DE69509875D1 - Nipecotinsäurederivate als antithrombische verbindungen - Google Patents

Nipecotinsäurederivate als antithrombische verbindungen

Info

Publication number: DE69509875D1
Authority: DE; Germany
Prior art keywords: compounds; antithrombic; acid derivatives; nipecotic acid; nipecotic
Prior art date: 1994-03-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69509875T

Other languages

English (en)

Other versions

DE69509875T2 (de

Inventor

Mary Beavers

Patricia Andrade-Gordon

William Hoekstra

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ortho Pharmaceutical Corp

Original Assignee

Ortho Pharmaceutical Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-16

Filing date

1995-03-14

Publication date

1999-07-01

1995-03-14 Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp

1999-07-01 Application granted granted Critical

1999-07-01 Publication of DE69509875D1 publication Critical patent/DE69509875D1/de

1999-12-09 Publication of DE69509875T2 publication Critical patent/DE69509875T2/de

2015-03-15 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)

DE69509875T 1994-03-16 1995-03-14 Nipecotinsäurederivate als antithrombische verbindungen Expired - Fee Related DE69509875T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US21377294A	1994-03-16	1994-03-16
US36489694A	1994-12-27	1994-12-27
PCT/US1995/003145 WO1995025091A2 (en)	1994-03-16	1995-03-14	Nipecotic acid derivatives as antithrombic compounds

Publications (2)

Publication Number	Publication Date
DE69509875D1 true DE69509875D1 (de)	1999-07-01
DE69509875T2 DE69509875T2 (de)	1999-12-09

Family

ID=26908383

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69509875T Expired - Fee Related DE69509875T2 (de)	1994-03-16	1995-03-14	Nipecotinsäurederivate als antithrombische verbindungen

Country Status (20)

Country	Link
US (1)	US5770575A (de)
EP (1)	EP0746545B1 (de)
JP (1)	JPH09510453A (de)
KR (1)	KR100328287B1 (de)
CN (1)	CN1083834C (de)
AT (1)	ATE180470T1 (de)
AU (1)	AU703397B2 (de)
CA (1)	CA2163027A1 (de)
DE (1)	DE69509875T2 (de)
DK (1)	DK0746545T3 (de)
ES (1)	ES2131313T3 (de)
FI (1)	FI113763B (de)
GR (1)	GR3030566T3 (de)
HU (1)	HUT74871A (de)
MX (1)	MX9504800A (de)
NO (1)	NO304885B1 (de)
NZ (1)	NZ283209A (de)
RU (1)	RU2135470C1 (de)
TW (1)	TW318179B (de)
WO (1)	WO1995025091A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT669912E (pt) *	1993-09-22	2002-03-28	Fujisawa Pharmaceutical Co	Derivados de n-(3-piperidinil-carbonil)-beta-alanina como antagonistas de paf
CA2215106A1 (en) *	1995-03-17	1996-09-26	Fujisawa Pharmaceutical Co., Ltd.	N-acylpiperidinylcarbonylaminocarboxylic acids and their use as glycoprotein iib/iiia antagonists and fibrinogen-blood platelets binding inhibitors
CA2248809A1 (en) *	1996-03-13	1997-09-18	Fujisawa Pharmaceutical Co., Ltd.	N-[(r)-1-{3-(4-piperidyl)propionyl}-3-piperidylcarbonyl]-2(s)-acetylamino-beta-alanine as fibrinogen receptor antagonist
WO1997041102A1 (en) *	1996-05-01	1997-11-06	Ortho Pharmaceutical Corporation	Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders
EP1184374B1 (de) *	1996-05-01	2009-01-28	Ortho-McNeil Pharmaceutical, Inc.	Carboxamidderivate von Pyrrolidin, Piperidin und Hexahydropiperizin für Behandlung von Thrombosen
DE19741235A1 (de) *	1997-09-18	1999-03-25	Hoechst Marion Roussel De Gmbh	Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US6066651A (en) *	1997-10-29	2000-05-23	Ortho-Mcneil Pharmaceutical, Inc.	Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders
US6020347A (en) *	1997-11-18	2000-02-01	Merck & Co., Inc.	4-substituted-4-piperidine carboxamide derivatives
AU1415099A (en) *	1997-11-18	1999-06-07	Merck & Co., Inc.	4-substituted-4-piperidine carboxamide derivatives
ES2199805T3 (es) *	1999-03-22	2004-03-01	Ortho-Mcneil Pharmaceutical, Inc.	Procedimiento para la preparacion de acido (s-(rs))-beta-(((1-(1-oxo-3-4-piperidinil)propil)-3-piperidinil)carbonil)amino)-3-piridinoproanoico y derivados.
AUPQ570100A0 (en) *	2000-02-17	2000-03-09	Fujisawa Pharmaceutical Co., Ltd.	Beta-alanine derivatives and their use as receptor antagonists
JP4910695B2 (ja)	2004-02-25	2012-04-04	アステラス製薬株式会社	血栓造影剤
RU2349304C1 (ru) *	2007-08-10	2009-03-20	Закрытое Акционерное Общество "Канонфарма Продакшн"	Таблетированная лекарственная форма клопидогрела или его фармацевтически приемлемой соли, способ ее получения и применение
EP3184149A1 (de) *	2015-12-23	2017-06-28	Julius-Maximilians-Universität Würzburg	Lösliches glycoprotein v zur behandlung von thrombose-erkrankungen
CN109734655B (zh) *	2019-03-11	2020-06-02	都创(上海)医药科技有限公司	一种fkbp配体的同型二聚体合成工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4857508A (en) *	1987-12-03	1989-08-15	Monsanto Company	Novel platelet-aggregation inhibitor peptide derivatives
US5318899A (en) *	1989-06-16	1994-06-07	Cor Therapeutics, Inc.	Platelet aggregation inhibitors
TW201303B (de) *	1990-07-05	1993-03-01	Hoffmann La Roche
MX9100517A (es) *	1990-08-06	1992-04-01	Smith Kline French Lab	Compuestos
CA2117282A1 (en) *	1991-11-22	1993-05-27	Ofer Lider	Non-peptidic surrogates of the arg-gly-asp sequence and pharmaceutical compositions comprosing them
US5219867A (en) *	1991-12-16	1993-06-15	Research Corporation Technologies, Inc.	Platelet aggregation inhibitory agents
ATE184882T1 (de) *	1992-12-11	1999-10-15	Univ Florida	Materialien und methoden zur schädlingsbekämpfung
US5559209A (en) *	1993-02-18	1996-09-24	The General Hospital Corporation	Regulator regions of G proteins

