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FI891980A0 - Menetelmä terapeuttisesti aktiivisten N1-(1,2-cis-2-halogeenisyklopropyyli)substituoitujen pyridonikarboksyylihappojohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti aktiivisten N1-(1,2-cis-2-halogeenisyklopropyyli)substituoitujen pyridonikarboksyylihappojohdannaisten valmistamiseksi

Info

Publication number
FI891980A0
FI891980A0 FI891980A FI891980A FI891980A0 FI 891980 A0 FI891980 A0 FI 891980A0 FI 891980 A FI891980 A FI 891980A FI 891980 A FI891980 A FI 891980A FI 891980 A0 FI891980 A0 FI 891980A0
Authority
FI
Finland
Prior art keywords
cis
acid derivatives
halogenocyclopropyl
preparation
carboxylic acid
Prior art date
Application number
FI891980A
Other languages
English (en)
Swedish (sv)
Other versions
FI96947B (fi
FI891980A (fi
FI96947C (fi
Inventor
Isao Hayakawa
Youichi Kimura
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of FI891980A0 publication Critical patent/FI891980A0/fi
Publication of FI891980A publication Critical patent/FI891980A/fi
Publication of FI96947B publication Critical patent/FI96947B/fi
Application granted granted Critical
Publication of FI96947C publication Critical patent/FI96947C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
FI891980A 1988-04-27 1989-04-26 Menetelmä terapeuttisesti aktiivisten N1-(1,2-cis-2-halogeenisyklopropyyli)substituoitujen pyridonikarboksyylihappojohdannaisten valmistamiseksi FI96947C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP10462588 1988-04-27
JP10462588 1988-04-27
JP29698488 1988-11-24
JP29698488 1988-11-24

Publications (4)

Publication Number Publication Date
FI891980A0 true FI891980A0 (fi) 1989-04-26
FI891980A FI891980A (fi) 1989-10-28
FI96947B FI96947B (fi) 1996-06-14
FI96947C FI96947C (fi) 1996-09-25

Family

ID=26445063

Family Applications (1)

Application Number Title Priority Date Filing Date
FI891980A FI96947C (fi) 1988-04-27 1989-04-26 Menetelmä terapeuttisesti aktiivisten N1-(1,2-cis-2-halogeenisyklopropyyli)substituoitujen pyridonikarboksyylihappojohdannaisten valmistamiseksi

Country Status (26)

