[go: up one dir, main page]

DE3850571D1 - 2',3'-dideoxyribofuranoxid-derivate. - Google Patents

2',3'-dideoxyribofuranoxid-derivate.

Info

Publication number
DE3850571D1
DE3850571D1 DE3850571T DE3850571T DE3850571D1 DE 3850571 D1 DE3850571 D1 DE 3850571D1 DE 3850571 T DE3850571 T DE 3850571T DE 3850571 T DE3850571 T DE 3850571T DE 3850571 D1 DE3850571 D1 DE 3850571D1
Authority
DE
Germany
Prior art keywords
group
acylated
dideoxyribofuranoxide
derivatives
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3850571T
Other languages
English (en)
Other versions
DE3850571T2 (de
Inventor
Jo Klaveness
Frode Rise
Kjell Undheim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nycomed Imaging AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878706991A external-priority patent/GB8706991D0/en
Priority claimed from GB878713464A external-priority patent/GB8713464D0/en
Application filed by Nycomed Imaging AS filed Critical Nycomed Imaging AS
Publication of DE3850571D1 publication Critical patent/DE3850571D1/de
Application granted granted Critical
Publication of DE3850571T2 publication Critical patent/DE3850571T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE3850571T 1987-03-24 1988-03-23 2',3'-dideoxyribofuranoxid-derivate. Expired - Fee Related DE3850571T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878706991A GB8706991D0 (en) 1987-03-24 1987-03-24 Chemical compounds
GB878713464A GB8713464D0 (en) 1987-06-09 1987-06-09 Chemical compounds
PCT/GB1988/000224 WO1988007532A1 (en) 1987-03-24 1988-03-23 2',3' dideoxyribofuranoxide derivatives

Publications (2)

Publication Number Publication Date
DE3850571D1 true DE3850571D1 (de) 1994-08-11
DE3850571T2 DE3850571T2 (de) 1994-10-27

Family

ID=26292055

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3850571T Expired - Fee Related DE3850571T2 (de) 1987-03-24 1988-03-23 2',3'-dideoxyribofuranoxid-derivate.

Country Status (9)

Country Link
EP (1) EP0342203B1 (de)
JP (1) JPH02503312A (de)
AT (1) ATE108183T1 (de)
AU (1) AU613026B2 (de)
DE (1) DE3850571T2 (de)
FI (1) FI93217C (de)
NZ (1) NZ223990A (de)
OA (1) OA09242A (de)
WO (1) WO1988007532A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448392B1 (en) 1985-03-06 2002-09-10 Chimerix, Inc. Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use
US5223263A (en) * 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
NZ223910A (en) * 1987-03-20 1991-02-26 Bristol Myers Co 2',3'-dideoxynucleosides, process for their production and intermediates therefor
IL86007A0 (en) * 1987-04-09 1988-09-30 Wellcome Found 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
ZA886890B (en) * 1987-10-09 1989-05-30 Hoffmann La Roche Novel dideoxycytidine derivatives
US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
US5817638A (en) * 1988-07-07 1998-10-06 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US6252060B1 (en) 1988-07-07 2001-06-26 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
GB8823320D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds
EP0366385B1 (de) * 1988-10-24 1993-06-09 The Wellcome Foundation Limited Guaninderivate mit antiviraler Wirkung und deren pharmazeutisch verträgliche Salze
NZ232993A (en) * 1989-04-24 1992-10-28 Squibb & Sons Inc Purinyl and pyrimidinyl tetrahydrofurans
US5059690A (en) * 1990-03-01 1991-10-22 E. R. Squibb & Sons, Inc. Purinyl tetrahydrofurans
US5145960A (en) * 1989-04-24 1992-09-08 E. R. Squibb & Sons, Inc. Pyrimidinyl tetrahydrofurans
US5164520A (en) * 1989-04-24 1992-11-17 E. R. Squibb & Sons, Inc. Intermediates for purinyl and pyrimidinyl tetrahydrofurans
US5071983A (en) * 1989-10-06 1991-12-10 Burroughs Wellcome Co. Therapeutic nucleosides
FI922014A0 (fi) * 1989-11-06 1992-05-05 Nycomed As Nukleosidderivat.
US5914331A (en) * 1990-02-01 1999-06-22 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US6703396B1 (en) 1990-02-01 2004-03-09 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US5728575A (en) 1990-02-01 1998-03-17 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
GB9007569D0 (en) * 1990-04-04 1990-05-30 Nycomed As Carbo-nucleoside derivatives
CA2079796A1 (en) * 1990-04-04 1991-10-05 Jo Klaveness Nucleoside derivatives
US5817667A (en) * 1991-04-17 1998-10-06 University Of Georgia Research Foudation Compounds and methods for the treatment of cancer
ES2067395B1 (es) * 1993-03-10 1996-01-01 Norsk Hydro As Derivados de nucleosidos o analogos a nucleosidos.
US20020120130A1 (en) 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
AU7954694A (en) 1993-09-10 1995-03-27 Centre National De La Recherche Scientifique (Cnrs) Nucleosides with anti-hepatitis b virus activity
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
IL115156A (en) 1994-09-06 2000-07-16 Univ Georgia Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en) 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
JP4413996B2 (ja) 1995-06-07 2010-02-10 エモリー・ユニバーシティ 抗ｂ型肝炎ウィルス活性を有するヌクレオシド
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
US6436948B1 (en) 2000-03-03 2002-08-20 University Of Georgia Research Foundation Inc. Method for the treatment of psoriasis and genital warts

