Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB39493/56A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
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Filing date
Publication date
Application filed by Merck and Co IncfiledCriticalMerck and Co Inc
Publication of GB834451ApublicationCriticalpatent/GB834451A/en
A 2 - methyl - 3 - hydroxy - 4 - (C1-5 alkoxy) methyl - 5 - hydroxymethylpyridine is obtained in a process that comprises intimately contacting an acidified aqueous solution of a 2-methyl - 3 - amino - 4 - (C1-5 alkoxy) - methyl-5 - aminomethylpyridine with a C1-5 alkyl nitrite. Suitable nitrites are ethyl nitrite, methyl nitrite, amyl nitrite and butyl nitrite. The The aqueous solution may be acidified with hydrochloric acid equivalent to about 4-5 mols. per mol. of the diamino pyridine compound. The aqueous solution is heated in the temperature range 40-90 DEG C. and the alkyl nitrite introduced in gaseous form. An example describes the preparation of 2 - methyl - 3 - hydroxy - 4 - methoxymethyl - 5 - hydroxymethylpyridine.