FI982733A0 - Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia - Google Patents
Trifenyylietyleeniantiestrogeenien liukoisia koostumuksiaInfo
- Publication number
- FI982733A0 FI982733A0 FI982733A FI982733A FI982733A0 FI 982733 A0 FI982733 A0 FI 982733A0 FI 982733 A FI982733 A FI 982733A FI 982733 A FI982733 A FI 982733A FI 982733 A0 FI982733 A0 FI 982733A0
- Authority
- FI
- Finland
- Prior art keywords
- triphenylethylene
- corresponding anion
- antiestrogens
- soluble compositions
- triphenylethylene antiestrogens
- Prior art date
Links
- MKYQPGPNVYRMHI-UHFFFAOYSA-N Triphenylethylene Chemical group C=1C=CC=CC=1C=C(C=1C=CC=CC=1)C1=CC=CC=C1 MKYQPGPNVYRMHI-UHFFFAOYSA-N 0.000 title abstract 3
- 229940046836 anti-estrogen Drugs 0.000 title abstract 3
- 230000001833 anti-estrogenic effect Effects 0.000 title abstract 3
- 239000000328 estrogen antagonist Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- 150000001450 anions Chemical class 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000006184 cosolvent Substances 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229940098779 methanesulfonic acid Drugs 0.000 abstract 1
- 150000002762 monocarboxylic acid derivatives Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Dental Preparations (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Detergent Compositions (AREA)
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI982733A FI982733L (fi) | 1998-12-17 | 1998-12-17 | Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia |
| AT99963614T ATE340591T1 (de) | 1998-12-17 | 1999-12-16 | Pharmazeutische lösungen von triphenylethylen- antiöstrogenen |
| PCT/FI1999/001046 WO2000035485A1 (en) | 1998-12-17 | 1999-12-16 | Soluble compositions of triphenylethylene antiestrogens |
| AU19855/00A AU767714B2 (en) | 1998-12-17 | 1999-12-16 | Soluble compositions of triphenylethylene antiestrogens |
| DE69933388T DE69933388T2 (de) | 1998-12-17 | 1999-12-16 | Pharmazeutische Lösungen VON TRIPHENYLETHYLEN-ANTIÖSTROGENEN |
| IL14357599A IL143575A0 (en) | 1998-12-17 | 1999-12-16 | Soluble compositions of triphenylethylene antiestrogens |
| US09/868,179 US6632841B1 (en) | 1998-12-17 | 1999-12-16 | Soluble compositions of triphenylethylene antiestrogens |
| ES99963614T ES2272092T3 (es) | 1998-12-17 | 1999-12-16 | Soluciones farmaceuticas que comprenden antiestrogenos de triofeniletileno. |
| CA002355175A CA2355175C (en) | 1998-12-17 | 1999-12-16 | Soluble compositions of triphenylethylene antiestrogens |
| NZ512270A NZ512270A (en) | 1998-12-17 | 1999-12-16 | Soluble compositions of triphenylethylene antiestrogens |
| EP99963614A EP1140196B1 (en) | 1998-12-17 | 1999-12-16 | pharmaceutical solutions comprising triphenylethylene antiestrogens |
| JP2000587804A JP4523167B2 (ja) | 1998-12-17 | 1999-12-16 | トリフェニルエチレン型抗エストロゲンの水溶性組成物 |
| IL143575A IL143575A (en) | 1998-12-17 | 2001-06-05 | Soluble compositions of triphenylethylene antiestrogens |
| NO20012793A NO330251B1 (no) | 1998-12-17 | 2001-06-06 | Farmasoytisk losning og fremgangsmater for fremstilling derav |
