FI955498A - Nipekotiinihappojohdannaisia hyytymistä estävinä aineina - Google Patents

Nipekotiinihappojohdannaisia hyytymistä estävinä aineina Download PDF

Info

Publication number: FI955498A
Authority: FI; Finland
Prior art keywords: anticoagulants; acid derivatives; nipecotinic acid; nipecotinic; telet
Prior art date: 1994-03-16

Application number

FI955498A

Other languages

English (en)

Swedish (sv)

Other versions

FI955498A0 (fi

FI113763B (fi

Inventor

Mary Pat Beavers

Patricia Andrade-Gordon

William J Hoekstra

Original Assignee

Ortho Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-16

Filing date

1995-11-15

Publication date

1996-01-15

1995-11-15 Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp

1995-11-15 Publication of FI955498A0 publication Critical patent/FI955498A0/fi

1996-01-15 Publication of FI955498A publication Critical patent/FI955498A/fi

2004-06-15 Application granted granted Critical

2004-06-15 Publication of FI113763B publication Critical patent/FI113763B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

FI955498A 1994-03-16 1995-11-15 Nipekotiinihappojohdannaisia hyytymistä estävinä aineina FI113763B (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US21377294A	1994-03-16	1994-03-16
US21377294		1994-03-16
US36489694A	1994-12-27	1994-12-27
US36489694		1994-12-27
PCT/US1995/003145 WO1995025091A2 (en)	1994-03-16	1995-03-14	Nipecotic acid derivatives as antithrombic compounds
US9503145		1995-03-14

Publications (3)

Publication Number	Publication Date
FI955498A0 FI955498A0 (fi)	1995-11-15
FI955498A true FI955498A (fi)	1996-01-15
FI113763B FI113763B (fi)	2004-06-15

Family

ID=26908383

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI955498A FI113763B (fi)	1994-03-16	1995-11-15	Nipekotiinihappojohdannaisia hyytymistä estävinä aineina

Country Status (20)

