FI852807L - Nya foereningar. - Google Patents

Nya foereningar.

Info

Publication number: FI852807L
Authority: FI; Finland
Prior art keywords: image; foereningar; nya; nya foereningar; anion
Prior art date: 1984-07-18

Application number

FI852807A

Other languages

English (en)

Other versions

FI85019B (fi

FI85019C (fi

FI852807A0 (fi

Inventor

Roy Archibald Swaringen Jr

Hassan Ali El-Sayad

David Arthur Yeowell

John Joseph Savarese

Original Assignee

Wellcome Found

Gen Hospital Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-07-18

Filing date

1985-07-17

Publication date

1986-01-19

1985-07-17 Application filed by Wellcome Found, Gen Hospital Corp filed Critical Wellcome Found

1985-07-17 Publication of FI852807A0 publication Critical patent/FI852807A0/fi

1986-01-19 Publication of FI852807L publication Critical patent/FI852807L/fi

1991-11-15 Publication of FI85019B publication Critical patent/FI85019B/fi

1992-02-25 Application granted granted Critical

1992-02-25 Publication of FI85019C publication Critical patent/FI85019C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Public Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Jib Cranes (AREA)
Superconductors And Manufacturing Methods Therefor (AREA)
Medicinal Preparation (AREA)
Cosmetics (AREA)
Fats And Perfumes (AREA)
Meat, Egg Or Seafood Products (AREA)
Cephalosporin Compounds (AREA)

FI852807A 1984-07-18 1985-07-17 Foerfarande foer framstaellning av terapeutiskt anvaendbara (e)-4-oktendioylbis (oxitrimetylen) bis (1,2,3,4-tetrahydro-6,7-dimetoxi-2-metyl-1-(3,4,5-trimetoxibensyl) isokinolinium) foereningar. FI85019C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB848418303A GB8418303D0 (en)	1984-07-18	1984-07-18	Compounds
GB8418303		1984-07-18

Publications (4)

Publication Number	Publication Date
FI852807A0 FI852807A0 (fi)	1985-07-17
FI852807L true FI852807L (fi)	1986-01-19
FI85019B FI85019B (fi)	1991-11-15
FI85019C FI85019C (fi)	1992-02-25

Family

ID=10564058

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI852807A FI85019C (fi)	1984-07-18	1985-07-17	Foerfarande foer framstaellning av terapeutiskt anvaendbara (e)-4-oktendioylbis (oxitrimetylen) bis (1,2,3,4-tetrahydro-6,7-dimetoxi-2-metyl-1-(3,4,5-trimetoxibensyl) isokinolinium) foereningar.

Country Status (30)

