GB970130A - Piperazine derivatives - Google Patents
Piperazine derivativesInfo
- Publication number
- GB970130A GB970130A GB3821961A GB3821961A GB970130A GB 970130 A GB970130 A GB 970130A GB 3821961 A GB3821961 A GB 3821961A GB 3821961 A GB3821961 A GB 3821961A GB 970130 A GB970130 A GB 970130A
- Authority
- GB
- United Kingdom
- Prior art keywords
- radical
- formula
- phenyl
- compounds
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
The invention comprises piperazine derivatives of the formula <FORM:0970130/C1/1> in which R1 is a phenyl, 4-methoxyphenyl or 3,4-dimethoxyphenyl radical, R2 is a 2-pyridyl, phenyl, 2-halogenophenyl or 2-alkoxyphenyl radical, the alkoxy group containing 1 to 3 carbon atoms and Z is a linear divalent aliphatic hydrocarbon radical containing from 1 to 3 carbon atoms and comprising in the chain either a ketone function or a secondary alcohol function which may be etherified by methyl alcohol. These compounds are prepared by reacting a compound of the formula <FORM:0970130/C1/2> with a compound of the formula <FORM:0970130/C1/3> in which Q is a hydroxyl radical, a halogen atom, an <FORM:0970130/C1/4> radical or an alkoxy radical having from 1 to 4 carbon atoms, preferably in the presence of an inert solvent which can be brought to the boiling point. Compounds of the formula <FORM:0970130/C1/5> in which X is a linear divalent aliphatic hydrocarbon radical and comprising in the chain a secondary alcohol function which may be etherified by methyl alcohol are prepared by reducing a compound of Formula I, for example using a double metal hydride such as lithium aluminium hydride in the presence of an anhydrous, non-hydroxylated and inert organic solvent. The compounds are active as hypotensors, adrenolytics, central depressants and anti-emetics. 4-Phenyl-2-methoxy-butyric acid is prepared by reacting 4-phenyl-2-hydroxy-butyric acid with silver oxide and methyl iodide and thereafter reacting the resulting ester with a solution methanolic potash.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3821961A GB970130A (en) | 1961-10-25 | 1961-10-25 | Piperazine derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3821961A GB970130A (en) | 1961-10-25 | 1961-10-25 | Piperazine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB970130A true GB970130A (en) | 1964-09-16 |
Family
ID=10402038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3821961A Expired GB970130A (en) | 1961-10-25 | 1961-10-25 | Piperazine derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB970130A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3530131A (en) * | 1961-02-08 | 1970-09-22 | Ciba Geigy Corp | Benzyl ethers |
-
1961
- 1961-10-25 GB GB3821961A patent/GB970130A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3530131A (en) * | 1961-02-08 | 1970-09-22 | Ciba Geigy Corp | Benzyl ethers |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE7409654L (en) | ||
| ES396446A1 (en) | Process for the production of polyglycolether compounds and their use | |
| GB842804A (en) | Preparation of substituted piperazines | |
| GB970130A (en) | Piperazine derivatives | |
| GB888657A (en) | Piperidine carbinols | |
| GB1378446A (en) | Process for the manufacture of dicyanovinyl compounds | |
| ES396221A1 (en) | Phosphorus-containing unsaturated carboxylic acid derivatives | |
| ES274329A1 (en) | Procedure for the preparation of new compounds of 1,5-benzodioxepano (Machine-translation by Google Translate, not legally binding) | |
| GB2004543A (en) | A process for preparing phenylalkane carboxylic acids | |
| GB1070139A (en) | Novel imidazothiazole derivatives and a process for preparation thereof | |
| ES394970A1 (en) | 3-lower alkyl-5-(o-(omega-amino-alkoxy)-phenoxymethyl)-isoxazoles and salts thereof | |
| GB1062626A (en) | Synthesis of í¸s,14-bisdehydrooestrone 3-ethers and intermediates therefor | |
| GB1352089A (en) | Bis-styryltriazoles their use for the optical brightening of organic materials and processes for their manufacture | |
| GB1021511A (en) | New alkylphosphonothioates and pesticidal compositions containing them | |
| GB937183A (en) | 3,8-diazabicyclo-[3,2,1]-octanes | |
| GB1070309A (en) | 4-aminoquinoline derivatives | |
| GB965293A (en) | New benzhydryl ethers | |
| ES274332A1 (en) | Preparation of derivatives of 1, 4-benzodioxan | |
| ES409589A1 (en) | A procedure for the preparation of cefalosporine compounds. (Machine-translation by Google Translate, not legally binding) | |
| GB915472A (en) | Process for arylindandiones | |
| GB957230A (en) | Tricyclic compounds and their manufacture | |
| GB944642A (en) | Pyridyl-propene compounds | |
| ES8105281A1 (en) | Procedure to prepare buffet (tio) lactonas (Machine-translation by Google Translate, not legally binding) | |
| GB966015A (en) | New basic dibenzo-oxepin and dibenzo-thiepin derivatives | |
| GB969198A (en) | Naphthol derivatives |