FI952198L - Stabiili kiteinen (6S)- ja (6R)-tetrahydrofoolihappo - Google Patents

Stabiili kiteinen (6S)- ja (6R)-tetrahydrofoolihappo Download PDF

Info

Publication number: FI952198L
Authority: FI; Finland
Prior art keywords: tetrahydrofolic acid; stable crystalline; crystalline; stable; tetrahydrofolic
Prior art date: 1994-05-09

Application number

FI952198A

Other languages

English (en)

Swedish (sv)

Other versions

FI952198A0 (fi

FI120585B (fi

Inventor

Hans Rudolf Mueller

Martin Ulmann

Rudolf Moser

Thomas Ammann

Original Assignee

Eprova Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-09

Filing date

1995-05-08

Publication date

1995-11-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4210562&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI952198(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-05-08 Application filed by Eprova Ag filed Critical Eprova Ag

1995-05-08 Publication of FI952198A0 publication Critical patent/FI952198A0/fi

1995-11-10 Publication of FI952198L publication Critical patent/FI952198L/fi

2009-12-15 Application granted granted Critical

2009-12-15 Publication of FI120585B publication Critical patent/FI120585B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Toxicology (AREA)
Nutrition Science (AREA)
Obesity (AREA)
Transplantation (AREA)
Tropical Medicine & Parasitology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

FI952198A 1994-05-09 1995-05-08 Stabiili kiteinen (6S)- ja (6R)-tetrahydrofoolihappo FI120585B (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH144294		1994-05-09
CH144294A CH686369A5 (de)	1994-05-09	1994-05-09	Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure.

Publications (3)

Publication Number	Publication Date
FI952198A0 FI952198A0 (fi)	1995-05-08
FI952198L true FI952198L (fi)	1995-11-10
FI120585B FI120585B (fi)	2009-12-15

Family

ID=4210562

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI952198A FI120585B (fi)	1994-05-09	1995-05-08	Stabiili kiteinen (6S)- ja (6R)-tetrahydrofoolihappo

Country Status (19)

Country	Link
US (2)	US6271374B1 (fi)
EP (1)	EP0682026B2 (fi)
JP (2)	JP3419585B2 (fi)
KR (1)	KR950032192A (fi)
CN (1)	CN1063444C (fi)
AT (1)	ATE188699T1 (fi)
AU (1)	AU704363B2 (fi)
CA (1)	CA2148671C (fi)
CH (1)	CH686369A5 (fi)
DE (1)	DE59507591D1 (fi)
DK (1)	DK0682026T4 (fi)
ES (1)	ES2144066T5 (fi)
FI (1)	FI120585B (fi)
GR (1)	GR3032984T3 (fi)
HU (1)	HUT71612A (fi)
NO (1)	NO313673B1 (fi)
PT (1)	PT682026E (fi)
RU (1)	RU2165422C2 (fi)
ZA (1)	ZA953673B (fi)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH689831A5 (de) *	1995-11-07	1999-12-15	Eprova Ag	Stabile kristalline Tetrahydrofolsaeure-Salze.
CH693905A5 (de)	1999-04-15	2004-04-15	Eprova Ag	Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
CH694251A5 (de)	1999-07-14	2004-10-15	Eprova Ag	Herstellung von Tetrahydropterin und Derivaten.
CH695217A5 (de) *	1999-07-14	2006-01-31	Merck Eprova Ag	Verfahren zur Trennung optischer Isomeren von Tetrahydrofolsäureestersalzen und Tetrahydrofolsäure.
ITMI20020132A1 (it)	2002-01-25	2003-07-25	Gmt Fine Chemicals Sa	Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolico
AU2004291149C1 (en)	2003-11-17	2021-01-21	Biomarin Pharmaceutical Inc.	Methods and Compositions for the Treatment of Metabolic Disorders
DE602005026352D1 (de) *	2004-09-15	2011-03-31	Nipro Corp	Wässrige, stabile (6S)-Folinsäurelösung zur Injektion
WO2006063215A2 (en) *	2004-12-08	2006-06-15	Biomarin Pharmaceutical Inc.	Methods and compositions for the treatment of pulmonary hypertension of the newborn
SI2451299T1 (sl)	2009-07-10	2016-10-28	Iii Linzy O. Scott	Metode in sestave za zdravljenje s ščitnico- povezanih zdravstvenih stanj z reduciranimi folati
EP3949973A3 (en)	2010-02-12	2022-07-06	Gentelon, Inc.	Compositions and methods for treating depression
WO2013163917A1 (zh)	2012-04-13	2013-11-07	连云港金康和信药业有限公司	化合物jk12a及其制备
US9629846B1 (en)	2013-11-14	2017-04-25	Argent Development Group, Llc	Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women
US9492421B1 (en)	2013-11-14	2016-11-15	Argent Development Group, Llc	Nutritional supplements for treatment of iron deficiency anemia
WO2016185413A1 (en)	2015-05-20	2016-11-24	Nestec S.A.	Modified release formulations
US10059710B2 (en) *	2016-02-17	2018-08-28	Merck & Cie	Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid
AU2017397463B2 (en)	2016-11-03	2022-01-06	HedoniaUSA, Inc.	Compositions and methods for treating depression
CN110461845B (zh)	2017-03-31	2023-05-12	默克专利股份有限公司	5-甲基-（6s）-四氢叶酸的结晶钠盐
PL3609894T3 (pl)	2017-03-31	2024-12-16	Merck Patent Gmbh	Krystaliczna sól sodowa kwasu 5-metylo-(6s)-tetrahydrofoliowego
EP4501315A1 (en)	2023-08-04	2025-02-05	Lesaffre et Compagnie	Liquid formulations of folates

