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ATE77554T1 - Pharmazeutisches praeparat mit 3'-desoxythymidin2'-en(3'-desoxy-2',3'-didehydrothymidin) zur behandlung von patienten mit retroviralen infektionen. - Google Patents

Pharmazeutisches praeparat mit 3'-desoxythymidin2'-en(3'-desoxy-2',3'-didehydrothymidin) zur behandlung von patienten mit retroviralen infektionen.

Info

Publication number
ATE77554T1
ATE77554T1 AT87118407T AT87118407T ATE77554T1 AT E77554 T1 ATE77554 T1 AT E77554T1 AT 87118407 T AT87118407 T AT 87118407T AT 87118407 T AT87118407 T AT 87118407T AT E77554 T1 ATE77554 T1 AT E77554T1
Authority
AT
Austria
Prior art keywords
didehydrothymidine
desoxy
patients
treatment
pharmaceutical preparation
Prior art date
Application number
AT87118407T
Other languages
English (en)
Inventor
Tai-Shun Lin
William H Prusoff
Original Assignee
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25478432&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE77554(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Yale filed Critical Univ Yale
Application granted granted Critical
Publication of ATE77554T1 publication Critical patent/ATE77554T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
AT87118407T 1986-12-17 1987-12-11 Pharmazeutisches praeparat mit 3'-desoxythymidin2'-en(3'-desoxy-2',3'-didehydrothymidin) zur behandlung von patienten mit retroviralen infektionen. ATE77554T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/942,666 US4978655A (en) 1986-12-17 1986-12-17 Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
EP87118407A EP0273277B1 (de) 1986-12-17 1987-12-11 Pharmazeutisches Präparat mit 3'-Desoxythymidin-2'-en(3'-desoxy-2',3'-didehydrothymidin) zur Behandlung von Patienten mit retroviralen Infektionen

Publications (1)

Publication Number Publication Date
ATE77554T1 true ATE77554T1 (de) 1992-07-15

Family

ID=25478432

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87118407T ATE77554T1 (de) 1986-12-17 1987-12-11 Pharmazeutisches praeparat mit 3'-desoxythymidin2'-en(3'-desoxy-2',3'-didehydrothymidin) zur behandlung von patienten mit retroviralen infektionen.

Country Status (22)

Country Link
US (1) US4978655A (de)
EP (1) EP0273277B1 (de)
JP (1) JPH07116041B2 (de)
KR (1) KR960000433B1 (de)
AT (1) ATE77554T1 (de)
AU (1) AU593405B2 (de)
CA (1) CA1293447C (de)
DE (1) DE3780016T2 (de)
DK (1) DK174627B1 (de)
EG (1) EG19157A (de)
ES (1) ES2038650T3 (de)
FI (1) FI875544A (de)
GR (1) GR3005691T3 (de)
HK (1) HK55896A (de)
IE (1) IE60866B1 (de)
IL (1) IL84790A (de)
LU (1) LU88822I2 (de)
NL (1) NL960024I2 (de)
NZ (1) NZ222935A (de)
PH (1) PH26380A (de)
PT (1) PT86346B (de)
ZA (1) ZA877171B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175292A (en) * 1988-01-20 1992-12-29 Regents Of The University Of Minnesota Intermediates for the preparation of dideoxycarbocyclic nucleosides
US5631370A (en) * 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
FI95269C (fi) * 1989-05-15 1996-01-10 Squibb Bristol Myers Co 2',3'-dideoksi-inosiinimonohydraatin, 2',3'-dideoksi-2',3'-didehydrot ymidiinimonohydraatin ja 2',3'-dideoksi-2'-fluori-inosiinihemihydraatin antiviraalisia, hyvin vesiliukoisia, stabiileja, kiteisiä suoloja
US6207650B1 (en) 1989-05-15 2001-03-27 Bristol-Myers Squibb Company Antiviral, highly water soluble, stable, crystalline salts of 2′, 3′-dideoxyinosine, 2′, 3′-dideoxy-2′, 3′-didehydrothymidine and 2′, 3′-dideoxy-2′-fluoroinosine
US5608048A (en) * 1995-06-05 1997-03-04 Bristol-Myers Squibb Company d4 T polymorphic Form 1 process
US5840711A (en) * 1995-06-21 1998-11-24 University Of Kentucky Research Foundation Compositions containing lithium inorganic salts and anti-viral drugs and method of treating viral infections such as acquired immunodeficiency syndrome
CA2189097A1 (en) 1995-11-15 1997-05-16 Pin-Fang Lin Composition and method of treating retroviral infection
US5719132A (en) * 1996-06-27 1998-02-17 Bristol-Myers Squibb Company Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil
WO2000016625A1 (en) * 1998-09-23 2000-03-30 University Of Kentucky Research Foundation Antiviral drug compositions containing lithium inorganic salts
US7135465B2 (en) 2000-03-30 2006-11-14 Bristol-Myers Squibb Company Sustained release beadlets containing stavudine
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
WO2005011709A1 (en) 2003-02-19 2005-02-10 Yale University Anti-viral nucleoside analogs and methods for treating viral infections, especially hiv infections
US20040200730A1 (en) * 2003-04-14 2004-10-14 Kyo Jibiki Hydrometallurgical copper recovery process
EP1778251B1 (de) 2004-07-27 2011-04-13 Gilead Sciences, Inc. Nukleosid phosphonat konjugate als anti hiv mittel
ES2352216T3 (es) * 2005-08-31 2011-02-16 Cipla Limited Combinaciones farmacéuticas que contienen lamivudina, estavudina y nevirapina.
TWI432436B (zh) 2008-12-09 2014-04-01 Gilead Sciences Inc 類鐸受體的調節劑
US20110223131A1 (en) 2010-02-24 2011-09-15 Gilead Sciences, Inc. Antiviral compounds
WO2016001907A1 (en) 2014-07-02 2016-01-07 Prendergast Patrick T Mogroside iv and mogroside v as agonist/stimulator/un-blocking agent for toll-like receptor 4 and adjuvant for use in human/animal vaccine and to stimulate immunity against disease agents.
CA2954056C (en) 2014-07-11 2020-04-28 Gilead Sciences, Inc. Modulators of toll-like receptors for the treatment of hiv
US20180263985A1 (en) 2015-09-15 2018-09-20 Gilead Sciences, Inc. Modulators of toll-like receptors for the treatment of hiv

