[go: up one dir, main page]

FI117923B - Kielenalainen tai poskensisäinen farmaseuttinen koostumus - Google Patents

Kielenalainen tai poskensisäinen farmaseuttinen koostumus Download PDF

Info

Publication number
FI117923B
FI117923B FI963398A FI963398A FI117923B FI 117923 B FI117923 B FI 117923B FI 963398 A FI963398 A FI 963398A FI 963398 A FI963398 A FI 963398A FI 117923 B FI117923 B FI 117923B
Authority
FI
Finland
Prior art keywords
sublingual
pharmaceutical composition
methyl
chloro
tetrahydro
Prior art date
Application number
FI963398A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI963398L (fi
FI963398A0 (fi
Inventor
Johannes Hubertus Wieringa
Leonardus Petrus C Delbressine
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8216678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI117923(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Organon Nv filed Critical Organon Nv
Publication of FI963398L publication Critical patent/FI963398L/fi
Publication of FI963398A0 publication Critical patent/FI963398A0/fi
Application granted granted Critical
Publication of FI117923B publication Critical patent/FI117923B/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI963398A 1994-03-02 1996-08-30 Kielenalainen tai poskensisäinen farmaseuttinen koostumus FI117923B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP94200521 1994-03-02
EP94200521 1994-03-02
EP9500765 1995-03-01
PCT/EP1995/000765 WO1995023600A1 (en) 1994-03-02 1995-03-01 Sublingual or buccal pharmaceutical composition

Publications (3)

Publication Number Publication Date
FI963398L FI963398L (fi) 1996-08-30
FI963398A0 FI963398A0 (fi) 1996-08-30
FI117923B true FI117923B (fi) 2007-04-30

Family

ID=8216678

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963398A FI117923B (fi) 1994-03-02 1996-08-30 Kielenalainen tai poskensisäinen farmaseuttinen koostumus

Country Status (23)