Country Link
US (4) US5587386A (fi)
EP (1) EP0341493B1 (fi)
JP (5) JP2714597B2 (fi)
KR (1) KR0184614B1 (fi)
CN (1) CN1033751C (fi)
AT (1) ATE182145T1 (fi)
AU (1) AU625414B2 (fi)
BG (1) BG61122B2 (fi)
CA (1) CA1340801C (fi)
DE (1) DE68929030T2 (fi)
DK (1) DK175467B1 (fi)
ES (1) ES2135372T3 (fi)
FI (1) FI96947C (fi)
GR (1) GR3031365T3 (fi)
HK (1) HK1002108A1 (fi)
HU (1) HU211136A9 (fi)
IL (1) IL90062A (fi)
LV (1) LV10092B (fi)
MY (1) MY105136A (fi)
NO (1) NO175939C (fi)
NZ (1) NZ228893A (fi)
PT (1) PT90377B (fi)
RU (1) RU2075475C1 (fi)
SG (1) SG48036A1 (fi)
UA (1) UA29378C2 (fi)
YU (1) YU48432B (fi)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL90062A (en) * 1988-04-27 1994-10-07 Daiichi Seiyaku Co History of pyridonecarboxylic acid, their preparation and pharmaceutical preparations containing them
JPH0674261B2 (ja) * 1988-06-21 1994-09-21 塩野義製薬株式会社 キノロンカルボン酸誘導体
CA1336090C (en) * 1988-08-31 1995-06-27 Isao Hayakawa Spiro-substituted cyclic amines of quinolone derivatives
CA2036516A1 (en) * 1990-02-19 1991-08-20 Yoshikazu Asahina Optically active 8-methoxyouinolonecarboxylic acid derivatives, their preparative processes and their intermediates
MY109714A (en) * 1990-10-18 1997-04-30 Daiichi Seiyaku Co Process for preparing 8-chloroquinolone derivatives
CA2110260C (en) * 1991-05-28 2001-12-04 Isao Hayakawa Pyridonecarboxylic acid derivatives
JPH0678335B2 (ja) * 1991-06-19 1994-10-05 ファイザー・インコーポレーテッド アザスピロキノロン化合物、その製法および抗菌組成物
KR960011370B1 (ko) * 1991-12-31 1996-08-22 재단법인 한국화학연구소 스피로알킬아민 유도체와 그의 제조방법
JP3268098B2 (ja) * 1992-12-25 2002-03-25 第一製薬株式会社 二環性環状アミン誘導体
ZA946853B (en) * 1993-09-10 1995-04-24 Daiichi Seiyaku Co Crystals of antimicrobial compound.
WO1996002512A1 (fr) * 1994-07-18 1996-02-01 Ube Industries, Ltd. Acide du type trifluoromethylquinoleinecarboxylique
ES2315432T3 (es) * 1995-02-02 2009-04-01 Daiichi Sankyo Company, Limited Derivados de acido piridonacarboxilico y su uso como agentes antibacterianos.
EA003334B1 (ru) * 1995-02-07 2003-04-24 Дайити Фармасьютикал Ко., Лтд. Производные пиридонкарбоновой кислоты и антибактериальная композиция на их основе
JPH09124556A (ja) 1995-08-30 1997-05-13 Dai Ichi Seiyaku Co Ltd ハロゲン化シクロプロパン誘導体の製造方法
US6121285A (en) 1995-11-22 2000-09-19 Daiichi Pharmaceutical Co., Ltd. Substituted aminocycloalkylpyrrolidine derivatives and cis-substituted aminocycloalkylpyrrolidine derivatives
KR19990071558A (ko) * 1995-11-22 1999-09-27 스즈키 다다시 치환된 아미노시클로알킬피롤리딘 유도체
ZA971023B (en) * 1996-02-09 1997-09-25 Toyama Chemical Co Ltd Quinolonecarboxylic acid derivatives or their salts.
TW425394B (en) * 1996-04-24 2001-03-11 Daiichi Seiyaku Co Antimicrobial quinolone derivatives having 3-(N-cycloalkyl) aminomethylpyrrolidine group
AU1040597A (en) * 1996-12-04 1998-06-29 Daiichi Pharmaceutical Co., Ltd. Substituted aminomethylpyrrolidine derivatives
CN1173971C (zh) 1998-11-24 2004-11-03 第一制药株式会社 环烷基取代的氨甲基吡咯烷衍生物
AU2940300A (en) 1999-03-10 2000-09-28 Daiichi Pharmaceutical Co., Ltd. Aminomethylpyrrolidine derivatives having aromatic substituents
EP1161956A4 (en) 1999-03-17 2005-03-16 Daiichi Seiyaku Co DRUG COMPOSITIONS
RU2297420C2 (ru) * 2000-02-09 2007-04-20 Дайити Фармасьютикал Ко., Лтд. Средство против кислотоустойчивых бактерий, содержащее гетероциклические производные бензоксазина в качестве активного компонента
NZ522667A (en) * 2000-03-31 2004-06-25 Daiichi Seiyaku Co Quinolonecarboxylic acid derivative with high antibacterial acitivity and safety and highly stable to light and ahumidity.
KR100858228B1 (ko) * 2000-04-24 2008-09-12 다이이찌 세이야꾸 가부시기가이샤 광안정성 액상 제제 및 광조사에 대해 시타플록사신을 안정화시키는 방법
AU2001276748A1 (en) * 2000-08-08 2002-02-18 Daiichi Pharmaceutical Co., Ltd. Highly absorbable solid preparation
RU2004136997A (ru) * 2002-05-17 2005-06-27 Дайити Фармасьютикал Ко., Лтд. (JP) Способ получения производных хинолонкарбоновой кислоты
EP1582513B1 (en) * 2003-01-07 2010-11-17 Daiichi Sankyo Company, Limited Process for reductive dehalogenation
US7085154B2 (en) * 2003-06-03 2006-08-01 Samsung Electronics Co., Ltd. Device and method for pulse width control in a phase change memory device
WO2005111015A1 (ja) * 2004-05-13 2005-11-24 Daiichi Pharmaceutical Co., Ltd. 置換ピロリジン誘導体
JP5063032B2 (ja) * 2005-05-19 2012-10-31 第一三共株式会社 トリ−、テトラ−置換−３−アミノピロリジン誘導体
US7563805B2 (en) 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
JP5017101B2 (ja) * 2005-05-20 2012-09-05 第一三共株式会社 不斉四置換炭素原子含有化合物の製法
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
TWI386401B (zh) 2006-03-27 2013-02-21 Daiichi Seiyaku Co 醫藥用水合物
EP2097400B1 (en) 2007-01-05 2013-07-03 Daiichi Sankyo Company, Limited Fused substituted aminopyrrolidine derivative
CN102089439B (zh) 2008-07-11 2013-11-13 住友化学株式会社 (1s，2r)-2-氯-2-氟环丙烷羧酸的制造方法
FR2961207B1 (fr) * 2010-06-09 2013-01-18 Oreal Utilisation d'un derive de 4- carboxy 2-pyrrolidinone comme solvant dans les compositions cosmetiques ; compositions cosmetiques les contenant ; nouveaux composes
CN103467448B (zh) * 2013-09-18 2015-04-15 浙江司太立制药股份有限公司 7-(3-氨基-4-烷氧亚胺基-1-哌啶基)-1-[(1r,2s)-2-氟环丙基]喹诺酮羧酸类化合物及其制备方法
EP2957561A1 (en) * 2014-06-18 2015-12-23 Université Paris 6 Pierre et Marie Curie UPMC Novel fluoroquinolones and use thereof to treat bacterial infections
CN105330590B (zh) * 2015-10-15 2018-09-25 广州市朗启医药科技有限责任公司 西他沙星五元环侧链中间体的制备方法
CN109912504B (zh) * 2019-04-04 2020-11-10 山东省联合农药工业有限公司 一种喹啉羧酸类化合物及其制备方法与用途

