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DE19675039I2 - Bis-dimethoxymethyl(trimethox-ybenzyl)isochinolinium-Salze ihre Herstellung und diese enthaltende pharmazeutische Zusammensetzungen - Google Patents

Bis-dimethoxymethyl(trimethox-ybenzyl)isochinolinium-Salze ihre Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Info

Publication number
DE19675039I2
DE19675039I2 DE1996175039 DE19675039C DE19675039I2 DE 19675039 I2 DE19675039 I2 DE 19675039I2 DE 1996175039 DE1996175039 DE 1996175039 DE 19675039 C DE19675039 C DE 19675039C DE 19675039 I2 DE19675039 I2 DE 19675039I2
Authority
DE
Germany
Prior art keywords
trimethox
ybenzyl
dimethoxymethyl
bis
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE1996175039
Other languages
English (en)
Inventor
Swaringen, Jr
Hassan Ali El-Sayad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
General Hospital Corp
Original Assignee
Wellcome Foundation Ltd
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd, General Hospital Corp filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of DE19675039I2 publication Critical patent/DE19675039I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Jib Cranes (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
  • Cosmetics (AREA)
  • Fats And Perfumes (AREA)
  • Meat, Egg Or Seafood Products (AREA)
DE1996175039 1984-07-18 1985-07-17 Bis-dimethoxymethyl(trimethox-ybenzyl)isochinolinium-Salze ihre Herstellung und diese enthaltende pharmazeutische Zusammensetzungen Active DE19675039I2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848418303A GB8418303D0 (en) 1984-07-18 1984-07-18 Compounds

Publications (1)

Publication Number Publication Date
DE19675039I2 true DE19675039I2 (de) 2003-01-09

Family

ID=10564058

Family Applications (2)

Application Number Title Priority Date Filing Date
DE1996175039 Active DE19675039I2 (de) 1984-07-18 1985-07-17 Bis-dimethoxymethyl(trimethox-ybenzyl)isochinolinium-Salze ihre Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE8585305097T Expired - Lifetime DE3581699D1 (de) 1984-07-18 1985-07-17 Bis-dimethoxymethyl(trimethoxybenzyl)isochinolinium-salze, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8585305097T Expired - Lifetime DE3581699D1 (de) 1984-07-18 1985-07-17 Bis-dimethoxymethyl(trimethoxybenzyl)isochinolinium-salze, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Country Status (30)