Country	Link
US (1)	US4761418A (fi)
EP (1)	EP0181055B1 (fi)
JP (1)	JPH0662568B2 (fi)
AT (1)	ATE60759T1 (fi)
AU (1)	AU574481B2 (fi)
BG (1)	BG60411B2 (fi)
CA (1)	CA1273341A (fi)
CY (1)	CY1687A (fi)
DD (1)	DD235638A5 (fi)
DE (2)	DE3581699D1 (fi)
DK (1)	DK168093B1 (fi)
ES (1)	ES8609260A1 (fi)
FI (1)	FI85019C (fi)
GB (1)	GB8418303D0 (fi)
GE (1)	GEP19960468B (fi)
HK (1)	HK47593A (fi)
HU (1)	HU193996B (fi)
IE (1)	IE58138B1 (fi)
IL (1)	IL75833A (fi)
LT (1)	LT2078B (fi)
LU (1)	LU88801I2 (fi)
LV (1)	LV5483A3 (fi)
MC (1)	MC1690A1 (fi)
MX (1)	MX9203667A (fi)
NL (1)	NL940023I2 (fi)
NZ (1)	NZ212766A (fi)
PL (1)	PL146066B1 (fi)
SG (1)	SG3493G (fi)
SU (1)	SU1468414A3 (fi)
ZA (1)	ZA855407B (fi)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5453510A (en) *	1990-07-13	1995-09-26	Burroughs Wellcome Co.	Neuromuscular blocking agents
US5240939A (en) *	1991-10-31	1993-08-31	Anaquest, Inc.	Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) *	1994-09-06	1996-04-23	Bencherif; Merouane	Depolarizing skeletal muscle relaxants
DE69819703T2 (de) *	1997-03-25	2004-09-30	Avera Pharmaceuticals, Inc., San Diego	Substituierte isochinoline als ultra kurz wirkende neuromuskuläre blocker
GB0204087D0 (en) *	2002-02-21	2002-04-10	Legislator 1563 Ltd	Di-ester derivatives as short acting neuromuscular blockers
EP1684753A2 (en) *	2003-10-28	2006-08-02	Cornell Research Foundation, Inc.	Neuromuscular blocking agents and antagonists thereof
US7872137B2 (en) *	2006-06-20	2011-01-18	Farmabios S.P.A.	Process for the preparation of mivacurium chloride
ATE554769T1 (de) *	2006-12-06	2012-05-15	Cornell Res Foundation Inc	Neuromuskuläre blocker mit mittlerer dauer und antagonisten advon
WO2008107887A2 (en) *	2007-03-08	2008-09-12	Chemagis Ltd.	(1r,1'r)-atracurium salts separation process
CA2681060A1 (en) *	2007-03-26	2008-10-02	Chemagis Ltd.	(1r,1'r)-atracurium salts separation process
US8293912B2 (en) *	2007-05-01	2012-10-23	Chemagis Ltd.	Process for producing cisatracurium compounds and associated intermediates
WO2008132746A1 (en) *	2007-05-01	2008-11-06	Chemagis Ltd.	Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
US8357805B2 (en) *	2007-06-18	2013-01-22	Chemagis Ltd.	(1R,1′R)-atracurium salts separation process
EP2176227A1 (en) *	2007-07-09	2010-04-21	Chemagis Ltd.	Process for producing cisatracurium and associated intermediates
CA2702535A1 (en) *	2007-10-29	2009-05-07	Chemagis Ltd.	Novel r,r'-atracurium salts
ITMI20080319A1 (it) *	2008-02-28	2009-08-29	Recordati Chem Pharm	Processo per la risoluzione di derivati isochinolinici
CA2722651A1 (en) *	2008-05-01	2009-11-05	Chemagis Ltd.	Cisatracurium derivatives, preparation and uses thereof
WO2010107488A1 (en)	2009-03-17	2010-09-23	Cornell University	Reversible nondepolarizing neuromuscular blockade agents and methods for their use
US9220700B2 (en)	2009-08-19	2015-12-29	Cornell University	Cysteine for physiological injection
WO2013021398A2 (en) *	2011-08-05	2013-02-14	Sequent Scientific Limited	A process for preparation of mivacurium chloride
EP2867219B1 (en)	2012-06-29	2017-02-15	Cornell University	Asymmetrical reversible neuromuscular blocking agents of ultra-short, short, or intermediate duration
CN103373959A (zh) *	2013-06-14	2013-10-30	安徽省先锋制药有限公司	顺式苄基异喹啉类化合物的制备方法及其用途
CN107782821B (zh) *	2016-08-26	2021-11-09	四川科瑞德制药股份有限公司	一种神经肌肉阻滞剂的分析方法
CN107778237A (zh) *	2016-08-26	2018-03-09	四川科瑞德制药股份有限公司	一种神经肌肉阻滞剂中间体的新晶型及其制备方法和用途
CN108938573B (zh) *	2017-05-26	2021-08-10	四川科瑞德制药股份有限公司	一种神经肌肉阻滞剂组合物及其制备方法和用途
CN108503564A (zh) *	2017-09-30	2018-09-07	武汉嘉诺康医药技术有限公司	一种米库氯铵中间体及利用该中间体合成米库氯铵的方法
CN110361472B (zh) *	2019-07-29	2022-04-29	武汉嘉诺康医药技术有限公司	一种米库氯铵中间体miv-g异构体的hplc检测方法
CN111004179B (zh) *	2019-11-11	2021-03-09	武汉大安制药有限公司	一种5’-甲氧基劳丹素的拆分方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3004031A (en) *	1958-07-03	1961-10-10	Allen & Hauburys Ltd	Diquaternary salts of papaverino esters
GB863717A (en) *	1958-07-03	1961-03-22	Allen & Hanburys Ltd	Tetrahydropapaverine derivatives and their preparation
AU506657B2 (en) *	1975-12-10	1980-01-17	Wellcome Foundation Limited, The	Isoquinoline derivatives
ZA784331B (en) *	1977-08-01	1979-12-27	Massachusetts Gen Hospital	Neuromuscular blocking agents
US4192877A (en) *	1977-08-01	1980-03-11	Massachusetts General Hospital	Neuromuscular blocking agents
US4235906A (en) *	1978-07-21	1980-11-25	Massachusetts General Hospital	Bis-isoquinolinium compounds, compositions and methods of use
CA1125287A (en) *	1978-07-21	1982-06-08	John J. Savarese	Bis isoquinolinium compositions and methods of use
CA1153380A (en) *	1979-10-19	1983-09-06	Hassan A. El-Sayad	Neuromuscular blocking tetrahydroisoquinolinium salts
US4491665A (en) *	1979-10-19	1985-01-01	Burroughs Wellcome Co.	Method of preparing isomers of bis isoquinolinium compounds
EP0054309B1 (en) *	1980-12-17	1984-08-22	The Wellcome Foundation Limited	Long duration neuromuscular blocking agents, pharmaceutical compositions containing them and processes for their preparation
JPS5899465A (ja) *	1981-11-23	1983-06-13	ザ・ウエルカム・フアウンデ−シヨン・リミテツド	イソキノリン誘導体

