FI905418A0 - Menetelmä terapeuttisesti käyttökelpoisten 4- tai 6-substituoitujen trimetyylipyrrolo/2,3-b/indolikarbamaattien valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten 4- tai 6-substituoitujen trimetyylipyrrolo/2,3-b/indolikarbamaattien valmistamiseksi

Info

Publication number: FI905418A0
Authority: FI; Finland
Prior art keywords: preparation; loweralkyl; indolcarbamates; trimethylpyrrolo; substituted
Prior art date: 1989-09-28

Application number

FI905418A

Other languages

English (en)

Swedish (sv)

Other versions

FI92701B (fi

FI92701C (fi

Inventor

Edward J Glamkowski

Barbara E Kurys

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-28

Filing date

1990-11-01

Publication date

1990-11-01

1990-11-01 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1990-11-01 Publication of FI905418A0 publication Critical patent/FI905418A0/fi

1993-07-07 Priority to FI933119A priority Critical patent/FI94761C/fi

1994-09-15 Publication of FI92701B publication Critical patent/FI92701B/fi

1994-12-27 Application granted granted Critical

1994-12-27 Publication of FI92701C publication Critical patent/FI92701C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Cephalosporin Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Indole Compounds (AREA)
Medicinal Preparation (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

FI905418A 1989-09-28 1990-11-01 Menetelmä terapeuttisesti käyttökelpoisten 4- tai 6-substituoitujen trimetyylipyrrolo/2,3-b/indolikarbamaattien valmistamiseksi FI92701C (fi)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
FI933119A FI94761C (fi)	1989-11-03	1993-07-07	4- ja 6-substituoidut 1,2,3,3a,8,8a-heksahydro-1,3a,8-trimetyylipyrrolo/2,3-b/indolijohdannaiset

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US07/413,901 US4914102A (en)	1989-09-28	1989-09-28	N-aminocarbamates related to physostigmine, pharmacentical compositions and use
US41390189		1989-09-28
US43110389		1989-11-03
US07/431,103 US5081117A (en)	1989-09-28	1989-11-03	4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof

Publications (3)

Publication Number	Publication Date
FI905418A0 true FI905418A0 (fi)	1990-11-01
FI92701B FI92701B (fi)	1994-09-15
FI92701C FI92701C (fi)	1994-12-27

Family

ID=40149690

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
FI904730A FI93961C (fi)	1989-09-28	1990-09-26	Menetelmä terapeuttisesti käyttökelpoisten 1,2,3,3a,8,8a-heksahydro-1,3a,8-trimetyylipyrrolo-/2,3-b/indoli-5-yylimorfolinyyli- ja piperidinyylikarbamaatin valmistamiseksi
FI905418A FI92701C (fi)	1989-09-28	1990-11-01	Menetelmä terapeuttisesti käyttökelpoisten 4- tai 6-substituoitujen trimetyylipyrrolo/2,3-b/indolikarbamaattien valmistamiseksi

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
FI904730A FI93961C (fi)	1989-09-28	1990-09-26	Menetelmä terapeuttisesti käyttökelpoisten 1,2,3,3a,8,8a-heksahydro-1,3a,8-trimetyylipyrrolo-/2,3-b/indoli-5-yylimorfolinyyli- ja piperidinyylikarbamaatin valmistamiseksi

Country Status (21)

