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FI964213L - Användning av bisfosfonater för förhindrande av benresorption efter implantering av en ortopedisk protes - Google Patents

Användning av bisfosfonater för förhindrande av benresorption efter implantering av en ortopedisk protes Download PDF

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Publication number
FI964213L
FI964213L FI964213A FI964213A FI964213L FI 964213 L FI964213 L FI 964213L FI 964213 A FI964213 A FI 964213A FI 964213 A FI964213 A FI 964213A FI 964213 L FI964213 L FI 964213L
Authority
FI
Finland
Prior art keywords
bisphosphonates
bone resorption
prevent bone
orthopedic prosthesis
prosthesis implantation
Prior art date
Application number
FI964213A
Other languages
English (en)
Finnish (fi)
Other versions
FI964213A0 (sv
Inventor
Ashley J Yates
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI964213L publication Critical patent/FI964213L/sv
Publication of FI964213A0 publication Critical patent/FI964213A0/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI964213A 1994-04-21 1996-10-18 Användning av bisfosfonater för förhindrande av benresorption efter implantering av en ortopedisk protes FI964213A0 (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/230,670 US5646134A (en) 1994-04-21 1994-04-21 Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices
PCT/US1995/004498 WO1995028936A1 (en) 1994-04-21 1995-04-17 Use of bisphophonates for inhibiting bone resorption following implantation of orthopedic prosthesis

Publications (2)

Publication Number Publication Date
FI964213L true FI964213L (sv) 1996-10-18
FI964213A0 FI964213A0 (sv) 1996-10-18

Family

ID=22866129

Family Applications (1)

Application Number Title Priority Date Filing Date
FI964213A FI964213A0 (sv) 1994-04-21 1996-10-18 Användning av bisfosfonater för förhindrande av benresorption efter implantering av en ortopedisk protes

Country Status (29)

