[go: up one dir, main page]

FI941085A0 - O-heteroaryyli-, O-alkyyliheteroaryyli-, O-alkenyyliheteroaryyli- ja O-alkynyyliheteroaryylimakrolideja - Google Patents

O-heteroaryyli-, O-alkyyliheteroaryyli-, O-alkenyyliheteroaryyli- ja O-alkynyyliheteroaryylimakrolideja

Info

Publication number
FI941085A0
FI941085A0 FI941085A FI941085A FI941085A0 FI 941085 A0 FI941085 A0 FI 941085A0 FI 941085 A FI941085 A FI 941085A FI 941085 A FI941085 A FI 941085A FI 941085 A0 FI941085 A0 FI 941085A0
Authority
FI
Finland
Prior art keywords
alkenylheteroaryl
alkylheteroaryl
heteroaryl
diseases
alkynylheteroaryl macrolides
Prior art date
Application number
FI941085A
Other languages
English (en)
Swedish (sv)
Other versions
FI941085A (fi
Inventor
Peter J Sinclair
Frederick Wong
Joung Goulet
Mark Goulet
William H Parsons
Matthew J Wyvratt
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI941085A0 publication Critical patent/FI941085A0/fi
Publication of FI941085A publication Critical patent/FI941085A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measurement Of Force In General (AREA)
  • Steroid Compounds (AREA)
FI941085A 1991-09-09 1994-03-08 O-heteroaryyli-, O-alkyyliheteroaryyli-, O-alkenyyliheteroaryyli- ja O-alkynyyliheteroaryylimakrolideja FI941085A (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75694691A 1991-09-09 1991-09-09
US07/921,851 US5252732A (en) 1991-09-09 1992-08-05 D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
PCT/US1992/007508 WO1993005058A1 (en) 1991-09-09 1992-09-02 O-heteroaryl, o-alkylheteroaryl, o-alkenylheteroaryl and o-alkynylheteroarylmacrolides

Publications (2)

Publication Number Publication Date
FI941085A0 true FI941085A0 (fi) 1994-03-08
FI941085A FI941085A (fi) 1994-05-03

Family

ID=27116312

Family Applications (1)

Application Number Title Priority Date Filing Date
FI941085A FI941085A (fi) 1991-09-09 1994-03-08 O-heteroaryyli-, O-alkyyliheteroaryyli-, O-alkenyyliheteroaryyli- ja O-alkynyyliheteroaryylimakrolideja

Country Status (21)

