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FI941084A0 - Imidatsolidyylimakrolidit - Google Patents

Imidatsolidyylimakrolidit

Info

Publication number
FI941084A0
FI941084A0 FI941084A FI941084A FI941084A0 FI 941084 A0 FI941084 A0 FI 941084A0 FI 941084 A FI941084 A FI 941084A FI 941084 A FI941084 A FI 941084A FI 941084 A0 FI941084 A0 FI 941084A0
Authority
FI
Finland
Prior art keywords
diseases
imidazolidyl
macrolides
imidazolidyl macrolides
arylation
Prior art date
Application number
FI941084A
Other languages
English (en)
Swedish (sv)
Other versions
FI941084A (fi
Inventor
Mark Goulet
Peter J Sinclair
Frederick Wong
Matthew J Wyvratt
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI941084A publication Critical patent/FI941084A/fi
Publication of FI941084A0 publication Critical patent/FI941084A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Saccharide Compounds (AREA)
  • Detergent Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI941084A 1991-09-09 1994-03-08 Imidatsolidyylimakrolidit FI941084A0 (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75663391A 1991-09-09 1991-09-09
US07/921,181 US5247076A (en) 1991-09-09 1992-08-04 Imidazolidyl macrolides having immunosuppressive activity
CA002116674A CA2116674C (en) 1991-09-09 1992-09-02 Imidazolidyl macrolides
PCT/US1992/007539 WO1993005059A1 (en) 1991-09-09 1992-09-02 Imidazolidyl macrolides

Publications (2)

Publication Number Publication Date
FI941084A FI941084A (fi) 1994-03-08
FI941084A0 true FI941084A0 (fi) 1994-03-08

Family

ID=27169717

Family Applications (1)

Application Number Title Priority Date Filing Date
FI941084A FI941084A0 (fi) 1991-09-09 1994-03-08 Imidatsolidyylimakrolidit

Country Status (23)

Country Link
US (2) US5247076A (fi)
EP (1) EP0536896B1 (fi)
JP (1) JP3098032B2 (fi)
AT (1) ATE161266T1 (fi)
AU (1) AU669672B2 (fi)
BG (1) BG98640A (fi)
CA (1) CA2116674C (fi)
CZ (1) CZ47394A3 (fi)
DE (1) DE69223583T2 (fi)
DK (1) DK0536896T3 (fi)
ES (1) ES2111615T3 (fi)
FI (1) FI941084A0 (fi)
GR (1) GR3025993T3 (fi)
HU (1) HUT67267A (fi)
IL (1) IL103011A (fi)
NO (1) NO940804L (fi)
NZ (1) NZ244154A (fi)
PL (2) PL172637B1 (fi)
RO (1) RO112620B1 (fi)
RU (1) RU2108338C1 (fi)
SK (1) SK28694A3 (fi)
WO (1) WO1993005059A1 (fi)
ZA (1) ZA926813B (fi)