Country Link
US (3) US5646134A (sv)
EP (2) EP1197213A3 (sv)
JP (1) JPH09512268A (sv)
CN (1) CN1078073C (sv)
AT (1) ATE236641T1 (sv)
AU (1) AU2374895A (sv)
BG (1) BG63102B1 (sv)
CA (1) CA2188030C (sv)
CO (1) CO4370025A1 (sv)
CZ (1) CZ305596A3 (sv)
DE (1) DE69530293T2 (sv)
DK (1) DK0756483T3 (sv)
DZ (1) DZ1873A1 (sv)
ES (1) ES2194050T3 (sv)
FI (1) FI964213A0 (sv)
HR (1) HRP950239A2 (sv)
HU (1) HUT74911A (sv)
IL (1) IL113361A (sv)
MY (1) MY114265A (sv)
NO (1) NO312124B1 (sv)
NZ (1) NZ284295A (sv)
PL (1) PL318552A1 (sv)
PT (1) PT756483E (sv)
RU (1) RU2161032C2 (sv)
SK (1) SK133396A3 (sv)
TW (1) TW406021B (sv)
WO (1) WO1995028936A1 (sv)
YU (1) YU25295A (sv)
ZA (1) ZA953185B (sv)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646134A (en) * 1994-04-21 1997-07-08 Merck & Co., Inc. Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices
GB9408775D0 (en) * 1994-05-04 1994-06-22 Ciba Geigy Ag Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration
US6117856A (en) * 1996-02-14 2000-09-12 Binderman; Itzhak Topical bisphosphonates for prevention of bone resorption
JP2000504718A (ja) * 1996-02-14 2000-04-18 バインダーマン，イザク 骨吸収を予防するための局所用ビスホスホネート
US5853759A (en) * 1996-05-17 1998-12-29 Merck & Co.. Inc. Effervescent alendronate formulation
US20010031244A1 (en) 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
US6432932B1 (en) 1997-07-22 2002-08-13 Merck & Co., Inc. Method for inhibiting bone resorption
US6015801A (en) * 1997-07-22 2000-01-18 Merck & Co., Inc. Method for inhibiting bone resorption
US5994329A (en) 1997-07-22 1999-11-30 Merck & Co., Inc. Method for inhibiting bone resorption
CN1166365C (zh) * 1997-07-22 2004-09-15 麦克公司 阿仑膦酸的药物组合物及其在制备抑制人的骨吸收的药物中的用途
IT1296495B1 (it) * 1997-11-21 1999-06-25 Prodotti Antibiotici Spa Impiego di bisfosfonati nella preparazione di forme farmaceutiche per somministrazione intramuscolare
US6414006B1 (en) 1998-10-15 2002-07-02 Merck Frosst Canada & Co. Methods for inhibiting bone resorption
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
KR100453779B1 (ko) 1998-12-04 2004-10-20 로쉐 디아그노스틱스 게엠베하 내인공삽입물의 골형성을 개선시키기 위한 이밴드론산염의용도
JP3219402B2 (ja) 1998-12-25 2001-10-15 山之内製薬株式会社 多発性骨髄腫の骨病変治療用医薬組成物
AU4652100A (en) * 1999-04-22 2000-11-10 Hydromed Sciences A Division Of Gp Strategies Corporation Controlled delivery of bisphosphonates
AU781068B2 (en) * 1999-08-19 2005-05-05 Sydney Children's Hospitals Network (Randwick and Westmead) (incorporating The Royal Alexandra Hospital for Children), The Drug for treating fractures
AUPQ232599A0 (en) * 1999-08-19 1999-09-09 Royal Alexandra Hospital For Children, The Drug for treating fractures
AU2001287260A1 (en) * 2000-07-12 2002-01-21 Ecole Polytechnique Federale De Lausanne (Epfl) Active biocoating for bone implant
CH694935A5 (de) * 2000-07-26 2005-09-30 Straumann Holding Ag Oberflaechenmodifizierte Implantate.
WO2002040073A1 (en) * 2000-11-20 2002-05-23 Université De Genève Endosseous implant
GB0029111D0 (en) * 2000-11-29 2001-01-10 Novartis Ag Organic compounds
CA2435552C (en) 2001-02-06 2010-04-27 The Royal Alexandra Hospital For Children A drug for the treatment of osteonecrosis and for the management of patients at risk of developing osteonecrosis
NZ528659A (en) * 2001-04-03 2005-02-25 Royal Alexandra Hosp Children A drug for use in bone grafting
KR20020080018A (ko) * 2001-04-10 2002-10-23 한국화학연구원 비스포스포네이트 골 흡수억제제의 이식형 서방성제제
CA2347330C (en) * 2001-05-10 2002-03-12 Pharmaceutical Partners Of Canada Inc. Liquid injectable formulation of disodium pamidronate
AUPR553701A0 (en) * 2001-06-07 2001-07-12 Royal Alexandra Hospital For Children, The A device for the delivery of a drug to a fractured bone
RU2294203C2 (ru) * 2001-12-21 2007-02-27 Дзе Проктер Энд Гэмбл Компани Способ лечения костных нарушений
US20050070504A1 (en) * 2001-12-21 2005-03-31 The Procter & Gamble Co. Risedronate compositions and their methods of use
US7488496B2 (en) * 2002-03-06 2009-02-10 Christer Rosen Effervescent compositions comprising bisphosphonates and methods related thereto
KR20050010778A (ko) * 2002-05-03 2005-01-28 밀레늄 바이올로직스 인코포레이티드 결합조직 자극 펩티드
US20040137058A1 (en) * 2002-07-09 2004-07-15 Katdare Ashok V. Effervescent bisphosphonate formulation
ES2561463T3 (es) * 2003-08-21 2016-02-26 Addbio Ab Dispositivo de implante recubierto con bisfosfonato y método para el mismo
US20050181043A1 (en) * 2004-02-12 2005-08-18 Indranil Nandi Alendronate salt tablet compositions
US7674454B2 (en) * 2004-03-06 2010-03-09 Innovata Limited Enzyme-prodrug therapy for prosthetic joint repair
KR100564628B1 (ko) * 2004-06-16 2006-03-28 삼성전자주식회사 스플릿 게이트형 플래쉬 메모리 소자 및 그 제조방법
US20060134190A1 (en) * 2004-12-16 2006-06-22 Banner Pharmacaps Inc. Formulations of bisphosphonate drugs with improved bioavailability
US8071574B2 (en) * 2005-02-22 2011-12-06 John Dennis Bobyn Implant improving local bone formation
WO2006100527A1 (en) * 2005-03-24 2006-09-28 Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. Effervescent tablet containing sodium alendronate and related use and process
US20070087052A1 (en) * 2005-10-19 2007-04-19 Katdare Ashok V Effervescent bisphosphonate formulation
FR2904784B1 (fr) * 2006-08-10 2010-09-03 Surfactis Technologies Procede de recouvrement de surfaces metalliques et minerales par de monocouches autoassemblees de composes bisphosphoniques et leurs utilisations
US20100144679A1 (en) * 2007-03-21 2010-06-10 Duke University Medication kits and formulations for preventing, treating or reducing secondary fractures after previous fracture
WO2009061516A1 (en) * 2007-11-08 2009-05-14 New York University School Of Medicine Medical implants containing adenosine receptor agonists and methods for inhibiting medical implant loosening
PL2473172T3 (pl) 2009-09-01 2015-08-31 Univ Duke Kompozycje bisfosfonianowe i sposoby do leczenia niewydolności serca
US8882740B2 (en) * 2009-12-23 2014-11-11 Stryker Trauma Gmbh Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone
PT2648702T (pt) * 2010-12-06 2019-03-29 Effrx Pharmaceuticals Sa Formulações de bifosfonatos efervescentes estáveis com caracteristicas de rápida solubilização
US8858979B1 (en) 2011-01-28 2014-10-14 Clemson University Service induced byproducts for localized drug delivery in orthopaedic implants
CN108329391A (zh) * 2011-05-27 2018-07-27 埃博灵克斯股份有限公司 使用rankl结合肽抑制骨质吸收
US9949992B2 (en) 2011-11-16 2018-04-24 Duke University Bisphosphonate compositions and methods for treating and\or reducing cardiac dysfunction
RU2653627C1 (ru) * 2016-11-09 2018-05-11 Федеральное государственное автономное образовательное учреждение высшего образования "Крымский федеральный университет имени В.И. Вернадского" Способ моделирования асептического аминобисфосфонатного остеонекроза нижней челюсти у лабораторных белых крыс
US12029640B2 (en) 2017-12-07 2024-07-09 Paul V. Fenton, Jr. Method and injection system for bone tissue implant

