GB1330829A - Layered bolus for animal husbandry providing for immediate and sustained release of medicament - Google Patents
Layered bolus for animal husbandry providing for immediate and sustained release of medicamentInfo
- Publication number
- GB1330829A GB1330829A GB2342672A GB2342672A GB1330829A GB 1330829 A GB1330829 A GB 1330829A GB 2342672 A GB2342672 A GB 2342672A GB 2342672 A GB2342672 A GB 2342672A GB 1330829 A GB1330829 A GB 1330829A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sustained release
- bolus
- medicament
- immediate
- release layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000013268 sustained release Methods 0.000 title abstract 9
- 239000012730 sustained-release form Substances 0.000 title abstract 9
- 239000003814 drug Substances 0.000 title abstract 7
- 239000012729 immediate-release (IR) formulation Substances 0.000 title abstract 5
- 241000282849 Ruminantia Species 0.000 abstract 4
- 230000003179 granulation Effects 0.000 abstract 4
- 238000005469 granulation Methods 0.000 abstract 4
- 239000000945 filler Substances 0.000 abstract 3
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 1
- 241000195947 Lycopodium Species 0.000 abstract 1
- RHCOJUBIAOBGKL-UHFFFAOYSA-N O(I)I.[Mg] Chemical compound O(I)I.[Mg] RHCOJUBIAOBGKL-UHFFFAOYSA-N 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- 239000011398 Portland cement Substances 0.000 abstract 1
- 235000021355 Stearic acid Nutrition 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 230000000507 anthelmentic effect Effects 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 abstract 1
- 239000008116 calcium stearate Substances 0.000 abstract 1
- 235000013539 calcium stearate Nutrition 0.000 abstract 1
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Inorganic materials [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 abstract 1
- PASHVRUKOFIRIK-UHFFFAOYSA-L calcium sulfate dihydrate Chemical compound O.O.[Ca+2].[O-]S([O-])(=O)=O PASHVRUKOFIRIK-UHFFFAOYSA-L 0.000 abstract 1
- ZOMBKNNSYQHRCA-UHFFFAOYSA-J calcium sulfate hemihydrate Chemical compound O.[Ca+2].[Ca+2].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O ZOMBKNNSYQHRCA-UHFFFAOYSA-J 0.000 abstract 1
- 239000004568 cement Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229960005091 chloramphenicol Drugs 0.000 abstract 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 abstract 1
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 abstract 1
- 229960001076 chlorpromazine Drugs 0.000 abstract 1
- 229940110456 cocoa butter Drugs 0.000 abstract 1
- 235000019868 cocoa butter Nutrition 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- PLHJDBGFXBMTGZ-WEVVVXLNSA-N furazolidone Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)OCC1 PLHJDBGFXBMTGZ-WEVVVXLNSA-N 0.000 abstract 1
- 229960001625 furazolidone Drugs 0.000 abstract 1
- 239000010439 graphite Substances 0.000 abstract 1
- 229910002804 graphite Inorganic materials 0.000 abstract 1
- 239000011507 gypsum plaster Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 235000019359 magnesium stearate Nutrition 0.000 abstract 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 abstract 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 abstract 1
- 239000012188 paraffin wax Substances 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- NQQWFVUVBGSGQN-UHFFFAOYSA-N phosphoric acid;piperazine Chemical compound OP(O)(O)=O.C1CNCCN1 NQQWFVUVBGSGQN-UHFFFAOYSA-N 0.000 abstract 1
- 229960001954 piperazine phosphate Drugs 0.000 abstract 1
- 210000004767 rumen Anatomy 0.000 abstract 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 abstract 1
- 239000008117 stearic acid Substances 0.000 abstract 1
- ASWVTGNCAZCNNR-UHFFFAOYSA-N sulfamethazine Chemical compound CC1=CC(C)=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ASWVTGNCAZCNNR-UHFFFAOYSA-N 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
- 239000013589 supplement Substances 0.000 abstract 1
- 239000000454 talc Substances 0.000 abstract 1
- 229910052623 talc Inorganic materials 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
- 229940125725 tranquilizer Drugs 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
- 150000003722 vitamin derivatives Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0068—Rumen, e.g. rumen bolus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fodder In General (AREA)
Abstract