Country Link
US (2) US5252732A (fi)
EP (1) EP0532088B1 (fi)
JP (1) JPH0813819B2 (fi)
KR (1) KR930006030A (fi)
CN (1) CN1073443A (fi)
AT (1) ATE145915T1 (fi)
AU (1) AU647665B2 (fi)
BG (1) BG98639A (fi)
CA (1) CA2077331A1 (fi)
CZ (1) CZ53194A3 (fi)
DE (1) DE69215615T2 (fi)
FI (1) FI941085A (fi)
HU (1) HUT66855A (fi)
IL (1) IL103009A0 (fi)
MX (1) MX9205137A (fi)
NO (1) NO940805L (fi)
NZ (1) NZ244153A (fi)
RO (1) RO114331B1 (fi)
SK (1) SK26094A3 (fi)
WO (1) WO1993005058A1 (fi)
YU (1) YU89792A (fi)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565560A (en) * 1991-05-13 1996-10-15 Merck & Co., Inc. O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5563172A (en) * 1991-09-05 1996-10-08 Abbott Laboratories Macrocyclic amide and urea immunomodulators
US5561137A (en) * 1991-09-05 1996-10-01 Abbott Laboratories Thio-heterocyclic macrolactam immunomodulators
US5247076A (en) * 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
US5310903A (en) * 1993-03-05 1994-05-10 Merck & Co., Inc. Imidazolidyl rapamycin derivatives
US5310901A (en) * 1993-03-05 1994-05-10 Merck & Co., Inc. O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynlheteroarylrapamycin derivatives
US5457194A (en) * 1993-03-17 1995-10-10 Abbott Laboratories Substituted aliphatic amine-containing macrocyclic immunomodulators
US5352783A (en) * 1993-06-09 1994-10-04 Merck & Co., Inc. Microbial transformation product having immunosuppressive activity
TW270114B (fi) * 1993-10-22 1996-02-11 Hoffmann La Roche
WO1995015328A1 (en) * 1993-11-30 1995-06-08 Abbott Laboratories Macrocyclic immunomodulators with novel cyclohexyl ring replacements
US5612350A (en) * 1993-11-30 1997-03-18 Abbott Laboratories Macrocyclic immunomodulators with novel cyclohexyl ring replacements
US5496831A (en) * 1994-05-13 1996-03-05 The General Hospital Corporation Inhibition of insulin-induced adiposis
US5880280A (en) * 1994-06-15 1999-03-09 Merck & Co., Inc. Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity
US5693648A (en) * 1994-09-30 1997-12-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
ES2173978T3 (es) 1994-10-26 2002-11-01 Novartis Ag Utilizacion de un alcohol graso insaturado.
AR004480A1 (es) * 1995-04-06 1998-12-16 Amico Derin C D Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen
US6187757B1 (en) * 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
US5777105A (en) * 1995-08-24 1998-07-07 Merck & Co., Inc. Process for the preparation of imidazolyl macrolide immunosuppressants
JPH11512096A (ja) * 1995-08-24 1999-10-19 メルク エンド カンパニー インコーポレーテッド イミダゾリルマクロライド免疫抑制剤の製造方法
US5877184A (en) * 1996-08-06 1999-03-02 Merck & Co., Inc. Macrolides having immunosuppressive activity
KR100440553B1 (ko) 1998-03-26 2004-07-15 후지사와 야꾸힝 고교 가부시키가이샤 서방성 제제
GB9817064D0 (en) * 1998-08-05 1998-10-07 Fujisawa Pharmaceutical Co New use
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
US7063857B1 (en) 1999-04-30 2006-06-20 Sucampo Ag Use of macrolide compounds for the treatment of dry eye
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
AU783158B2 (en) * 1999-08-24 2005-09-29 Ariad Pharmaceuticals, Inc. 28-epirapalogs
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
PT1478648E (pt) * 2002-02-01 2014-07-15 Ariad Pharma Inc Compostos contendo fósforo e suas utilizações
EP2181704B1 (en) 2002-12-30 2015-05-06 Angiotech International Ag Drug delivery from rapid gelling polymer composition
EP1699456A1 (en) * 2003-12-30 2006-09-13 Astellas Pharma Inc. Use of macrolides for treating or preventing airflow obstruction
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US20080207670A1 (en) * 2004-09-16 2008-08-28 Bayer Healthcare Ag Dermally Applicable Formulations For Treating Skin Diseases in Animals
US20060189551A1 (en) * 2004-10-04 2006-08-24 Duke University Combination therapies for fungal pathogens
WO2006078724A2 (en) * 2005-01-20 2006-07-27 Array Biopharma Nc. Macrocyclic analogs for the treatment of immunoregulatory disorders and respiratory diseases
DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
US20080194842A1 (en) * 2005-08-10 2008-08-14 Replidyne, Inc. Transition Metal Catalyzed Cross-Coupling Of 1-Halo-1-Haloalkene Compounds
MX2009002893A (es) 2006-09-18 2009-07-10 Raptor Pharmaceutical Inc Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
AU2007319825B2 (en) * 2006-11-14 2014-01-23 Ariad Pharmaceuticals, Inc. Oral formulations
CA2711765A1 (en) * 2008-01-11 2009-07-16 Massachusetts Eye & Ear Infirmary Conditional-stop dimerizable caspase transgenic animals
MY163048A (en) 2009-05-06 2017-08-15 Laboratory Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
CA2815085C (en) 2010-10-22 2022-06-21 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US9562271B2 (en) 2012-04-20 2017-02-07 T2 Biosystems, Inc. Compositions and methods for detection of Candida species
WO2014200659A1 (en) 2013-06-11 2014-12-18 Clontech Laboratories, Inc. Protein enriched microvesicles and methods of making and using the same
JPWO2016068208A1 (ja) 2014-10-28 2017-08-10 晃史 山口 妊娠状態を改善するための薬剤及びその利用
AU2017210033B2 (en) 2016-01-21 2022-09-29 T2 Biosystems, Inc. NMR methods and systems for the rapid detection of bacteria
CN106074367A (zh) * 2016-07-20 2016-11-09 中山大学中山眼科中心 含fk506类化合物/fkbp蛋白二聚体的药物组合物及其制备方法
WO2020032252A1 (ja) 2018-08-10 2020-02-13 晃史 山口 母体と胎児との関係における液性免疫関連疾患の治療薬
CN109467579B (zh) * 2018-11-01 2021-10-15 海南大学 一种具有免疫抑制活性的pks i型聚酮类化合物及其制备方法和应用
WO2020129348A1 (ja) 2018-12-18 2020-06-25 晃史 山口 不妊・不育症または妊娠状態を改善するための薬剤

