FI953170L - Oligunokleotidit isoprenyyliproteiinitransferaasin ilmentämisen inhibiboimiseksi - Google Patents

Oligunokleotidit isoprenyyliproteiinitransferaasin ilmentämisen inhibiboimiseksi Download PDF

Info

Publication number: FI953170L
Authority: FI; Finland
Prior art keywords: oligonucleotides; inhibiting; expression; protein transferase; isoprenyl protein
Prior art date: 1994-06-29

Application number

FI953170A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI953170A0 (fi

Inventor

Soudhir Colote

Eduardo Pirotzky

Original Assignee

Scras

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-29

Filing date

1995-06-27

Publication date

1995-12-30

1995-06-27 Application filed by Scras filed Critical Scras

1995-06-27 Publication of FI953170A0 publication Critical patent/FI953170A0/fi

1995-12-30 Publication of FI953170L publication Critical patent/FI953170L/fi

Links

108091034117 Oligonucleotide Proteins 0.000 title 1
102000004357 Transferases Human genes 0.000 title 1
108090000992 Transferases Proteins 0.000 title 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
-1 isoprenyl Chemical group 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
- C12Y205/01029—Geranylgeranyl diphosphate synthase (2.5.1.29)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Veterinary Medicine (AREA)
Microbiology (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Plant Pathology (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)

FI953170A 1994-06-29 1995-06-27 Oligunokleotidit isoprenyyliproteiinitransferaasin ilmentämisen inhibiboimiseksi FI953170L (fi)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB9413035A GB9413035D0 (en)	1994-06-29	1994-06-29	Antisense oligonucleeotides

Publications (2)

Publication Number	Publication Date
FI953170A0 FI953170A0 (fi)	1995-06-27
FI953170L true FI953170L (fi)	1995-12-30

Family

ID=10757497

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI953170A FI953170L (fi)	1994-06-29	1995-06-27	Oligunokleotidit isoprenyyliproteiinitransferaasin ilmentämisen inhibiboimiseksi

Country Status (25)

Country	Link
US (1)	US5856461A (hu)
EP (1)	EP0692535A1 (hu)
JP (1)	JPH0851985A (hu)
KR (1)	KR960000914A (hu)
CN (1)	CN1124142A (hu)
AU (1)	AU689887B2 (hu)
BR (1)	BR9503015A (hu)
CA (1)	CA2152233A1 (hu)
CZ (1)	CZ291496B6 (hu)
DZ (1)	DZ1903A1 (hu)
FI (1)	FI953170L (hu)
FR (2)	FR2721930B1 (hu)
GB (2)	GB9413035D0 (hu)
HU (1)	HU219823B (hu)
IE (1)	IE950477A1 (hu)
MA (1)	MA23595A1 (hu)
NO (1)	NO952601L (hu)
NZ (1)	NZ272398A (hu)
OA (1)	OA10221A (hu)
PL (1)	PL309384A1 (hu)
RU (1)	RU2112766C1 (hu)
SE (1)	SE9502259L (hu)
SK (1)	SK83895A3 (hu)
TN (1)	TNSN95068A1 (hu)
ZA (1)	ZA955288B (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0840605A4 (en) *	1995-07-13	2000-05-10	Univ Cincinnati	COMPOUNDS FOR USE IN THE TREATMENT OF NEUROFIBROMATOSE
CN1301731A (zh) *	1999-12-24	2001-07-04	上海博德基因开发有限公司	一种新的多肽——多异戊二烯基合成酶蛋白9和编码这种多肽的多核苷酸
US20030157598A1 (en) *	2000-12-07	2003-08-21	Ramanathan Chandra S.	Novel human G-protein coupled receptor, HGPRBMY23, expressed highly in kidney
US20030212017A1 (en) *	2002-05-10	2003-11-13	Isis Pharmaceuticals Inc.	Antisense modulation of farnesyl transferase beta subunit expression
US7507808B2 (en) *	2002-12-12	2009-03-24	Isis Pharmaceuticals, Inc.	Modulation of endothelial lipase expression
PL1667522T3 (pl)	2003-09-09	2018-06-29	Geron Corporation	Zmodyfikowane oligonukleotydy do hamowania telomerazy
WO2008094640A2 (en)	2007-01-30	2008-08-07	Geron Corporation	Compounds having anti-adhesive effects on cancer cells
JOP20200257A1 (ar)	2014-05-01	2017-06-16	Geron Corp	تركيبات أوليجو نوكليوتيد وطرق لتحضيرها

