FI781161A - 2-(2,2-diarylalkyl)-1-azabicyklo 2.2.2-oktan - Google Patents

2-(2,2-diarylalkyl)-1-azabicyklo 2.2.2-oktan

Info

Publication number: FI781161A
Authority: FI; Finland
Prior art keywords: diarylalkyl; azabicyclo; octane
Prior art date: 1977-04-18

Application number

FI781161A

Other languages

English (en)

Inventor

Chung Hwai Yen

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-04-18

Filing date

1978-04-17

Publication date

1978-10-19

1978-04-17 Application filed by Searle & Co filed Critical Searle & Co

1978-10-19 Publication of FI781161A publication Critical patent/FI781161A/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)

FI781161A 1977-04-18 1978-04-17 2-(2,2-diarylalkyl)-1-azabicyklo 2.2.2-oktan FI781161A (fi)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/788,189 US4125531A (en)	1977-04-18	1977-04-18	2-Substituted-1-azabicyclo[2.2.2]octanes

Publications (1)

Publication Number	Publication Date
FI781161A true FI781161A (fi)	1978-10-19

Family

ID=25143721

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI781161A FI781161A (fi)	1977-04-18	1978-04-17	2-(2,2-diarylalkyl)-1-azabicyklo 2.2.2-oktan

Country Status (19)

Country	Link
US (1)	US4125531A (fi)
JP (1)	JPS53132596A (fi)
AT (1)	AT357553B (fi)
AU (1)	AU3516178A (fi)
BE (1)	BE866031A (fi)
DE (1)	DE2816633A1 (fi)
DK (1)	DK166978A (fi)
ES (1)	ES468874A1 (fi)
FI (1)	FI781161A (fi)
FR (1)	FR2387980A1 (fi)
GB (1)	GB1569249A (fi)
IE (1)	IE46737B1 (fi)
IL (1)	IL54519A0 (fi)
NL (1)	NL7804145A (fi)
NO (1)	NO781333L (fi)
NZ (1)	NZ186991A (fi)
PT (1)	PT67910B (fi)
SE (1)	SE7804307L (fi)
ZA (1)	ZA782212B (fi)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4203989A (en) *	1979-04-30	1980-05-20	G. D. Searle & Co.	Anti-diarrheal diaryl-(1-azabicyclo(2.2.2)octan-2-yl)-alkanols and related compounds
US4203990A (en) *	1979-04-30	1980-05-20	G. D. Searle & Co.	Anti-diarrheal 2-substituted quinuclidines
US4599344A (en) *	1984-10-31	1986-07-08	Schering A.G.	Quinuclidines and quinuclidinium salts as antiarrhythmic agents
CA2022886A1 (en) *	1989-08-08	1991-02-09	Raymond Baker	Substituted pyridines, their preparation, formulations and use in dementia
DE69220258T2 (de) *	1991-02-11	1997-12-18	Merck Sharp & Dohme	Azabicyclische Verbindungen, diese enthaltende pharmazeutische Zubereitungen und ihre therapeutische Verwendung
US6190691B1 (en)	1994-04-12	2001-02-20	Adolor Corporation	Methods for treating inflammatory conditions
US5962477A (en) *	1994-04-12	1999-10-05	Adolor Corporation	Screening methods for cytokine inhibitors
US6573282B1 (en)	1995-09-12	2003-06-03	Adolor Corporation	Peripherally active anti-hyperalgesic opiates
US5849761A (en) *	1995-09-12	1998-12-15	Regents Of The University Of California	Peripherally active anti-hyperalgesic opiates
US6353004B1 (en)	1997-07-14	2002-03-05	Adolor Coporation	Peripherally acting anti-pruritic opiates
US5849762A (en) *	1997-07-14	1998-12-15	Adolor Corporation	Peripherally acting anti-pruritic opiates
CN104383542B (zh)	2003-04-08	2017-09-26	普罗热尼奇制药公司	包含甲基纳曲酮的药物配方
AR057325A1 (es)	2005-05-25	2007-11-28	Progenics Pharm Inc	Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es)	2005-05-25	2007-11-14	Progenics Pharm Inc	SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
EP2565195B1 (en)	2007-03-29	2015-05-06	Wyeth LLC	Peripheral opioid receptor and antagonists and uses thereof
CA2865661C (en)	2007-03-29	2016-05-17	Progenics Pharmaceuticals, Inc.	Peripheral opioid receptor antagonists and uses thereof
EP2134718A2 (en)	2007-03-29	2009-12-23	Progenics Pharmaceuticals, Inc.	Crystal forms of (r)-n-methylnaltrexone bromide and uses thereof
WO2009099411A1 (en)	2008-02-06	2009-08-13	Progenics Pharmaceuticals, Inc.	Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
CA2676881C (en)	2008-09-30	2017-04-25	Wyeth	Peripheral opioid receptor antagonists and uses thereof
CN110372571B (zh)	2018-04-12	2022-11-15	中国科学院大连化学物理研究所	一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3506672A (en) *	1968-03-29	1970-04-14	Aldrich Chem Co Inc	2-(4,4'-dihalo)-benzhydryl-3-quinuclidinols
SU495310A1 (ru) *	1974-03-05	1975-12-15	Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе	Хинуклидил-3-диарал(гетерил) карбинолы, про вл ющие антигистаминную, антисеротониновую и антиаллергическую активность и способ их получени
US4013667A (en) *	1976-03-08	1977-03-22	G. D. Searle & Co.	2,2-Diaryl-3-(1-azabicyclo[2.2.2]oct-2-yl)propionamides and intermediates thereto

