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FR2481280A1 - Procede de preparation de derives de 2-guanidinothiazole, nouveaux produits ainsi obtenus et leur utilisation comme agents contre les ulceres d'estomac - Google Patents

Procede de preparation de derives de 2-guanidinothiazole, nouveaux produits ainsi obtenus et leur utilisation comme agents contre les ulceres d'estomac Download PDF

Info

Publication number
FR2481280A1
FR2481280A1 FR8108468A FR8108468A FR2481280A1 FR 2481280 A1 FR2481280 A1 FR 2481280A1 FR 8108468 A FR8108468 A FR 8108468A FR 8108468 A FR8108468 A FR 8108468A FR 2481280 A1 FR2481280 A1 FR 2481280A1
Authority
FR
France
Prior art keywords
group
thiazole
compound according
ethylthiomethyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8108468A
Other languages
English (en)
French (fr)
Other versions
FR2481280B1 (de
Inventor
Kentaro Hirai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of FR2481280A1 publication Critical patent/FR2481280A1/fr
Application granted granted Critical
Publication of FR2481280B1 publication Critical patent/FR2481280B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR8108468A 1980-04-29 1981-04-28 Procede de preparation de derives de 2-guanidinothiazole, nouveaux produits ainsi obtenus et leur utilisation comme agents contre les ulceres d'estomac Granted FR2481280A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14494680A 1980-04-29 1980-04-29

Publications (2)

Publication Number Publication Date
FR2481280A1 true FR2481280A1 (fr) 1981-10-30
FR2481280B1 FR2481280B1 (de) 1983-10-28

Family

ID=22510873

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8108468A Granted FR2481280A1 (fr) 1980-04-29 1981-04-28 Procede de preparation de derives de 2-guanidinothiazole, nouveaux produits ainsi obtenus et leur utilisation comme agents contre les ulceres d'estomac

Country Status (16)

Country Link
JP (1) JPS574977A (de)
AR (1) AR231538A1 (de)
AU (1) AU540239B2 (de)
BE (1) BE888602A (de)
CH (1) CH646964A5 (de)
DE (1) DE3116890A1 (de)
DK (1) DK188881A (de)
ES (1) ES8206501A1 (de)
FR (1) FR2481280A1 (de)
GB (1) GB2076397B (de)
IE (1) IE51151B1 (de)
IL (1) IL62747A (de)
IT (1) IT1146750B (de)
NL (1) NL8102099A (de)
NZ (1) NZ196923A (de)
SE (1) SE452462B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501747A (en) * 1982-05-10 1985-02-26 Sanofi Certain amide derivatives of 2-guanidino-thiazoles and compositions containing same
FR2531705B1 (fr) * 1982-08-13 1986-12-05 Sanofi Sa Amidobenzamides, leurs sels, procede pour leur preparation et compositions pharmaceutiques les renfermant
JPS59104370A (ja) * 1982-12-03 1984-06-16 Kotobuki Seiyaku Kk チアゾ−ル誘導体及びその製造方法
GB2138803B (en) * 1983-04-26 1986-06-18 Shionogi & Co 2-guanidino-4-hydroxymethylthiazole and derivatives thereof
US4680300A (en) * 1985-01-10 1987-07-14 Syntex (U.S.A.) Inc. Anti-inflammatory guanidines
US4837316A (en) * 1985-08-29 1989-06-06 Fujirebio Kabushiki Kaisha Alkylamide derivatives with H2 -receptor antagonistic and cytoprotective action
EP0385525B1 (de) * 1989-03-03 1994-04-13 Akzo Nv Aminoethylthiazole und Aminoethyloxazol-Derivate.

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4165377A (en) * 1977-04-20 1979-08-21 Ici Americas Inc. Guanidino imidazoles and thiazoles
US4165378A (en) * 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
EP0003640A2 (de) * 1978-01-18 1979-08-22 Imperial Chemical Industries Plc Antisekretorische Guanidinderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
EP0010418A1 (de) * 1978-10-16 1980-04-30 Imperial Chemical Industries Plc Antisekretorische Guanidinderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
EP0010893A1 (de) * 1978-10-16 1980-05-14 Imperial Chemical Industries Plc Verzweigtkettige heterozyklische Guanidinderivate mit antisekretorischer Wirkung, Verfahren zu ihrer Herstellung, Zwischenprodukte und die genannten Derivate enthaltende pharmazeutische Zusammensetzungen
EP0014057A1 (de) * 1979-01-18 1980-08-06 Imperial Chemical Industries Plc Guanidin-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH16099A (en) * 1979-03-06 1983-06-24 Yamanouchi Pharma Co Ltd Guanidinothiazole compounds,process for preparing them and medical composition containing them
GR71929B (de) * 1979-11-13 1983-08-19 Ici Ltd
JPS5754177A (ja) * 1980-09-19 1982-03-31 Teikoku Hormone Mfg Co Ltd Chikanchiazoorujudotai
JPS57102852A (en) * 1980-12-19 1982-06-26 Shionogi & Co Ltd Dicarboxylic acid diamide

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4165377A (en) * 1977-04-20 1979-08-21 Ici Americas Inc. Guanidino imidazoles and thiazoles
US4165378A (en) * 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
EP0003640A2 (de) * 1978-01-18 1979-08-22 Imperial Chemical Industries Plc Antisekretorische Guanidinderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
EP0010418A1 (de) * 1978-10-16 1980-04-30 Imperial Chemical Industries Plc Antisekretorische Guanidinderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
EP0010893A1 (de) * 1978-10-16 1980-05-14 Imperial Chemical Industries Plc Verzweigtkettige heterozyklische Guanidinderivate mit antisekretorischer Wirkung, Verfahren zu ihrer Herstellung, Zwischenprodukte und die genannten Derivate enthaltende pharmazeutische Zusammensetzungen
EP0014057A1 (de) * 1979-01-18 1980-08-06 Imperial Chemical Industries Plc Guanidin-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CA1979 *

Also Published As

Publication number Publication date
NZ196923A (en) 1983-12-16
ES501736A0 (es) 1982-08-16
SE452462B (sv) 1987-11-30
DK188881A (da) 1981-10-30
GB2076397A (en) 1981-12-02
BE888602A (fr) 1981-10-28
SE8102683L (sv) 1981-10-30
IE51151B1 (en) 1986-10-15
JPH027952B2 (de) 1990-02-21
AU540239B2 (en) 1984-11-08
IE810956L (en) 1981-10-29
CH646964A5 (de) 1984-12-28
IL62747A (en) 1984-10-31
AU6996681A (en) 1981-11-05
IL62747A0 (en) 1981-06-29
IT8167585A0 (it) 1981-04-29
NL8102099A (nl) 1981-11-16
IT1146750B (it) 1986-11-19
ES8206501A1 (es) 1982-08-16
FR2481280B1 (de) 1983-10-28
GB2076397B (en) 1984-02-08
DE3116890A1 (de) 1982-03-04
JPS574977A (en) 1982-01-11
AR231538A1 (es) 1984-12-28

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