Country Link
US (1) US5763476A (no)
EP (1) EP0746317B1 (no)
JP (2) JP4099224B2 (no)
KR (1) KR100330942B1 (no)
CN (1) CN1079670C (no)
AT (1) ATE167057T1 (no)
AU (1) AU692530B2 (no)
BR (2) BR9506924A (no)
CA (1) CA2182981C (no)
CZ (1) CZ284633B6 (no)
DE (2) DE69502939T2 (no)
DK (1) DK0746317T3 (no)
ES (1) ES2118584T3 (no)
FI (1) FI117923B (no)
FR (1) FR10C0056I2 (no)
HK (1) HK1008417A1 (no)
HU (1) HU225051B1 (no)
LU (1) LU91751I2 (no)
NO (2) NO308772B1 (no)
NZ (1) NZ282394A (no)
PL (1) PL180465B1 (no)
RU (1) RU2139051C1 (no)
WO (1) WO1995023600A1 (no)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2418499A (en) * 1997-12-19 1999-07-12 Akzo Nobel N.V. Org-5222 in the treatment of depression
US7993674B2 (en) * 2002-02-13 2011-08-09 Weibel Michael K Drug dose-form and method of manufacture
US7276246B2 (en) * 2003-05-09 2007-10-02 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
US7306812B2 (en) 2003-05-09 2007-12-11 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
AU2004237951A1 (en) * 2003-05-16 2004-11-25 Pfizer Products Inc. Therapeutic combinations of atypical antipsychotics with GABA modulators, anticonvulsants or benzodiazapines
TWI327915B (en) * 2003-06-12 2010-08-01 Organon Nv Pharmaceutical composition comprising antipsychotic agent and use of the antipsychotic agent for treating patients with overweight
RU2392004C2 (ru) * 2003-09-22 2010-06-20 Бакстер Интернэшнл Инк. Стерилизация под высоким давлением для заключительной стерилизации фармацевтических препаратов и медицинских изделий
EP1753460A2 (en) * 2004-05-11 2007-02-21 Pfizer Products Inc. Combination of atypical antipsychotics and 5-ht1b receptor antagonists
GB0416861D0 (en) * 2004-07-29 2004-09-01 Quadrant Drug Delivery Ltd Composition
JP2008516925A (ja) * 2004-10-15 2008-05-22 ナームローゼ・フエンノートチヤツプ・オルガノン 双極性障害および随伴症状の治療
NZ562124A (en) * 2005-04-07 2010-07-30 Organon Nv Crystal form of asenapine maleate
BRPI0610677A2 (pt) 2005-04-07 2012-10-30 Organon Nv derivado de trans-aminoácido, e, processos para a preparação do mesmo e para a preparação de asenapina
US7872147B2 (en) 2005-04-07 2011-01-18 N. V. Organon Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
US7741358B2 (en) 2005-04-14 2010-06-22 N.V. Organon Crystal form of asenapine maleate
US7750167B2 (en) 2006-07-05 2010-07-06 N.V. Organon Process for the preparation of asenapine and intermediate products used in said process
US7875729B2 (en) 2007-01-05 2011-01-25 Synthon Bv Process for making asenapine
PE20091156A1 (es) * 2007-12-17 2009-09-03 Astrazeneca Ab Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo
WO2009156889A1 (en) * 2008-06-25 2009-12-30 Pfizer Inc. Diaryl compounds and uses thereof
WO2010127674A1 (en) * 2009-05-06 2010-11-11 Sunin K/S Transdermal compositions of asenapine for the treatment of psychiatric disorders
RU2012102247A (ru) 2009-06-24 2013-07-27 Мсд Осс Б.В. Инъекционные композиции, содержащие асенапин и способ лечения с их применением
TW201118102A (en) 2009-07-29 2011-06-01 Organon Nv Hydroxyasenapine compounds, derivatives thereof and pharmaceutical compositions comprising same
US8779161B2 (en) 2010-06-18 2014-07-15 Dr. Reddy's Laboratories Limited Asenapine maleate
EP2598496B1 (en) 2010-07-29 2014-03-19 Laboratorios Lesvi, S.L. Novel process for the preparation of asenapine
WO2012038975A2 (en) * 2010-09-22 2012-03-29 Msn Laboratories Limited Process for the preparation of (3ars,12brs)-5-chloro-2-methyl-2,3,3a12b-tetrahydro-1hdibenzo[2,3:6,7] oxepino [4,5-c]pyrrole maleate and it's pharmaceutical composition thereof
MX383953B (es) 2010-11-15 2025-03-14 Agenebio Inc Derivados de piridazina, composiciones y metodos para tratar deterioro cognitivo.
WO2012066565A2 (en) 2010-11-16 2012-05-24 Cadila Healthcare Limited Asenapine maleate amorphous and crystalline form and process for preparation thereof
EP2468750A1 (en) 2010-12-13 2012-06-27 Chemo Ibérica, S.A. Polymorphic forms of asenapine maleate and processes for their preparation
WO2012123325A1 (en) 2011-03-11 2012-09-20 Medichem S.A. NEW CRYSTAL FORMS OF THE SALT OF TRANS-5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE WITH MALEIC ACID
EP2524919A1 (en) 2011-05-17 2012-11-21 Sandoz AG Novel crystalline salts of Asenapine with organic Di-acids and Tri-acids
EP2709616B1 (en) 2011-05-18 2018-01-24 Laboratorios Lesvi, S.L. Synthesis of a stable micronised monoclinic form of asenapine maleate
US9533994B2 (en) 2011-05-18 2017-01-03 Laboratorios Lesvi S.L. Monoclinic crystalline form of asenapine maleate with a specific particle size distribution
EP2572703A1 (en) 2011-09-21 2013-03-27 Hexal AG Compressed oral dosage form for asenapine maleate
WO2013041604A1 (en) 2011-09-21 2013-03-28 Sandoz Ag Crystal form of asenapine maleate
CN102657635B (zh) * 2012-05-04 2013-08-07 上海现代药物制剂工程研究中心有限公司 具有微孔的海绵状的阿塞那平舌下膜剂及其制备方法
ITMI20121810A1 (it) 2012-10-24 2014-04-25 Chemo Iberica Sa Poliformi di maleato di asenapina e processo per la loro preparazione
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia
US9597291B2 (en) 2012-12-11 2017-03-21 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Orally disintegrating tablet containing asenapine
