GB927896A - Therapeutically active n-carboxyalkyl-2-phenylethylamine derivatives - Google Patents
Therapeutically active n-carboxyalkyl-2-phenylethylamine derivativesInfo
- Publication number
- GB927896A GB927896A GB2464959A GB2464959A GB927896A GB 927896 A GB927896 A GB 927896A GB 2464959 A GB2464959 A GB 2464959A GB 2464959 A GB2464959 A GB 2464959A GB 927896 A GB927896 A GB 927896A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- formula
- hydrogen atom
- amino group
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000003277 amino group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- MHDVGSVTJDSBDK-UHFFFAOYSA-N dibenzyl ether Chemical group C=1C=CC=CC=1COCC1=CC=CC=C1 MHDVGSVTJDSBDK-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical group O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000572 bronchospasmolytic effect Effects 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L21/00—Processes or apparatus adapted for the manufacture or treatment of semiconductor or solid state devices or of parts thereof
- H01L21/02—Manufacture or treatment of semiconductor devices or of parts thereof
- H01L21/04—Manufacture or treatment of semiconductor devices or of parts thereof the devices having potential barriers, e.g. a PN junction, depletion layer or carrier concentration layer
- H01L21/48—Manufacture or treatment of parts, e.g. containers, prior to assembly of the devices, using processes not provided for in a single one of the groups H01L21/18 - H01L21/326 or H10D48/04 - H10D48/07
Landscapes
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Manufacturing & Machinery (AREA)
- Computer Hardware Design (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Power Engineering (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises a compound of the general formula I <FORM:0927896/IV(a)/1> or an acid addition salt thereof, in which R1 represents a straight or branched chain alkylene group containing 1 to 6 carbon atoms, and R2 represents an alkyl group containing 1 to 5 carbon atoms, and the preparation thereof by (a) reacting a compound of formula II <FORM:0927896/IV(a)/2> or the nuclear mono- or di-benzyloxy derivative thereof with a compound of formula III <FORM:0927896/IV(a)/3> in which one of the symbols X and Y represents a halogen atom and the other an amino group, R represents a keto-oxygen when X represents a halogen atom, or represents a hydrogen atom and a hydroxyl group when X represents an amino group, and, if necessary, reducing the compound formed; or (b) reacting a compound of formula XII <FORM:0927896/IV(a)/4> or the nuclear mono- or di-benzyloxy derivative thereof with a compound of formula XIII <FORM:0927896/IV(a)/5> in which one of the symbols X1 and Y1 represents the oxygen atom of a carbonyl group and the other represents an amino group and a hydrogen atom, R11 represents a residue consisting of R1 as hereinbefore defined less a hydrogen atom, and reducing the Schiff's base so formed; or (c) carrying out the reaction (b) under reducing conditions without isolating the Schiff's base. Pharmaceutical compositions having bronchospasmolytic activity comprise the compounds of the invention mixed with or dissolved in pharmaceutically-acceptable fillers or solvents. Particularly in injection liquids, the acid addition salts are used, and in tablets, the free bases.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL229793 | 1958-07-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB927896A true GB927896A (en) | 1963-06-06 |
Family
ID=19751291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2464959A Expired GB927896A (en) | 1958-07-21 | 1959-07-17 | Therapeutically active n-carboxyalkyl-2-phenylethylamine derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB927896A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4337207A (en) | 1980-09-04 | 1982-06-29 | Regents Of The University Of California | Biologically active catecholamine derivatives |
-
1959
- 1959-07-17 GB GB2464959A patent/GB927896A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4337207A (en) | 1980-09-04 | 1982-06-29 | Regents Of The University Of California | Biologically active catecholamine derivatives |
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