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US4446052A (en) * 1982-05-17 1984-05-01 The Procter & Gamble Company Aqueous gel containing tricalcium di(1-hydroxy-3-aminopropane-1,1-diphosphonate
US4753652A (en) * 1984-05-04 1988-06-28 Children's Medical Center Corporation Biomaterial implants which resist calcification
CN1046853C (zh) * 1988-01-20 1999-12-01 山之内制药株式会社 制备药用组合物的方法
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
DE69329199D1 (de) * 1992-05-29 2000-09-14 Procter & Gamble Pharma Schwefel-enthaltende phosphonat-verbindungen zur behandlung von abnormalem calzium- und phosphat- metabolismus
EP0675723A4 (en) * 1992-12-23 1998-08-05 Merck & Co Inc BIPHOSPHONATE / ESTROGEN THERAPY FOR TREATING AND PREVENTING BONE LOSS.
US5403829A (en) * 1993-03-24 1995-04-04 Leiras Oy Use of bisphosphonates in endo-osteal bone surgery
FI92465C (sv) * 1993-04-14 1994-11-25 Risto Tapani Lehtinen Förfarande för behandling av endo-ostealt material
US5646134A (en) * 1994-04-21 1997-07-08 Merck & Co., Inc. Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices
GB9408775D0 (en) * 1994-05-04 1994-06-22 Ciba Geigy Ag Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration

Also Published As

Publication number Publication date
JPH09512268A (ja) 1997-12-09
CN1078073C (zh) 2002-01-23
HU9602888D0 (en) 1996-12-30
CA2188030C (en) 2003-07-29
RU2161032C2 (ru) 2000-12-27
NO964441L (no) 1996-10-18
IL113361A (en) 1999-11-30
PL318552A1 (en) 1997-06-23
HUT74911A (en) 1997-03-28
WO1995028936A1 (en) 1995-11-02
EP1197213A3 (en) 2002-09-25
DZ1873A1 (fr) 2002-02-17
CO4370025A1 (es) 1996-10-07
TW406021B (en) 2000-09-21
ZA953185B (en) 1995-12-27
DK0756483T3 (da) 2003-04-28
EP0756483B1 (en) 2003-04-09
NO312124B1 (no) 2002-03-25
MY114265A (en) 2002-09-30
PT756483E (pt) 2003-07-31
CA2188030A1 (en) 1995-11-02
EP0756483A1 (en) 1997-02-05
DE69530293T2 (de) 2004-02-05
FI964213A0 (sv) 1996-10-18
US5891863A (en) 1999-04-06
ES2194050T3 (es) 2003-11-16
NO964441D0 (no) 1996-10-18
US5972913A (en) 1999-10-26
YU25295A (sh) 1999-09-27
AU2374895A (en) 1995-11-16
DE69530293D1 (de) 2003-05-15
IL113361A0 (en) 1995-07-31
SK133396A3 (en) 1997-05-07
CN1146152A (zh) 1997-03-26
US5646134A (en) 1997-07-08
CZ305596A3 (en) 1997-06-11
HRP950239A2 (en) 1997-04-30
BG100910A (en) 1998-03-31
NZ284295A (en) 2000-06-23
BG63102B1 (bg) 2001-04-30
ATE236641T1 (de) 2003-04-15
EP1197213A2 (en) 2002-04-17

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