Country	Link
US (2)	US4914102A (fi)
EP (2)	EP0420140B1 (fi)
JP (2)	JPH0723377B2 (fi)
KR (1)	KR100189665B1 (fi)
AT (2)	ATE156825T1 (fi)
AU (3)	AU639943B2 (fi)
CA (2)	CA2026381A1 (fi)
CZ (1)	CZ279604B6 (fi)
DE (2)	DE69031259T2 (fi)
DK (2)	DK0420140T3 (fi)
ES (2)	ES2104572T3 (fi)
FI (2)	FI93961C (fi)
GR (2)	GR3019468T3 (fi)
HU (1)	HU206355B (fi)
IE (1)	IE72153B1 (fi)
IL (2)	IL95807A (fi)
NO (2)	NO174469B (fi)
NZ (2)	NZ235460A (fi)
PL (1)	PL287618A1 (fi)
PT (2)	PT95449B (fi)
ZA (2)	ZA907725B (fi)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4791107A (en) *	1986-07-16	1988-12-13	Hoechst-Roussel Pharmaceuticals, Inc.	Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
US4971992A (en) *	1989-03-27	1990-11-20	Hoechst-Roussel Pharmaceuticals Inc.	Carbonate derivatives of eseroline
ES2075102T3 (es) *	1989-09-19	1995-10-01	Hoechst Roussel Pharma	Procedimiento para la resolucion quimica de (+/-)-1,3-dimetiloxiindoliletilaminas 5-alcoxi sustituidas.
US4914102A (en) *	1989-09-28	1990-04-03	Hoechst Roussel Pharmaceuticals, Inc.	N-aminocarbamates related to physostigmine, pharmacentical compositions and use
US5077289A (en) *	1989-11-30	1991-12-31	Hoechst Roussel Pharmaceuticals Inc.	Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine
DE69032595T2 (de) *	1990-01-22	1999-03-25	Hoechst Marion Roussel, Inc., Kansas City, Mo. 64137	Verfahren zur enantioselektiven Synthese alkylierter Oxindole zur Verwendung als Zwischenprodukte bei der Herstellung von Physostigminen
ES2113859T3 (es) *	1990-06-27	1998-05-16	Hoechst Marion Roussel Inc	Tetrahidroisoquinolinilcarbamatos de 1,2,3,3a,8,8a-hexahidro-1,3a,8-trimetilpirrolo(2,3-b)indol.
WO1993006105A1 (en) *	1991-09-26	1993-04-01	United States Government, As Represented By Secret	Substituted phenserines and phenylcarbamates of (-)-eseroline, (-)-n1-noreseroline, and (-)-n1-benzylnoreseroline; as specific inhibitors of acetylcholinesterase
US5171750A (en) *	1991-09-26	1992-12-15	The United States Of America As Represented By The Department Of Health And Human Services	Substituted phenserines as specific inhibitors of acetylcholinesterase
US5153193A (en) *	1991-10-01	1992-10-06	Hoechst-Roussel Pharmaceuticals Incorporated	Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
IT1253007B (it) *	1991-12-31	1995-07-10	Aesculapius Farma Srl	Derivati dell'eserolina ad attivita' anticolinesterasica,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
US5302721A (en) *	1992-07-21	1994-04-12	Hoechst-Roussel Pharmaceuticals Incorporated	Method of preparation of physostigmine carbamate derivatives from eseretholes
NZ248180A (en) *	1992-07-21	1995-02-24	Hoechst Roussel Pharma	Process for the preparation of physostigmine carbamate derivatives
US5409948A (en) *	1992-11-23	1995-04-25	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Method for treating cognitive disorders with phenserine
US5665880A (en) *	1996-10-31	1997-09-09	Hoechst Marion Roussel, Inc.	Method of preparation of physostigmine carbamate derivatives from eseretholes
US5677457A (en) *	1996-12-19	1997-10-14	Hoechst Marion Roussel, Inc.	Method of preparation of physostigmine carbamate derivatives from eseroline ethers
US6218383B1 (en)	1998-08-07	2001-04-17	Targacept, Inc.	Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
NZ537090A (en)	2002-06-14	2006-02-24	Toyama Chemical Co Ltd	Medicinal compositions improving brain function and method for improving brain function
US7897639B2 (en) *	2003-10-21	2011-03-01	Colucid Pharmaceuticals, Inc.	Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents
WO2005072713A2 (en)	2004-01-27	2005-08-11	The Feinstein Institute For Medical Research	Cholinesterase inhibitors for treating inflammation
US20050182044A1 (en) *	2004-02-17	2005-08-18	Bruinsma Gosse B.	Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate
CA2508585A1 (en) *	2004-06-01	2005-12-01	Axonyx, Inc.	Transdermal delivery system for treatment of cognitive disorders
EP1604686A1 (en) *	2004-06-08	2005-12-14	Axonyx, Inc.	Use of phenserine and a HMG CoA reductase inhibitor for delaying Alzheimer's disease progression
WO2006060082A1 (en) *	2004-10-22	2006-06-08	THE GOVERNMENT OF THE U.S.A. as represented by THE SEC., DEPT. OF HEALTH & HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH	Tricyclic compounds, preparation thereof and use thereof as cholinesterase activity inhibitors
CA2789014C (en)	2010-02-09	2019-01-15	Michela Gallagher	Methods and compositions for improving cognitive function
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
DK2931276T3 (en)	2012-12-13	2018-03-26	H Lundbeck As	COMPOSITIONS INCLUDING VORTIOXETIN AND DONEPEZIL
US11160785B2 (en)	2013-03-15	2021-11-02	Agenebio Inc.	Methods and compositions for improving cognitive function
EP2968237A4 (en)	2013-03-15	2016-08-31	Univ Johns Hopkins	METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
EA034167B8 (ru)	2015-05-22	2021-04-27	Эйджинбайо, Инк.	Фармацевтические композиции леветирацетама пролонгированного высвобождения

