FI861684L - Imidazokinoliner, antitrombogena hjaertmediciner. - Google Patents

Imidazokinoliner, antitrombogena hjaertmediciner. Download PDF

Info

Publication number: FI861684L
Authority: FI; Finland
Prior art keywords: imidazoquinoliner; hjaertmediciner; antitrombogen; antitrombogen hjaertmediciner
Prior art date: 1985-04-25

Application number

FI861684A

Other languages

English (en)

Other versions

FI83316B (fi

FI83316C (fi

FI861684A0 (fi

Inventor

Nicholas A Meanwell

John J Wright

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-25

Filing date

1986-04-22

Publication date

1986-10-26

1986-04-22 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1986-04-22 Publication of FI861684A0 publication Critical patent/FI861684A0/fi

1986-10-26 Publication of FI861684L publication Critical patent/FI861684L/fi

1991-03-15 Publication of FI83316B publication Critical patent/FI83316B/fi

1991-06-25 Application granted granted Critical

1991-06-25 Publication of FI83316C publication Critical patent/FI83316C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

FI861684A 1985-04-25 1986-04-22 Foerfarande foer framstaellning av farmaceutiskt aktiva 1,3-dihydro-2h-imidazo/4,5-b/kinolin-2-onderivat. FI83316C (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US72686985A	1985-04-25	1985-04-25
US72686985		1985-04-25
US83221286		1986-02-26
US06/832,212 US4668686A (en)	1985-04-25	1986-02-26	Imidazoquinoline antithrombrogenic cardiotonic agents

Publications (4)

Publication Number	Publication Date
FI861684A0 FI861684A0 (fi)	1986-04-22
FI861684L true FI861684L (fi)	1986-10-26
FI83316B FI83316B (fi)	1991-03-15
FI83316C FI83316C (fi)	1991-06-25

Family

ID=27111398

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI861684A FI83316C (fi)	1985-04-25	1986-04-22	Foerfarande foer framstaellning av farmaceutiskt aktiva 1,3-dihydro-2h-imidazo/4,5-b/kinolin-2-onderivat.

Country Status (32)

