IL102610A - Process for the preparation of demethylepipodoph- yllotoxin -b-d- glucosides and certain novel b-d- glucosides - Google Patents

Process for the preparation of demethylepipodoph- yllotoxin -b-d- glucosides and certain novel b-d- glucosides

Info

Publication number: IL102610A
Authority: IL; Israel
Prior art keywords: glucosides; group; yllotoxin; demethylepipodoph; preparation
Prior art date: 1991-07-23

Application number

IL102610A

Other languages

English (en)

Original Assignee

Sicor Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-23

Filing date

1992-07-22

Publication date

1997-03-18

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11360401&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL102610(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-07-22 Application filed by Sicor Spa filed Critical Sicor Spa

1997-03-18 Publication of IL102610A publication Critical patent/IL102610A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IL102610A 1991-07-23 1992-07-22 Process for the preparation of demethylepipodoph- yllotoxin -b-d- glucosides and certain novel b-d- glucosides IL102610A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI912025A IT1250692B (it)	1991-07-23	1991-07-23	Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.

Publications (1)

Publication Number	Publication Date
IL102610A true IL102610A (en)	1997-03-18

Family

ID=11360401

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL102610A IL102610A (en)	1991-07-23	1992-07-22	Process for the preparation of demethylepipodoph- yllotoxin -b-d- glucosides and certain novel b-d- glucosides

Country Status (16)

Country	Link
US (1)	US5688925A (xx)
EP (1)	EP0595888B1 (xx)
JP (1)	JP3231765B2 (xx)
AT (1)	ATE159026T1 (xx)
AU (1)	AU666322B2 (xx)
CA (1)	CA2113894C (xx)
DE (1)	DE69222643T2 (xx)
DK (1)	DK0595888T3 (xx)
ES (1)	ES2107546T3 (xx)
FI (1)	FI110782B (xx)
GR (1)	GR3025729T3 (xx)
IL (1)	IL102610A (xx)
IT (1)	IT1250692B (xx)
MX (1)	MX9204334A (xx)
WO (1)	WO1993002094A1 (xx)
ZA (1)	ZA925515B (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0778282B1 (en) *	1995-12-04	2003-04-09	Nippon Kayaku Kabushiki Kaisha	Process for producing etoposide
IL132319A (en) *	1997-06-02	2003-07-06	Bristol Myers Squibb Co	Process for preparing etoposide
CN1376159A (zh)	1998-09-10	2002-10-23	加拿大植原药物公司	抗肿瘤药亿妥谱赛的制造方法
FR2791681B1 (fr) *	1999-03-29	2001-06-22	Pf Medicament	Nouveau procede de preparation de l'etoposide
GB0019124D0 (en) *	2000-08-03	2000-09-27	Pfizer	Novel process
WO2006077424A1 (en)	2005-01-21	2006-07-27	Astex Therapeutics Limited	Pharmaceutical compounds
US8883790B2 (en)	2006-10-12	2014-11-11	Astex Therapeutics Limited	Pharmaceutical combinations
EP2073803B1 (en)	2006-10-12	2018-09-19	Astex Therapeutics Limited	Pharmaceutical combinations
US10047116B2 (en)	2011-10-03	2018-08-14	Mx Adjuvac Ab	Nanoparticles, process for preparation and use thereof as carrier for amphipatic and hydrophobic molecules in fields of medicine including cancer treatment and food related compounds
AR095962A1 (es)	2013-04-01	2015-11-25	Moreinx Ab	Nanopartículas, compuestas de esterol y saponina de quillaja saponaria molina, proceso para preparación y uso de las mismas como portadores para moléculas anfipáticas o hidrófobas en el campo de la medicina incluyendo tratamiento de cáncer y compuestos relacionados con alimentos
EP3616688A1 (en)	2018-08-27	2020-03-04	Centre National de la Recherche Scientifique - CNRS	Preparation of nanosuspension comprising nanocrystals of active pharmaceutical ingredients with little or no stabilizing agents
EP3669890A1 (en)	2018-12-18	2020-06-24	Croda International PLC	Filamentous nanoparticles having vaccine adjuvant effect
CN113121618A (zh) *	2021-04-07	2021-07-16	梯尔希（南京）药物研发有限公司	两种依托泊苷杂质的制备方法
CN115197281B (zh) *	2021-04-09	2024-06-14	四川汇宇制药股份有限公司	依托泊苷中间体的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0111058B1 (en) *	1982-11-26	1987-11-04	Nippon Kayaku Kabushiki Kaisha	Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
JPS60246393A (ja) *	1984-05-22	1985-12-06	Nippon Kayaku Co Ltd	エトポシドの新規製造法
IL77334A (en) *	1985-12-16	1991-04-15	Univ Bar Ilan	Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
DK39886D0 (da) *	1986-01-27	1986-01-27	Hans Goeran Magnusson	Hydroxybeskyttelsesgrupper
US4904768A (en) *	1987-08-04	1990-02-27	Bristol-Myers Company	Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4965348A (en) *	1989-05-19	1990-10-23	Bristol-Myers Company	Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) *	1989-06-07	1991-07-30	Bristol-Myers Company	Acylated derivatives of etoposide
DE3935016A1 (de) *	1989-10-20	1991-04-25	Behringwerke Ag	Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisiertem tumorspezifischen enzym-konjugaten
FR2658824B1 (fr) *	1990-02-27	1992-07-03	Pf Medicament	Tris acetyl-2",3",4' ethylidene-4",6" beta-d-glucopyranosides, leur preparation et leur utilisation pour la preparation d'ethylidene beta-d-glucopyranoside de demethyl-4' epipodophyllotoxine.
US5081234A (en) *	1990-04-30	1992-01-14	Bristol-Myers Squibb Co.	4'-demethylepipodophyllotoxin glycosides
CN1025918C (zh) *	1990-06-07	1994-09-14	国家医药管理局上海医药工业研究院	抗肿瘤药表鬼臼毒吡喃糖甙的合成新工艺

1991
- 1991-07-23 IT ITMI912025A patent/IT1250692B/it active IP Right Grant
1992
- 1992-07-15 ES ES92915482T patent/ES2107546T3/es not_active Expired - Lifetime
- 1992-07-15 JP JP50258193A patent/JP3231765B2/ja not_active Expired - Fee Related
- 1992-07-15 EP EP92915482A patent/EP0595888B1/en not_active Expired - Lifetime
- 1992-07-15 WO PCT/EP1992/001605 patent/WO1993002094A1/en active IP Right Grant
- 1992-07-15 AU AU23265/92A patent/AU666322B2/en not_active Ceased
- 1992-07-15 DE DE69222643T patent/DE69222643T2/de not_active Expired - Fee Related
- 1992-07-15 DK DK92915482.1T patent/DK0595888T3/da active
- 1992-07-15 AT AT92915482T patent/ATE159026T1/de not_active IP Right Cessation
- 1992-07-15 CA CA002113894A patent/CA2113894C/en not_active Expired - Fee Related
- 1992-07-22 IL IL102610A patent/IL102610A/xx not_active IP Right Cessation
- 1992-07-22 ZA ZA925515A patent/ZA925515B/xx unknown
- 1992-07-23 MX MX9204334A patent/MX9204334A/es unknown
1994
- 1994-01-20 FI FI940280A patent/FI110782B/fi not_active IP Right Cessation
1995
- 1995-05-15 US US08/441,210 patent/US5688925A/en not_active Expired - Fee Related
1997
- 1997-12-22 GR GR970403378T patent/GR3025729T3/el unknown

