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FR2381520A1 - Compositions pour usage rectal - Google Patents

Compositions pour usage rectal

Info

Publication number
FR2381520A1
FR2381520A1 FR7805692A FR7805692A FR2381520A1 FR 2381520 A1 FR2381520 A1 FR 2381520A1 FR 7805692 A FR7805692 A FR 7805692A FR 7805692 A FR7805692 A FR 7805692A FR 2381520 A1 FR2381520 A1 FR 2381520A1
Authority
FR
France
Prior art keywords
compositions
rectal use
rectal
water
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7805692A
Other languages
English (en)
Other versions
FR2381520B1 (fr
Inventor
Hitoshi Sezaki
Shozo Muranishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of FR2381520A1 publication Critical patent/FR2381520A1/fr
Application granted granted Critical
Publication of FR2381520B1 publication Critical patent/FR2381520B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des compositions pour usage rectal. La composition formant une solution micellaire pour usage rectal comprend une drogue soluble à l'eau faiblement absorbable lors d'une administration par voie orale, au moins un des composés constitués par un acide gras intermédiaire et le mono ou di-glycéride dudit acide, et au moins un des composés constitues par l'acide biliaire et/ou un agent tensio-actif non ionique, et de l'eau. La présente invention permet une administration rectale de compositions habituellement administrées par injection.
FR7805692A 1977-02-28 1978-02-28 Compositions pour usage rectal Granted FR2381520A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2172077A JPS53107408A (en) 1977-02-28 1977-02-28 Micellar preparation for rectal infusion

Publications (2)

Publication Number Publication Date
FR2381520A1 true FR2381520A1 (fr) 1978-09-22
FR2381520B1 FR2381520B1 (fr) 1981-05-08

Family

ID=12062904

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7805692A Granted FR2381520A1 (fr) 1977-02-28 1978-02-28 Compositions pour usage rectal

Country Status (5)

Country Link
US (1) US4156719A (fr)
JP (1) JPS53107408A (fr)
DE (1) DE2807248C2 (fr)
FR (1) FR2381520A1 (fr)
GB (1) GB1601613A (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2455897A1 (fr) * 1979-05-10 1980-12-05 Kyoto Pharma Ind Adjuvant du type acide gras pour favoriser l'absorption de substances pharmacologiquement actives par le rectum, composition de base pour administration rectale comprenant cet adjuvant et composition pharmaceutique comprenant cet adjuvant
EP0147526A1 (fr) * 1983-08-27 1985-07-10 BASF Aktiengesellschaft Méthode pour l'augmentation de la résorption entérique de l'héparine et préparations contenant de l'héparine ainsi obtenues
EP0211434A2 (fr) * 1985-08-05 1987-02-25 F. Hoffmann-La Roche Ag Formes de dosage rectales pour le ceftriaxone
FR2620336A1 (fr) * 1987-09-15 1989-03-17 Sandoz Sa Utilisation de monoesters solubles dans l'eau d'acides gras comme solubilisants de medicaments
DE3830494A1 (de) * 1987-09-15 1989-03-23 Sandoz Ag Wasserloesliche monoester als solubilisatoren fuer pharmakologische wirkstoffe und pharmazeutische hilfsstoffe
WO1991001129A1 (fr) * 1989-07-25 1991-02-07 Henning Berlin Gmbh Chemie- Und Pharmawerk Preparation pharmaceutique pour administration rectale
US5378470A (en) * 1989-07-25 1995-01-03 Henning Berlin Gmbh Rectally administered pharmaceutical preparation
WO1995013795A1 (fr) * 1993-11-16 1995-05-26 Cortecs Limited Preparations hydrophobes
WO1996017594A1 (fr) * 1994-12-09 1996-06-13 Cortecs Limited Agents sequestrants

