BE866031A - Nouveaux 2-(2,2-diarylalkyl)-1-azabicyclo (2,2,2)octanes, utiles notamment comme antidiarrheiques, et leur procede de preparation - Google Patents

Nouveaux 2-(2,2-diarylalkyl)-1-azabicyclo (2,2,2)octanes, utiles notamment comme antidiarrheiques, et leur procede de preparation

Info

Publication number: BE866031A
Authority: BE; Belgium
Prior art keywords: antidiarrheics; diarylalkyl; octanes; azabicyclo; useful
Prior art date: 1977-04-18

Application number

BE186827A

Other languages

English (en)

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-04-18

Filing date

1978-04-17

Publication date

1978-10-17

1978-04-17 Application filed by Searle & Co filed Critical Searle & Co

1978-10-17 Publication of BE866031A publication Critical patent/BE866031A/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)

BE186827A 1977-04-18 1978-04-17 Nouveaux 2-(2,2-diarylalkyl)-1-azabicyclo (2,2,2)octanes, utiles notamment comme antidiarrheiques, et leur procede de preparation BE866031A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/788,189 US4125531A (en)	1977-04-18	1977-04-18	2-Substituted-1-azabicyclo[2.2.2]octanes

Publications (1)

Publication Number	Publication Date
BE866031A true BE866031A (fr)	1978-10-17

Family

ID=25143721

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE186827A BE866031A (fr)	1977-04-18	1978-04-17	Nouveaux 2-(2,2-diarylalkyl)-1-azabicyclo (2,2,2)octanes, utiles notamment comme antidiarrheiques, et leur procede de preparation

Country Status (19)

Country	Link
US (1)	US4125531A (fr)
JP (1)	JPS53132596A (fr)
AT (1)	AT357553B (fr)
AU (1)	AU3516178A (fr)
BE (1)	BE866031A (fr)
DE (1)	DE2816633A1 (fr)
DK (1)	DK166978A (fr)
ES (1)	ES468874A1 (fr)
FI (1)	FI781161A (fr)
FR (1)	FR2387980A1 (fr)
GB (1)	GB1569249A (fr)
IE (1)	IE46737B1 (fr)
IL (1)	IL54519A0 (fr)
NL (1)	NL7804145A (fr)
NO (1)	NO781333L (fr)
NZ (1)	NZ186991A (fr)
PT (1)	PT67910B (fr)
SE (1)	SE7804307L (fr)
ZA (1)	ZA782212B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4203989A (en) *	1979-04-30	1980-05-20	G. D. Searle & Co.	Anti-diarrheal diaryl-(1-azabicyclo(2.2.2)octan-2-yl)-alkanols and related compounds
US4203990A (en) *	1979-04-30	1980-05-20	G. D. Searle & Co.	Anti-diarrheal 2-substituted quinuclidines
US4599344A (en) *	1984-10-31	1986-07-08	Schering A.G.	Quinuclidines and quinuclidinium salts as antiarrhythmic agents
CA2022886A1 (fr) *	1989-08-08	1991-02-09	Raymond Baker	Pyridines substituees, leur preparation, leurs formules et leur utilisation pour le traitement de la demence
DE69220258T2 (de) *	1991-02-11	1997-12-18	Merck Sharp & Dohme	Azabicyclische Verbindungen, diese enthaltende pharmazeutische Zubereitungen und ihre therapeutische Verwendung
US6190691B1 (en)	1994-04-12	2001-02-20	Adolor Corporation	Methods for treating inflammatory conditions
US5962477A (en) *	1994-04-12	1999-10-05	Adolor Corporation	Screening methods for cytokine inhibitors
US6573282B1 (en)	1995-09-12	2003-06-03	Adolor Corporation	Peripherally active anti-hyperalgesic opiates
US5849761A (en) *	1995-09-12	1998-12-15	Regents Of The University Of California	Peripherally active anti-hyperalgesic opiates
US6353004B1 (en)	1997-07-14	2002-03-05	Adolor Coporation	Peripherally acting anti-pruritic opiates
US5849762A (en) *	1997-07-14	1998-12-15	Adolor Corporation	Peripherally acting anti-pruritic opiates
CN104383542B (zh)	2003-04-08	2017-09-26	普罗热尼奇制药公司	包含甲基纳曲酮的药物配方
AR057325A1 (es)	2005-05-25	2007-11-28	Progenics Pharm Inc	Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es)	2005-05-25	2007-11-14	Progenics Pharm Inc	SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
EP2565195B1 (fr)	2007-03-29	2015-05-06	Wyeth LLC	Récepteur opioïde périphérique et son antagoniste ainsi que leurs utilisations
CA2865661C (fr)	2007-03-29	2016-05-17	Progenics Pharmaceuticals, Inc.	Antagonistes de recepteurs opioides peripheriques, et leurs utilisations
EP2134718A2 (fr)	2007-03-29	2009-12-23	Progenics Pharmaceuticals, Inc.	Formes cristallines, et leurs utilisations
WO2009099411A1 (fr)	2008-02-06	2009-08-13	Progenics Pharmaceuticals, Inc.	Préparation et utilisation de (r),(r)-2,2'-bis-méthylnaltrexone
CA2676881C (fr)	2008-09-30	2017-04-25	Wyeth	Antagonistes de recepteurs opioides peripheriques, et leurs utilisations
CN110372571B (zh)	2018-04-12	2022-11-15	中国科学院大连化学物理研究所	一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3506672A (en) *	1968-03-29	1970-04-14	Aldrich Chem Co Inc	2-(4,4'-dihalo)-benzhydryl-3-quinuclidinols
SU495310A1 (ru) *	1974-03-05	1975-12-15	Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе	Хинуклидил-3-диарал(гетерил) карбинолы, про вл ющие антигистаминную, антисеротониновую и антиаллергическую активность и способ их получени
US4013667A (en) *	1976-03-08	1977-03-22	G. D. Searle & Co.	2,2-Diaryl-3-(1-azabicyclo[2.2.2]oct-2-yl)propionamides and intermediates thereto