Also Published As

Publication number	Publication date
FI110782B (fi)	2003-03-31
MX9204334A (es)	1993-02-01
EP0595888B1 (en)	1997-10-08
AU666322B2 (en)	1996-02-08
ITMI912025A0 (it)	1991-07-23
US5688925A (en)	1997-11-18
EP0595888A1 (en)	1994-05-11
CA2113894C (en)	2003-12-16
DK0595888T3 (da)	1998-05-18
CA2113894A1 (en)	1993-02-04
ES2107546T3 (es)	1997-12-01
AU2326592A (en)	1993-02-23
JPH06509334A (ja)	1994-10-20
FI940280A0 (fi)	1994-01-20
ATE159026T1 (de)	1997-10-15
FI940280L (fi)	1994-01-20
ZA925515B (en)	1993-04-28
JP3231765B2 (ja)	2001-11-26
GR3025729T3 (en)	1998-03-31
DE69222643D1 (de)	1997-11-13
IT1250692B (it)	1995-04-21
ITMI912025A1 (it)	1993-01-24
WO1993002094A1 (en)	1993-02-04
DE69222643T2 (de)	1998-02-05

Publication	Publication Date	Title
IL102610A (en)	1997-03-18	Process for the preparation of demethylepipodoph- yllotoxin -b-d- glucosides and certain novel b-d- glucosides
JPS57131791A (en)	1982-08-14	Benzodiazepine derivative and its preparation
ZA835143B (en)	1984-04-25	Intermediates for the preparation of omeprazole
HUT60719A (en)	1992-10-28	Process for producing 3-aminopiperidine derivatives
ATE10097T1 (de)	1984-11-15	Tricyclische arylether, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel.
ZA947182B (en)	1995-03-17	Process for the preparation of 3-arylbenzofuranones
HUT37631A (en)	1986-01-23	Process for producing 6,6-ethylene-15,16-methylene-3-oxo.17-alpha-pregn-4-ene-21,17-carbolavtones and pharmaceutical compositions containing them
ZA858418B (en)	1986-07-30	5-alkyl-1-phenyl-2-piperazinoalkylpyrazoline-3-one compounds and methods for the preparation thereof,intermediates for use in the preparation of said compounds and medicaments containing said compounds
JPS57171998A (en)	1982-10-22	Adenosine derivative and its salt, preparation thereof and medicinal composition containing the same
ES8403911A1 (es)	1984-04-16	Procedimiento de preparacion de mononitratos de 1.4,3.6- dianhidro-hexito sustituidos en 2-0 y 5-0
IE831004L (en)	1983-11-04	Long-acting theophylline in medicinal form
DE3160133D1 (en)	1983-05-05	7,8-amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines, process for their preparation and pharmaceutical compositions containing them
EP0316124A3 (en)	1989-10-18	Ethylated avermectins
ES8609331A1 (es)	1986-09-01	Un procedimiento para preparar 2-bencil-7,7-dimetil-6,8- dioxa-2-espiro(3,5)nonano
HUT65533A (en)	1994-06-28	Process for producing 2-amino-pyrimidine-4-carboxamide derivatives and pharmaceutical preparations containing them
DE3564426D1 (en)	1988-09-22	Polyprenyl compound, process of producing it and pharmaceutical use
IE44403L (en)	1977-06-16	CIS-4a-PHENYL-ISOQUINOLINES
JPS5653654A (en)	1981-05-13	Preparation of novel aniline derivative
JPS5772996A (en)	1982-05-07	Novel oligomannoside and its preparation
PT75251B (en)	1985-10-04	Process for the preparation of 6-<3,6-dihydro-1(2h)-pyridyl>-pyrimidine-3-oxides
JPS53127451A (en)	1978-11-07	1-alkoxytricyclo (4.3.1.1. u2,5 ) their preparation, and perfume compositions containing the same
PH18551A (en)	1985-08-09	Fluorophenoxybenzyl esters and the composition containing same
JPS5772997A (en)	1982-05-07	Novel oligomannoside and its preparation
JPS5671061A (en)	1981-06-13	O-sulfonamidophenol derivative
JPS5738780A (en)	1982-03-03	Emetine type compound and its preparation

Legal Events

Date	Code	Title
1997-09-30	FF	Patent granted
1998-01-04	KB	Patent renewed
1998-12-27	KB	Patent renewed
2002-08-14	KB	Patent renewed
2007-05-21	MM9K	Patent not in force due to non-payment of renewal fees