EP0675723A4 - BIPHOSPHONATE / ESTROGEN THERAPY FOR TREATING AND PREVENTING BONE LOSS. - Google Patents

BIPHOSPHONATE / ESTROGEN THERAPY FOR TREATING AND PREVENTING BONE LOSS.

Info

Publication number: EP0675723A4
Authority: EP; European Patent Office
Prior art keywords: biphosphonate; treating; bone loss; preventing bone; estrogen therapy
Prior art date: 1992-12-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

EP94905419A

Other languages

German (de)

French (fr)

Other versions

EP0675723A1 (en

Inventor

Donna T Whiteford

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-23

Filing date

1993-12-17

Publication date

1998-08-05

1993-12-17 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

1995-10-11 Publication of EP0675723A1 publication Critical patent/EP0675723A1/en

1998-08-05 Publication of EP0675723A4 publication Critical patent/EP0675723A4/en

Status Ceased legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP94905419A 1992-12-23 1993-12-17 BIPHOSPHONATE / ESTROGEN THERAPY FOR TREATING AND PREVENTING BONE LOSS. Ceased EP0675723A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US99641892A	1992-12-23	1992-12-23
US996418		1992-12-23
PCT/US1993/012302 WO1994014455A1 (en)	1992-12-23	1993-12-17	Bisphosphonate/estrogen therapy for treating and preventing bone loss

Publications (2)

Publication Number	Publication Date
EP0675723A1 EP0675723A1 (en)	1995-10-11
EP0675723A4 true EP0675723A4 (en)	1998-08-05

Family

ID=25542895

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP94905419A Ceased EP0675723A4 (en)	1992-12-23	1993-12-17	BIPHOSPHONATE / ESTROGEN THERAPY FOR TREATING AND PREVENTING BONE LOSS.

Country Status (5)