Country	Link
US (1)	US5770575A (fi)
EP (1)	EP0746545B1 (fi)
JP (1)	JPH09510453A (fi)
KR (1)	KR100328287B1 (fi)
CN (1)	CN1083834C (fi)
AT (1)	ATE180470T1 (fi)
AU (1)	AU703397B2 (fi)
CA (1)	CA2163027A1 (fi)
DE (1)	DE69509875T2 (fi)
DK (1)	DK0746545T3 (fi)
ES (1)	ES2131313T3 (fi)
FI (1)	FI113763B (fi)
GR (1)	GR3030566T3 (fi)
HU (1)	HUT74871A (fi)
MX (1)	MX9504800A (fi)
NO (1)	NO304885B1 (fi)
NZ (1)	NZ283209A (fi)
RU (1)	RU2135470C1 (fi)
TW (1)	TW318179B (fi)
WO (1)	WO1995025091A2 (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6380215B1 (en) *	1993-09-22	2002-04-30	Fujisawa Pharmaceutical Co., Ltd	Beta-alanine derivative and a process for the preparation thereof
US6384028B1 (en) *	1995-03-17	2002-05-07	Fujisawa Pharmaceutical Co., Ltd.	N-acylpiperidinylcarbonylaminocarboxylic acids and their use as glycoprotein IIb/IIIa antagonists and fibrinogen-blood platelets binding inhibitors
EP0888302A1 (en) *	1996-03-13	1999-01-07	Fujisawa Pharmaceutical Co., Ltd.	N- (r)-1- 3-(4-piperidyl)propionyl-3-piperidylcarbonyl]-2(s)-acetylamino-beta-alanine as fibrinogen receptor antagonist
ES2243996T3 (es) *	1996-05-01	2005-12-01	Ortho-Mcneil Pharmaceutical, Inc.	Derivados carboxamida de pirrolidina, piperidina y hexahidroazepina utilizados en el tratamiento de trastornos de trombosis.
EP1184374B1 (en) *	1996-05-01	2009-01-28	Ortho-McNeil Pharmaceutical, Inc.	Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders
DE19741235A1 (de) *	1997-09-18	1999-03-25	Hoechst Marion Roussel De Gmbh	Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US6066651A (en)	1997-10-29	2000-05-23	Ortho-Mcneil Pharmaceutical, Inc.	Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders
US6020347A (en) *	1997-11-18	2000-02-01	Merck & Co., Inc.	4-substituted-4-piperidine carboxamide derivatives
AU1415099A (en) *	1997-11-18	1999-06-07	Merck & Co., Inc.	4-substituted-4-piperidine carboxamide derivatives
WO2000056730A1 (en) *	1999-03-22	2000-09-28	Ortho-Mcneil Pharmaceutical, Inc.	PROCESS FOR PREPARING [S-(R,S)] -β -[[[1-[1-OXO-3- (4-PIPERIDINYL) PROPYL] -3-PIPERIDINYL] CARBONYL] AMINO] -3- PYRIDINEPROPANOIC ACID AND DERIVATIVES
AUPQ570100A0 (en) *	2000-02-17	2000-03-09	Fujisawa Pharmaceutical Co., Ltd.	Beta-alanine derivatives and their use as receptor antagonists
EP1719529A4 (en)	2004-02-25	2008-05-21	Astellas Pharma Inc	CONTRASTING FOR THROMBUS EDUCATION
EP3184149A1 (en) *	2015-12-23	2017-06-28	Julius-Maximilians-Universität Würzburg	Soluble glycoprotein v for treating thrombotic diseases
CN109734655B (zh) *	2019-03-11	2020-06-02	都创(上海)医药科技有限公司	一种fkbp配体的同型二聚体合成工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4857508A (en) *	1987-12-03	1989-08-15	Monsanto Company	Novel platelet-aggregation inhibitor peptide derivatives
US5318899A (en) *	1989-06-16	1994-06-07	Cor Therapeutics, Inc.	Platelet aggregation inhibitors
TW201303B (fi) *	1990-07-05	1993-03-01	Hoffmann La Roche
MX9100517A (es) *	1990-08-06	1992-04-01	Smith Kline French Lab	Compuestos
EP0617705B1 (en) *	1991-11-22	1997-09-24	Yeda Research And Development Company, Ltd.	Non-peptidic surrogates of the arg-gly-asp sequence and pharmaceutical compositions comprising them
US5219867A (en) *	1991-12-16	1993-06-15	Research Corporation Technologies, Inc.	Platelet aggregation inhibitory agents
EP0673387B1 (en) *	1992-12-11	1999-09-22	University Of Florida	Materials and methods for control of pests
US5559209A (en) *	1993-02-18	1996-09-24	The General Hospital Corporation	Regulator regions of G proteins

1995
- 1995-03-06 US US08/395,533 patent/US5770575A/en not_active Expired - Lifetime
- 1995-03-14 WO PCT/US1995/003145 patent/WO1995025091A2/en active IP Right Grant
- 1995-03-14 EP EP95914023A patent/EP0746545B1/en not_active Expired - Lifetime
- 1995-03-14 RU RU95122287A patent/RU2135470C1/ru not_active IP Right Cessation
- 1995-03-14 JP JP7524128A patent/JPH09510453A/ja active Pending
- 1995-03-14 NZ NZ283209A patent/NZ283209A/en unknown
- 1995-03-14 MX MX9504800A patent/MX9504800A/es not_active IP Right Cessation
- 1995-03-14 CA CA002163027A patent/CA2163027A1/en not_active Abandoned
- 1995-03-14 AT AT95914023T patent/ATE180470T1/de not_active IP Right Cessation
- 1995-03-14 HU HU9503270A patent/HUT74871A/hu unknown
- 1995-03-14 ES ES95914023T patent/ES2131313T3/es not_active Expired - Lifetime
- 1995-03-14 KR KR1019950705100A patent/KR100328287B1/ko not_active IP Right Cessation
- 1995-03-14 DE DE69509875T patent/DE69509875T2/de not_active Expired - Fee Related
- 1995-03-14 DK DK95914023T patent/DK0746545T3/da active
- 1995-03-14 CN CN95190367A patent/CN1083834C/zh not_active Expired - Fee Related
- 1995-03-14 AU AU21191/95A patent/AU703397B2/en not_active Ceased
- 1995-11-15 NO NO954609A patent/NO304885B1/no unknown
- 1995-11-15 FI FI955498A patent/FI113763B/fi active
- 1995-12-18 TW TW084113492A patent/TW318179B/zh active
1999
- 1999-06-17 GR GR990401649T patent/GR3030566T3/el unknown