| US10/408,321 US6887888B2 (en) | 1998-12-17 | 2003-04-08 | Soluble compositions of triphenylethylene antiestrogens |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI982733A FI982733L (fi) | 1998-12-17 | 1998-12-17 | Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI982733A0 true FI982733A0 (fi) | 1998-12-17 |
| FI982733L FI982733L (fi) | 2000-06-18 |
Family
ID=8553138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI982733A FI982733L (fi) | 1998-12-17 | 1998-12-17 | Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6632841B1 (fi) |
| EP (1) | EP1140196B1 (fi) |
| JP (1) | JP4523167B2 (fi) |
| AT (1) | ATE340591T1 (fi) |
| AU (1) | AU767714B2 (fi) |
| CA (1) | CA2355175C (fi) |
| DE (1) | DE69933388T2 (fi) |
| ES (1) | ES2272092T3 (fi) |
| FI (1) | FI982733L (fi) |
| IL (2) | IL143575A0 (fi) |
| NO (1) | NO330251B1 (fi) |
| NZ (1) | NZ512270A (fi) |
| WO (1) | WO2000035485A1 (fi) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI982733L (fi) * | 1998-12-17 | 2000-06-18 | Orion Yhtymae Oyj | Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia |
| US7964734B2 (en) | 2002-09-30 | 2011-06-21 | A/S Gea Farmaceutisk Fabrik | Raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these |
| US7968532B2 (en) * | 2003-12-15 | 2011-06-28 | Besins Healthcare Luxembourg | Treatment of gynecomastia with 4-hydroxy tamoxifen |
| US7507769B2 (en) * | 2004-03-22 | 2009-03-24 | Laboratoires Besins International | Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen |
| DK2373305T3 (en) * | 2008-12-11 | 2017-05-15 | Besins Healthcare Lu Sarl | TRANSDERMAL PHARMACEUTICAL COMPOSITIONS INCLUDING A SERM |
| WO2014043618A1 (en) * | 2012-09-17 | 2014-03-20 | Bind Therapeutics, Inc. | Process for preparing therapeutic nanoparticles |
| RU2682332C2 (ru) | 2013-09-16 | 2019-03-19 | Астразенека Аб | Терапевтические полимерные наночастицы и способы их получения и применения |
| EP3015453B1 (en) * | 2014-10-28 | 2016-10-12 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Process for the preparation of Clomiphene |
| US10364212B2 (en) | 2016-04-22 | 2019-07-30 | F.I.S.—Fabbrica Italiana Sintetici S.p.A. | Process for the preparation of enclomiphene citrate having needle shaped crystal habit |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE293263C (fi) | ||||
| FR2558373B1 (fr) | 1984-01-20 | 1987-07-03 | Mauvais Jarvis Pierre | Medicament antioestrogene a base de 4-hydroxytamoxifene pour administration percutanee |
| GB8604528D0 (en) * | 1986-02-24 | 1986-04-03 | Ici Plc | Therapeutic agents |
| ATE107643T1 (de) | 1989-05-05 | 1994-07-15 | Asta Medica Ag | Salze des azelastins mit verbesserter löslichkeit. |
| US5189212A (en) * | 1990-09-07 | 1993-02-23 | University Of Georgia Research Foundation, Inc. | Triarylethylene carboxylic acids with estrogenic activity |
| GB9126209D0 (en) | 1991-12-10 | 1992-02-12 | Orion Yhtymae Oy | Drug formulations for parenteral use |
| GB9207437D0 (en) | 1992-04-03 | 1992-05-20 | Orion Yhtymae Oy | Topical administration of toremifene and its metabolites |
| IT1263831B (it) * | 1993-01-29 | 1996-09-04 | Paolo Chiesi | Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo basico, un acido ed una ciclodestrina |