1977
- 1977-04-18 US US05/788,189 patent/US4125531A/en not_active Expired - Lifetime
1978
- 1978-04-17 BE BE186827A patent/BE866031A/xx unknown
- 1978-04-17 AT AT266178A patent/AT357553B/de not_active IP Right Cessation
- 1978-04-17 NO NO781333A patent/NO781333L/no unknown
- 1978-04-17 IE IE745/78A patent/IE46737B1/en unknown
- 1978-04-17 GB GB14965/78A patent/GB1569249A/en not_active Expired
- 1978-04-17 AU AU35161/78A patent/AU3516178A/en active Pending
- 1978-04-17 ES ES468874A patent/ES468874A1/es not_active Expired
- 1978-04-17 NZ NZ186991A patent/NZ186991A/xx unknown
- 1978-04-17 FI FI781161A patent/FI781161A/fi not_active Application Discontinuation
- 1978-04-17 DE DE19782816633 patent/DE2816633A1/de not_active Withdrawn
- 1978-04-17 PT PT67910A patent/PT67910B/pt unknown
- 1978-04-17 DK DK166978A patent/DK166978A/da not_active IP Right Cessation
- 1978-04-17 SE SE7804307A patent/SE7804307L/xx unknown
- 1978-04-17 IL IL54519A patent/IL54519A0/xx unknown
- 1978-04-18 JP JP4578878A patent/JPS53132596A/ja active Pending
- 1978-04-18 ZA ZA00782212A patent/ZA782212B/xx unknown
- 1978-04-18 FR FR7811370A patent/FR2387980A1/fr not_active Withdrawn
- 1978-04-18 NL NL7804145A patent/NL7804145A/xx not_active Application Discontinuation

Also Published As

Publication number	Publication date
SE7804307L (sv)	1978-10-19
NO781333L (no)	1978-10-19
IE780745L (en)	1978-10-18
PT67910B (en)	1979-11-14
US4125531A (en)	1978-11-14
JPS53132596A (en)	1978-11-18
ES468874A1 (es)	1978-12-01
PT67910A (en)	1978-05-01
GB1569249A (en)	1980-06-11
AU3516178A (en)	1979-10-25
NL7804145A (nl)	1978-10-20
AT357553B (de)	1980-07-25
IE46737B1 (en)	1983-09-07
ATA266178A (de)	1979-12-15
DK166978A (da)	1978-10-19
DE2816633A1 (de)	1978-10-19
IL54519A0 (en)	1978-07-31
FR2387980A1 (fr)	1978-11-17
ZA782212B (en)	1979-11-28
BE866031A (fr)	1978-10-17
NZ186991A (en)	1979-12-11

Publication	Publication Date	Title
NO161737C (no)	1989-09-20	1,2,5-tiadiazolderivater.
FI850198L (fi)	1985-01-16	Expressionsplasmid.
FI781161A (fi)	1978-10-19	2-(2,2-diarylalkyl)-1-azabicyklo 2.2.2-oktan
ES256673Y (es)	1981-12-16	Guardavistas.
NO153847C (no)	1986-06-04	2,4,4-triklor-4-formyl-butyronitril.
ES254327Y (es)	1982-02-16	Portillon.
FI73548B (fi)	1987-06-30	Oeverstroemskyddskrets foer effekttransistor.
NL7920160A (nl)	1980-12-31	24,24-difluor-25-hydroxycholecalciferol.
NO802172L (no)	1981-02-11	Substituerte difenyletere.
NO793494L (no)	1981-05-04	Sylinderlaas i.
IT7823796A0 (it)	1978-05-25	1,2,4-triazolidin-3-oni e-tioni.
NO853995L (no)	1978-10-03	"2-(2`,2`,2`-trihalogenetyl)-4-halogencyklobutan-1-oner.
FI73539B (fi)	1987-06-30	Multiplexanslutningsenhet foer en digitalstation.
IT1196913B (it)	1988-11-25	6,7 secoergoline
NL7901111A (nl)	1979-10-05	2,3-dihydro-4h-1-benzopyran-4-on-0-carbamoyloximen.
IT8021230A0 (it)	1980-04-04	Amminoacetonitrili idrossiimmino sostituiti.
NL7803610A (nl)	1978-10-09	2,4,6-trigesubstitueerde 2,3-dihydrobenzofuranen.
NL7808193A (nl)	1979-02-06	Biocide-actieve 1,2,3-benzotrisulfiden.
IT1209140B (it)	1989-07-10	6 alfa-fluoro-prednisolone 17,21-diesteri.
IT7925626A0 (it)	1979-09-11	2,6-metano-3-benzazocine.
ES240710Y (es)	1979-12-01	Nivel perfeccionado.
ES230161Y (es)	1978-02-16	Husillo.
FI850195A0 (fi)	1985-01-16	Foerfarande foer framstaellning av 2 -hydroximetyl-3,4,5-trihydroxipiperidinderivat.
ES244281Y (es)	1980-06-16	Somier simplificado.
FI860774A (fi)	1986-02-21	3,4,5-trihydroxipiperidinderivat.

Legal Events

Date	Code	Title	Description
2004-08-31	FD	Application lapsed	Owner name: G D SEARLE & CO.