Also Published As

Publication number	Publication date
AU2119195A (en)	1995-10-03
AU703397B2 (en)	1999-03-25
EP0746545B1 (en)	1999-05-26
KR100328287B1 (ko)	2002-10-11
EP0746545A1 (en)	1996-12-11
CA2163027A1 (en)	1995-09-21
ES2131313T3 (es)	1999-07-16
FI955498A0 (fi)	1995-11-15
NO954609L (no)	1996-01-05
CN1128022A (zh)	1996-07-31
JPH09510453A (ja)	1997-10-21
WO1995025091A3 (en)	1995-10-12
WO1995025091A2 (en)	1995-09-21
GR3030566T3 (en)	1999-10-29
NO304885B1 (no)	1999-03-01
NZ283209A (en)	1998-04-27
TW318179B (en)	1997-10-21
DE69509875T2 (de)	1999-12-09
NO954609D0 (no)	1995-11-15
MX9504800A (es)	1997-05-31
FI113763B (fi)	2004-06-15
ATE180470T1 (de)	1999-06-15
US5770575A (en)	1998-06-23
RU2135470C1 (ru)	1999-08-27
HU9503270D0 (en)	1996-05-28
HUT74871A (en)	1997-02-28
DK0746545T3 (da)	1999-11-08
CN1083834C (zh)	2002-05-01
DE69509875D1 (de)	1999-07-01

Publication	Publication Date	Title
KR970706824A (ko)	1997-12-01	붕산 에스테르 및 붕산 화합물, 이의 합성 방법 및 용도(boronic ester and acid compounds, synthesis and uses)
BR9804214A (pt)	1999-12-14	Compostos.
NO971538L (no)	1997-06-04	Purin- og guaninforbindelser som inhibitorer for PNP
EA199900853A1 (ru)	2000-10-30	Замещенные производные бензопирана для лечения воспалительных процессов
BR9900177A (pt)	2000-04-11	Inibidores de metaloprotease.
PT923554E (pt)	2002-07-31	N-benzilpiperidina e derivados tetrahidropiridina
NO963370L (no)	1996-10-11	Nye mercaptoacetylamido-1,3,4,5-tetrahydrobenzo[cÅazepin-3-on-disulfidderivater som er anvendbare som inhibitorer av enkefalinase og ACE
FI955498A (fi)	1996-01-15	Nipekotiinihappojohdannaisia hyytymistä estävinä aineina
EA200000826A1 (ru)	2001-04-23	Галоидированные производные амидиноаминокислот, применимые в качестве ингибиторов no-синтазы
EA200200510A1 (ru)	2002-10-31	4-карбоксиамино-2-этил-1,2,3,4-тетрагидрохинолин в кристаллической форме как ингибитор сетр
EA200000204A1 (ru)	2000-10-30	Производные пирролопирролона в качестве ингибиторов эластазы нейтрофилов
ES2168355T3 (es)	2002-06-16	Derivados de bisulfuro de indano-2-mercaptoacetilamida utiles como inhibidores de la encefalinasa.
ES2123728T3 (es)	1999-01-16	Derivados de pirrolo-pirazina de actividad 5-ht3.
FI880868A (fi)	1988-08-26	Välituotteina käyttökelpoisia tetratsoliyhdisteitä
DK0574271T3 (da)	1999-05-25	Benzyl- og benzhydrylalkoholer
BR9407232A (pt)	1996-09-24	Compostos de tiocarbamoíla
NO950212L (no)	1995-03-16	Indolinyl-N-hydroksyurinstoff- og -N-hydroksamsyrederivater som lipoksygenase-inhibitorer