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FI921693A - Substituerade 3-(pyridinylamino)-indoler och benso/b/-tiofener, foerfarande foer framstaellning av dessa och anvaendning av dessa som laekemedel - Google Patents

Substituerade 3-(pyridinylamino)-indoler och benso/b/-tiofener, foerfarande foer framstaellning av dessa och anvaendning av dessa som laekemedel Download PDF

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Publication number
FI921693A
FI921693A FI921693A FI921693A FI921693A FI 921693 A FI921693 A FI 921693A FI 921693 A FI921693 A FI 921693A FI 921693 A FI921693 A FI 921693A FI 921693 A FI921693 A FI 921693A
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FI
Finland
Prior art keywords
loweralkyl
dessa
hydrogen
chem
arylloweralkyl
Prior art date
Application number
FI921693A
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English (en)
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FI921693A0 (fi
FI105096B (fi
Inventor
Richard Charles Effland
Joseph Thomas Klein
Lawrence Leo Martin
Original Assignee
Hoechst Roussel Pharma
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Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of FI921693A0 publication Critical patent/FI921693A0/fi
Publication of FI921693A publication Critical patent/FI921693A/fi
Application granted granted Critical
Publication of FI105096B publication Critical patent/FI105096B/fi

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI921693A 1991-04-17 1992-04-15 Menetelmä terapeuttisesti käyttökelpoisten 3-(pyridinyyliamino)indolien ja -bentso[b]tiofeenien valmistamiseksi FI105096B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/688,964 US5177088A (en) 1991-04-17 1991-04-17 Substituted 3-(pyridinylamino)-indoles
US68896491 1991-04-17

Publications (3)

Publication Number Publication Date
FI921693A0 FI921693A0 (fi) 1992-04-15
FI921693A true FI921693A (fi) 1992-10-18
FI105096B FI105096B (fi) 2000-06-15

Family

ID=24766519

Family Applications (1)

Application Number Title Priority Date Filing Date
FI921693A FI105096B (fi) 1991-04-17 1992-04-15 Menetelmä terapeuttisesti käyttökelpoisten 3-(pyridinyyliamino)indolien ja -bentso[b]tiofeenien valmistamiseksi

Country Status (25)

Country Link
US (1) US5177088A (fi)
EP (1) EP0509402B1 (fi)
JP (1) JP2617650B2 (fi)
KR (1) KR100254027B1 (fi)
AT (1) ATE161840T1 (fi)
AU (1) AU655253B2 (fi)
BG (1) BG61034B1 (fi)
CA (1) CA2066332C (fi)
CS (1) CS117192A3 (fi)
DE (1) DE69223837T2 (fi)
DK (1) DK0509402T3 (fi)
ES (1) ES2111580T3 (fi)
FI (1) FI105096B (fi)
GR (1) GR3026317T3 (fi)
HU (1) HU215113B (fi)
IE (1) IE921235A1 (fi)
IL (1) IL101599A (fi)
MX (1) MX9201759A (fi)
NO (1) NO180486C (fi)
NZ (1) NZ242359A (fi)
PL (1) PL168905B1 (fi)
RO (1) RO109847B1 (fi)
RU (1) RU2060254C1 (fi)
TW (1) TW200477B (fi)
ZA (1) ZA922807B (fi)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264442A (en) * 1990-08-13 1993-11-23 Hoechst-Roussel Pharmaceuticals Incorporated Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
US5185350A (en) * 1991-09-23 1993-02-09 Hoechst-Roussel Pharmaceuticals Incorporated Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles
US5356910A (en) * 1993-07-19 1994-10-18 Hoechst-Roussel Pharmaceuticals Inc. Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder
WO1996039397A1 (en) * 1995-06-06 1996-12-12 Hoechst Marion Roussel, Inc. Benzisoxazole and indazole derivatives as antipsychotic agents
US5668154A (en) * 1995-06-06 1997-09-16 Hoechst Marion Roussel Inc. Pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles
CA2276203C (en) * 1996-12-27 2003-07-22 Hoechst Marion Roussel, Inc. N-(pyridinylamino)isoindolines and related compounds
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
EE200200134A (et) * 1999-09-14 2003-04-15 Aventis Pharmaceuticals Inc. D4 retseptori antagonistidena toimivad bensisoksasolüül-, püridoisoksasolüül- ja benstienüülfenoksüderivaadid
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
US7253165B2 (en) * 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
DE10029371A1 (de) 2000-06-20 2002-01-03 Merck Patent Gmbh Heterocyclische Aminoalkylpyridinderivate als Psychopharmaka
GB0217920D0 (en) * 2002-04-23 2002-09-11 Aventis Pharm Prod Inc Interleukin-4 Gene Expression inhibitors
BRPI0511722A (pt) 2004-06-01 2008-01-08 Hoffmann La Roche 3-amino-1-arilpropilindóis como inibidores da recaptação de monoamina
BRPI0619263A2 (pt) 2005-11-30 2011-09-27 Hoffmann La Roche indóis de 3-amino-1-arilpropila e indóis aza-substituìdos, métodos para prepará-los, composição farmacêutica e uso dos referidos indóis
RU2008120141A (ru) 2005-11-30 2010-01-10 Ф. Хоффманн-Ля Рош Аг (Ch) 3-амино-2-арилпропилазаиндолы и их применения
EP2351737A1 (en) * 2005-11-30 2011-08-03 F. Hoffmann-La Roche AG 3-Amino-1-arylpropyl indoles and aza-substituted indoles
KR101098583B1 (ko) * 2008-01-04 2011-12-26 주식회사 엘지생명과학 세포, 조직 및 장기 보존 효과를 갖는 인돌 및 인다졸 유도체