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US5565560A (en) * 1991-05-13 1996-10-15 Merck & Co., Inc. O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5563172A (en) * 1991-09-05 1996-10-08 Abbott Laboratories Macrocyclic amide and urea immunomodulators
US5561137A (en) * 1991-09-05 1996-10-01 Abbott Laboratories Thio-heterocyclic macrolactam immunomodulators
US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
US5247076A (en) * 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5310903A (en) * 1993-03-05 1994-05-10 Merck & Co., Inc. Imidazolidyl rapamycin derivatives
US5310901A (en) * 1993-03-05 1994-05-10 Merck & Co., Inc. O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynlheteroarylrapamycin derivatives
US5457194A (en) * 1993-03-17 1995-10-10 Abbott Laboratories Substituted aliphatic amine-containing macrocyclic immunomodulators
WO1994021253A1 (en) * 1993-03-17 1994-09-29 Abbott Laboratories Substituted aliphatic amine-containing macrocyclic immunomodulators
WO1995020590A1 (en) * 1994-01-27 1995-08-03 The Trustees Of Columbia University In The City Of New York Enantioselective receptors for amino acid derivatives, and other compounds
US5496831A (en) * 1994-05-13 1996-03-05 The General Hospital Corporation Inhibition of insulin-induced adiposis
US5880280A (en) * 1994-06-15 1999-03-09 Merck & Co., Inc. Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity
US5491159A (en) * 1994-08-30 1996-02-13 American Home Products Corporation 2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-oxazoles as anti-atherosclerotic agents
US5693648A (en) * 1994-09-30 1997-12-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
ES2173978T3 (es) 1994-10-26 2002-11-01 Novartis Ag Utilizacion de un alcohol graso insaturado.
AR004480A1 (es) * 1995-04-06 1998-12-16 Amico Derin C D Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen
US6187757B1 (en) * 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
US6124453A (en) * 1995-07-04 2000-09-26 Novartis Ag Macrolides
US5777105A (en) * 1995-08-24 1998-07-07 Merck & Co., Inc. Process for the preparation of imidazolyl macrolide immunosuppressants
JPH11512096A (ja) * 1995-08-24 1999-10-19 メルク エンド カンパニー インコーポレーテッド イミダゾリルマクロライド免疫抑制剤の製造方法
DE19533975A1 (de) * 1995-09-14 1997-03-20 Merck Patent Gmbh Arylalkyl-diazinone
US5877184A (en) * 1996-08-06 1999-03-02 Merck & Co., Inc. Macrolides having immunosuppressive activity
GB9713730D0 (en) 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
KR100440553B1 (ko) 1998-03-26 2004-07-15 후지사와 야꾸힝 고교 가부시키가이샤 서방성 제제
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
US7063857B1 (en) 1999-04-30 2006-06-20 Sucampo Ag Use of macrolide compounds for the treatment of dry eye
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
AU783158B2 (en) * 1999-08-24 2005-09-29 Ariad Pharmaceuticals, Inc. 28-epirapalogs
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP2181704B1 (en) 2002-12-30 2015-05-06 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US7179827B2 (en) * 2004-03-31 2007-02-20 Lexicon Genetics Incorporated Thiazoles and methods of their use
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US20060189551A1 (en) * 2004-10-04 2006-08-24 Duke University Combination therapies for fungal pathogens
DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
WO2007141441A1 (fr) 2006-06-07 2007-12-13 Peugeot Citroën Automobiles S.A. 'monomères et polymères améliorés porteurs de groupements imidazoles et benzimidazoles et membrane à conduction protonique en contenant pour la fabrication d'une pile à combustible'.
MX2009002893A (es) 2006-09-18 2009-07-10 Raptor Pharmaceutical Inc Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
CA2711765A1 (en) * 2008-01-11 2009-07-16 Massachusetts Eye & Ear Infirmary Conditional-stop dimerizable caspase transgenic animals
MY163048A (en) 2009-05-06 2017-08-15 Laboratory Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
CA2815085C (en) 2010-10-22 2022-06-21 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US9562271B2 (en) 2012-04-20 2017-02-07 T2 Biosystems, Inc. Compositions and methods for detection of Candida species
WO2014200659A1 (en) 2013-06-11 2014-12-18 Clontech Laboratories, Inc. Protein enriched microvesicles and methods of making and using the same
JPWO2016068208A1 (ja) 2014-10-28 2017-08-10 晃史 山口 妊娠状態を改善するための薬剤及びその利用
US10945997B2 (en) 2016-01-08 2021-03-16 Nippon Kayaku Kabushiki Kaisha Polymer derivative of macrolide immunosuppressant
AU2017210033B2 (en) 2016-01-21 2022-09-29 T2 Biosystems, Inc. NMR methods and systems for the rapid detection of bacteria
WO2020032252A1 (ja) 2018-08-10 2020-02-13 晃史 山口 母体と胎児との関係における液性免疫関連疾患の治療薬
WO2020129348A1 (ja) 2018-12-18 2020-06-25 晃史 山口 不妊・不育症または妊娠状態を改善するための薬剤