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5554666U (fr) * 1978-10-02 1980-04-12
DE3171774D1 (en) 1980-03-31 1985-09-19 Teijin Ltd Pharmaceutical composition for intrarectal administration, and suppository prepared therefrom
EP0071433A1 (fr) * 1981-07-28 1983-02-09 Kowa Company, Ltd. Médicament pour le traitement du diabète
SE8206744D0 (sv) * 1982-11-26 1982-11-26 Fluidcarbon International Ab Preparat for kontrollerad avgivning av substanser
US5116817A (en) * 1982-12-10 1992-05-26 Syntex (U.S.A.) Inc. LHRH preparations for intranasal administration
CA1256799A (fr) * 1984-02-22 1989-07-04 Walter Fuller Suppositoires
GB8417895D0 (en) * 1984-07-13 1984-08-15 Marples B A Pharmaceutical anti-fungal composition
JPS60149519A (ja) * 1984-09-03 1985-08-07 Kyoto Yakuhin Kogyo Kk 直腸投与用組成物
US4874795A (en) * 1985-04-02 1989-10-17 Yesair David W Composition for delivery of orally administered drugs and other substances
JPS61204227U (fr) * 1985-06-10 1986-12-23
CA1331559C (fr) * 1986-04-21 1994-08-23 Jon Joseph Kabara Compositions et methodes pour la conservation antimicrobienne
US5208257A (en) * 1986-04-21 1993-05-04 Kabara Jon J Topical antimicrobial pharmaceutical compositions and methods
US5389366A (en) * 1986-09-19 1995-02-14 Yamanouchi Pharmaceutical Co., Ltd. Neocarzinostatin derivative composition for oral administration
GB8630273D0 (en) * 1986-12-18 1987-01-28 Til Medical Ltd Pharmaceutical delivery systems
US5030442A (en) * 1987-03-30 1991-07-09 Liposome Technology, Inc. Non-crystalline minoxidil composition
US5756450A (en) * 1987-09-15 1998-05-26 Novartis Corporation Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
HU203204B (en) * 1987-09-15 1991-06-28 Sandoz Ag Process for producing suppository containing calcitonin and taurocholic acid
US5001112A (en) * 1988-04-12 1991-03-19 Bristol-Myers Company Antitumor antibiotic kedarcidin
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
CA2033725C (fr) * 1990-01-24 2001-05-29 Folker Pittrof Compositions pharmaceutiques et cosmetiques
JP3249147B2 (ja) * 1990-06-01 2002-01-21 キリン−アムジエン・インコーポレーテツド 生理活性蛋白含有経口製剤
US5571517A (en) * 1990-08-13 1996-11-05 Yesair; David W. Mixed lipid-bicarbonate colloidal particles for delivering drugs or calories
US5891466A (en) * 1990-08-13 1999-04-06 Yesair; David W. Mixed Liped-Bicarbonate colloidal particles for delivering drugs or calories
DE69109297T2 (de) * 1990-08-13 1995-11-09 David W. Byfield Mass. Yesair Gemischte lipid-bicarbonat-kolloidale partikel zur abgabe von arzneien und kalorien.
US5234914A (en) * 1991-06-11 1993-08-10 Patent Biopharmaceutics, Inc. Methods of treating hemorrhoids and anorecial disease
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
HU208084B (en) * 1991-10-31 1993-08-30 Hyd Kutato Fejlesztoe Kft Process for producing compositions suitable for curing tumorous diseases
US5342612A (en) * 1991-12-20 1994-08-30 American Cyanamid Company Compositions for the treatment of mammalian diseases
DK0642332T3 (da) 1992-05-13 1997-06-16 Sandoz Ltd Ophthalmiske præparater indeholdende cyclosporin
US5281420A (en) * 1992-05-19 1994-01-25 The Procter & Gamble Company Solid dispersion compositions of tebufelone
GB9212511D0 (en) * 1992-06-12 1992-07-22 Cortecs Ltd Pharmaceutical compositions
ES2168271T3 (es) 1992-09-25 2002-06-16 Novartis Ag Composiciones farmaceuticas que contienen ciclosporinas.
SE9302135D0 (sv) * 1993-06-18 1993-06-18 Kabi Pharmacia Ab New pharmaceutical composition
US20020099067A1 (en) * 1993-07-08 2002-07-25 Ulrich Posanski Pharmaceutical compositions for sparingly soluble therapeutic agents
WO1995025084A1 (fr) * 1994-03-14 1995-09-21 Morten Sloth Weidner Procede permettant de rendre des composes organiques solubles dans les systemes gras, nouveaux complexes chimiques de tels composes et leurs diverses applications
ATE218359T1 (de) 1994-11-03 2002-06-15 Novartis Erfind Verwalt Gmbh Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
WO1997009978A1 (fr) * 1995-09-13 1997-03-20 Morten Sloth Weidner Utilisation d'esters de polyols pour augmenter la biodisponibilite orale de substances medicamenteuses, nouveaux esters et compositions pharmaceutiques les contenant
DE19549852B4 (de) 1995-11-29 2009-06-04 Novartis Ag Cyclosporin enthaltende Präparate
GB9613858D0 (en) * 1996-07-02 1996-09-04 Cortecs Ltd Hydrophobic preparations
TR199901686T2 (xx) * 1997-01-30 1999-09-21 Norvartis Ag Esasen ya�s�z farmakolojik kompozisyonlar� i�eren sert jelatin kaps�ller.
DE19722831A1 (de) * 1997-05-30 1998-12-03 Univ Halle Wittenberg Vehikelsysteme für Arzneistoffe
US6350458B1 (en) 1998-02-10 2002-02-26 Generex Pharmaceuticals Incorporated Mixed micellar drug deliver system and method of preparation
US7070799B1 (en) * 1998-02-10 2006-07-04 Generex Pharmaceuticals, Inc. Method for administering insulin to the buccal region
US6849263B2 (en) * 1998-12-21 2005-02-01 Generex Pharmaceutical Incorporated Pharmaceutical compositions for buccal delivery of pain relief medications
US7087215B2 (en) * 1998-12-21 2006-08-08 Generex Pharmaceuticals Incorporated Methods of administering and enhancing absorption of pharmaceutical agents
US6451286B1 (en) 1998-12-21 2002-09-17 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds
US6375975B1 (en) 1998-12-21 2002-04-23 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary application
US6761903B2 (en) 1999-06-30 2004-07-13 Lipocine, Inc. Clear oil-containing pharmaceutical compositions containing a therapeutic agent
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6982281B1 (en) * 2000-11-17 2006-01-03 Lipocine Inc Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US20030236236A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US6458383B2 (en) 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US6867183B2 (en) * 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7196059B2 (en) * 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
GB2398495B (en) * 2003-01-23 2007-08-22 Kent G Lau A drug delivery preparation comprising at least one anti-tumour drug and a topical carrier for the drug
EP1661556A4 (fr) * 2003-08-20 2010-05-19 Ajinomoto Kk Preparation medicinale ayant des proprietes de dissolution ameliorees
JP2006199589A (ja) * 2003-09-03 2006-08-03 Ltt Bio-Pharma Co Ltd 生理活性タンパク質またはペプチドを含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる外用剤
US20060003002A1 (en) * 2003-11-03 2006-01-05 Lipocine, Inc. Pharmaceutical compositions with synchronized solubilizer release
US20070219131A1 (en) * 2004-04-15 2007-09-20 Ben-Sasson Shmuel A Compositions capable of facilitating penetration across a biological barrier
MXPA06011871A (es) 2004-04-15 2007-10-08 Chiasma Inc Composiciones capaces de facilitar la penetracion a traves de una barrera biologica.
GB0522942D0 (en) 2005-11-10 2005-12-21 Leigh Steven Dissolution composition
GB0623768D0 (en) * 2006-11-28 2007-01-10 Chopra Sunil A bleomycin preparation for use against skin tumours
CN102176900B (zh) 2008-09-17 2017-09-26 克艾思马有限公司 药物组合物和相关的给药方法
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
EP2505188A1 (fr) * 2009-12-02 2012-10-03 Bettina Heil Suppositoire pour administration rectale, vaginale ou urétrale
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
US20170246187A1 (en) 2014-08-28 2017-08-31 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
WO2016033556A1 (fr) 2014-08-28 2016-03-03 Lipocine Inc. Esters de (17-β)-hydroxy-4-androstène-3-one biodisponibles à l'état solide
MA41462A (fr) 2015-02-03 2021-05-12 Chiasma Inc Méthode de traitement de maladies
JP2020503269A (ja) 2016-11-28 2020-01-30 リポカイン インコーポレーテッド 経口ウンデカン酸テストステロン療法
CN112074274B (zh) 2018-03-19 2024-03-26 艾匹赛特制药公司 用于治疗因缺钙引起的病状的组合物
WO2020018974A1 (fr) 2018-07-20 2020-01-23 Lipocine Inc. Maladie du foie
US11141457B1 (en) 2020-12-28 2021-10-12 Amryt Endo, Inc. Oral octreotide therapy and contraceptive methods

