150A (ja) 1990-01-05
EP0315467A2 (en) 1989-05-10

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