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3244592A (en) * 1962-06-09 1966-04-05 Arai Tadashi Ascomycin and process for its production
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
ES2071681T3 (es) * 1987-12-09 1995-07-01 Fisons Plc Compuestos macrociclicos.
EP0356399A3 (en) * 1988-08-26 1991-03-20 Sandoz Ag Substituted 4-azatricyclo (22.3.1.04.9) octacos-18-ene derivatives, their preparation and pharmaceutical compositions containing them
WO1990015805A1 (en) * 1989-06-14 1990-12-27 Sandoz Ltd Heteroatoms-containing tricyclic compounds
US5208228A (en) * 1989-11-13 1993-05-04 Merck & Co., Inc. Aminomacrolides and derivatives having immunosuppressive activity
IE904050A1 (en) * 1989-11-13 1991-05-22 Merck & Co Inc Aminomacrolides and derivatives having immunosuppressive¹activity
US5064835A (en) * 1990-03-01 1991-11-12 Merck & Co., Inc. Hydroxymacrolide derivatives having immunosuppressive activity
US5190950A (en) * 1990-06-25 1993-03-02 Merck & Co., Inc. Antagonists of immunosuppressive macrolides
GB9014136D0 (en) * 1990-06-25 1990-08-15 Fujisawa Pharmaceutical Co Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same
CA2044846A1 (en) * 1990-06-25 1991-12-26 Thomas R. Beattie Antagonists of immunosuppressive macrolides
GB2245891A (en) * 1990-07-09 1992-01-15 Fujisawa Pharmaceutical Co Tricyclo compounds
WO1992003441A1 (en) * 1990-08-18 1992-03-05 Fisons Plc Macrocyclic compounds
JPH04165249A (ja) * 1990-10-29 1992-06-11 Matsushita Electric Ind Co Ltd 多室型空気調和機
US5143918A (en) * 1990-10-11 1992-09-01 Merck & Co., Inc. Halomacrolides and derivatives having immunosuppressive activity
US5162334A (en) * 1991-05-13 1992-11-10 Merck & Co., Inc. Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity
US5262533A (en) * 1991-05-13 1993-11-16 Merck & Co., Inc. Amino O-aryl macrolides having immunosuppressive activity
US5250678A (en) * 1991-05-13 1993-10-05 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5118677A (en) * 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin
US5189042A (en) * 1991-08-22 1993-02-23 Merck & Co. Inc. Fluoromacrolides having immunosuppressive activity
US5208241A (en) * 1991-09-09 1993-05-04 Merck & Co., Inc. N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
US5247076A (en) * 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity

Also Published As

Publication number Publication date
IL103009A0 (en) 1993-02-21
CZ53194A3 (en) 1994-08-17
SK26094A3 (en) 1994-08-10
CA2077331A1 (en) 1993-03-10
HUT66855A (en) 1995-01-30
MX9205137A (es) 1993-04-01
YU89792A (sh) 1996-01-08
NZ244153A (en) 1995-04-27
JPH0813819B2 (ja) 1996-02-14
NO940805L (no) 1994-05-06
WO1993005058A1 (en) 1993-03-18
RO114331B1 (ro) 1999-03-30
FI941085A (fi) 1994-05-03
CN1073443A (zh) 1993-06-23
ATE145915T1 (de) 1996-12-15
AU647665B2 (en) 1994-03-24
US5252732A (en) 1993-10-12
KR930006030A (ko) 1993-04-20
NO940805D0 (no) 1994-03-08
EP0532088B1 (en) 1996-12-04
AU2282992A (en) 1993-03-11
JPH06116274A (ja) 1994-04-26
DE69215615D1 (de) 1997-01-16
HU9400686D0 (en) 1994-06-28
US5349061A (en) 1994-09-20
DE69215615T2 (de) 1997-06-26
EP0532088A1 (en) 1993-03-17
BG98639A (bg) 1995-03-31

Similar Documents

Publication Publication Date Title
FI941085A0 (fi) O-heteroaryyli-, O-alkyyliheteroaryyli-, O-alkenyyliheteroaryyli- ja O-alkynyyliheteroaryylimakrolideja
FI941084A0 (fi) Imidatsolidyylimakrolidit
RU94020407A (ru) Имидазолидильные макролиды, способ их получения, фармацевтическая композиция, способ лечения
NO20000573D0 (no) Kjemiske forbindelser
FI930753A0 (fi) Nya fosfolipidderivat av nukleosider, deras framstaellning och deras anvaendning saosom antivirala laekemedel
ES2077071T3 (es) Derivados de quinolin-3-carboxamida.
DK0504645T3 (da) Anvendelse af sulfaterede oligosaccharider til behandling af arteriosklerotiske sygdomme og til forebyggelse af restenose
ES2115760T3 (es) Derivados de 4''-desoxieritromicina.
DK0457090T3 (da) Fremgangsmåde til fremstilling af 3-amino-2-(het)-aroyl-acrylsyrederivater
ITRM910146U1 (it) Strumento chirurgico per l'introduzione di protesi peniene.
DK0418990T3 (da) 13-brom- og 13,14-dibrom-ergoliner, deres fremstilling og anvendelse i lægemidler
DE69116057D1 (de) Mikrobische Herstellung des 13-beta-13-deoxy-22,23,-dihydroavermectin-Bla/B1b-Aglycons
EP0431450A3 (en) 1-bromo-3-chloro-1,2-diaryle-2-propanols, process for the stereoselective preparation of erythro-1-bromo-3-chloro-1,2-diaryle-2-propanols and their conversion into azolyle methyloxiranes
IL95384A0 (en) 1,3-oxazines,their preparation and pharmaceutical compositions containing them
DE59208712D1 (de) Neue cytarabin-derivate, ihre herstellung und verwendung