[go: up one dir, main page]

FR2385696A2 - Nouveaux acides 15-desoxy-16-hydroxyprostanoiques 16-substitues doues d'activites pharmaceutiques et leur procede de preparation - Google Patents

Nouveaux acides 15-desoxy-16-hydroxyprostanoiques 16-substitues doues d'activites pharmaceutiques et leur procede de preparation

Info

Publication number
FR2385696A2
FR2385696A2 FR7809306A FR7809306A FR2385696A2 FR 2385696 A2 FR2385696 A2 FR 2385696A2 FR 7809306 A FR7809306 A FR 7809306A FR 7809306 A FR7809306 A FR 7809306A FR 2385696 A2 FR2385696 A2 FR 2385696A2
Authority
FR
France
Prior art keywords
alkyl
hypotensives
selective
sch2
natural
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR7809306A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/782,858 external-priority patent/US4131737A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of FR2385696A2 publication Critical patent/FR2385696A2/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/02—Lithium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1896—Compounds having one or more Si-O-acyl linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Acides prostanoïques et apparentés et leurs dérivés, leur préparation et leurs utilisations thérapeutiques. Ces composés répondent à la formule genérale :
FR7809306A 1977-03-30 1978-03-30 Nouveaux acides 15-desoxy-16-hydroxyprostanoiques 16-substitues doues d'activites pharmaceutiques et leur procede de preparation Pending FR2385696A2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/782,858 US4131737A (en) 1976-07-19 1977-03-30 15-Deoxy-16-hydroxy-16-substituted-3-thia-prostanoic acids

Publications (1)

Publication Number Publication Date
FR2385696A2 true FR2385696A2 (fr) 1978-10-27

Family

ID=25127398

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7809306A Pending FR2385696A2 (fr) 1977-03-30 1978-03-30 Nouveaux acides 15-desoxy-16-hydroxyprostanoiques 16-substitues doues d'activites pharmaceutiques et leur procede de preparation

Country Status (9)

Country Link
JP (1) JPS5439047A (fr)
AU (1) AU3437478A (fr)
BE (1) BE865428R (fr)
DE (1) DE2813342A1 (fr)
DK (1) DK137778A (fr)
ES (2) ES468353A1 (fr)
FR (1) FR2385696A2 (fr)
NL (1) NL7803418A (fr)
SE (1) SE7803619L (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2410648A1 (fr) * 1977-12-05 1979-06-29 American Cyanamid Co Nouveaux esters d'alkyle des 15-desoxy-16-vinyl- et 16-cyclopropylprostaglandines e, utiles notamment comme agents hypotenseurs, et leur procede de preparation
WO1996028419A1 (fr) * 1995-03-10 1996-09-19 Vivus, Incorporated Procede de preparation des prostaglandines e1 et e2 et d'analogues de celles-ci au moyen de reactifs de furylcuivre

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0424232Y2 (fr) * 1987-09-14 1992-06-08
FR2621376B1 (fr) * 1987-10-01 1989-12-22 Pont A Mousson Garniture d'etancheite pour joints verrouilles telescopiques
FR2655705B1 (fr) * 1989-12-11 1992-05-29 Pont A Mousson Garniture d'etancheite composite pour assemblage verrouille de tuyaux a bout male et emboitement.
CA2147461A1 (fr) * 1992-10-21 1994-04-28 Takehiro Amano Analogues de la prostaglandine e1

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2274289A1 (fr) * 1974-03-26 1976-01-09 Searle & Co Nouveaux derives d'acide oxy-16 prostanoique, leur procede de preparation et leur utilisation therapeutique
FR2410648A1 (fr) * 1977-12-05 1979-06-29 American Cyanamid Co Nouveaux esters d'alkyle des 15-desoxy-16-vinyl- et 16-cyclopropylprostaglandines e, utiles notamment comme agents hypotenseurs, et leur procede de preparation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2274289A1 (fr) * 1974-03-26 1976-01-09 Searle & Co Nouveaux derives d'acide oxy-16 prostanoique, leur procede de preparation et leur utilisation therapeutique
FR2410648A1 (fr) * 1977-12-05 1979-06-29 American Cyanamid Co Nouveaux esters d'alkyle des 15-desoxy-16-vinyl- et 16-cyclopropylprostaglandines e, utiles notamment comme agents hypotenseurs, et leur procede de preparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/79 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2410648A1 (fr) * 1977-12-05 1979-06-29 American Cyanamid Co Nouveaux esters d'alkyle des 15-desoxy-16-vinyl- et 16-cyclopropylprostaglandines e, utiles notamment comme agents hypotenseurs, et leur procede de preparation
WO1996028419A1 (fr) * 1995-03-10 1996-09-19 Vivus, Incorporated Procede de preparation des prostaglandines e1 et e2 et d'analogues de celles-ci au moyen de reactifs de furylcuivre
US5618959A (en) * 1995-03-10 1997-04-08 Vivus Incorporated Process for preparing prostaglandin E1, E2 and analogs thereof using furylcopper reagents

