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FR2526434A1 - Nouveaux azepino-indoles, leur preparation et leur utilisation comme medicaments - Google Patents

Nouveaux azepino-indoles, leur preparation et leur utilisation comme medicaments Download PDF

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Publication number
FR2526434A1
FR2526434A1 FR8307089A FR8307089A FR2526434A1 FR 2526434 A1 FR2526434 A1 FR 2526434A1 FR 8307089 A FR8307089 A FR 8307089A FR 8307089 A FR8307089 A FR 8307089A FR 2526434 A1 FR2526434 A1 FR 2526434A1
Authority
FR
France
Prior art keywords
alkyl
compound
acid addition
addition salt
hexahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR8307089A
Other languages
English (en)
French (fr)
Inventor
Fulvio Gadient
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2526434A1 publication Critical patent/FR2526434A1/fr
Priority to DK148984A priority Critical patent/DK148984A/da
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR8307089A 1982-05-06 1983-04-27 Nouveaux azepino-indoles, leur preparation et leur utilisation comme medicaments Pending FR2526434A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK148984A DK148984A (da) 1983-04-27 1984-02-29 Azepinoindoler

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH2806/82A CH649553A5 (de) 1982-05-06 1982-05-06 Azepinoindole und verfahren zu deren herstellung.

Publications (1)

Publication Number Publication Date
FR2526434A1 true FR2526434A1 (fr) 1983-11-10

Family

ID=4242007

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8307089A Pending FR2526434A1 (fr) 1982-05-06 1983-04-27 Nouveaux azepino-indoles, leur preparation et leur utilisation comme medicaments

Country Status (17)

Country Link
JP (1) JPS58203993A (da)
AU (1) AU1425683A (da)
BE (1) BE896590A (da)
CH (1) CH649553A5 (da)
DE (1) DE3315467A1 (da)
DK (1) DK199883A (da)
ES (1) ES522008A0 (da)
FI (1) FI831475L (da)
FR (1) FR2526434A1 (da)
GB (1) GB2120662B (da)
HU (1) HU189275B (da)
IL (1) IL68576A0 (da)
IT (1) IT1197644B (da)
NL (1) NL8301552A (da)
PT (1) PT76632B (da)
SE (1) SE8302554L (da)
ZA (1) ZA833266B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8500370A (nl) * 1984-02-22 1985-09-16 Sandoz Ag Diazepinoindolen, werkwijzen voor hun bereiding en farmaceutische preparaten die ze bevatten.
AU582564B2 (en) * 1985-02-20 1989-04-06 Sandoz Ltd. 2,3,4,5-tetrahydro-11-phenyl-1H-``1,4``diazepino``1,7-a`` indoles, their production and pharmaceutical compositions containing them
EP1319004A2 (en) * 2000-09-20 2003-06-18 PHARMACIA & UPJOHN COMPANY Substituted azepino[4,5-b]indole derivatives
EP1414819B1 (en) 2001-08-08 2005-10-12 Pharmacia & Upjohn Company LLC THERAPEUTIC 1H-PYRIDO[4,3-b]INDOLES
US7893051B2 (en) * 2006-01-19 2011-02-22 Athersys, Inc. Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof
NZ586120A (en) 2008-01-11 2012-07-27 Albany Molecular Res Inc (1-azinone) -substituted pyridoindoles as mch antagonists
US8618299B2 (en) 2009-07-01 2013-12-31 Albany Molecular Research, Inc. Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
WO2011003021A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2011003005A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
US8629158B2 (en) 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US8697700B2 (en) 2010-12-21 2014-04-15 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028381A2 (en) * 1979-11-02 1981-05-13 Sandoz Ag Azepinoindoles, process for their production and pharmaceutical compositions containing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028381A2 (en) * 1979-11-02 1981-05-13 Sandoz Ag Azepinoindoles, process for their production and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FI831475L (fi) 1983-11-07
PT76632A (en) 1983-06-01
SE8302554D0 (sv) 1983-05-04
AU1425683A (en) 1983-11-10
HU189275B (en) 1986-06-30
IT8348232A0 (it) 1983-05-06
DK199883A (da) 1983-11-07
ES8502440A1 (es) 1985-01-01
ZA833266B (en) 1984-12-24
GB2120662B (en) 1985-09-11
CH649553A5 (de) 1985-05-31
PT76632B (en) 1986-01-27
JPS58203993A (ja) 1983-11-28
GB8312159D0 (en) 1983-06-08
BE896590A (fr) 1983-10-28
NL8301552A (nl) 1983-12-01
GB2120662A (en) 1983-12-07
SE8302554L (sv) 1983-11-07
ES522008A0 (es) 1985-01-01
IT1197644B (it) 1988-12-06
FI831475A0 (fi) 1983-04-29
DE3315467A1 (de) 1983-11-17
DK199883D0 (da) 1983-05-04
IL68576A0 (en) 1983-09-30

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