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3897451A (en) *	1973-04-27	1975-07-29	Univ Ohio State Res Found	Synthesis of oxindoles from anilines and intermediates therein
IT1109003B (it) *	1977-09-20	1985-12-16	Univ Firenze	Derivati dell 1 2 3 8 3 a 8 a esai dropirrolo 23 b indolo
IT1199076B (it) *	1984-03-01	1988-12-30	Consiglio Nazionale Ricerche	Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione
US4760083A (en) *	1986-04-10	1988-07-26	E. I. Dupont De Nemours & Company	3,3-disubstituted indolines
US4791107A (en) *	1986-07-16	1988-12-13	Hoechst-Roussel Pharmaceuticals, Inc.	Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
IT1225462B (it) *	1987-04-03	1990-11-14	Mediolanum Farmaceutici Srl	Sali organici di derivati della fisostigmina
US4741107A (en) *	1987-07-31	1988-05-03	Circle Jeffrey L	Artwork aid adapted for facilitating placement of lettering along arc of a circle
US4971992A (en) *	1989-03-27	1990-11-20	Hoechst-Roussel Pharmaceuticals Inc.	Carbonate derivatives of eseroline
US5006537A (en) *	1989-08-02	1991-04-09	Hoechst-Roussel Pharmaceuticals, Inc.	1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
ES2075102T3 (es) *	1989-09-19	1995-10-01	Hoechst Roussel Pharma	Procedimiento para la resolucion quimica de (+/-)-1,3-dimetiloxiindoliletilaminas 5-alcoxi sustituidas.
US4914102A (en) *	1989-09-28	1990-04-03	Hoechst Roussel Pharmaceuticals, Inc.	N-aminocarbamates related to physostigmine, pharmacentical compositions and use
US5077289A (en) *	1989-11-30	1991-12-31	Hoechst Roussel Pharmaceuticals Inc.	Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine
DE69032595T2 (de) *	1990-01-22	1999-03-25	Hoechst Marion Roussel, Inc., Kansas City, Mo. 64137	Verfahren zur enantioselektiven Synthese alkylierter Oxindole zur Verwendung als Zwischenprodukte bei der Herstellung von Physostigminen

