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GB999121A - Repository antimalarial compositions - Google Patents

Repository antimalarial compositions

Info

Publication number
GB999121A
GB999121A GB25855/63A GB2585563A GB999121A GB 999121 A GB999121 A GB 999121A GB 25855/63 A GB25855/63 A GB 25855/63A GB 2585563 A GB2585563 A GB 2585563A GB 999121 A GB999121 A GB 999121A
Authority
GB
United Kingdom
Prior art keywords
general formula
acid
methyl
radical
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB25855/63A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parke Davis and Co LLC
Original Assignee
Parke Davis and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis and Co LLC filed Critical Parke Davis and Co LLC
Publication of GB999121A publication Critical patent/GB999121A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds of the general formula <FORM:0999121/C2/1> wherein A is a C2- 12 acyl group, B is an amino, acetamido or nitro group and D is a hydrogen atom or methyl radical, may be prepared by reacting a compound of the general formula <FORM:0999121/C2/2> with the appropriate acyl halide in pyridine or with an acid anhydride in acetic acid. A specific example relates to the preparation of 31 - methyl - 41,4111 - sulphonylbis - (acetanilide) by treating 4,41-diamino-3-methyldiphenyl sulphone with acetic anhydride. Compounds in which B is -NH2 may also be prepared by the reduction of a compound of general formula <FORM:0999121/C2/3> where A and D are as defined above.ALSO:Repository antimalarial compositions comprise, as active ingredients, (a) an acylated sulphonyl-aniline of the general formula <FORM:0999121/A5-A6/1> wherein A is a C2-12 acyl group, B is an amino, nitro or acetamido group and D is a hydrogen atom or a methyl radical and, (b) a salt of an s-triazine derivative of the general formula <FORM:0999121/A5-A6/2> wherein R is a chloro, iodo, methyl or benzyloxy radical, R1 is a C1-4 alkyl radical and R2 is a hydrogen atom or a methyl radical with an acid of the general formula <FORM:0999121/A5-A6/3> wherein X is a hydrogen or bromine atom and Y is a direct bond or a methylene, benzylidene or thio group or a salt of 2,4-diamino-5-(p-chlorophenyl)-6-ethyl pyrimidine with an acid of Formula III above or with 4,41-bis-(1-hydroxy-2-naphthoic) acid; 2,6-dihydroxy isonicotinic acid; fluorescein or 2-hydroxy-11-H benz[a]carbazole-3-carboxylic acid. The compositions may be in the form of aqueous or oily injections which may contain conventional adjuvants for subcutaneous or intramuscular injection.
GB25855/63A 1962-06-29 1963-06-28 Repository antimalarial compositions Expired GB999121A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US206172A US3215600A (en) 1962-06-29 1962-06-29 Antimalarial composition containing an acylated sulfonylaniline with triazine or pyrimidine salt, and method of use

Publications (1)

Publication Number Publication Date
GB999121A true GB999121A (en) 1965-07-21

Family

ID=22765272

Family Applications (1)

Application Number Title Priority Date Filing Date
GB25855/63A Expired GB999121A (en) 1962-06-29 1963-06-28 Repository antimalarial compositions

Country Status (9)

Country Link
US (1) US3215600A (en)
AT (1) AT263205B (en)
BE (1) BE634276A (en)
BR (1) BR6350289D0 (en)
ES (1) ES289479A1 (en)
FR (1) FR2767M (en)
GB (1) GB999121A (en)
NL (1) NL6614309A (en)
SE (1) SE320460B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3876785A (en) * 1967-12-06 1975-04-08 Beecham Group Ltd 4,6-diamino-1,2-dihydro-arylmethoxy-1,3,5-triazines for combating plasmodium parasites
US3761590A (en) * 1970-05-18 1973-09-25 Research Corp Silver sulfadiazine used in the treatment of burns
CA964192A (en) * 1970-07-21 1975-03-11 Roy H. Reiner Long-acting narcotic antagonist formulations containing pamoate salts of dihydronormorphinone
WO1991008667A1 (en) * 1989-12-07 1991-06-27 Protos Corporation Inhibitors of pneumocystis carinii dihydrofolate reductase
GB0001565D0 (en) * 2000-01-24 2000-03-15 Isis Innovation Dihydrofolate reductase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2900385A (en) * 1959-08-18 Dihydrotriazines and method of
US1872826A (en) * 1927-08-16 1932-08-23 Winthrop Chem Co Inc Soluble salts of organic bases and the process of preparing the same
GB813560A (en) * 1957-02-28 1959-05-21 Sterling Drug Inc Substituted-1:2-dihydro-1:3:5-triazines

Also Published As

Publication number Publication date
AT263205B (en) 1968-07-10
FR2767M (en) 1964-08-31
SE320460B (en) 1970-02-09
NL6614309A (en) 1966-12-27
BR6350289D0 (en) 1973-08-02
ES289479A1 (en) 1963-11-01
BE634276A (en) 1963-11-04
US3215600A (en) 1965-11-02

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