GB1074085A - Dibenzocycloheptene compounds - Google Patents
Dibenzocycloheptene compoundsInfo
- Publication number
- GB1074085A GB1074085A GB35404/66A GB3540466A GB1074085A GB 1074085 A GB1074085 A GB 1074085A GB 35404/66 A GB35404/66 A GB 35404/66A GB 3540466 A GB3540466 A GB 3540466A GB 1074085 A GB1074085 A GB 1074085A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- alkyl
- radical
- formula
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
The invention comprises compounds of the Formulae I and II, wherein R0 represents a C1- 6\t alkyl radical, each of R11 and R111 represents a hydrogen atom or an alkyl, aryl or aralkyl radical, R1111 represents an alkyl, aryl or aralkyl radical and each of X and X1 represents a hydrogen or halogen atom or a C1- 6 alkyl, C2- 6 alkenyl, trifluoromethyl, hydroxyl, C1- 4 alkoxy, mercapto, C1- 4 alkylmercapto, C1- 4 alkylsulphonyl, sulphamoyl, C1- 4 alkylsulphamoyl or C2- 8 dialkylsulphamoyl radical and Ac represents an acyl radical; their preparation by reacting the corresponding 5-[3-(di-R0-substituted-amino) propylidene] dibenzocycloheptene derivatives with a haloformate of the formula Hal.COOR1111 where Hal represents a halogen atom; the conversion of compounds of the Formula I into compounds of the Formula III by hydrolysis under alkaline conditions followed by acid conditions, and the conversion of compounds of the Formula II into compounds of the Formula III by hydrolysis under alkaline conditions. <FORM:1074085/C2/1> <FORM:1074085/C2/2> <FORM:1074085/C2/3>
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US296463A US3390179A (en) | 1963-07-22 | 1963-07-22 | Novel 10, 11-dihydro-10, 11-dihydroxy-(3-substituted aminopropylidene)-5h-dibenzo [a, d] cycloheptenes |
| US4847870A | 1970-06-22 | 1970-06-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1074085A true GB1074085A (en) | 1967-06-28 |
Family
ID=26726156
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB35403/66A Expired GB1074084A (en) | 1963-07-22 | 1964-07-09 | Dibenzocycloheptene compounds |
| GB28412/64A Expired GB1074082A (en) | 1963-07-22 | 1964-07-09 | Dibenzocycloheptene compounds |
| GB35402/66A Expired GB1074083A (en) | 1963-07-22 | 1964-07-09 | Dibenzocycloheptene compounds |
| GB35404/66A Expired GB1074085A (en) | 1963-07-22 | 1964-07-09 | Dibenzocycloheptene compounds |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB35403/66A Expired GB1074084A (en) | 1963-07-22 | 1964-07-09 | Dibenzocycloheptene compounds |
| GB28412/64A Expired GB1074082A (en) | 1963-07-22 | 1964-07-09 | Dibenzocycloheptene compounds |
| GB35402/66A Expired GB1074083A (en) | 1963-07-22 | 1964-07-09 | Dibenzocycloheptene compounds |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US3390179A (en) |
| BE (1) | BE650800A (en) |
| BR (1) | BR6460953D0 (en) |
| CH (1) | CH494731A (en) |
| DE (1) | DE1468339A1 (en) |
| DK (3) | DK127723B (en) |
| FR (2) | FR1572128A (en) |
| GB (4) | GB1074084A (en) |
| IL (2) | IL21665A (en) |
| NL (1) | NL6408390A (en) |
| SE (3) | SE332820B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3905981A (en) * | 1973-10-12 | 1975-09-16 | Research Corp | N-dealkylation of tertiary amines |
| US4089864A (en) * | 1974-03-25 | 1978-05-16 | Merck & Co., Inc. | 4-(10,11-Dihydro-cis and trans-10,11-dihydroxy-5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidines |
| US3894032A (en) * | 1974-04-10 | 1975-07-08 | Merck & Co Inc | 10,11-Furo derivatives of cyproheptadine |
| US4044143A (en) * | 1975-01-30 | 1977-08-23 | Merck & Co., Inc. | 10,11-Bis-(hydroxyalkyl) derivatives of cyproheptadine |
| DE4232173A1 (en) * | 1992-09-25 | 1994-03-31 | Bayer Ag | 5-oxo-dibenzo (a, d) cyclohepta-1,4-diene |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3234279A (en) * | 1962-09-14 | 1966-02-08 | Merck & Co Inc | 5-(gamma-amino-propyl- and propylidene-) 5h-dibenzo[a, d]-10-hydroxy-10, 11-dihydrocycloheptenes and amine borane salts thereof |
-
1963
- 1963-07-22 US US296463A patent/US3390179A/en not_active Expired - Lifetime
-
1964
- 1964-07-02 SE SE09743/67A patent/SE332820B/xx unknown
- 1964-07-07 IL IL21665A patent/IL21665A/en unknown
- 1964-07-07 IL IL29677A patent/IL29677A/en unknown
- 1964-07-09 GB GB35403/66A patent/GB1074084A/en not_active Expired
- 1964-07-09 GB GB28412/64A patent/GB1074082A/en not_active Expired
- 1964-07-09 GB GB35402/66A patent/GB1074083A/en not_active Expired
- 1964-07-09 GB GB35404/66A patent/GB1074085A/en not_active Expired
- 1964-07-17 BR BR160953/64A patent/BR6460953D0/en unknown
- 1964-07-20 BE BE650800D patent/BE650800A/xx unknown
- 1964-07-21 SE SE09742/67A patent/SE332819B/xx unknown
- 1964-07-21 SE SE8875/64A patent/SE320963B/xx unknown
- 1964-07-21 DK DK362064AA patent/DK127723B/en unknown
- 1964-07-21 CH CH953364A patent/CH494731A/en not_active IP Right Cessation
- 1964-07-21 FR FR1572128D patent/FR1572128A/fr not_active Expired
- 1964-07-21 DE DE19641468339 patent/DE1468339A1/en active Pending
- 1964-07-22 NL NL6408390A patent/NL6408390A/xx unknown
- 1964-10-20 FR FR992062A patent/FR3905M/fr not_active Expired
-
1965
- 1965-07-09 DK DK351165AA patent/DK121757B/en unknown
- 1965-07-09 DK DK351265AA patent/DK121856B/en unknown
-
1970
- 1970-06-22 US US48478A patent/US3660389A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| BE650800A (en) | 1965-01-20 |
| US3660389A (en) | 1972-05-02 |
| SE320963B (en) | 1970-02-23 |
| IL29677A (en) | 1969-01-29 |
| IL21665A (en) | 1969-01-29 |
| GB1074083A (en) | 1967-06-28 |
| DK121856B (en) | 1971-12-13 |
| DK121757B (en) | 1971-11-29 |
| BR6460953D0 (en) | 1973-08-02 |
| FR3905M (en) | 1966-02-07 |
| GB1074082A (en) | 1967-06-28 |
| CH494731A (en) | 1970-08-15 |
| NL6408390A (en) | 1965-01-25 |
| SE332820B (en) | 1971-02-22 |
| FR1572128A (en) | 1969-06-27 |
| US3390179A (en) | 1968-06-25 |
| DE1468339A1 (en) | 1968-12-19 |
| DK127723B (en) | 1973-12-24 |
| GB1074084A (en) | 1967-06-28 |
| SE332819B (en) | 1971-02-22 |
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