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322747A (en) * 1965-04-01 1967-05-30 Merck & Co Inc Thionocarbonate nucleosides
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
JPS5943550B2 (ja) * 1975-08-29 1984-10-23 田辺製薬株式会社 不飽和ヌクレオシドの製法
DE3515870A1 (de) * 1985-05-03 1986-11-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 5-fluortoluol-2,4-disulfochlorid
US4710492A (en) * 1986-06-23 1987-12-01 Yale University 3'-azido-2',3'-dideoxy-5-halouridine and its use in treating patients infected with retroviruses
NL8700089A (nl) * 1987-01-15 1988-08-01 Stichting Rega V Z W Therapeutische toepassing van dideoxythymidine en dideoxythymidineen.
DE3806633A1 (de) * 1987-09-01 1989-03-09 Bayer Ag Antivirales mittel
JP2648329B2 (ja) * 1987-09-18 1997-08-27 エフ・ホフマン−ラ ロシュ アーゲー エイズの予防または治療用医薬組成物
SE8704298D0 (sv) * 1987-11-03 1987-11-03 Astra Ab Compounds for use in therapy
JPH0227782A (ja) * 1988-07-15 1990-01-30 Hikari Gijutsu Kenkyu Kaihatsu Kk 半導体発光素子
JPH0438727A (ja) * 1990-06-04 1992-02-07 Sharp Corp 光学式ピックアップ装置の対物レンズ塵埃付着防止機構

Also Published As

Publication number Publication date
PT86346A (en) 1988-01-01
JPH07116041B2 (ja) 1995-12-13
DE3780016D1 (de) 1992-07-30
FI875544A0 (fi) 1987-12-16
IE60866B1 (en) 1994-08-24
NL960024I2 (nl) 1997-06-02
LU88822I2 (fr) 1997-01-06
DK557087A (da) 1988-06-18
HK55896A (en) 1996-04-03
JPS63215632A (ja) 1988-09-08
NL960024I1 (nl) 1996-12-02
EG19157A (en) 1994-09-29
DK174627B1 (da) 2003-07-28
KR880007079A (ko) 1988-08-26
NZ222935A (en) 1990-09-26
US4978655A (en) 1990-12-18
ES2038650T3 (es) 1993-08-01
IL84790A (en) 1993-03-15
DK557087D0 (da) 1987-10-23
AU8090087A (en) 1988-06-23
ZA877171B (en) 1988-03-24
PH26380A (en) 1992-06-01
EP0273277B1 (de) 1992-06-24
CA1293447C (en) 1991-12-24
FI875544A (fi) 1988-06-18
KR960000433B1 (ko) 1996-01-06
IE873245L (en) 1988-06-17
AU593405B2 (en) 1990-02-08
IL84790A0 (en) 1988-05-31
EP0273277A3 (en) 1989-09-13
DE3780016T2 (de) 1992-12-24
EP0273277A2 (de) 1988-07-06
PT86346B (pt) 1990-11-07
GR3005691T3 (de) 1993-06-07

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