| DE4407742C1 (de) | 1994-03-08 | 1995-06-22 | Hexal Pharma Gmbh | Transdermales System in Form eines Pflasters mit einem Tamoxifen-Derivat |
| US5441986A (en) | 1994-07-19 | 1995-08-15 | Pfizer Inc. | Estrogen agonists as remedies for prostate and cardiovascular diseases |
| AU723987B2 (en) | 1996-08-28 | 2000-09-07 | Eli Lilly And Company | Amorphous benzothiophenes, methods of preparation, and methods of use |
| CZ341297A3 (cs) * | 1996-10-30 | 1998-05-13 | Eli Lilly And Company | Způsob zlepšení léčby nebo profylaxe rakoviny prsu |
| US6114395A (en) | 1996-11-15 | 2000-09-05 | Pfizer Inc. | Method of treating atherosclerosis |
| ATE214269T1 (de) | 1997-06-27 | 2002-03-15 | Akzo Nobel Nv | Oral anzuwendende flüssige arzneilösung |
| AU1143899A (en) * | 1997-11-10 | 1999-05-31 | Novo Nordisk A/S | Transdermal delivery of 3,4-diarylchromans |
| FI982733L (fi) * | 1998-12-17 | 2000-06-18 | Orion Yhtymae Oyj | Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia |
| FI109332B (fi) * | 1998-12-17 | 2002-07-15 | Orion Yhtymae Oyj | Toremifeenin liukoisia koostumuksia |
-
1998
- 1998-12-17 FI FI982733A patent/FI982733L/fi unknown
-
1999
- 1999-12-16 IL IL14357599A patent/IL143575A0/xx active IP Right Grant
- 1999-12-16 WO PCT/FI1999/001046 patent/WO2000035485A1/en active IP Right Grant
- 1999-12-16 AT AT99963614T patent/ATE340591T1/de not_active IP Right Cessation
- 1999-12-16 US US09/868,179 patent/US6632841B1/en not_active Expired - Lifetime
- 1999-12-16 DE DE69933388T patent/DE69933388T2/de not_active Expired - Lifetime
- 1999-12-16 AU AU19855/00A patent/AU767714B2/en not_active Ceased
- 1999-12-16 NZ NZ512270A patent/NZ512270A/xx not_active IP Right Cessation
- 1999-12-16 ES ES99963614T patent/ES2272092T3/es not_active Expired - Lifetime
- 1999-12-16 EP EP99963614A patent/EP1140196B1/en not_active Expired - Lifetime
- 1999-12-16 CA CA002355175A patent/CA2355175C/en not_active Expired - Fee Related
- 1999-12-16 JP JP2000587804A patent/JP4523167B2/ja not_active Expired - Fee Related
-
2001
- 2001-06-05 IL IL143575A patent/IL143575A/en not_active IP Right Cessation
- 2001-06-06 NO NO20012793A patent/NO330251B1/no not_active IP Right Cessation
-
2003
- 2003-04-08 US US10/408,321 patent/US6887888B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU767714B2 (en) | 2003-11-20 |
| EP1140196A1 (en) | 2001-10-10 |
| ATE340591T1 (de) | 2006-10-15 |
| US20030181530A1 (en) | 2003-09-25 |
| NO20012793L (no) | 2001-08-09 |
| FI982733L (fi) | 2000-06-18 |
| US6887888B2 (en) | 2005-05-03 |
| NZ512270A (en) | 2003-01-31 |
| NO330251B1 (no) | 2011-03-14 |
| DE69933388D1 (de) | 2006-11-09 |
| AU1985500A (en) | 2000-07-03 |
| EP1140196B1 (en) | 2006-09-27 |
| US6632841B1 (en) | 2003-10-14 |
| JP2002532437A (ja) | 2002-10-02 |
| CA2355175C (en) | 2008-07-15 |
| NO20012793D0 (no) | 2001-06-06 |
| JP4523167B2 (ja) | 2010-08-11 |
| CA2355175A1 (en) | 2000-06-22 |
| IL143575A0 (en) | 2002-04-21 |
| WO2000035485A1 (en) | 2000-06-22 |
| IL143575A (en) | 2006-12-10 |
| DE69933388T2 (de) | 2007-08-23 |
| ES2272092T3 (es) | 2007-04-16 |
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