1330829 Immediate and sustained release layered bolus SMITH KLINE & FRENCH LABORATORIES 18 May 1972 [18 May 1971] 23426/72 Heading A5B A sustained release veterinary layered bolus comprising an immediate release layer and, contiguous therewith, a sustained release layer, the immediate release layer having a disintegration time in the rumen of less than 30 minutes and comprising sufficient of a medicament rapidly to provide a therapeutic level of the medicament in the blood of the ruminant animal to which the bolus is administered and the sustained release layer comprising a filler matrix of such a density that the bolus will lodge in the rumenoreticular sac of the ruminant animal and sufficient of the medicament that, at the rate of disintegration of the sustained release layer, a therapeutic level of the medicament is maintained in the blood of the ruminant animal to which the bolus is administered for at least 72 hours from the time of dosage, may be prepared by preparing separate immediate and sustained release granulations containing a medicament and a filler which at least in the sustained release granulation is of such a density that the bolus will lodge in the rumeno-reticular sac of the ruminant animal, placing the granulations in separate hoppers and selectively compressing the granulations into a layered bolus. The filler matrix may be iron powder, calcium sulphate dihydrate; Portland cement, plaster of Paris and/ or magnesium oxyiodide cement. The sustained release effect may be accomplished by employing a lubricant such as magnesium stearate, sodium stearate, calcium stearate, powdered stearic acid, talc, paraffin, cocoa butter, graphite and/or lycopodium. The medicament may be a sulphonamide derivative such as sulphamethazine or sulphathiazine; a tranquilizer such as chlorpromazine; an antibiotic such as chloramphenicol, tetracycline or penicillin; an anthelmintic such as piperazine phosphate, an anti-bloat agent such as organopolysilpxane; a hormone growth supplement such as stilbesterol, a vitamin or antibacterial such as furazolidone.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14449971A | 1971-05-18 | 1971-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1330829A true GB1330829A (en) | 1973-09-19 |
Family
ID=22508878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2342672A Expired GB1330829A (en) | 1971-05-18 | 1972-05-18 | Layered bolus for animal husbandry providing for immediate and sustained release of medicament |
Country Status (10)
| Country | Link |
|---|---|
| AU (1) | AU470023B2 (en) |
| BE (1) | BE783321A (en) |
| CA (1) | CA997677A (en) |
| DE (1) | DE2224390A1 (en) |
| ES (1) | ES402545A1 (en) |
| FR (1) | FR2138011B1 (en) |
| GB (1) | GB1330829A (en) |
| IE (1) | IE36335B1 (en) |
| NL (1) | NL7206328A (en) |
| ZA (1) | ZA722664B (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2500307A1 (en) * | 1981-02-23 | 1982-08-27 | Rech Applications Therap | ANTIBIOTIC PHARMACEUTICAL COMPOSITION FOR THE IMPLANTATION INTO A NATURAL, PATHOLOGICAL OR ARTIFICIAL CAVITY OF PHYSIOLOGICAL TISSUES, ITS PREPARATION AND USE |
| GB2155335A (en) * | 1984-03-07 | 1985-09-25 | Crb Virbac Sa | Device for sustained release of medicinal substances |
| US4661339A (en) * | 1982-07-20 | 1987-04-28 | National Research Development Corp. | Sustained release composition |
| US5190760A (en) * | 1989-07-08 | 1993-03-02 | Coopers Animal Health Limited | Solid pharmaceutical composition |
| WO2001032217A3 (en) * | 1999-11-02 | 2002-07-18 | Depomed Inc | Pharmacological inducement of the fed mode for enhanced drug administration to the stomach |
| US6682759B2 (en) | 2002-02-01 | 2004-01-27 | Depomed, Inc. | Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs |
| US6723340B2 (en) | 2001-10-25 | 2004-04-20 | Depomed, Inc. | Optimal polymer mixtures for gastric retentive tablets |
| US7736667B2 (en) | 2000-02-04 | 2010-06-15 | Depomed, Inc. | Shell-and-core dosage form approaching zero-order drug release |
| US7976870B2 (en) | 2001-10-25 | 2011-07-12 | Depomed, Inc. | Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract |
| US8685450B2 (en) | 2003-07-18 | 2014-04-01 | Depomed, Inc. | Dual drug dosage forms with improved separation of drugs |
| CN104523636A (en) * | 2014-12-25 | 2015-04-22 | 昆明振华制药厂有限公司 | Furazolidone sustained-release tablet and preparation method thereof |
| CN114582457A (en) * | 2020-11-30 | 2022-06-03 | 国际商业机器公司 | Time controlled medication |
| WO2025029158A1 (en) * | 2023-08-01 | 2025-02-06 | Ruminant Biotech Corp Limited | Improved bolus designs for administration to a ruminant animal and uses thereof |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4137300A (en) * | 1976-08-20 | 1979-01-30 | Ciba-Geigy Corporation | Sustained action dosage forms |
| NZ234227A (en) * | 1989-06-30 | 1991-08-27 | Smithkline Beecham Corp | Delayed release dosage form |
| GB8915716D0 (en) * | 1989-07-08 | 1989-08-31 | Coopers Animal Health | Pharmaceutical compositions |
| AU116209S (en) | 1991-12-23 | 1993-01-28 | The Wellcome Foundation Ltd | A pharmaceutical tablet |