1995
- 1995-03-06 US US08/395,533 patent/US5770575A/en not_active Expired - Lifetime
- 1995-03-14 AT AT95914023T patent/ATE180470T1/de not_active IP Right Cessation
- 1995-03-14 MX MX9504800A patent/MX9504800A/es not_active IP Right Cessation
- 1995-03-14 WO PCT/US1995/003145 patent/WO1995025091A2/en active IP Right Grant
- 1995-03-14 DK DK95914023T patent/DK0746545T3/da active
- 1995-03-14 AU AU21191/95A patent/AU703397B2/en not_active Ceased
- 1995-03-14 DE DE69509875T patent/DE69509875T2/de not_active Expired - Fee Related
- 1995-03-14 NZ NZ283209A patent/NZ283209A/en unknown
- 1995-03-14 CN CN95190367A patent/CN1083834C/zh not_active Expired - Fee Related
- 1995-03-14 CA CA002163027A patent/CA2163027A1/en not_active Abandoned
- 1995-03-14 EP EP95914023A patent/EP0746545B1/de not_active Expired - Lifetime
- 1995-03-14 ES ES95914023T patent/ES2131313T3/es not_active Expired - Lifetime
- 1995-03-14 RU RU95122287A patent/RU2135470C1/ru not_active IP Right Cessation
- 1995-03-14 KR KR1019950705100A patent/KR100328287B1/ko not_active Expired - Fee Related
- 1995-03-14 HU HU9503270A patent/HUT74871A/hu unknown
- 1995-03-14 JP JP7524128A patent/JPH09510453A/ja active Pending
- 1995-11-15 FI FI955498A patent/FI113763B/fi active
- 1995-11-15 NO NO954609A patent/NO304885B1/no unknown
- 1995-12-18 TW TW084113492A patent/TW318179B/zh active
1999
- 1999-06-17 GR GR990401649T patent/GR3030566T3/el unknown