Also Published As

Publication number Publication date
BE865428R (fr) 1978-09-29
JPS5439047A (en) 1979-03-24
SE7803619L (sv) 1978-11-17
ES468353A1 (es) 1979-10-01
AU3437478A (en) 1979-09-27
NL7803418A (nl) 1978-10-03
ES481198A1 (es) 1980-09-01
DK137778A (da) 1978-10-01
DE2813342A1 (de) 1978-10-05

Similar Documents

Publication Publication Date Title
ES482155A1 (es) Un procedimiento para la preparacion de derivados de feneta-nolamina.
LU92509I2 (fr) Travoprost et ses dérivés pharmaceutiquement acceptables (TRAVATAN)
PT73336A (en) Process for preparing carbamates of 1-(3,5-dihidroxiphenil)-2-butil terc.-amino)-ethanol with bronchial-spasmolitic activity and pharmaceutical compositions containing them
NO923081L (no) Neurobeskyttende 3-piperidino-4-hydroksykromanderivater og analoger derav
FR2385696A2 (fr) Nouveaux acides 15-desoxy-16-hydroxyprostanoiques 16-substitues doues d'activites pharmaceutiques et leur procede de preparation
DE69021823D1 (de) 3-Aryl-Oxazolidinone, Verfahren zu ihrer Herstellung und ihre Anwendung in der Therapie.
MY106976A (en) Piperidine derivatives.
AU532435B2 (en) Dental compositions
CO4960654A1 (es) Metodo para el tratamiento de enfermedades fisiologicas relacionadas con el uso o con las secuelas provocadas por el uso de la cocaina u otros estimulantes psicomotores
HUT37145A (en) Process for the production of new indole derivatives and of therapeutic preparations containing these derivatives
EA199600007A3 (ru) Новые трициклические производные, способ их получения, способы получения оптически активных или рацемических колхицина и тиоколхицина, их аналогов или производных с использованием трициклических соединений и промежуточные продукты синтеза
NZ332687A (en) use of 1-methyl-carbapenem derivatives as anti-helicobacter pylori agents
FR2698789B1 (fr) Utilisation de l'idazoxan et ses dérivés pour la préparation d'un médicament destiné au traitement de la maladie de Parkinson et de son évolution.
BR9708922A (pt) Piridil-e pirimidil-piperazinas no tratamento de doenças causadas por substâncias usadas em excesso
ES478568A1 (es) Un procedimiento de preparacion de (1r.5s)-6,6-dimetil-4(r)--(s)-ciano-(3'-fenoxifenil)-metoxi-3-oxa-biciclo (3-1-0)- hexan-2-ona.
FR2392004A1 (en) 3-Thia-13-trans-prostenoic acid derivs. - useful as selective and long lasting hypotensives, antisecretories, antiulcer agents, contraceptives, CNS regulators, abortifacients, etc.
DE69108326D1 (en) 15-deoxyprostaglandinderivat.
IT1126818B (it) Composti ipotensivi e vasodilatatori a base di prostaglandine per somministrazione topica o per iniezione
TW427978B (en) Tetrahydroisoquinoline derivatives
ES8307247A1 (es) "procedimiento para preparar nuevos derivados de 20,21-dinoreburnamenina".
IT1207238B (it) Composizioni copolimeriche idrofile, morbide e permeabili all'ossigeno.
NL7903227A (en) Hypotensive prostaglandin=E derivs. - are 9-oxo-11-alpha, 16-di:hydroxy-15-deoxy-16-vinyl or cyclopropyl-prostenoic and prostadienoic acid ester(s)
NL7803421A (en) Omega-cycloalkyl prostaglandin derivs. - useful as selective and long lasting vasodepressors, smooth muscle stimulants, CNS active agents, hypotensives, bronchodilators, etc.
GB2006186A (en) 15-Deoxy-16-substituted prostanoic acids
ES485392A1 (es) Un procedimiento para la preparacion de derivados de amino- alcoholes.