1984
- 1984-07-18 GB GB848418303A patent/GB8418303D0/en active Pending
1985
- 1985-07-11 PL PL1985254571A patent/PL146066B1/pl unknown
- 1985-07-17 DE DE8585305097T patent/DE3581699D1/de not_active Expired - Lifetime
- 1985-07-17 SU SU853926201A patent/SU1468414A3/ru active
- 1985-07-17 MC MC851781A patent/MC1690A1/xx unknown
- 1985-07-17 ES ES545319A patent/ES8609260A1/es not_active Expired
- 1985-07-17 HU HU852745A patent/HU193996B/hu unknown
- 1985-07-17 AT AT85305097T patent/ATE60759T1/de active
- 1985-07-17 DK DK324985A patent/DK168093B1/da not_active IP Right Cessation
- 1985-07-17 DE DE1996175039 patent/DE19675039I2/de active Active
- 1985-07-17 AU AU45108/85A patent/AU574481B2/en not_active Expired
- 1985-07-17 CA CA000486916A patent/CA1273341A/en not_active Expired - Lifetime
- 1985-07-17 JP JP60157963A patent/JPH0662568B2/ja not_active Expired - Lifetime
- 1985-07-17 US US06/756,025 patent/US4761418A/en not_active Expired - Lifetime
- 1985-07-17 ZA ZA855407A patent/ZA855407B/xx unknown
- 1985-07-17 LU LU88801C patent/LU88801I2/fr unknown
- 1985-07-17 IL IL75833A patent/IL75833A/xx not_active IP Right Cessation
- 1985-07-17 EP EP85305097A patent/EP0181055B1/en not_active Expired - Lifetime
- 1985-07-17 FI FI852807A patent/FI85019C/fi not_active IP Right Cessation
- 1985-07-17 IE IE179185A patent/IE58138B1/en not_active IP Right Cessation
- 1985-07-17 NZ NZ212766A patent/NZ212766A/en unknown
- 1985-07-17 DD DD85278691A patent/DD235638A5/de unknown
1992
- 1992-06-26 MX MX9203667A patent/MX9203667A/es unknown
1993
- 1993-01-08 SG SG34/93A patent/SG3493G/en unknown
- 1993-03-10 LV LV930178A patent/LV5483A3/xx unknown
- 1993-04-07 LT LTRP478A patent/LT2078B/xx not_active IP Right Cessation
- 1993-05-13 HK HK475/93A patent/HK47593A/xx not_active IP Right Cessation
- 1993-09-14 BG BG098109A patent/BG60411B2/bg unknown
- 1993-10-10 CY CY1687A patent/CY1687A/xx unknown
- 1993-12-06 GE GEAP19931677A patent/GEP19960468B/en unknown
1994
- 1994-11-18 NL NL940023C patent/NL940023I2/nl unknown