1989
- 1989-09-28 US US07/413,901 patent/US4914102A/en not_active Expired - Fee Related
- 1989-11-03 US US07/431,103 patent/US5081117A/en not_active Expired - Fee Related
1990
- 1990-09-25 DE DE69031259T patent/DE69031259T2/de not_active Expired - Fee Related
- 1990-09-25 EP EP90118376A patent/EP0420140B1/en not_active Expired - Lifetime
- 1990-09-25 DK DK90118376.4T patent/DK0420140T3/da active
- 1990-09-25 AT AT90118376T patent/ATE156825T1/de not_active IP Right Cessation
- 1990-09-25 ES ES90118376T patent/ES2104572T3/es not_active Expired - Lifetime
- 1990-09-26 IL IL9580790A patent/IL95807A/en not_active IP Right Cessation
- 1990-09-26 NZ NZ235460A patent/NZ235460A/xx unknown
- 1990-09-26 FI FI904730A patent/FI93961C/fi not_active IP Right Cessation
- 1990-09-27 AU AU63227/90A patent/AU639943B2/en not_active Ceased
- 1990-09-27 JP JP2255477A patent/JPH0723377B2/ja not_active Expired - Lifetime
- 1990-09-27 CA CA002026381A patent/CA2026381A1/en not_active Abandoned
- 1990-09-27 NO NO904209A patent/NO174469B/no not_active IP Right Cessation
- 1990-09-27 PT PT95449A patent/PT95449B/pt not_active IP Right Cessation
- 1990-09-27 ZA ZA907725A patent/ZA907725B/xx unknown
- 1990-11-01 NZ NZ235921A patent/NZ235921A/en unknown
- 1990-11-01 IL IL9620990A patent/IL96209A/en not_active IP Right Cessation
- 1990-11-01 FI FI905418A patent/FI92701C/fi not_active IP Right Cessation
- 1990-11-01 KR KR1019900017657A patent/KR100189665B1/ko not_active IP Right Cessation
- 1990-11-02 CZ CS905407A patent/CZ279604B6/cs not_active IP Right Cessation
- 1990-11-02 JP JP2295595A patent/JPH0780885B2/ja not_active Expired - Fee Related
- 1990-11-02 PL PL28761890A patent/PL287618A1/xx unknown
- 1990-11-02 CA CA002029265A patent/CA2029265C/en not_active Expired - Fee Related
- 1990-11-02 AU AU65712/90A patent/AU635575B2/en not_active Ceased
- 1990-11-02 HU HU906999A patent/HU206355B/hu not_active IP Right Cessation
- 1990-11-02 ZA ZA908800A patent/ZA908800B/xx unknown
- 1990-11-02 NO NO904783A patent/NO175980C/no not_active IP Right Cessation
- 1990-11-02 PT PT95772A patent/PT95772B/pt not_active IP Right Cessation
- 1990-11-02 IE IE396590A patent/IE72153B1/en not_active IP Right Cessation
- 1990-11-07 DK DK90121267.0T patent/DK0484573T3/da active
- 1990-11-07 ES ES90121267T patent/ES2085309T3/es not_active Expired - Lifetime
- 1990-11-07 EP EP90121267A patent/EP0484573B1/en not_active Expired - Lifetime
- 1990-11-07 AT AT90121267T patent/ATE135355T1/de not_active IP Right Cessation
- 1990-11-07 DE DE69025941T patent/DE69025941T2/de not_active Expired - Fee Related
1993
- 1993-01-27 AU AU32046/93A patent/AU646986B2/en not_active Ceased
1996
- 1996-03-29 GR GR960400847T patent/GR3019468T3/el unknown
1997
- 1997-10-14 GR GR970402666T patent/GR3025021T3/el unknown