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DE3576335D1 (de) * 1984-12-14 1990-04-12 Daiichi Seiyaku Co Chinolincarbonsaeure-derivate.
AU5427286A (en) * 1985-03-08 1986-09-11 Kyorin Pharmaceutical Co. Ltd. 7-(1-pyrrolidinyl)-3-quinolinecarboxylic acid derivatives
DE3509546A1 (de) * 1985-03-16 1986-09-25 Bayer Ag, 5090 Leverkusen 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4657913A (en) 1985-04-18 1987-04-14 Warner-Lambert Company Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
US4668680A (en) * 1985-12-12 1987-05-26 Warner-Lambert Company 5-amino-6,8-difluoroquinolones as antibacterial agents
US4735949A (en) 1986-02-18 1988-04-05 Warner-Lambert Company Disubstituted-7-pyrrolidinonaphthyridine antibacterial agents
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
DE3702393A1 (de) * 1987-01-28 1988-08-11 Bayer Ag 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel
US5290934A (en) * 1987-04-16 1994-03-01 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
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FI95130C (fi) * 1988-07-20 1995-12-27 Sankyo Co Menetelmä lääkeaineena käyttökelpoisten 4-oksokinoliini-3-karboksyylihapon johdannaisten valmistamiseksi
US5286723A (en) 1988-08-31 1994-02-15 Daiichi Seiyaku Co., Ltd. Spiro compound
FI901201A0 (fi) * 1989-03-13 1990-03-09 Bristol Myers Squibb Co Antibakteriella 5-substituerade 1,4-dihydro-4-oxonaftyridin-3-karboxylatderivat och deras framstaellning.
DE3910663A1 (de) * 1989-04-03 1990-10-04 Bayer Ag 5-alkylchinoloncarbonsaeuren
NZ522667A (en) * 2000-03-31 2004-06-25 Daiichi Seiyaku Co Quinolonecarboxylic acid derivative with high antibacterial acitivity and safety and highly stable to light and ahumidity.
WO2005111015A1 (ja) * 2004-05-13 2005-11-24 Daiichi Pharmaceutical Co., Ltd. 置換ピロリジン誘導体

Also Published As

Publication number Publication date
IL90062A (en) 1994-10-07
UA29378C2 (uk) 2000-11-15
AU625414B2 (en) 1992-07-09
BG61122B2 (bg) 1996-11-29
ES2135372T3 (es) 1999-11-01
US6031102A (en) 2000-02-29
USRE41149E1 (en) 2010-02-23
CA1340801C (en) 1999-10-26
NO175939B (no) 1994-09-26
NZ228893A (en) 1990-06-26
DK205789A (da) 1989-10-28
KR900016205A (ko) 1990-11-12
JPH02231475A (ja) 1990-09-13
JP2903292B2 (ja) 1999-06-07
DE68929030D1 (de) 1999-08-19
JP2917010B2 (ja) 1999-07-12
SG48036A1 (en) 1998-04-17
GR3031365T3 (en) 2000-01-31
NO891698D0 (no) 1989-04-25
HK1002108A1 (en) 1998-07-31
HU211136A9 (en) 1995-10-30
CN1033751C (zh) 1997-01-08
RU2075475C1 (ru) 1997-03-20
PT90377A (pt) 1989-11-10
MY105136A (en) 1994-08-30
FI96947B (fi) 1996-06-14
CN1037507A (zh) 1989-11-29
DK175467B1 (da) 2004-11-01
LV10092B (en) 1995-02-20
DK205789D0 (da) 1989-04-27
US5587386A (en) 1996-12-24
FI891980A (fi) 1989-10-28
KR0184614B1 (ko) 1999-05-01
US5767127A (en) 1998-06-16
FI96947C (fi) 1996-09-25
EP0341493B1 (en) 1999-07-14
AU3370289A (en) 1989-11-02
PT90377B (pt) 1994-09-30
IL90062A0 (en) 1989-12-15
JPH11124380A (ja) 1999-05-11
NO891698L (no) 1989-10-30
YU87589A (en) 1990-12-31
JP2714597B2 (ja) 1998-02-16
EP0341493A3 (en) 1990-12-19
DE68929030T2 (de) 2000-03-23
JPH07300416A (ja) 1995-11-14
ATE182145T1 (de) 1999-07-15
JPH1067779A (ja) 1998-03-10
JPH11124367A (ja) 1999-05-11
YU48432B (sh) 1998-07-10
EP0341493A2 (en) 1989-11-15
NO175939C (no) 1995-01-04

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Legal Events

Date Code Title Description
BB Publication of examined application
TC Name/ company changed in patent

Owner name: DAIICHI PHARMACEUTICAL CO., LTD.

FG Patent granted

Owner name: DAIICHI PHARMACEUTICAL CO., LTD.

MA Patent expired