Country	Link
EP (1)	EP0675723A4 (en)
JP (1)	JPH08505142A (en)
AU (1)	AU5953894A (en)
CA (1)	CA2151240A1 (en)
WO (1)	WO1994014455A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2162470C (en) *	1993-05-15	1998-06-16	Walter Preis	Tablet with improved bioavailability containing dichloromethylenediphosphonic acid as the active substance
US5646134A (en) *	1994-04-21	1997-07-08	Merck & Co., Inc.	Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices
ZA956029B (en) *	1994-07-22	1997-01-20	Lilly Co Eli	Combination treatment for inhibiting bone loss
US5780455A (en) *	1994-08-24	1998-07-14	Merck & Co., Inc.	Intravenous alendronate formulations
US5914099A (en) *	1995-05-12	1999-06-22	Merck & Co., Inc.	Prevention of tooth loss by the administration of alendronate or its salts
US5545635A (en) *	1995-05-23	1996-08-13	Eli Lilly And Company	Inhibiting bone loss with equilenin
US5616571A (en) *	1995-06-06	1997-04-01	Merck & Co., Inc.	Bisphosphonates prevent bone loss associated with immunosuppressive therapy
IL120265A0 (en) *	1996-02-28	1997-06-10	Pfizer	Combination therapy to treat osteoporosis - polyphosphonates or progestins and estrogen agonists
IL120270A0 (en) *	1996-02-28	1997-06-10	Pfizer	Combination therapy to treat osteoporosis
US5853759A (en) *	1996-05-17	1998-12-29	Merck & Co.. Inc.	Effervescent alendronate formulation
EP1378234A1 (en) *	1996-05-17	2004-01-07	MERCK & CO. INC.	Effervescent bisphosphonate formulation
ATE256456T1 (en) *	1996-05-17	2004-01-15	Merck & Co Inc	BIPHOSPHONATE FORMULATION WITH EFFORTABLE EFFECT
US6376477B2 (en)	1996-11-25	2002-04-23	Merck & Co., Inc.	Combination of an agent that binds to the androgen receptor and a bisphosphonic acid in the prevention and/or treatment of diseases involving calcium or phosphate metabolism
WO1998023274A1 (en) *	1996-11-25	1998-06-04	Merck & Co., Inc.	Androgenic and bisphosphonic agents coadministered to treat diseases
DE19719680A1 (en)	1997-05-09	1998-11-19	Boehringer Mannheim Gmbh	Use of diphosphonic acids for the preventive treatment of long-term consequences of bladder enlargement or replacement
WO1999033473A1 (en) *	1997-12-25	1999-07-08	Toray Industries, Inc.	Remedies for intramedullary diseases
CA2353528C (en) *	1998-12-04	2007-04-24	Roche Diagnostics Gmbh	Use of ibandronate for promoting osseointegration of endoprostheses
WO2000064516A1 (en) *	1999-04-22	2000-11-02	Hydromed Sciences A Division Of Gp Strategies Corporation	Controlled delivery of bisphosphonates
AUPQ232599A0 (en) *	1999-08-19	1999-09-09	Royal Alexandra Hospital For Children, The	Drug for treating fractures
FR2803521B1 (en)	2000-01-12	2002-10-25	Ceva Sante Animale	USE OF TILUDRONIC ACID AND ITS DERIVATIVES IN POULTRY FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR PREVENTING AND TREATING OSTEOPOROSIS
EP1365769B1 (en)	2001-02-06	2011-01-26	The Sydney Children's Hospitals Network (Randwick and Westmead) (incorporating The Royal Alexandra Hospital for Children)	A drug for the treatment of osteonecrosis and for the management of patients at risk of developing osteonecrosis
JP2004526747A (en) *	2001-04-03	2004-09-02	ザロイヤルアレクサンドラホスピタルフォーチルドレン	Drugs used in bone transplantation
AUPR553701A0 (en) *	2001-06-07	2001-07-12	Royal Alexandra Hospital For Children, The	A device for the delivery of a drug to a fractured bone
TWI315982B (en)	2001-07-19	2009-10-21	Novartis Ag	Combinations comprising epothilones and pharmaceutical uses thereof
MXPA04006310A (en)	2001-12-24	2005-04-19	Teva Pharma	Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it.
US7488496B2 (en)	2002-03-06	2009-02-10	Christer Rosen	Effervescent compositions comprising bisphosphonates and methods related thereto
EP1508343B1 (en) *	2003-08-21	2015-11-04	AddBIO AB	Bisphosponate coated implant device and method therefor
ES2379485T3 (en) *	2005-10-27	2012-04-26	Thommen Medical Ag	Dental implant and manufacturing procedure
US8882740B2 (en)	2009-12-23	2014-11-11	Stryker Trauma Gmbh	Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992005187A1 (en) *	1990-09-18	1992-04-02	Boehringer Mannheim Gmbh	NEW 17-β-OESTRADIOL DERIVATIVES, A METHOD OF PREPARING THEM, AND DRUGS CONTAINING THEM
EP0496520A1 (en) *	1991-01-22	1992-07-29	Merck & Co. Inc.	Novel bone acting agents
WO1992014474A1 (en) *	1991-02-26	1992-09-03	Norwich Eaton Pharmaceuticals, Inc.	Methods for the treatment of osteoporosis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3623397A1 (en) *	1986-07-11	1988-01-14	Boehringer Mannheim Gmbh	NEW DIPHOSPHONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

1993
- 1993-12-17 JP JP6515312A patent/JPH08505142A/en active Pending
- 1993-12-17 CA CA002151240A patent/CA2151240A1/en not_active Abandoned
- 1993-12-17 WO PCT/US1993/012302 patent/WO1994014455A1/en not_active Ceased
- 1993-12-17 AU AU59538/94A patent/AU5953894A/en not_active Abandoned
- 1993-12-17 EP EP94905419A patent/EP0675723A4/en not_active Ceased

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992005187A1 (en) *	1990-09-18	1992-04-02	Boehringer Mannheim Gmbh	NEW 17-β-OESTRADIOL DERIVATIVES, A METHOD OF PREPARING THEM, AND DRUGS CONTAINING THEM
EP0496520A1 (en) *	1991-01-22	1992-07-29	Merck & Co. Inc.	Novel bone acting agents
WO1992014474A1 (en) *	1991-02-26	1992-09-03	Norwich Eaton Pharmaceuticals, Inc.	Methods for the treatment of osteoporosis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CIMINERA N. ET AL: "Studio Comparativo degli effeti di estrogeni e difosfonati sulla perdita ossea postmenopausale", ANN. OSTET. GINECOL. MED. PERINAT., vol. 113, no. 5, 1992, pages 232 - 237, XP002064831 *
See also references of WO9414455A1 *

