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FI940280L - Förfarande för framställning av demetylepydofyllotoxin - Google Patents

Förfarande för framställning av demetylepydofyllotoxin Download PDF

Info

Publication number
FI940280L
FI940280L FI940280A FI940280A FI940280L FI 940280 L FI940280 L FI 940280L FI 940280 A FI940280 A FI 940280A FI 940280 A FI940280 A FI 940280A FI 940280 L FI940280 L FI 940280L
Authority
FI
Finland
Prior art keywords
demethylepipodophyllotoxin
preparing
preparing demethylepipodophyllotoxin
Prior art date
Application number
FI940280A
Other languages
English (en)
Finnish (fi)
Other versions
FI110782B (sv
FI940280A0 (sv
Inventor
Pietro Allevi
Mario Anastasia
Ettore Bigatti
Peter Macdonald
Original Assignee
Sicor Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11360401&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI940280(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sicor Spa filed Critical Sicor Spa
Publication of FI940280A0 publication Critical patent/FI940280A0/sv
Publication of FI940280L publication Critical patent/FI940280L/sv
Application granted granted Critical
Publication of FI110782B publication Critical patent/FI110782B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI940280A 1991-07-23 1994-01-20 Demetylepipodofyllotoxin-beeta-D-glukosider, förfarande för framställning av dessa, beeta-D-glukosderivat och förfarande för framställning av dimerer av demetylepipodofyllotoxin-beeta-D-glukos FI110782B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ITMI912025 1991-07-23
ITMI912025A IT1250692B (it) 1991-07-23 1991-07-23 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
PCT/EP1992/001605 WO1993002094A1 (en) 1991-07-23 1992-07-15 A process for the preparation of demethylepypodophyllotoxin
EP9201605 1992-07-15

Publications (3)

Publication Number Publication Date
FI940280A0 FI940280A0 (sv) 1994-01-20
FI940280L true FI940280L (sv) 1994-01-20
FI110782B FI110782B (sv) 2003-03-31

Family

ID=11360401

Family Applications (1)

Application Number Title Priority Date Filing Date
FI940280A FI110782B (sv) 1991-07-23 1994-01-20 Demetylepipodofyllotoxin-beeta-D-glukosider, förfarande för framställning av dessa, beeta-D-glukosderivat och förfarande för framställning av dimerer av demetylepipodofyllotoxin-beeta-D-glukos

Country Status (16)

Country Link
US (1) US5688925A (sv)
EP (1) EP0595888B1 (sv)
JP (1) JP3231765B2 (sv)
AT (1) ATE159026T1 (sv)
AU (1) AU666322B2 (sv)
CA (1) CA2113894C (sv)
DE (1) DE69222643T2 (sv)
DK (1) DK0595888T3 (sv)
ES (1) ES2107546T3 (sv)
FI (1) FI110782B (sv)
GR (1) GR3025729T3 (sv)
IL (1) IL102610A (sv)
IT (1) IT1250692B (sv)
MX (1) MX9204334A (sv)
WO (1) WO1993002094A1 (sv)
ZA (1) ZA925515B (sv)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0778282B1 (en) * 1995-12-04 2003-04-09 Nippon Kayaku Kabushiki Kaisha Process for producing etoposide
IL132319A (en) * 1997-06-02 2003-07-06 Bristol Myers Squibb Co Process for preparing etoposide
CN1376159A (zh) 1998-09-10 2002-10-23 加拿大植原药物公司 抗肿瘤药亿妥谱赛的制造方法
FR2791681B1 (fr) * 1999-03-29 2001-06-22 Pf Medicament Nouveau procede de preparation de l'etoposide
GB0019124D0 (en) * 2000-08-03 2000-09-27 Pfizer Novel process
WO2006077424A1 (en) 2005-01-21 2006-07-27 Astex Therapeutics Limited Pharmaceutical compounds
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
EP2073803B1 (en) 2006-10-12 2018-09-19 Astex Therapeutics Limited Pharmaceutical combinations
US10047116B2 (en) 2011-10-03 2018-08-14 Mx Adjuvac Ab Nanoparticles, process for preparation and use thereof as carrier for amphipatic and hydrophobic molecules in fields of medicine including cancer treatment and food related compounds
AR095962A1 (es) 2013-04-01 2015-11-25 Moreinx Ab Nanopartículas, compuestas de esterol y saponina de quillaja saponaria molina, proceso para preparación y uso de las mismas como portadores para moléculas anfipáticas o hidrófobas en el campo de la medicina incluyendo tratamiento de cáncer y compuestos relacionados con alimentos
EP3616688A1 (en) 2018-08-27 2020-03-04 Centre National de la Recherche Scientifique - CNRS Preparation of nanosuspension comprising nanocrystals of active pharmaceutical ingredients with little or no stabilizing agents
EP3669890A1 (en) 2018-12-18 2020-06-24 Croda International PLC Filamentous nanoparticles having vaccine adjuvant effect
CN113121618A (zh) * 2021-04-07 2021-07-16 梯尔希（南京）药物研发有限公司 两种依托泊苷杂质的制备方法
CN115197281B (zh) * 2021-04-09 2024-06-14 四川汇宇制药股份有限公司 依托泊苷中间体的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
DK39886D0 (da) * 1986-01-27 1986-01-27 Hans Goeran Magnusson Hydroxybeskyttelsesgrupper
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
DE3935016A1 (de) * 1989-10-20 1991-04-25 Behringwerke Ag Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisiertem tumorspezifischen enzym-konjugaten
FR2658824B1 (fr) * 1990-02-27 1992-07-03 Pf Medicament Tris acetyl-2",3",4' ethylidene-4",6" beta-d-glucopyranosides, leur preparation et leur utilisation pour la preparation d'ethylidene beta-d-glucopyranoside de demethyl-4' epipodophyllotoxine.
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
CN1025918C (zh) * 1990-06-07 1994-09-14 国家医药管理局上海医药工业研究院 抗肿瘤药表鬼臼毒吡喃糖甙的合成新工艺

Also Published As

Publication number Publication date
FI110782B (sv) 2003-03-31
MX9204334A (es) 1993-02-01
EP0595888B1 (en) 1997-10-08
AU666322B2 (en) 1996-02-08
ITMI912025A0 (it) 1991-07-23
US5688925A (en) 1997-11-18
EP0595888A1 (en) 1994-05-11
CA2113894C (en) 2003-12-16
DK0595888T3 (da) 1998-05-18
CA2113894A1 (en) 1993-02-04
ES2107546T3 (es) 1997-12-01
AU2326592A (en) 1993-02-23
JPH06509334A (ja) 1994-10-20
IL102610A (en) 1997-03-18
FI940280A0 (sv) 1994-01-20
ATE159026T1 (de) 1997-10-15
ZA925515B (en) 1993-04-28
JP3231765B2 (ja) 2001-11-26
GR3025729T3 (en) 1998-03-31
DE69222643D1 (de) 1997-11-13
IT1250692B (it) 1995-04-21
ITMI912025A1 (it) 1993-01-24
WO1993002094A1 (en) 1993-02-04
DE69222643T2 (de) 1998-02-05

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