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS497416A (fi) *	1972-05-12	1974-01-23
US4665176A (en) *	1984-10-23	1987-05-12	Mitsui Toatsu Chemicals, Incorporated	Process for the preparation of 5,6,7,8-tetrahydrofolic acid
GB8621268D0 (en) *	1986-09-03	1986-10-08	Univ Strathclyde	Separation of substances
CH673459A5 (fi) *	1987-05-15	1990-03-15	Eprova Ag
DE3821875C1 (fi) *	1988-06-29	1990-02-15	Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
DE69027585T2 (de) *	1989-12-11	1997-01-16	American Cyanamid Co	Verfahren zur Herstellung von optisch reinen Diastereoisomeren von Tetrahydrofolatverbindungen
CH680731A5 (fi) *	1990-04-12	1992-10-30	Sapec Fine Chemicals
CH681303A5 (fi) *	1991-01-16	1993-02-26	Eprova Ag
CH683261A5 (it) *	1991-10-10	1994-02-15	Applied Pharma Res	Procedimento per la preparazione dell'acido metiltetraidrofolico nella forma (6(R,S)(-))N-5 e separazione del diastereoisomero attivo (6(S)(-))N-5) sotto forma di sali.
US5198547A (en) *	1992-03-16	1993-03-30	South Alabama Medical Science Foundation, Usa	Process for N5-formylating tetrahydropteridines
US5698693A (en) *	1992-11-16	1997-12-16	The United States Of America As Represented By The Department Of Health And Human Services	Process of separating the diastereomers of (6R,6S) -5,6,7,8-tetrahydrofolic acid derivatives
CH686672A5 (de) *	1992-12-01	1996-05-31	Cerbios Pharma Sa	Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
AU2001268035A1 (en)	2000-03-21	2001-10-03	Bbj Environmental Solutions Inc.	Aqueous cleaning composition with controlled ph

1994
- 1994-05-09 CH CH144294A patent/CH686369A5/de not_active IP Right Cessation
1995
- 1995-04-27 AT AT95106285T patent/ATE188699T1/de active
- 1995-04-27 DK DK95106285T patent/DK0682026T4/da active
- 1995-04-27 DE DE59507591T patent/DE59507591D1/de not_active Expired - Lifetime
- 1995-04-27 ES ES95106285T patent/ES2144066T5/es not_active Expired - Lifetime
- 1995-04-27 PT PT95106285T patent/PT682026E/pt unknown
- 1995-04-27 EP EP95106285A patent/EP0682026B2/de not_active Expired - Lifetime
- 1995-05-02 JP JP10888195A patent/JP3419585B2/ja not_active Expired - Fee Related
- 1995-05-04 CA CA002148671A patent/CA2148671C/en not_active Expired - Lifetime
- 1995-05-05 RU RU95107144/04A patent/RU2165422C2/ru active
- 1995-05-08 FI FI952198A patent/FI120585B/fi not_active IP Right Cessation
- 1995-05-08 CN CN95106005A patent/CN1063444C/zh not_active Expired - Lifetime
- 1995-05-08 HU HU9501348A patent/HUT71612A/hu unknown
- 1995-05-08 ZA ZA953673A patent/ZA953673B/xx unknown
- 1995-05-08 NO NO19951796A patent/NO313673B1/no not_active IP Right Cessation
- 1995-05-08 AU AU17931/95A patent/AU704363B2/en not_active Ceased
- 1995-05-09 KR KR1019950011214A patent/KR950032192A/ko not_active Ceased
1998
- 1998-01-26 US US09/013,266 patent/US6271374B1/en not_active Expired - Lifetime
2000
- 2000-03-16 GR GR20000400684T patent/GR3032984T3/el not_active IP Right Cessation
2001
- 2001-01-08 US US09/755,072 patent/US6596721B2/en not_active Expired - Fee Related
2003
- 2003-01-28 JP JP2003019261A patent/JP4898081B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP2003201291A (ja)	2003-07-18
ATE188699T1 (de)	2000-01-15
HUT71612A (en)	1996-01-29
NO313673B1 (no)	2002-11-11
CH686369A5 (de)	1996-03-15
ES2144066T3 (es)	2000-06-01
JPH0841062A (ja)	1996-02-13
EP0682026B1 (de)	2000-01-12
AU704363B2 (en)	1999-04-22
FI952198A0 (fi)	1995-05-08
DE59507591D1 (de)	2000-02-17
DK0682026T4 (da)	2003-02-24
DK0682026T3 (da)	2000-04-17
AU1793195A (en)	1995-11-16
US20010002398A1 (en)	2001-05-31
CA2148671A1 (en)	1995-11-10
CA2148671C (en)	2000-08-15
EP0682026A1 (de)	1995-11-15
CN1122337A (zh)	1996-05-15
US6271374B1 (en)	2001-08-07
EP0682026B2 (de)	2003-02-05
RU2165422C2 (ru)	2001-04-20
JP4898081B2 (ja)	2012-03-14
GR3032984T3 (en)	2000-07-31
JP3419585B2 (ja)	2003-06-23
FI120585B (fi)	2009-12-15
KR950032192A (ko)	1995-12-20
ES2144066T5 (es)	2003-11-01
PT682026E (pt)	2000-05-31
NO951796L (no)	1995-11-10
RU95107144A (ru)	1997-03-20
NO951796D0 (no)	1995-05-08
ZA953673B (en)	1996-01-12
CN1063444C (zh)	2001-03-21
US6596721B2 (en)	2003-07-22

Publication	Publication Date	Title
FI952198L (fi)	1995-11-10	Stabiili kiteinen (6S)- ja (6R)-tetrahydrofoolihappo
FI954250L (fi)	1995-09-11	Kiteinen vapaa keftiofuurihappo
FI954404L (fi)	1995-09-18	Fenoksifenyylietikkahappojohdannaiset
EG18666A (en)	1994-04-30	Pyrimidine derivatives and herbicidal composition
PT769965E (pt)	2002-04-29	Formulacoes aquosas de risperidona
DE69219107D1 (de)	1997-05-22	Verdampfer
FI932950A7 (fi)	1993-12-26	Hydroxiaminsyra derivat
FI934140A0 (fi)	1993-09-22	Radio med tysta respektive hoerbara larmsignaler
FI955166L (fi)	1995-10-27	Risperidonipamoaatti
FI920180L (fi)	1992-07-17	Foerfarande foer framstaellning av (6s) - och (6r)-tetrahydrofolsyra.
FI942976A7 (fi)	1995-02-28	5-amino-8-metyyli-7-pyrrolidinyylikinoliini-3-karboksyylihappojohdannaiset
DE69524611D1 (de)	2002-01-24	Pyrimidon-derivate
FI941942L (fi)	1994-10-29	Kiteinen spirostanyyliglykosidaali-monohydraatti
FI941712L (fi)	1994-10-16	Heterosykliset iminobismetyleenibisfosfonihappojohdannaiset
DE59402621D1 (de)	1997-06-12	Fluor-trifluormethylbenzoesäure-Derivate
FI941230L (fi)	1994-09-19	Heterotrisyklisesti substituoituja fenyylisykloheksaanikarboksyylihappojohdannaisia
FI932953A7 (fi)	1993-12-27	Imidazolylsubstituerade fenylpropion- och -kanelsyraderivat
FI941064A7 (fi)	1994-09-12	Asyylioksiheksaanihappojohdannaiset
ZA948297B (en)	1995-06-12	Pyrimidine derivatives
FI953727L (fi)	1995-09-13	Stabiilit vesipitoiset dipeptidisuspensiot
FI931424L (fi)	1993-10-02	Cykloalkyl- och heterocyklylsubstituerade imidazolylpropensyraderivat
KR920011399U (ko)	1992-07-24	볼형 구멍모따기공구의 구조
KR950003486U (ko)	1995-02-16	차량용 수면보조받침대
KR950021263U (ko)	1995-07-28	소켓홀더의 구조개선
DE69302425D1 (de)	1996-06-05	Quadratsäurederivate

Legal Events

Date	Code	Title	Description
2009-12-15	FG	Patent granted	Ref document number: 120585 Country of ref document: FI
2015-06-22	MA	Patent expired

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2009-12-15

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2015-06-22

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