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3244592A (en) * 1962-06-09 1966-04-05 Arai Tadashi Ascomycin and process for its production
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
WO1990015805A1 (en) * 1989-06-14 1990-12-27 Sandoz Ltd Heteroatoms-containing tricyclic compounds
IE904050A1 (en) * 1989-11-13 1991-05-22 Merck & Co Inc Aminomacrolides and derivatives having immunosuppressive¹activity
US5208228A (en) * 1989-11-13 1993-05-04 Merck & Co., Inc. Aminomacrolides and derivatives having immunosuppressive activity
US5064835A (en) * 1990-03-01 1991-11-12 Merck & Co., Inc. Hydroxymacrolide derivatives having immunosuppressive activity
CA2044846A1 (en) * 1990-06-25 1991-12-26 Thomas R. Beattie Antagonists of immunosuppressive macrolides
US5190950A (en) * 1990-06-25 1993-03-02 Merck & Co., Inc. Antagonists of immunosuppressive macrolides
GB9014136D0 (en) * 1990-06-25 1990-08-15 Fujisawa Pharmaceutical Co Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same
GB2245891A (en) * 1990-07-09 1992-01-15 Fujisawa Pharmaceutical Co Tricyclo compounds
WO1992003441A1 (en) * 1990-08-18 1992-03-05 Fisons Plc Macrocyclic compounds
PT98990A (pt) * 1990-09-19 1992-08-31 American Home Prod Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
US5118678A (en) * 1991-04-17 1992-06-02 American Home Products Corporation Carbamates of rapamycin
US5162334A (en) * 1991-05-13 1992-11-10 Merck & Co., Inc. Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity
US5262533A (en) * 1991-05-13 1993-11-16 Merck & Co., Inc. Amino O-aryl macrolides having immunosuppressive activity
US5250678A (en) * 1991-05-13 1993-10-05 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5118677A (en) * 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin
US5189042A (en) * 1991-08-22 1993-02-23 Merck & Co. Inc. Fluoromacrolides having immunosuppressive activity
US5208241A (en) * 1991-09-09 1993-05-04 Merck & Co., Inc. N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
US5247076A (en) * 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity

Also Published As

Publication number Publication date
DE69223583T2 (de) 1998-07-02
EP0536896B1 (en) 1997-12-17
AU669672B2 (en) 1996-06-20
NO940804D0 (no) 1994-03-08
IL103011A (en) 1997-02-18
US5344925A (en) 1994-09-06
HU9400687D0 (en) 1994-06-28
DE69223583D1 (de) 1998-01-29
HUT67267A (en) 1995-03-28
CZ47394A3 (en) 1994-10-19
DK0536896T3 (da) 1998-01-19
CA2116674C (en) 2002-09-17
SK28694A3 (en) 1994-08-10
PL172789B1 (pl) 1997-11-28
JPH06510303A (ja) 1994-11-17
ZA926813B (en) 1994-03-07
IL103011A0 (en) 1993-02-21
ATE161266T1 (de) 1998-01-15
BG98640A (en) 1995-05-31
FI941084A (fi) 1994-03-08
NZ244154A (en) 1995-05-26
JP3098032B2 (ja) 2000-10-10
AU2660992A (en) 1993-04-05
RO112620B1 (ro) 1997-11-28
WO1993005059A1 (en) 1993-03-18
EP0536896A1 (en) 1993-04-14
CA2116674A1 (en) 1993-03-18
PL172637B1 (pl) 1997-10-31
ES2111615T3 (es) 1998-03-16
RU2108338C1 (ru) 1998-04-10
US5247076A (en) 1993-09-21
GR3025993T3 (en) 1998-04-30
NO940804L (no) 1994-05-06

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