Also Published As

Publication number	Publication date
ATE180470T1 (de)	1999-06-15
NO304885B1 (no)	1999-03-01
EP0746545B1 (de)	1999-05-26
JPH09510453A (ja)	1997-10-21
NO954609D0 (no)	1995-11-15
HUT74871A (en)	1997-02-28
FI955498L (fi)	1996-01-15
CA2163027A1 (en)	1995-09-21
WO1995025091A2 (en)	1995-09-21
CN1083834C (zh)	2002-05-01
NO954609L (no)	1996-01-05
FI955498A0 (fi)	1995-11-15
AU2119195A (en)	1995-10-03
NZ283209A (en)	1998-04-27
MX9504800A (es)	1997-05-31
KR100328287B1 (ko)	2002-10-11
HU9503270D0 (en)	1996-05-28
DE69509875T2 (de)	1999-12-09
CN1128022A (zh)	1996-07-31
US5770575A (en)	1998-06-23
TW318179B (en)	1997-10-21
FI113763B (fi)	2004-06-15
DK0746545T3 (da)	1999-11-08
AU703397B2 (en)	1999-03-25
RU2135470C1 (ru)	1999-08-27
GR3030566T3 (en)	1999-10-29
WO1995025091A3 (en)	1995-10-12
EP0746545A1 (de)	1996-12-11
ES2131313T3 (es)	1999-07-16

Publication	Publication Date	Title
DE69509875D1 (de)	1999-07-01	Nipecotinsäurederivate als antithrombische verbindungen
NO971538L (no)	1997-06-04	Purin- og guaninforbindelser som inhibitorer for PNP
PT896533E (pt)	2004-02-27	Pentafluorobenzenosulfonamidas e analogos
DE69325944D1 (de)	1999-09-16	s-Triazinderivate als Lichtschutzmittel
NO931695L (no)	1993-05-27	Nye 4-arylpiperaciner og 4-arylpiperidiner
DE69330733D1 (de)	2001-10-18	9-[(Substituierte Glycyl)amido]-6-demethyl-6-deoxytetracycline als antibiotische Mittel
TR199700844T1 (xx)	1998-01-21	Pirazolil-Benzoil T�revleri.
ATE215530T1 (de)	2002-04-15	7-substituierte-8-substituierte-9-substituierte amino-7-demethyl-6-deoxy-tetracycline als antibiotische mittel
DK1485359T3 (da)	2008-04-14	Natriumkanalblokkere
ATE177078T1 (de)	1999-03-15	Amidino-derivate als no-synthetase inhibitoren
DE69006131D1 (de)	1994-03-03	Substituierte Chinazolinone als Angiotensin II-Antagonisten.
BR9900177A (pt)	2000-04-11	Inibidores de metaloprotease.
PT923554E (pt)	2002-07-31	N-benzilpiperidina e derivados tetrahidropiridina
EA200000826A1 (ru)	2001-04-23	Галоидированные производные амидиноаминокислот, применимые в качестве ингибиторов no-синтазы
EA200100607A1 (ru)	2001-12-24	3,4,5-тризамещенные арилнитроны и содержащие их фармацевтические композиции
NO980643L (no)	1998-04-07	Propylendopeptidase inhibitorer
ITMI931012A1 (it)	1994-11-18	Composti spiro-piranici dotati di caratteristiche fotocromatiche
DE60041001D1 (de)	2009-01-15	Substituierte homopiperidylbenzimidazolanaloga als fundusrelaxantien
ES2104174T3 (es)	1997-10-01	Derivados de bencilamino, bencilamido y bencilimido ciclicos utilizados como agentes antipsicoticos.
DE69524064D1 (de)	2002-01-03	Indan-2-mercaptoacetylamid disulfidderivate als enkephalinase inhibitoren
GR1000887B (el)	1993-03-16	Νεα παραγωγα σπιροφουρανης.
ES2123728T3 (es)	1999-01-16	Derivados de pirrolo-pirazina de actividad 5-ht3.
ATE145911T1 (de)	1996-12-15	Inositol-phosphat-analog als kalzium- antagonistische substanz
DK0574271T3 (da)	1999-05-25	Benzyl- og benzhydrylalkoholer
DE69527854D1 (de)	2002-09-26	Derivate substituierter amidinonaphthylester

Legal Events

Date	Code	Title	Description
2000-06-21	8364	No opposition during term of opposition
2006-06-29	8328	Change in the person/name/address of the agent	Representative=s name: BOEHMERT & BOEHMERT, 28209 BREMEN
2009-01-22	8339	Ceased/non-payment of the annual fee