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4571421A (en) *	1979-11-05	1986-02-18	Genentech, Inc.	Mammalian gene for microbial expression
US5004803A (en) *	1988-11-14	1991-04-02	Genetics Institute, Inc.	Production of procoagulant proteins
US5420245A (en) *	1990-04-18	1995-05-30	Board Of Regents, The University Of Texas	Tetrapeptide-based inhibitors of farnesyl transferase
US5185248A (en) *	1990-05-08	1993-02-09	E. R. Squibb & Sons, Inc.	Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation
DE69233158T2 (de) *	1991-03-07	2004-05-13	Connaught Technology Corp., Greenville	Gentechnologisch hergestellter stamm für impfstoffe
NZ244820A (en) *	1991-10-25	1994-01-26	Isis Pharmaceuticals Inc	Oligonucleotide inhibitor of epstein-barr virus.
US5348853A (en) *	1991-12-16	1994-09-20	Biotronics Corporation	Method for reducing non-specific priming in DNA amplification
US5585479A (en) *	1992-07-24	1996-12-17	The United States Of America As Represented By The Secretary Of The Navy	Antisense oligonucleotides directed against human ELAM-I RNA

1994
- 1994-06-29 GB GB9413035A patent/GB9413035D0/en active Pending
1995
- 1995-06-20 CA CA002152233A patent/CA2152233A1/en not_active Abandoned
- 1995-06-21 NZ NZ272398A patent/NZ272398A/en unknown
- 1995-06-21 SE SE9502259A patent/SE9502259L/xx not_active Application Discontinuation
- 1995-06-21 FR FR9507366A patent/FR2721930B1/fr not_active Expired - Fee Related
- 1995-06-21 FR FR9507367A patent/FR2721827A1/fr active Pending
- 1995-06-21 EP EP95401463A patent/EP0692535A1/fr not_active Withdrawn
- 1995-06-23 US US08/494,301 patent/US5856461A/en not_active Expired - Fee Related
- 1995-06-26 SK SK838-95A patent/SK83895A3/sk unknown
- 1995-06-26 TN TNTNSN95068A patent/TNSN95068A1/fr unknown
- 1995-06-26 ZA ZA955288A patent/ZA955288B/xx unknown
- 1995-06-27 DZ DZ950080A patent/DZ1903A1/fr active
- 1995-06-27 CZ CZ19951688A patent/CZ291496B6/cs not_active IP Right Cessation
- 1995-06-27 FI FI953170A patent/FI953170L/fi unknown
- 1995-06-27 AU AU23299/95A patent/AU689887B2/en not_active Ceased
- 1995-06-28 PL PL95309384A patent/PL309384A1/xx unknown
- 1995-06-28 RU RU95110774/04A patent/RU2112766C1/ru not_active IP Right Cessation
- 1995-06-28 KR KR1019950017763A patent/KR960000914A/ko not_active Application Discontinuation
- 1995-06-28 MA MA23939A patent/MA23595A1/fr unknown
- 1995-06-28 CN CN95108109A patent/CN1124142A/zh active Pending
- 1995-06-28 HU HU9501913A patent/HU219823B/hu not_active IP Right Cessation
- 1995-06-28 NO NO952601A patent/NO952601L/no not_active Application Discontinuation
- 1995-06-28 IE IE950477A patent/IE950477A1/en not_active IP Right Cessation
- 1995-06-29 JP JP7163358A patent/JPH0851985A/ja active Pending
- 1995-06-29 OA OA60679A patent/OA10221A/fr unknown
- 1995-06-29 BR BR9503015A patent/BR9503015A/pt not_active Application Discontinuation
- 1995-06-29 GB GB9513246A patent/GB2290791B/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
FR2721827A1 (fr)	1996-01-05
AU689887B2 (en)	1998-04-09
FI953170A0 (fi)	1995-06-27
GB2290791B (en)	1998-08-05
NZ272398A (en)	1996-04-26
CZ168895A3 (en)	1996-05-15
SE9502259D0 (sv)	1995-06-21
NO952601D0 (no)	1995-06-28
KR960000914A (ko)	1996-01-25
TNSN95068A1 (fr)	1996-02-06
AU2329995A (en)	1996-01-11
JPH0851985A (ja)	1996-02-27
SE9502259L (sv)	1995-12-30
GB9413035D0 (en)	1994-08-17
ZA955288B (en)	1996-01-31
DZ1903A1 (fr)	2002-02-17
EP0692535A1 (fr)	1996-01-17
GB9513246D0 (en)	1995-09-06
NO952601L (no)	1996-01-02
CN1124142A (zh)	1996-06-12
FR2721930A1 (fr)	1996-01-05
FR2721930B1 (fr)	1997-01-03
HU9501913D0 (en)	1995-08-28
GB2290791A (en)	1996-01-10
RU95110774A (ru)	1997-04-20
RU2112766C1 (ru)	1998-06-10
MA23595A1 (fr)	1995-12-31
PL309384A1 (en)	1996-01-08
IE950477A1 (en)	1996-01-10
US5856461A (en)	1999-01-05
HU219823B (hu)	2001-08-28
CA2152233A1 (en)	1995-12-30
BR9503015A (pt)	1996-06-04
CZ291496B6 (cs)	2003-03-12
OA10221A (fr)	1997-09-19
SK83895A3 (en)	1996-05-08
HUT72133A (en)	1996-03-28