Country Link
US (1) US4761418A (de)
EP (1) EP0181055B1 (de)
JP (1) JPH0662568B2 (de)
AT (1) ATE60759T1 (de)
AU (1) AU574481B2 (de)
BG (1) BG60411B2 (de)
CA (1) CA1273341A (de)
CY (1) CY1687A (de)
DD (1) DD235638A5 (de)
DE (2) DE19675039I2 (de)
DK (1) DK168093B1 (de)
ES (1) ES8609260A1 (de)
FI (1) FI85019C (de)
GB (1) GB8418303D0 (de)
GE (1) GEP19960468B (de)
HK (1) HK47593A (de)
HU (1) HU193996B (de)
IE (1) IE58138B1 (de)
IL (1) IL75833A (de)
LT (1) LT2078B (de)
LU (1) LU88801I2 (de)
LV (1) LV5483A3 (de)
MC (1) MC1690A1 (de)
MX (1) MX9203667A (de)
NL (1) NL940023I2 (de)
NZ (1) NZ212766A (de)
PL (1) PL146066B1 (de)
SG (1) SG3493G (de)
SU (1) SU1468414A3 (de)
ZA (1) ZA855407B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) * 1994-09-06 1996-04-23 Bencherif; Merouane Depolarizing skeletal muscle relaxants
EA002224B1 (ru) * 1997-03-25 2002-02-28 Глаксо Груп Лимитед Замещенные изохинолины в качестве нервно-мышечных блокаторов ультракраткосрочного действия
GB0204087D0 (en) * 2002-02-21 2002-04-10 Legislator 1563 Ltd Di-ester derivatives as short acting neuromuscular blockers
EP1684753A2 (de) * 2003-10-28 2006-08-02 Cornell Research Foundation, Inc. Neuromuskuläre blockiermittel und ihre antagonisten
US7872137B2 (en) * 2006-06-20 2011-01-18 Farmabios S.P.A. Process for the preparation of mivacurium chloride
JP5213137B2 (ja) * 2006-12-06 2013-06-19 コーネル リサーチ ファウンデーション， インコーポレイテッド 中程度の持続時間の神経筋遮断剤およびそのアンタゴニスト
WO2008107887A2 (en) * 2007-03-08 2008-09-12 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
AU2008231470A1 (en) * 2007-03-26 2008-10-02 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
WO2008132748A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
AU2008273724B2 (en) * 2007-05-01 2013-05-23 Chemagis Ltd. Process for Producing Cisatracurium and Associated Intermediates
BRPI0811687A2 (pt) * 2007-06-18 2015-02-18 Chemagis Ltd MÉTODO PARA SEPARAR O ISÔMETRO 1R-CIS, 1'R-CIS (cisatracúrio) DE UMA MISTURA DE ISÔMEROS DE SAIS DE (1R, 1'R) - ATRACÚRIO
BRPI0812625A2 (pt) * 2007-07-09 2019-02-19 Chemagis Ltd processo para preparar um sal de cis-atracúrio
CA2702535A1 (en) * 2007-10-29 2009-05-07 Chemagis Ltd. Novel r,r'-atracurium salts
ITMI20080319A1 (it) 2008-02-28 2009-08-29 Recordati Chem Pharm Processo per la risoluzione di derivati isochinolinici
AU2009241211A1 (en) * 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
WO2010107488A1 (en) 2009-03-17 2010-09-23 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
CN102573794B (zh) 2009-08-19 2017-03-15 康奈尔大学 供生理注射用的半胱氨酸
WO2013021398A2 (en) * 2011-08-05 2013-02-14 Sequent Scientific Limited A process for preparation of mivacurium chloride
JP6236077B2 (ja) 2012-06-29 2017-11-22 コーネル・ユニバーシティーＣｏｒｎｅｌｌ Ｕｎｉｖｅｒｓｉｔｙ 持続時間が超短期、短期、または中期の非対称性逆転可能神経筋遮断物質
CN103373959A (zh) * 2013-06-14 2013-10-30 安徽省先锋制药有限公司 顺式苄基异喹啉类化合物的制备方法及其用途
CN107782821B (zh) * 2016-08-26 2021-11-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂的分析方法
CN107778237A (zh) * 2016-08-26 2018-03-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂中间体的新晶型及其制备方法和用途
CN108938573B (zh) * 2017-05-26 2021-08-10 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂组合物及其制备方法和用途
CN108503564A (zh) * 2017-09-30 2018-09-07 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体及利用该中间体合成米库氯铵的方法
CN110361472B (zh) * 2019-07-29 2022-04-29 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体miv-g异构体的hplc检测方法
CN111004179B (zh) * 2019-11-11 2021-03-09 武汉大安制药有限公司 一种5’-甲氧基劳丹素的拆分方法
CN116410078A (zh) * 2021-12-29 2023-07-11 苏州特瑞药业股份有限公司 一种制备(e)-辛-4-烯-1,8-二酸的方法
WO2025140288A1 (zh) * 2023-12-25 2025-07-03 上海森辉医药有限公司 一种四氢异喹啉及其药物用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
GB863717A (en) * 1958-07-03 1961-03-22 Allen & Hanburys Ltd Tetrahydropapaverine derivatives and their preparation
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
BE869415A (fr) * 1977-08-01 1979-01-31 Massachusetts Gen Hospital Agents de blocage neuromusculaire
US4192877A (en) * 1977-08-01 1980-03-11 Massachusetts General Hospital Neuromuscular blocking agents
US4235906A (en) * 1978-07-21 1980-11-25 Massachusetts General Hospital Bis-isoquinolinium compounds, compositions and methods of use
CA1125287A (en) * 1978-07-21 1982-06-08 John J. Savarese Bis isoquinolinium compositions and methods of use
CA1153380A (en) * 1979-10-19 1983-09-06 Hassan A. El-Sayad Neuromuscular blocking tetrahydroisoquinolinium salts
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
DE3165714D1 (en) * 1980-12-17 1984-09-27 Wellcome Found Long duration neuromuscular blocking agents, pharmaceutical compositions containing them and processes for their preparation
JPS5899465A (ja) * 1981-11-23 1983-06-13 ザ・ウエルカム・フアウンデ−シヨン・リミテツド イソキノリン誘導体

Also Published As

Publication number Publication date
DE3581699D1 (de) 1991-03-14
EP0181055B1 (de) 1991-02-06
DK324985A (da) 1986-01-19
ES8609260A1 (es) 1986-09-01
NL940023I1 (nl) 1995-01-02
MX9203667A (es) 1992-07-31
US4761418A (en) 1988-08-02
EP0181055A1 (de) 1986-05-14
FI852807L (fi) 1986-01-19
IE58138B1 (en) 1993-07-14
IE851791L (en) 1986-01-18
FI85019B (fi) 1991-11-15
SG3493G (en) 1993-03-12
GEP19960468B (en) 1996-08-29
BG60411B2 (bg) 1995-02-28
ATE60759T1 (de) 1991-02-15
PL146066B1 (en) 1988-12-31
NL940023I2 (nl) 1998-06-02
HUT40626A (en) 1987-01-28
FI852807A0 (fi) 1985-07-17
AU574481B2 (en) 1988-07-07
DD235638A5 (de) 1986-05-14
AU4510885A (en) 1986-01-23
CA1273341A (en) 1990-08-28
LT2078B (lt) 1993-06-15
PL254571A1 (en) 1986-07-15
FI85019C (fi) 1992-02-25
SU1468414A3 (ru) 1989-03-23
IL75833A0 (en) 1985-11-29
MC1690A1 (fr) 1986-07-18
JPH0662568B2 (ja) 1994-08-17
DK324985D0 (da) 1985-07-17
DK168093B1 (da) 1994-02-07
JPS6187666A (ja) 1986-05-06
HK47593A (en) 1993-05-21
CY1687A (en) 1993-10-10
LU88801I2 (fr) 1996-11-05
ES545319A0 (es) 1986-09-01
IL75833A (en) 1988-11-30
HU193996B (en) 1987-12-28
NZ212766A (en) 1988-03-30
ZA855407B (en) 1986-04-30
LV5483A3 (lv) 1994-03-10
GB8418303D0 (en) 1984-08-22

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