Country	Link
US (1)	US4668686A (fi)
KR (1)	KR940000828B1 (fi)
CN (1)	CN1016175B (fi)
AT (1)	AT390257B (fi)
AU (1)	AU592983B2 (fi)
BE (1)	BE904671A (fi)
CA (1)	CA1298836C (fi)
CH (1)	CH675722A5 (fi)
CY (1)	CY1641A (fi)
DE (1)	DE3614132A1 (fi)
DK (3)	DK164868C (fi)
EG (1)	EG18104A (fi)
ES (3)	ES8708229A1 (fi)
FI (1)	FI83316C (fi)
FR (1)	FR2581065B1 (fi)
GB (1)	GB2174987B (fi)
GR (1)	GR861086B (fi)
HK (1)	HK64492A (fi)
HU (1)	HU195813B (fi)
IL (1)	IL78581A0 (fi)
IT (1)	IT1215651B (fi)
LU (1)	LU86406A1 (fi)
MY (1)	MY102086A (fi)
NL (1)	NL8601053A (fi)
NO (1)	NO163406C (fi)
NZ (1)	NZ215885A (fi)
OA (1)	OA08242A (fi)
PT (1)	PT82460B (fi)
SE (1)	SE461468B (fi)
SG (1)	SG29092G (fi)
SU (3)	SU1450746A3 (fi)
YU (1)	YU46054B (fi)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4775674A (en) *	1986-05-23	1988-10-04	Bristol-Myers Company	Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) *	1986-07-08	1987-10-20	Bristol-Myers Company	7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4743607A (en) *	1987-05-29	1988-05-10	Merrell Dow Pharmaceuticals Inc.	Cardiotonic tricyclic imidazolones
US4803210A (en) *	1987-05-29	1989-02-07	Merrell Dow Pharmaceuticals Inc.	Cardiotonic tricyclic oxazolones
US4943573A (en) *	1989-11-01	1990-07-24	Bristol-Myers Squibb Company	Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) *	1990-11-10	1996-10-02	Daimler Benz Ag	Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) *	1991-10-30	1998-06-18	Janssen Pharmaceutica Nv	1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5158958A (en) *	1992-04-03	1992-10-27	Bristol-Myers Squibb Company	Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5348960A (en) *	1992-04-03	1994-09-20	Bristol-Myers Squibb Company	Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5208237A (en) *	1992-04-03	1993-05-04	Bristol-Meyers Squibb Company	7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5196428A (en) *	1992-04-03	1993-03-23	Bristol-Myers Squibb Company	Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5552267A (en) *	1992-04-03	1996-09-03	The Trustees Of Columbia University In The City Of New York	Solution for prolonged organ preservation
AU2004266658A1 (en)	2003-08-12	2005-03-03	3M Innovative Properties Company	Hydroxylamine substituted imidazo-containing compounds
MY145983A (en)	2003-08-27	2012-05-31	3M Innovative Properties Co	Aryloxy and arylalkyleneoxy substituted imidazoquinolines
WO2005023190A2 (en)	2003-09-05	2005-03-17	3M Innovative Properties Company	Treatment for cd5+ b cell lymphoma
US7544697B2 (en)	2003-10-03	2009-06-09	Coley Pharmaceutical Group, Inc.	Pyrazolopyridines and analogs thereof
RU2412942C2 (ru)	2003-10-03	2011-02-27	3М Инновейтив Пропертиз Компани	Оксизамещенные имидазохинолины, способные модулировать биосинтез цитокинов
CA2545774A1 (en)	2003-11-14	2005-06-02	3M Innovative Properties Company	Oxime substituted imidazo ring compounds
WO2005048945A2 (en) *	2003-11-14	2005-06-02	3M Innovative Properties Company	Hydroxylamine substituted imidazo ring compounds
KR101130928B1 (ko)	2003-11-25	2012-04-12	쓰리엠 이노베이티브 프로퍼티즈 컴파니	치환된 이미다조 고리 시스템 및 방법
US8802853B2 (en)	2003-12-29	2014-08-12	3M Innovative Properties Company	Arylalkenyl and arylalkynyl substituted imidazoquinolines
JP2007517044A (ja)	2003-12-30	2007-06-28	スリーエムイノベイティブプロパティズカンパニー	イミダゾキノリニル、イミダゾピリジニル、およびイミダゾナフチリジニルスルホンアミド
CA2559863A1 (en)	2004-03-24	2005-10-13	3M Innovative Properties Company	Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
WO2005123080A2 (en)	2004-06-15	2005-12-29	3M Innovative Properties Company	Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
WO2006038923A2 (en)	2004-06-18	2006-04-13	3M Innovative Properties Company	Aryl substituted imidazonaphthyridines
WO2006065280A2 (en)	2004-06-18	2006-06-22	3M Innovative Properties Company	Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
WO2006009826A1 (en)	2004-06-18	2006-01-26	3M Innovative Properties Company	Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
EP1831226B1 (en)	2004-12-30	2012-08-08	3M Innovative Properties Company	Chiral tetracyclic compounds inducing interferon biosynthesis
ES2392648T3 (es)	2004-12-30	2012-12-12	3M Innovative Properties Company	Compuestos quirales sustituidos que contienen un núcleo 1,2-imidazo-4,5-c condensado
JP2008530022A (ja)	2005-02-04	2008-08-07	コーリーファーマシューティカルグループ，インコーポレイテッド	免疫反応調節物質を含む水性ゲル処方物
EP1846405A2 (en)	2005-02-11	2007-10-24	3M Innovative Properties Company	Oxime and hydroxylamine substituted imidazo 4,5-c ring compounds and methods
JP2008535832A (ja)	2005-04-01	2008-09-04	コーリーファーマシューティカルグループ，インコーポレイテッド	ピラゾロピリジン−１，４−ジアミン、およびそのアナログ
JP2008538550A (ja)	2005-04-01	2008-10-30	コーリーファーマシューティカルグループ，インコーポレイテッド	ウイルス感染および腫瘍性疾患を処置するためのサイトカイン生合成の調節因子としての１−置換ピラゾロ（３，４−ｃ）環状化合物
US7906506B2 (en)	2006-07-12	2011-03-15	3M Innovative Properties Company	Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
US8227603B2 (en)	2006-08-01	2012-07-24	Cytokinetics, Inc.	Modulating skeletal muscle
KR101410453B1 (ko)	2006-08-02	2014-06-27	싸이토키네틱스, 인코포레이티드	소정의 화학 물질, 조성물 및 방법
US8299248B2 (en)	2006-08-02	2012-10-30	Cytokinetics, Incorporated	Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
WO2008121333A1 (en) *	2007-03-30	2008-10-09	Cytokinetics, Incorporated	Certain chemical entities, compositions and methods
JP6145946B2 (ja)	2011-07-13	2017-06-14	サイトキネティックス，インコーポレイテッド	併用ａｌｓ療法
WO2024149378A1 (zh) *	2023-01-13	2024-07-18	上海超阳药业有限公司	喹啉酮化合物和萘啶酮化合物及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3932407A (en) *	1973-11-19	1976-01-13	Bristol-Myers Company	Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

