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FI894397A - Menetelmä terapeuttisesti aktiivisten nukleosidijohdannaisten estereiden ja amidien valmistamiseksi - Google Patents

Menetelmä terapeuttisesti aktiivisten nukleosidijohdannaisten estereiden ja amidien valmistamiseksi Download PDF

Info

Publication number
FI894397A
FI894397A FI894397A FI894397A FI894397A FI 894397 A FI894397 A FI 894397A FI 894397 A FI894397 A FI 894397A FI 894397 A FI894397 A FI 894397A FI 894397 A FI894397 A FI 894397A
Authority
FI
Finland
Prior art keywords
group
amides
esters
preparation
therapeutically active
Prior art date
Application number
FI894397A
Other languages
English (en)
Swedish (sv)
Other versions
FI93217C (fi
FI93217B (fi
FI894397A0 (fi
Inventor
Jo Klaveness
Frode Rise
Kjell Undheim
Original Assignee
Nycomed As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878706991A external-priority patent/GB8706991D0/en
Priority claimed from GB878713464A external-priority patent/GB8713464D0/en
Application filed by Nycomed As filed Critical Nycomed As
Publication of FI894397A publication Critical patent/FI894397A/fi
Publication of FI894397A0 publication Critical patent/FI894397A0/fi
Application granted granted Critical
Publication of FI93217B publication Critical patent/FI93217B/fi
Publication of FI93217C publication Critical patent/FI93217C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Furan Compounds (AREA)
FI894397A 1987-03-24 1989-09-18 Menetelmä terapeuttisesti aktiivisten nukleosidijohdannaisten estereiden ja amidien valmistamiseksi FI93217C (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB878706991A GB8706991D0 (en) 1987-03-24 1987-03-24 Chemical compounds
GB8706991 1987-03-24
GB8713464 1987-06-09
GB878713464A GB8713464D0 (en) 1987-06-09 1987-06-09 Chemical compounds
GB8800224 1988-01-06
PCT/GB1988/000224 WO1988007532A1 (en) 1987-03-24 1988-03-23 2',3' dideoxyribofuranoxide derivatives

Publications (4)

Publication Number Publication Date
FI894397A true FI894397A (fi) 1989-09-18
FI894397A0 FI894397A0 (fi) 1989-09-18
FI93217B FI93217B (fi) 1994-11-30
FI93217C FI93217C (fi) 1995-03-10

Family

ID=26292055

Family Applications (1)

Application Number Title Priority Date Filing Date
FI894397A FI93217C (fi) 1987-03-24 1989-09-18 Menetelmä terapeuttisesti aktiivisten nukleosidijohdannaisten estereiden ja amidien valmistamiseksi

Country Status (9)

Country Link
EP (1) EP0342203B1 (fi)
JP (1) JPH02503312A (fi)
AT (1) ATE108183T1 (fi)
AU (1) AU613026B2 (fi)
DE (1) DE3850571T2 (fi)
FI (1) FI93217C (fi)
NZ (1) NZ223990A (fi)
OA (1) OA09242A (fi)
WO (1) WO1988007532A1 (fi)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448392B1 (en) 1985-03-06 2002-09-10 Chimerix, Inc. Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use
US5223263A (en) * 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
NZ223910A (en) * 1987-03-20 1991-02-26 Bristol Myers Co 2',3'-dideoxynucleosides, process for their production and intermediates therefor
IL86007A0 (en) * 1987-04-09 1988-09-30 Wellcome Found 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
ZA886890B (en) * 1987-10-09 1989-05-30 Hoffmann La Roche Novel dideoxycytidine derivatives
US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
US6252060B1 (en) 1988-07-07 2001-06-26 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US5817638A (en) * 1988-07-07 1998-10-06 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
GB8823320D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds
EP0366385B1 (en) * 1988-10-24 1993-06-09 The Wellcome Foundation Limited Guanine derivatives having antiviral activity and their pharmaceutically acceptable salts
US5145960A (en) * 1989-04-24 1992-09-08 E. R. Squibb & Sons, Inc. Pyrimidinyl tetrahydrofurans
US5059690A (en) * 1990-03-01 1991-10-22 E. R. Squibb & Sons, Inc. Purinyl tetrahydrofurans
US5164520A (en) * 1989-04-24 1992-11-17 E. R. Squibb & Sons, Inc. Intermediates for purinyl and pyrimidinyl tetrahydrofurans
NZ232993A (en) * 1989-04-24 1992-10-28 Squibb & Sons Inc Purinyl and pyrimidinyl tetrahydrofurans
US5071983A (en) * 1989-10-06 1991-12-10 Burroughs Wellcome Co. Therapeutic nucleosides
JPH05501404A (ja) * 1989-11-06 1993-03-18 ニユコメド・アクシエセルカペト ヌクレオシド誘導体
US5728575A (en) * 1990-02-01 1998-03-17 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US6642245B1 (en) 1990-02-01 2003-11-04 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US6703396B1 (en) 1990-02-01 2004-03-09 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
GB9007569D0 (en) * 1990-04-04 1990-05-30 Nycomed As Carbo-nucleoside derivatives
AU7558491A (en) * 1990-04-04 1991-10-30 Nycomed Imaging As Nucleoside derivatives
US5817667A (en) * 1991-04-17 1998-10-06 University Of Georgia Research Foudation Compounds and methods for the treatment of cancer
ES2067395B1 (es) * 1993-03-10 1996-01-01 Norsk Hydro As Derivados de nucleosidos o analogos a nucleosidos.
AU7954694A (en) 1993-09-10 1995-03-27 Centre National De La Recherche Scientifique (Cnrs) Nucleosides with anti-hepatitis b virus activity
US20020120130A1 (en) 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
IL115156A (en) * 1994-09-06 2000-07-16 Univ Georgia Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
US5703058A (en) 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
WO1996040164A1 (en) 1995-06-07 1996-12-19 Emory University Nucleosides with anti-hepatitis b virus activity
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
US6436948B1 (en) 2000-03-03 2002-08-20 University Of Georgia Research Foundation Inc. Method for the treatment of psoriasis and genital warts

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4177348A (en) * 1977-12-13 1979-12-04 United States Government Carbocyclic analogs of cytosine nucleosides
FI87783C (fi) * 1985-05-15 1993-02-25 Wellcome Found Foerfarande foer framstaellning av terapeutiskt anvaendbara 2',3'-dideoxinukleosider
GB8712691D0 (en) * 1987-05-29 1987-07-01 Wellcome Found Therapeutic nucleosides
GB8823320D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds

Also Published As

Publication number Publication date
FI93217C (fi) 1995-03-10
AU613026B2 (en) 1991-07-25
OA09242A (en) 1992-06-30
DE3850571D1 (de) 1994-08-11
EP0342203A1 (en) 1989-11-23
FI93217B (fi) 1994-11-30
EP0342203B1 (en) 1994-07-06
AU1489388A (en) 1988-11-02
WO1988007532A1 (en) 1988-10-06
JPH02503312A (ja) 1990-10-11
DE3850571T2 (de) 1994-10-27
ATE108183T1 (de) 1994-07-15
NZ223990A (en) 1990-08-28
FI894397A0 (fi) 1989-09-18

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Legal Events

Date Code Title Description
HC Name/ company changed in application

Owner name: NYCOMED IMAGING AS

BB Publication of examined application
MM Patent lapsed
MM Patent lapsed

Owner name: NYCOMED IMAGING A S