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GB893391A - Improvements in or relating to new phenylacetic acid derivatives having central depressant activity and processes for their production - Google Patents

Improvements in or relating to new phenylacetic acid derivatives having central depressant activity and processes for their production

Info

Publication number
GB893391A
GB893391A GB2289259A GB2289259A GB893391A GB 893391 A GB893391 A GB 893391A GB 2289259 A GB2289259 A GB 2289259A GB 2289259 A GB2289259 A GB 2289259A GB 893391 A GB893391 A GB 893391A
Authority
GB
United Kingdom
Prior art keywords
alkyl
hydrogen
radical
general formula
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2289259A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nederlandsche Combinatie voor Chemische Industrie NV
Original Assignee
Nederlandsche Combinatie voor Chemische Industrie NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nederlandsche Combinatie voor Chemische Industrie NV filed Critical Nederlandsche Combinatie voor Chemische Industrie NV
Publication of GB893391A publication Critical patent/GB893391A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:0893391/IV (b)/1> (wherein R1 and R2 each represent a hydrogen atom, a C1-5 alkyl radical or phenyl radical, R3 represents a hydrogen atom or a C1-5 alkyl radical, R4 represents a hydrogen atom, an alkyl, alkenyl or alkynyl radical of not more than 5 carbon atoms, or a cycloalkyl, aralkyl, aryl or heteroaromatic radical, and Rn represents one or more hydrogen or halogen atoms or C1-5 alkyl or alkoxy radicals), and the preparation thereof by reacting a 2-halopyrazine of the general formula <FORM:0893391/IV (b)/2> (wherein Hal represents a halogen atom) with a phenylacetonitrile alkali metal compound of the general formula <FORM:0893391/IV (b)/3> (wherein Me represents an alkali metal atom), or, when R4 is other than hydrogen, by reacting an alkali metal compound of a compound in which R4 is hydrogen with an alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aryl or heteroaromatic halide. Alternatively, a compound of the first general formula above in which R4 represents a halogen atom may be reacted with a suitable alkali or alkaline-earth metal compound (e.g. phenyl lithium or an alkylmagnesium halide). The products have sedative or anticonvulsive activity. Specification 893,392 is referred to.
GB2289259A 1958-07-05 1959-07-03 Improvements in or relating to new phenylacetic acid derivatives having central depressant activity and processes for their production Expired GB893391A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL229365 1958-07-05

Publications (1)

Publication Number Publication Date
GB893391A true GB893391A (en) 1962-04-11

Family

ID=19751268

Family Applications (2)

Application Number Title Priority Date Filing Date
GB3714661A Expired GB893392A (en) 1958-07-05 1959-07-03 Improvements in or relating to new phenylacetic acid derivatives having central depressant activity and processes for their production
GB2289259A Expired GB893391A (en) 1958-07-05 1959-07-03 Improvements in or relating to new phenylacetic acid derivatives having central depressant activity and processes for their production

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB3714661A Expired GB893392A (en) 1958-07-05 1959-07-03 Improvements in or relating to new phenylacetic acid derivatives having central depressant activity and processes for their production

Country Status (5)

Country Link
BE (1) BE580400A (en)
CH (1) CH386429A (en)
DE (1) DE1101425B (en)
ES (1) ES250532A1 (en)
GB (2) GB893392A (en)

Also Published As

Publication number Publication date
GB893392A (en) 1962-04-11
DE1101425B (en) 1961-03-09
CH386429A (en) 1965-01-15
ES250532A1 (en) 1959-12-16
BE580400A (en) 1959-11-03

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