1977
- 1977-04-18 US US05/788,189 patent/US4125531A/en not_active Expired - Lifetime
1978
- 1978-04-17 BE BE186827A patent/BE866031A/fr unknown
- 1978-04-17 AT AT266178A patent/AT357553B/de not_active IP Right Cessation
- 1978-04-17 NO NO781333A patent/NO781333L/no unknown
- 1978-04-17 IE IE745/78A patent/IE46737B1/en unknown
- 1978-04-17 GB GB14965/78A patent/GB1569249A/en not_active Expired
- 1978-04-17 AU AU35161/78A patent/AU3516178A/en active Pending
- 1978-04-17 ES ES468874A patent/ES468874A1/es not_active Expired
- 1978-04-17 NZ NZ186991A patent/NZ186991A/xx unknown
- 1978-04-17 FI FI781161A patent/FI781161A/fi not_active Application Discontinuation
- 1978-04-17 DE DE19782816633 patent/DE2816633A1/de not_active Withdrawn
- 1978-04-17 PT PT67910A patent/PT67910B/pt unknown
- 1978-04-17 DK DK166978A patent/DK166978A/da not_active IP Right Cessation
- 1978-04-17 SE SE7804307A patent/SE7804307L/xx unknown
- 1978-04-17 IL IL54519A patent/IL54519A0/xx unknown
- 1978-04-18 JP JP4578878A patent/JPS53132596A/ja active Pending
- 1978-04-18 ZA ZA00782212A patent/ZA782212B/xx unknown
- 1978-04-18 FR FR7811370A patent/FR2387980A1/fr not_active Withdrawn
- 1978-04-18 NL NL7804145A patent/NL7804145A/xx not_active Application Discontinuation

Also Published As

Publication number	Publication date
SE7804307L (sv)	1978-10-19
NO781333L (no)	1978-10-19
IE780745L (en)	1978-10-18
PT67910B (en)	1979-11-14
US4125531A (en)	1978-11-14
JPS53132596A (en)	1978-11-18
ES468874A1 (es)	1978-12-01
PT67910A (en)	1978-05-01
GB1569249A (en)	1980-06-11
AU3516178A (en)	1979-10-25
NL7804145A (nl)	1978-10-20
AT357553B (de)	1980-07-25
IE46737B1 (en)	1983-09-07
ATA266178A (de)	1979-12-15
DK166978A (da)	1978-10-19
DE2816633A1 (de)	1978-10-19
IL54519A0 (en)	1978-07-31
FR2387980A1 (fr)	1978-11-17
ZA782212B (en)	1979-11-28
FI781161A (fi)	1978-10-19
NZ186991A (en)	1979-12-11

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