Also Published As

Publication number	Publication date
NL940023I2 (nl)	1998-06-02
ES8609260A1 (es)	1986-09-01
LT2078B (lt)	1993-06-15
HUT40626A (en)	1987-01-28
SU1468414A3 (ru)	1989-03-23
CA1273341A (en)	1990-08-28
AU4510885A (en)	1986-01-23
EP0181055B1 (en)	1991-02-06
DE3581699D1 (de)	1991-03-14
AU574481B2 (en)	1988-07-07
BG60411B2 (bg)	1995-02-28
GEP19960468B (en)	1996-08-29
FI85019B (fi)	1991-11-15
US4761418A (en)	1988-08-02
DD235638A5 (de)	1986-05-14
DK324985D0 (da)	1985-07-17
FI85019C (fi)	1992-02-25
DK168093B1 (da)	1994-02-07
IE851791L (en)	1986-01-18
NZ212766A (en)	1988-03-30
DE19675039I2 (de)	2003-01-09
PL146066B1 (en)	1988-12-31
CY1687A (en)	1993-10-10
PL254571A1 (en)	1986-07-15
JPH0662568B2 (ja)	1994-08-17
DK324985A (da)	1986-01-19
LU88801I2 (fr)	1996-11-05
SG3493G (en)	1993-03-12
HK47593A (en)	1993-05-21
ATE60759T1 (de)	1991-02-15
IL75833A0 (en)	1985-11-29
IE58138B1 (en)	1993-07-14
LV5483A3 (lv)	1994-03-10
MC1690A1 (fr)	1986-07-18
EP0181055A1 (en)	1986-05-14
JPS6187666A (ja)	1986-05-06
ES545319A0 (es)	1986-09-01
IL75833A (en)	1988-11-30
FI852807A0 (fi)	1985-07-17
NL940023I1 (nl)	1995-01-02
GB8418303D0 (en)	1984-08-22
HU193996B (en)	1987-12-28
MX9203667A (es)	1992-07-31
ZA855407B (en)	1986-04-30

Publication	Publication Date	Title
FI852807L (fi)	1986-01-19	Nya foereningar.
ES538757A0 (es)	1985-11-01	Procedimiento para la preparacion de 11b-aril-estradienos
ZA862289B (en)	1986-11-26	Application of azolylmethyloxiranes for the treatmazolylmethyloxiranes,their preparation and their uent of viral diseases se as crop protection agents
ZA895090B (en)	1990-05-30	Novel benzopyran derivatives,processes for their preparation and their use and preparations containing the compounds
ZA857270B (en)	1986-05-28	Tetralin derivatives,their preparation and their use
NZ208831A (en)	1988-09-29	Imidazolium derivatives and pharmaceutical compositions
DE3173954D1 (en)	1986-04-10	Use of adenosin derivatives for the manufacture of psychopharmacons
DE3785046A1 (fi)	1993-04-29
EP0331092A3 (en)	1990-11-07	Alpha-amino-carboxylic-acid derivatives, their preparation and use
NO162557C (no)	1990-01-17	Analogifremgangsmaate ved fremstilling av terapeutisk aktive (pyrrol-1-yl)-fenyldihydropyridazinoner.
ES477785A1 (es)	1980-02-01	Procedimiento para la preparacion de nuevas 2-fenilimino- imidazolidinas sustituidas.
DE2966809D1 (en)	1984-04-19	3,4-diaza-bicyclo(4.1.0)hepten-2-ones-5, process for their preparation and therapeutical compositions containing them
ES2096559T3 (es)	1997-03-16	Interferon gamma humano, procedimiento para la preparacion de dicho interferon gamma humano, y su uso.
EP0418990A3 (en)	1991-07-03	13-bromo and 13,14-dibromo ergoline, their preparation and their use
ES520206A0 (es)	1983-12-01	Procedimiento para la preparacion de 11 -cloro-15-esteroides.
NO903585D0 (no)	1990-08-15	Fremgangsmaate for fremstilling av terapeutisk aktive 1,3-oksaziner.
DK159184A (da)	1985-01-13	Pterinforbindelser

Legal Events

Date	Code	Title	Description
1995-05-04	ND	Supplementary protection certificate (spc) granted
1995-05-04	SPCG	Supplementary protection certificate granted	Spc suppl protection certif: L39 Extension date: 20071208
2004-08-31	FG	Patent granted	Owner name: THE GENERAL HOSPITAL CORPORATION Owner name: THE WELLCOME FOUNDATION LIMITED
2005-08-08	MA	Patent expired