1986
- 1986-02-26 US US06/832,212 patent/US4668686A/en not_active Expired - Fee Related
- 1986-03-26 CA CA000505136A patent/CA1298836C/en not_active Expired - Fee Related
- 1986-04-18 NZ NZ215885A patent/NZ215885A/xx unknown
- 1986-04-21 AU AU56413/86A patent/AU592983B2/en not_active Ceased
- 1986-04-22 IL IL78581A patent/IL78581A0/xx not_active IP Right Cessation
- 1986-04-22 FI FI861684A patent/FI83316C/fi not_active IP Right Cessation
- 1986-04-23 CN CN86102747A patent/CN1016175B/zh not_active Expired
- 1986-04-23 EG EG237/86A patent/EG18104A/xx active
- 1986-04-24 DK DK190986A patent/DK164868C/da not_active IP Right Cessation
- 1986-04-24 SE SE8601907A patent/SE461468B/sv not_active IP Right Cessation
- 1986-04-24 BE BE0/216585A patent/BE904671A/fr not_active IP Right Cessation
- 1986-04-24 CH CH1679/86A patent/CH675722A5/de not_active IP Right Cessation
- 1986-04-24 SU SU864027355A patent/SU1450746A3/ru active
- 1986-04-24 NL NL8601053A patent/NL8601053A/xx not_active Application Discontinuation
- 1986-04-24 GB GB8610037A patent/GB2174987B/en not_active Expired
- 1986-04-24 PT PT82460A patent/PT82460B/pt not_active IP Right Cessation
- 1986-04-24 FR FR868605966A patent/FR2581065B1/fr not_active Expired - Fee Related
- 1986-04-24 LU LU86406A patent/LU86406A1/fr unknown
- 1986-04-24 GR GR861086A patent/GR861086B/el unknown
- 1986-04-24 NO NO861617A patent/NO163406C/no unknown
- 1986-04-24 ES ES554336A patent/ES8708229A1/es not_active Expired
- 1986-04-24 IT IT8620206A patent/IT1215651B/it active
- 1986-04-25 HU HU861723A patent/HU195813B/hu not_active IP Right Cessation
- 1986-04-25 OA OA58845A patent/OA08242A/xx unknown
- 1986-04-25 AT AT0112186A patent/AT390257B/de not_active IP Right Cessation
- 1986-04-25 DE DE19863614132 patent/DE3614132A1/de not_active Ceased
- 1986-04-25 KR KR1019860003204A patent/KR940000828B1/ko not_active Expired - Lifetime
1987
- 1987-02-27 SU SU874202071A patent/SU1470192A3/ru active
- 1987-05-14 ES ES557551A patent/ES8801829A1/es not_active Expired
- 1987-05-14 ES ES557552A patent/ES8802521A1/es not_active Expired
- 1987-06-23 YU YU116787A patent/YU46054B/sh unknown
- 1987-09-25 SU SU874203391A patent/SU1560056A3/ru active
- 1987-09-29 MY MYPI87002266A patent/MY102086A/en unknown
1991
- 1991-04-30 DK DK080291A patent/DK165248C/da not_active IP Right Cessation
- 1991-05-01 DK DK081091A patent/DK165249C/da not_active IP Right Cessation
1992
- 1992-03-10 SG SG290/92A patent/SG29092G/en unknown
- 1992-08-27 HK HK644/92A patent/HK64492A/xx unknown
- 1992-11-06 CY CY1641A patent/CY1641A/en unknown