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3166987D1 (en) * 1980-09-18 1984-12-06 Asahi Chemical Ind 3-aminoindazole derivatives and process for preparation thereof
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
US4717658A (en) * 1985-12-03 1988-01-05 Miles Inc. Gram negative bacteria screening method with horseshoe crab amebocyte lysate (LAL)
US4970218A (en) * 1987-04-24 1990-11-13 Hoechst-Roussel Pharmaceuticals Inc. N-(pyridinyl)-1H-indol-1-amines
US4806554A (en) * 1988-01-11 1989-02-21 Hoechst-Roussel Pharmaceuticals, Inc. Pyrazol and indazolpyridinamines
US4954502A (en) * 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
DE69021645T2 (de) * 1989-05-19 1996-02-22 Hoechst-Roussel Pharmaceuticals Inc., Somerville, N.J. N-(aryloxyalkyl)heteroarylpiperidine und -heteroarylpiperazine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente.
US4983615A (en) * 1989-06-28 1991-01-08 Hoechst-Roussel Pharmaceuticals Inc. Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
CA2030051C (en) * 1989-11-17 2001-08-07 Haruhiko Kikuchi Indole derivatives

Also Published As

Publication number Publication date
GR3026317T3 (en) 1998-06-30
DK0509402T3 (da) 1998-09-07
ATE161840T1 (de) 1998-01-15
AU1512192A (en) 1992-10-22
HUT62572A (en) 1993-05-28
NO921505L (no) 1992-10-19
IL101599A (en) 1996-05-14
FI921693A0 (fi) 1992-04-15
IE921235A1 (en) 1992-10-21
ZA922807B (en) 1992-11-25
EP0509402A1 (en) 1992-10-21
HU215113B (hu) 1998-12-28
KR920019777A (ko) 1992-11-20
MX9201759A (es) 1992-10-01
ES2111580T3 (es) 1998-03-16
RO109847B1 (ro) 1995-06-30
JP2617650B2 (ja) 1997-06-04
TW200477B (fi) 1993-02-21
CA2066332C (en) 2003-07-29
CS117192A3 (en) 1992-11-18
NO180486C (no) 1997-04-30
KR100254027B1 (ko) 2000-05-01
FI105096B (fi) 2000-06-15
JPH05117266A (ja) 1993-05-14
NO921505D0 (no) 1992-04-15
AU655253B2 (en) 1994-12-08
US5177088A (en) 1993-01-05
HU9201297D0 (en) 1992-07-28
DE69223837D1 (de) 1998-02-12
DE69223837T2 (de) 1998-06-25
RU2060254C1 (ru) 1996-05-20
BG96202A (bg) 1993-12-24
BG61034B1 (bg) 1996-09-30
IL101599A0 (en) 1992-12-30
PL294239A1 (en) 1993-06-14
CA2066332A1 (en) 1992-10-18
NO180486B (no) 1997-01-20
NZ242359A (en) 1995-03-28
EP0509402B1 (en) 1998-01-07
PL168905B1 (pl) 1996-05-31

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Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: HOECHST MARION ROUSSEL, INC.

PC Transfer of assignment of patent

Owner name: AVENTIS PHARMACEUTICALS INC.