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NL45481C (fr) * 1900-01-01
DE576616C (de) * 1929-07-28 1933-05-12 Wanderer Werke Vorm Winklhofer Verbindung einer Rechenmaschine mit einer Kartenlochmaschine
CH211204A (de) * 1938-12-13 1940-08-31 Chem Ind Basel Verfahren zur Herstellung einer Suppositoriengrundmasse.
DE932083C (de) * 1954-03-31 1955-08-22 Upha Chem Pharm Praeparate G M Verfahren zur Herstellung stabiler waessriger Injektionsloesungen von 2-Methyl-5, 8-dimethoxy-furanochromon
FR1100599A (fr) * 1953-05-19 1955-09-21 Edelfettwerke Gmbh Procédé de préparation d'excipients pour la fabrication de pommades et suppositoires
DE1916084A1 (de) * 1968-03-28 1969-10-16 Kyowa Hakko Kogyo Kk Suppositorien mit Wasser als Vehiculm
FR2096879A1 (en) * 1970-07-09 1972-03-03 Rougier Andre Antibiotic/corticosteroid solns - for rectal administration
FR2183677A1 (fr) * 1972-03-06 1973-12-21 Takeda Chemical Industries Ltd
FR2277594A1 (fr) * 1974-07-10 1976-02-06 Pfrimmer & Co J Solution d'infusion pour nutrition par voie parenterale