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4177348A (en) * 1977-12-13 1979-12-04 United States Government Carbocyclic analogs of cytosine nucleosides
PT82580B (pt) * 1985-05-15 1989-01-17 Wellcome Found Processo para a preparacao de 2',3'- didesoxinucleosidos e de composicoes farmaceuticas que os contem
GB8712691D0 (en) * 1987-05-29 1987-07-01 Wellcome Found Therapeutic nucleosides
GB8823320D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds

Also Published As

Publication number Publication date
FI93217B (fi) 1994-11-30
ATE108183T1 (de) 1994-07-15
AU613026B2 (en) 1991-07-25
FI894397A0 (fi) 1989-09-18
FI894397L (fi) 1989-09-18
JPH02503312A (ja) 1990-10-11
FI93217C (fi) 1995-03-10
EP0342203A1 (de) 1989-11-23
WO1988007532A1 (en) 1988-10-06
NZ223990A (en) 1990-08-28
OA09242A (en) 1992-06-30
AU1489388A (en) 1988-11-02
EP0342203B1 (de) 1994-07-06
DE3850571T2 (de) 1994-10-27

Similar Documents

Publication Publication Date Title
ATE108183T1 (de) 2',3'-dideoxyribofuranoxid-derivate.
FR2596761B1 (fr) Derives de nucleosides et leur utilisation pour la synthese d'oligonucleotides
PT756595E (pt) 1,3-oxatiolanos substituidos com propriedades anti-virais
IL88755A (en) (1:, 2, 3:)-3-substituted-2- hydroxycyclo- butanemethanol derivatives and pharmaceutical and veterinary compositions containing the same
BE905109A (fr) Derives de distamycine et leur procede de fabrication.
AU670154B2 (en) Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
HUP9903632A2 (hu) Neuraminsav vegyületek, azokat tartalmazó gyógyszerkészítmények és eljárás e készítmények előállítására
ES8501416A1 (es) 5'-alquil o alquenil-fosfatos de nucleosidos.
NO176052C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive nukleosidderivater
DE69030665D1 (de) (1,2n) und (3,2n)-karbozyklische-2-amino-tetralinderivate
MC2081A1 (fr) Procede de preparation cyclohexaneacetamides
DK0654473T3 (da) Cyclopropanderivater og antivirale midler med indhold deraf
DK0570850T3 (da) Benzo(b)thiophen-3-yl-piperaziner, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
AU6101390A (en) Substituted purines for use in the treatment of viruses
EP0401049A3 (de) Beta-lactam-Elastase-Inhibitoren
RO88666A (ro) Procedeu de obtinere a unor derivati de 6 &-metilprednisolon
ES2067395A1 (es) Derivados de nucleosidos o analogos a nucleosidos.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee