ITMI20020132A1 - Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolico - Google Patents
Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolicoInfo
- Publication number
- ITMI20020132A1 ITMI20020132A1 IT2002MI000132A ITMI20020132A ITMI20020132A1 IT MI20020132 A1 ITMI20020132 A1 IT MI20020132A1 IT 2002MI000132 A IT2002MI000132 A IT 2002MI000132A IT MI20020132 A ITMI20020132 A IT MI20020132A IT MI20020132 A1 ITMI20020132 A1 IT MI20020132A1
- Authority
- IT
- Italy
- Prior art keywords
- acid
- suspension
- isomer
- tetrahydropholic
- obtaining acid
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000002253 acid Substances 0.000 title abstract 2
- 239000000725 suspension Substances 0.000 abstract 3
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 abstract 2
- MSTNYGQPCMXVAQ-RYUDHWBXSA-N (6S)-5,6,7,8-tetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-RYUDHWBXSA-N 0.000 abstract 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 229960000304 folic acid Drugs 0.000 abstract 1
- 235000019152 folic acid Nutrition 0.000 abstract 1
- 239000011724 folic acid Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 238000010956 selective crystallization Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002MI000132A ITMI20020132A1 (it) | 2002-01-25 | 2002-01-25 | Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolico |
| DE60306900T DE60306900T2 (de) | 2002-01-25 | 2003-01-21 | Verfahren zur herstellung von (6s)-5,6,7,8- tetrahydrofolsäure |
| EP03731683A EP1478647B1 (en) | 2002-01-25 | 2003-01-21 | (6s)-5,6,7,8-tetrahydrofolic acid production process |
| AU2003236824A AU2003236824B2 (en) | 2002-01-25 | 2003-01-21 | (6S)-5,6,7,8-tetrahydrofolic acid production process |
| CA2474317A CA2474317C (en) | 2002-01-25 | 2003-01-21 | (6s)-5,6,7,8-tetrahydrofolic acid production process |
| AT03731683T ATE333458T1 (de) | 2002-01-25 | 2003-01-21 | Verfahren zur herstellung von (6s)-5,6,7,8- tetrahydrofolsäure |
| PCT/EP2003/000547 WO2003062239A1 (en) | 2002-01-25 | 2003-01-21 | (6s)-5,6,7,8-tetrahydrofolic acid production process |
| ES03731683T ES2268371T3 (es) | 2002-01-25 | 2003-01-21 | Procedimiento de produccion del acido (6s)-5,6,7,8-tetrahidrofolico. |
| US10/502,615 US7193082B2 (en) | 2002-01-25 | 2003-01-21 | (6S)-5,6,7,8-tetrahydrofolic acid production process |
| JP2003562116A JP4423437B2 (ja) | 2002-01-25 | 2003-01-21 | （６ｓ）−５，６，７，８−テトラヒドロ葉酸の製造方法 |
| DK03731683T DK1478647T3 (da) | 2002-01-25 | 2003-01-21 | Fremgangsmåde til fremstilling af (6S)-5,6,7,8-tetrahydrofolinsyre |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002MI000132A ITMI20020132A1 (it) | 2002-01-25 | 2002-01-25 | Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolico |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITMI20020132A0 ITMI20020132A0 (it) | 2002-01-25 |
| ITMI20020132A1 true ITMI20020132A1 (it) | 2003-07-25 |
Family
ID=11448991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2002MI000132A ITMI20020132A1 (it) | 2002-01-25 | 2002-01-25 | Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolico |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7193082B2 (it) |
| EP (1) | EP1478647B1 (it) |
| JP (1) | JP4423437B2 (it) |
| AT (1) | ATE333458T1 (it) |
| AU (1) | AU2003236824B2 (it) |
| CA (1) | CA2474317C (it) |
| DE (1) | DE60306900T2 (it) |
| DK (1) | DK1478647T3 (it) |
| ES (1) | ES2268371T3 (it) |
| IT (1) | ITMI20020132A1 (it) |
| WO (1) | WO2003062239A1 (it) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109265460B (zh) * | 2018-12-04 | 2020-08-11 | 北京斯利安药业有限公司 | 一种叶酸的纯化方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5043876A (en) | 1988-05-27 | 1991-08-27 | International Business Machines Corporation | N-level file shadowing and recovery in a shared file system |
| DE3821875C1 (it) * | 1988-06-29 | 1990-02-15 | Eprova Ag, Forschungsinstitut, Schaffhausen, Ch | |
| CH681303A5 (it) * | 1991-01-16 | 1993-02-26 | Eprova Ag | |
| JP2725731B2 (ja) * | 1991-02-28 | 1998-03-11 | 株式会社島津製作所 | 過剰蛍光試薬のクエンチング方法 |
| CH682664A5 (en) | 1991-10-15 | 1993-10-29 | Eprova Ag | Stable salts of 5,10-methylene tetrahydrofolate. |
| CH683690A5 (de) | 1991-12-21 | 1994-04-29 | Sapec Fine Chemicals | Verfahren zur Herstellung von diastereoisomerenreinen Tetrahydrofolaten. |
| CH686672A5 (de) | 1992-12-01 | 1996-05-31 | Cerbios Pharma Sa | Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure. |
| CH686369A5 (de) * | 1994-05-09 | 1996-03-15 | Eprova Ag | Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure. |
| CH695217A5 (de) | 1999-07-14 | 2006-01-31 | Merck Eprova Ag | Verfahren zur Trennung optischer Isomeren von Tetrahydrofolsäureestersalzen und Tetrahydrofolsäure. |
-
2002
- 2002-01-25 IT IT2002MI000132A patent/ITMI20020132A1/it unknown
-
2003
- 2003-01-21 DK DK03731683T patent/DK1478647T3/da active
- 2003-01-21 WO PCT/EP2003/000547 patent/WO2003062239A1/en active IP Right Grant
- 2003-01-21 JP JP2003562116A patent/JP4423437B2/ja not_active Expired - Lifetime
- 2003-01-21 ES ES03731683T patent/ES2268371T3/es not_active Expired - Lifetime
- 2003-01-21 AU AU2003236824A patent/AU2003236824B2/en not_active Ceased
- 2003-01-21 CA CA2474317A patent/CA2474317C/en not_active Expired - Fee Related
- 2003-01-21 DE DE60306900T patent/DE60306900T2/de not_active Expired - Lifetime
- 2003-01-21 AT AT03731683T patent/ATE333458T1/de active
- 2003-01-21 EP EP03731683A patent/EP1478647B1/en not_active Expired - Lifetime
- 2003-01-21 US US10/502,615 patent/US7193082B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2268371T3 (es) | 2007-03-16 |
| US7193082B2 (en) | 2007-03-20 |
| CA2474317C (en) | 2011-06-21 |
| DK1478647T3 (da) | 2006-10-30 |
| EP1478647B1 (en) | 2006-07-19 |
| JP2005519911A (ja) | 2005-07-07 |
| DE60306900T2 (de) | 2007-01-18 |
| CA2474317A1 (en) | 2003-07-31 |
| EP1478647A1 (en) | 2004-11-24 |
| ATE333458T1 (de) | 2006-08-15 |
| US20050171348A1 (en) | 2005-08-04 |
| JP4423437B2 (ja) | 2010-03-03 |
| ITMI20020132A0 (it) | 2002-01-25 |
| AU2003236824B2 (en) | 2008-02-21 |
| WO2003062239A1 (en) | 2003-07-31 |
| DE60306900D1 (de) | 2006-08-31 |
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