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Publication number Priority date Publication date Assignee Title
NL45481C (fr) * 1900-01-01
DE576616C (de) * 1929-07-28 1933-05-12 Wanderer Werke Vorm Winklhofer Verbindung einer Rechenmaschine mit einer Kartenlochmaschine
CH211204A (de) * 1938-12-13 1940-08-31 Chem Ind Basel Verfahren zur Herstellung einer Suppositoriengrundmasse.
FR1100599A (fr) * 1953-05-19 1955-09-21 Edelfettwerke Gmbh Procédé de préparation d'excipients pour la fabrication de pommades et suppositoires
DE932083C (de) * 1954-03-31 1955-08-22 Upha Chem Pharm Praeparate G M Verfahren zur Herstellung stabiler waessriger Injektionsloesungen von 2-Methyl-5, 8-dimethoxy-furanochromon
DE1916084A1 (de) * 1968-03-28 1969-10-16 Kyowa Hakko Kogyo Kk Suppositorien mit Wasser als Vehiculm
FR2096879A1 (en) * 1970-07-09 1972-03-03 Rougier Andre Antibiotic/corticosteroid solns - for rectal administration
FR2183677A1 (fr) * 1972-03-06 1973-12-21 Takeda Chemical Industries Ltd
FR2277594A1 (fr) * 1974-07-10 1976-02-06 Pfrimmer & Co J Solution d'infusion pour nutrition par voie parenterale

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2455897A1 (fr) * 1979-05-10 1980-12-05 Kyoto Pharma Ind Adjuvant du type acide gras pour favoriser l'absorption de substances pharmacologiquement actives par le rectum, composition de base pour administration rectale comprenant cet adjuvant et composition pharmaceutique comprenant cet adjuvant
EP0147526A1 (fr) * 1983-08-27 1985-07-10 BASF Aktiengesellschaft Méthode pour l'augmentation de la résorption entérique de l'héparine et préparations contenant de l'héparine ainsi obtenues
EP0211434A2 (fr) * 1985-08-05 1987-02-25 F. Hoffmann-La Roche Ag Formes de dosage rectales pour le ceftriaxone
EP0211434A3 (fr) * 1985-08-05 1987-10-07 F. Hoffmann-La Roche Ag Formes de dosage rectales pour le ceftriaxone
GR880100602A (el) * 1987-09-15 1989-06-22 Sandoz Ag Υδατοδιαλυτοι μονοεστερες ως διαλυτοποιητες για φαρμακολογικως δραστικες ενωσεις και φαρμακευτικα εκδοχα
DE3830494A1 (de) * 1987-09-15 1989-03-23 Sandoz Ag Wasserloesliche monoester als solubilisatoren fuer pharmakologische wirkstoffe und pharmazeutische hilfsstoffe
FR2620336A1 (fr) * 1987-09-15 1989-03-17 Sandoz Sa Utilisation de monoesters solubles dans l'eau d'acides gras comme solubilisants de medicaments
BE1001204A5 (fr) * 1987-09-15 1989-08-16 Sandoz Sa Utilisation de monoesters solubles dans l'eau d'acides gras comme solubilisants de medicaments.
DE3830494B4 (de) * 1987-09-15 2006-05-18 Novartis Ag Wasserlösliche Monoester als Solubilisatoren für pharmakologische Wirkstoffe und pharmazeutische Hilfsstoffe
WO1991001129A1 (fr) * 1989-07-25 1991-02-07 Henning Berlin Gmbh Chemie- Und Pharmawerk Preparation pharmaceutique pour administration rectale
US5378470A (en) * 1989-07-25 1995-01-03 Henning Berlin Gmbh Rectally administered pharmaceutical preparation
WO1995013795A1 (fr) * 1993-11-16 1995-05-26 Cortecs Limited Preparations hydrophobes
US6368619B1 (en) 1993-11-16 2002-04-09 Provalis Uk Limited Hydrophobic preparations of hydrophilic species and process for their preparation
WO1996017594A1 (fr) * 1994-12-09 1996-06-13 Cortecs Limited Agents sequestrants

Also Published As

Publication number Publication date
JPS5619847B2 (fr) 1981-05-09
DE2807248C2 (de) 1986-07-24
DE2807248A1 (de) 1978-08-31
JPS53107408A (en) 1978-09-19
US4156719A (en) 1979-05-29
GB1601613A (en) 1981-11-04
FR2381520B1 (fr) 1981-05-08

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