Also Published As

Publication number	Publication date
US4668686A (en)	1987-05-26
SE461468B (sv)	1990-02-19
NO163406B (no)	1990-02-12
DK165249B (da)	1992-10-26
FI83316B (fi)	1991-03-15
AT390257B (de)	1990-04-10
NO861617L (no)	1986-10-27
PT82460A (en)	1986-05-01
MY102086A (en)	1992-03-31
GR861086B (en)	1986-09-01
DK165248C (da)	1993-03-22
DK81091A (da)	1991-05-01
DK80291D0 (da)	1991-04-30
ES8708229A1 (es)	1987-10-01
ATA112186A (de)	1989-09-15
ES554336A0 (es)	1987-10-01
GB2174987B (en)	1989-08-02
DK164868C (da)	1993-01-11
CH675722A5 (fi)	1990-10-31
CY1641A (en)	1992-11-06
ES8802521A1 (es)	1988-07-16
ES8801829A1 (es)	1988-02-16
FR2581065A1 (fr)	1986-10-31
AU5641386A (en)	1986-10-30
FI83316C (fi)	1991-06-25
ES557551A0 (es)	1988-02-16
KR940000828B1 (ko)	1994-02-02
CA1298836C (en)	1992-04-14
PT82460B (pt)	1988-11-30
OA08242A (en)	1987-10-30
DE3614132A1 (de)	1986-11-27
SU1560056A3 (ru)	1990-04-23
DK80291A (da)	1991-04-30
DK165249C (da)	1993-03-22
FI861684A0 (fi)	1986-04-22
LU86406A1 (fr)	1986-11-05
DK190986A (da)	1986-10-26
BE904671A (fr)	1986-10-24
SG29092G (en)	1992-05-15
DK165248B (da)	1992-10-26
IL78581A0 (en)	1986-08-31
HK64492A (en)	1992-09-04
SE8601907D0 (sv)	1986-04-24
NZ215885A (en)	1989-04-26
DK190986D0 (da)	1986-04-24
HUT42089A (en)	1987-06-29
FR2581065B1 (fr)	1990-02-02
NL8601053A (nl)	1986-11-17
CN86102747A (zh)	1987-02-04
HU195813B (en)	1988-07-28
DK81091D0 (da)	1991-05-01
EG18104A (en)	1992-09-30
YU46054B (sh)	1992-12-21
IT8620206A0 (it)	1986-04-24
AU592983B2 (en)	1990-02-01
SU1470192A3 (ru)	1989-03-30
KR860008177A (ko)	1986-11-12
DK164868B (da)	1992-08-31
ES557552A0 (es)	1988-07-16
GB8610037D0 (en)	1986-05-29
SU1450746A3 (ru)	1989-01-07
CN1016175B (zh)	1992-04-08
YU116787A (en)	1988-04-30
IT1215651B (it)	1990-02-22
GB2174987A (en)	1986-11-19
NO163406C (no)	1990-05-23
SE8601907L (sv)	1986-10-26

Publication	Publication Date	Title
FI861842L (fi)	1986-11-17	Makromerfoerstaerkt, tryckkaensligt hudlim.
FI860860L (fi)	1986-09-02	Stabiliserat, flytande tvaettmedel foer textiler.
FI863778A0 (fi)	1986-09-18	Tugg- och snuskompositioner, vilka innehaoller oerter.
FI861684L (fi)	1986-10-26	Imidazokinoliner, antitrombogena hjaertmediciner.
FI865192L (fi)	1987-06-22	Laettoeppnade, steriliserbara foerpackningar.
FI863532L (fi)	1987-03-04	Raekneanordning foer fiskar, i synnerhet fiskyngel.
FI854870A0 (fi)	1985-12-10	Oljekyld, flerdelad saenkkolv foer slagkolvsfoerbraenningsmotor.
FI853853L (fi)	1987-04-05	Kalander, t.ex. superkalander.
FI853553A0 (fi)	1985-09-17	Kontinuerligt arbetande, tryckvalsfoersedd paorullningsanordning.
FI864584A0 (fi)	1986-11-11	Koextruderad, biaxialt straeckt flerskiktsfolie.
FI871692A (fi)	1987-04-16	Sorteringsmaskin, i synnerhet foer smaopaket.
FI863236A0 (fi)	1986-08-07	Filteranordning, saerskilt sugfilter.
FI863721L (fi)	1987-03-26	Skaeranordning foer skivmaterial, saerskilt faner.
FI861009L (fi)	1986-09-12	Hydroelastisk uppbaerningsanordning foer mobila, sjaelvlyftande borrplattformar.
ATE68471T1 (de)	1991-11-15	Gem-dihalo-1,8-diamino-4-aza-oktane.
FI855170A0 (fi)	1985-12-27	Sorterare, saerskilt vertikalsikt.
FI863012L (fi)	1987-01-28	Bilslaepvagn, speciellt husvagn.
FI861494A0 (fi)	1986-04-08	Kristallinisk, vattenfri natrium-19 -deoxiaglykondianemycin.
FI851927L (fi)	1986-11-16	Maonganvaendbar grubbelmoessa, saerskilt en tryckutblaosningsluva.
FI852812A0 (fi)	1985-07-17	Traegaordsredskap, speciellt kratta.
FI851030A0 (fi)	1985-03-14	Glidande, reglerbar bottenkonstruktion.
FI850313L (fi)	1986-07-25	Kombinerad arkrotationstryckmaskin foer vaerdepapper, speciellt sedlar.
FI875199A0 (fi)	1987-11-25	Sjaelvinstaellande, laosbart lyftblock.
FI853166A0 (fi)	1985-08-16	Trikaoprodukt, speciellt strumpa.
FI863966L (fi)	1987-05-22	Valsbantorkare, speciellt foer faner.

Legal Events

Date	Code	Title	Description
1994-04-22	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: BRISTOL-MYERS SQUIBB COMPANY