Also Published As

Publication number	Publication date
EP0675723A1 (en)	1995-10-11
JPH08505142A (en)	1996-06-04
WO1994014455A1 (en)	1994-07-07
AU5953894A (en)	1994-07-19
CA2151240A1 (en)	1994-07-07

Publication	Publication Date	Title
EP0675723A4 (en)	1998-08-05	BIPHOSPHONATE / ESTROGEN THERAPY FOR TREATING AND PREVENTING BONE LOSS.
DE69739758D1 (en)	2010-03-25	VACCINE FOR THE TREATMENT OF LYMPHOMA AND LEUKEMIA
EP1079741A4 (en)	2004-12-08	IMPLANTABLE TISSUE CLOSURE AND SYSTEM FOR TREATING GASTROESOPHAGIC REFLOW
DE69312624D1 (en)	1997-09-04	DEVICE FOR DISTINATING TACHYCARDIA AND FIBRILLATIONS AND FOR THE TREATMENT THEREOF
ATA11989A (en)	1990-12-15	AGENTS FOR PREVENTING AND TREATING PERIODONTOPATHIES
DE69525473D1 (en)	2002-03-21	DEVICE FOR TREATING BLOOD VESSELS
DE69730604D1 (en)	2004-10-14	OXADIC ACIDS AND RELATED COMPOUNDS FOR TREATING SKIN DISORDER
DE69524682D1 (en)	2002-01-31	Treatments for wounds
DE59410094D1 (en)	2002-05-08	DEVICE FOR TREATING BIOLOGICAL TISSUE AND BODY CONCERMENTS
DE69018457D1 (en)	1995-05-11	OBJECTS FOR TREATING PERIODONTITIS AND BONE DEFECTS.
DE69427869D1 (en)	2001-09-06	BOTULINUMTOXINS FOR TREATING HYPERHYDROSIS
ATA76995A (en)	2002-04-15	STABLE PREPARATION FOR TREATING BLOOD COIST DISORDERS
EP0709090A3 (en)	1996-08-28	Compositions for the treatment of resistant tumors
DE69526684D1 (en)	2002-06-13	Aeration mixer for the treatment of molten metal
DE69112480D1 (en)	1995-10-05	Method and device for treating medical waste.
DE69318693D1 (en)	1998-06-25	Magnetic conditioner for the treatment of liquids
DE69220051D1 (en)	1997-07-03	Grain treatment device
DE69817862D1 (en)	2003-10-09	NARINGIN AND NARINGENIN AS A MEDICINE FOR PREVENTING OR TREATING LIVER DISEASES
DE69421196D1 (en)	1999-11-18	DEVICE FOR TREATING OVERBIT
DE69527140D1 (en)	2002-07-25	ACTIVE SUBSTANCE FOR PREVENTING OR TREATING OSTEOPOROSIS
DE69506019D1 (en)	1998-12-24	Pain treatment device
DE69729004D1 (en)	2004-06-09	PHOTODYNAMIC THERAPY FOR TREATING OSTEOSRTHRITIS
DE69727240D1 (en)	2004-02-19	COMBINATIONS CONTAINING VX478, ZIDOVUDIN AND 3TC FOR THE TREATMENT OF HIV
DE59501606D1 (en)	1998-04-16	DEVICE FOR TREATING PCBS
DE69825319D1 (en)	2004-09-02	PREPARATION FOR THE PREVENTION AND TREATMENT OF INFLAMMATION

Legal Events

Date	Code	Title	Description
1995-08-25	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1995-10-11	17P	Request for examination filed	Effective date: 19950724
1995-10-11	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
1998-08-05	A4	Supplementary search report drawn up and despatched	Effective date: 19980619
1998-08-05	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
1998-11-25	17Q	First examination report despatched	Effective date: 19981008
2004-02-06	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED
2004-03-24	18R	Application refused	Effective date: 20031106
2006-07-28	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1009249 Country of ref document: HK