Publication	Publication Date	Title
FI963597A0 (fi)	1996-09-12	Isoprenyylitransferaasi-inhibiittoreita
NO20010053L (no)	2001-03-02	Farnesyl proteintransferaseinhibitorer for behandling av artropatier
EE9700314A (et)	1998-06-15	Farnesüül-proteiini transferaasi inhibiitorid
BR9611724A (pt)	1999-06-01	Inibidor de quinase c de proteína
NO996571L (no)	2000-02-23	Inhibitorer for farnesyl-protein-transferase
EE9800262A (et)	1999-02-15	Farnesüül-proteiini transferaasi inhibiitorid
EE9800408A (et)	1999-06-15	Proteiinfarnesüültransferaasi inhibiitorid
ATE546139T1 (de)	2012-03-15	Isoprentransferase proteine inhibitoren
FI973492L (fi)	1997-08-26	NO-syntaasin estäjät
BR9609797A (pt)	1999-03-16	Inibição de expressão de gene
DK0815348T3 (da)	2001-10-22	Hydrathæmning
DE69924876D1 (de)	2005-05-25	Farnesyl protein transferase inhibitoren
BR9609726A (pt)	1999-03-16	Inibição de expressão de gene
FI953170L (fi)	1995-12-30	Oligunokleotidit isoprenyyliproteiinitransferaasin ilmentämisen inhibiboimiseksi
FI973277A0 (fi)	1997-08-08	Farmaseuttisia valmisteita TNF:n estämiseksi
ZA985210B (en)	1999-01-07	Compounds for the inhibition of farnesyl protein transferase
SG32382A1 (en)	1996-08-13	Oligonucleotides to inhibit the expression of isoprenyl protein transferases
ZA996763B (en)	2000-05-15	Inhibitors of protein isoprenyl transferases.