Also Published As

Publication number	Publication date
IL96209A0 (en)	1991-08-16
NO904209D0 (no)	1990-09-27
GR3019468T3 (en)	1996-06-30
HU906999D0 (en)	1991-05-28
HU206355B (en)	1992-10-28
ZA908800B (en)	1991-08-28
NO904783D0 (no)	1990-11-02
AU6322790A (en)	1991-04-11
NO174469B (no)	1994-01-31
FI93961C (fi)	1995-06-26
AU635575B2 (en)	1993-03-25
NO904209L (no)	1991-04-02
DE69025941T2 (de)	1996-09-05
CA2029265A1 (en)	1991-05-04
PT95449A (pt)	1991-05-22
CZ279604B6 (cs)	1995-05-17
CZ540790A3 (en)	1994-11-16
EP0484573A1 (en)	1992-05-13
AU646986B2 (en)	1994-03-10
CA2029265C (en)	2001-08-14
DE69025941D1 (de)	1996-04-18
NO174469C (fi)	1994-05-18
IL95807A0 (en)	1991-06-30
KR100189665B1 (ko)	1999-06-01
DK0484573T3 (da)	1996-07-22
HUT57772A (en)	1991-12-30
NO175980C (no)	1995-01-11
JPH03153688A (ja)	1991-07-01
NZ235921A (en)	1994-10-26
PT95772A (pt)	1991-09-13
NO904783L (no)	1991-05-06
IE72153B1 (en)	1997-03-26
ATE135355T1 (de)	1996-03-15
ATE156825T1 (de)	1997-08-15
IE903965A1 (en)	1991-05-08
IL95807A (en)	1994-10-21
FI93961B (fi)	1995-03-15
NZ235460A (en)	1993-01-27
ES2085309T3 (es)	1996-06-01
NO175980B (no)	1994-10-03
PT95449B (pt)	1997-07-31
PT95772B (pt)	1997-11-28
DE69031259T2 (de)	1998-01-15
DK0420140T3 (da)	1998-03-16
EP0420140A3 (en)	1991-11-13
AU639943B2 (en)	1993-08-12
ZA907725B (en)	1991-07-31
DE69031259D1 (de)	1997-09-18
JPH0780885B2 (ja)	1995-08-30
PL287618A1 (en)	1992-05-04
FI92701B (fi)	1994-09-15
US4914102A (en)	1990-04-03
FI904730A0 (fi)	1990-09-26
EP0484573B1 (en)	1996-03-13
CA2026381A1 (en)	1991-03-29
GR3025021T3 (en)	1998-01-30
JPH0723377B2 (ja)	1995-03-15
EP0420140A2 (en)	1991-04-03
KR910009706A (ko)	1991-06-28
EP0420140B1 (en)	1997-08-13
ES2104572T3 (es)	1997-10-16
AU3204693A (en)	1993-03-25
IL96209A (en)	1995-07-31
FI92701C (fi)	1994-12-27
AU6571290A (en)	1991-05-23
JPH03120281A (ja)	1991-05-22
US5081117A (en)	1992-01-14

Publication	Publication Date	Title
FI905418A0 (fi)	1990-11-01	Menetelmä terapeuttisesti käyttökelpoisten 4- tai 6-substituoitujen trimetyylipyrrolo/2,3-b/indolikarbamaattien valmistamiseksi
NO895222D0 (no)	1989-12-22	Fremgangsmaate for fremstilling av n-pyridinyl-9h-karbazol-9-aminer.
FI861001A0 (fi)	1986-03-11	Benzo/c/-1,5-naftyridiner, foerfarande foer deras framstaellning och i deras framstaellning anvaendbara mellanprodukter samt deras anvaendning saosom laekemedel.
NO911998D0 (no)	1991-05-24	Pyrido(3,4-b)(pyrrolo(1,2-e)(1,4,5)oksadiazepin og beslektede analoger og fremgangsmaate for fremstilling derav.
AU619985B2 (en)	1992-02-06	4,5,5a,6-tetrahydro-3h-isoxazolo(5,4,3-kl)acridines derivatives, a process for their preparation and their use as medicaments

Legal Events

Date	Code	Title	Description
1990-11-01	FG	Patent granted	Owner name: HOECHST MARION ROUSSEL, INC.
1994-08-16	BB	Publication of examined application
1997-06-24	PC	Transfer of assignment of patent	Owner name: HOECHST MARION ROUSSEL, INC.
2004-08-31	MM	Patent lapsed	Owner name: HOECHST MARION ROUSSEL INC., INC.