| USD376847S (en) | 1992-06-30 | 1996-12-24 | Burroughs Wellcome Co. | Pharmaceutical tablet |
| LT4037666T (en) | 2020-12-08 | 2024-06-10 | Ruminant Biotech Corp Limited | Improvements to devices and methods for delivery of substances to animals |
-
1972
- 1972-04-19 ZA ZA722664A patent/ZA722664B/en unknown
- 1972-04-27 IE IE562/72A patent/IE36335B1/en unknown
- 1972-05-09 ES ES402545A patent/ES402545A1/en not_active Expired
- 1972-05-10 BE BE783321A patent/BE783321A/en not_active IP Right Cessation
- 1972-05-10 NL NL7206328A patent/NL7206328A/xx not_active Application Discontinuation
- 1972-05-15 AU AU42309/72A patent/AU470023B2/en not_active Expired
- 1972-05-17 FR FR727217600A patent/FR2138011B1/fr not_active Expired
- 1972-05-17 CA CA142,402A patent/CA997677A/en not_active Expired
- 1972-05-18 DE DE2224390A patent/DE2224390A1/en active Pending
- 1972-05-18 GB GB2342672A patent/GB1330829A/en not_active Expired
Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2500307A1 (en) * | 1981-02-23 | 1982-08-27 | Rech Applications Therap | ANTIBIOTIC PHARMACEUTICAL COMPOSITION FOR THE IMPLANTATION INTO A NATURAL, PATHOLOGICAL OR ARTIFICIAL CAVITY OF PHYSIOLOGICAL TISSUES, ITS PREPARATION AND USE |
| US4661339A (en) * | 1982-07-20 | 1987-04-28 | National Research Development Corp. | Sustained release composition |
| GB2155335A (en) * | 1984-03-07 | 1985-09-25 | Crb Virbac Sa | Device for sustained release of medicinal substances |
| US5190760A (en) * | 1989-07-08 | 1993-03-02 | Coopers Animal Health Limited | Solid pharmaceutical composition |
| WO2001032217A3 (en) * | 1999-11-02 | 2002-07-18 | Depomed Inc | Pharmacological inducement of the fed mode for enhanced drug administration to the stomach |
| AU781718B2 (en) * | 1999-11-02 | 2005-06-09 | Depomed, Inc. | Pharmacological inducement of the fed mode for enhanced drug administration to the stomach |
| EP1790334A3 (en) * | 1999-11-02 | 2008-02-20 | Depomed, Inc. | Pharmacological inducement of the fed mode for enhanced drug administration to the stomach |
| US7405238B2 (en) | 1999-11-02 | 2008-07-29 | Depomed Inc. | Pharmacological inducement of the fed mode for enhanced drug administration to the stomach |
| US9597338B2 (en) | 2000-02-04 | 2017-03-21 | Depomed, Inc. | Shell-and-core dosage form approaching zero-order drug release |
| US8329215B2 (en) | 2000-02-04 | 2012-12-11 | Depomed, Inc. | Shell and core dosage form approaching zero-order drug release |
| US7736667B2 (en) | 2000-02-04 | 2010-06-15 | Depomed, Inc. | Shell-and-core dosage form approaching zero-order drug release |
| US8945619B2 (en) | 2000-02-04 | 2015-02-03 | Depomed, Inc. | Shell-and-core dosage form approaching zero-order drug release |
| US8043630B2 (en) | 2000-02-04 | 2011-10-25 | Depomed, Inc. | Shell-and-core dosage form approaching zero-order drug release |
| US6723340B2 (en) | 2001-10-25 | 2004-04-20 | Depomed, Inc. | Optimal polymer mixtures for gastric retentive tablets |
| US7976870B2 (en) | 2001-10-25 | 2011-07-12 | Depomed, Inc. | Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract |
| US9980903B2 (en) | 2001-10-25 | 2018-05-29 | Depomed, Inc. | Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract |
| US6682759B2 (en) | 2002-02-01 | 2004-01-27 | Depomed, Inc. | Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs |
| US8685450B2 (en) | 2003-07-18 | 2014-04-01 | Depomed, Inc. | Dual drug dosage forms with improved separation of drugs |
| US8999388B2 (en) | 2003-07-18 | 2015-04-07 | Depomed, Inc. | Dual drug dosage forms with improved separation of drugs |
| US9572780B2 (en) | 2003-07-18 | 2017-02-21 | Depomed, Inc. | Dual drug dosage forms with improved separation of drugs |
| CN104523636A (en) * | 2014-12-25 | 2015-04-22 | 昆明振华制药厂有限公司 | Furazolidone sustained-release tablet and preparation method thereof |
| CN104523636B (en) * | 2014-12-25 | 2017-07-18 | 昆明振华制药厂有限公司 | A kind of furazolidone sustained release tablets and preparation method thereof |
| CN114582457A (en) * | 2020-11-30 | 2022-06-03 | 国际商业机器公司 | Time controlled medication |
| WO2025029158A1 (en) * | 2023-08-01 | 2025-02-06 | Ruminant Biotech Corp Limited | Improved bolus designs for administration to a ruminant animal and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2138011B1 (en) | 1973-07-13 |
| ZA722664B (en) | 1973-01-31 |
| AU470023B2 (en) | 1976-03-04 |
| BE783321A (en) | 1972-11-10 |
| ES402545A1 (en) | 1975-04-01 |
| DE2224390A1 (en) | 1973-12-13 |
| NL7206328A (en) | 1972-11-21 |
| IE36335L (en) | 1972-11-18 |
| CA997677A (en) | 1976-09-28 |
| IE36335B1 (en) | 1976-10-13 |
| AU4230972A (en) | 1973-11-22 |
| FR2138011A1 (en) | 1972-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PE20 | Patent expired after termination of 20 years |