EP2934486A2 (en) 2012-12-20 2015-10-28 Kashiv Pharma, LLC Orally disintegrating tablet formulation for enhanced bioavailability
CN103893139B (zh) * 2012-12-28 2018-06-08 石药集团中奇制药技术（石家庄）有限公司 一种阿塞那平组合物及其制备方法
CN103120688A (zh) * 2013-01-11 2013-05-29 盛世泰科生物医药技术(苏州)有限公司 一种闪释制剂的药物组合
US9545376B2 (en) 2013-01-23 2017-01-17 Arx, Llc Production of unit dose constructs
WO2014127786A1 (en) 2013-02-22 2014-08-28 Zentiva, K.S. Orally disintegrating pharmaceutical composition comprising asenapine
WO2014207664A2 (en) * 2013-06-28 2014-12-31 Alembic Pharmaceuticals Limited Stable pharmaceutical composition of asenapine
US10329301B2 (en) 2013-12-20 2019-06-25 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20170007537A1 (en) * 2014-02-18 2017-01-12 Hetero Research Foundation Pharmaceutical compositions of asenapine
RU2728787C2 (ru) 2014-04-04 2020-07-31 Интра-Селлулар Терапиз, Инк. Органические соединения
TR201509009A1 (en) * 2014-12-11 2017-02-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi THIN FILM STRIP OF ASENAPINE
CA2987081C (en) 2015-06-11 2022-08-30 Alrise Biosystems Gmbh Process for the preparation of drug loaded microparticles
EA036844B1 (ru) 2015-06-19 2020-12-28 Эйджинбайо, Инк. Производные бензодиазепина, композиции и способы для лечения когнитивного нарушения
PL3838274T3 (pl) 2016-01-26 2024-04-02 Intra-Cellular Therapies, Inc. Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN
PT3407889T (pt) 2016-03-25 2021-07-14 Intra Cellular Therapies Inc Compostos orgânicos e a sua utilização no tratamento ou prevenção de distúrbios do sistema nervoso central
US10085971B2 (en) 2016-08-22 2018-10-02 Navinta Iii Inc Pharmaceutical solution of asenapine for sublingual or buccal use
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
BR112019012821A2 (pt) 2016-12-19 2019-11-26 Agenebio Inc derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo
MX382132B (es) 2016-12-20 2025-03-13 Lts Lohmann Therapie Systeme Ag Sistema terapeutico transdermico que contiene asenapina y polisiloxano o poliisobutileno
EP3338768B1 (en) 2016-12-20 2019-10-30 LTS Lohmann Therapie-Systeme AG Transdermal therapeutic system containing asenapine
WO2018126140A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
JP6987868B2 (ja) 2016-12-29 2022-01-05 イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. 有機化合物
WO2018175969A1 (en) 2017-03-24 2018-09-27 Intra-Cellular Therapies, Inc. Novel compositions and methods
WO2019002204A1 (en) 2017-06-26 2019-01-03 Lts Lohmann Therapie-Systeme Ag TRANSDERMAL THERAPEUTIC SYSTEM CONTAINING ASENAPINE AND SILICONE-TYPE ACRYLIC HYBRID POLYMER
US11980617B2 (en) 2018-03-16 2024-05-14 Intra-Cellular Therapies, Inc. Methods of treating acute depression and/or acute anxiety
CA3094949A1 (en) 2018-03-23 2019-09-26 Intra-Cellular Therapies, Inc. Deuterated heterocycle fused gamma-carbolines
JP7514534B2 (ja) 2018-06-19 2024-07-11 エージンバイオ， インコーポレイテッド 認知障害を処置するためのベンゾジアゼピン誘導体、組成物および方法
CA3101420A1 (en) 2018-06-20 2019-12-26 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine
US12329862B2 (en) 2018-06-20 2025-06-17 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine
WO2020047241A1 (en) 2018-08-29 2020-03-05 Intra-Cellular Therapies, Inc. Novel compositions and methods
JP7457000B2 (ja) 2018-08-31 2024-03-27 イントラ－セルラー・セラピーズ・インコーポレイテッド 新規方法
JP7546546B2 (ja) 2018-08-31 2024-09-06 イントラ－セルラー・セラピーズ・インコーポレイテッド 新規方法
US20210000822A1 (en) 2019-07-07 2021-01-07 Intra-Cellular Therapies, Inc. Novel methods
AU2023324882A1 (en) 2022-08-19 2025-03-20 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7605526A (nl) * 1976-05-24 1977-11-28 Akzo Nv Nieuwe tetracyclische derivaten.
GB1548022A (en) * 1976-10-06 1979-07-04 Wyeth John & Brother Ltd Pharmaceutial dosage forms
IE45770B1 (en) * 1976-10-06 1982-11-17 Wyeth John & Brother Ltd Pharmaceutical dosage forms
FR2480283A1 (fr) * 1980-04-10 1981-10-16 Science Union & Cie Nouveaux derives tricycliques, leurs procedes de preparation et leur utilisation comme medicament
JPS5967218A (ja) * 1982-10-07 1984-04-16 Grelan Pharmaceut Co Ltd 軟質な口腔製剤
GB8613688D0 (en) * 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
CA2027243A1 (en) * 1989-10-17 1991-04-18 Everett H. Ellinwood, Jr. Intraoral formulated trifluorobenzodiazepines and the use thereof
WO1992017209A1 (en) * 1991-04-08 1992-10-15 Sumitomo Pharmaceuticals Company, Limited Porous solid preparation containing physiologically active protein substance
CA2095499A1 (en) * 1992-05-08 1993-11-09 Petrus J. M. Van Den Oetelaar Depot preparation
EP0569096A1 (en) * 1992-05-08 1993-11-10 Akzo Nobel N.V. Depot preparation

Also Published As

Publication number Publication date
US5763476A (en) 1998-06-09
HUT76319A (en) 1997-08-28
PL180465B1 (pl) 2001-02-28
NO2010024I2 (no) 2012-04-10
BR9506924A (pt) 1997-09-30
NO963639L (no) 1996-10-30
LU91751I2 (fr) 2011-01-04
AU1947895A (en) 1995-09-18
DE69502939T2 (de) 1998-10-22
CN1079670C (zh) 2002-02-27
WO1995023600A1 (en) 1995-09-08
AU692530B2 (en) 1998-06-11
CA2182981A1 (en) 1995-09-08
NO2010024I1 (no) 2011-01-03
DE69502939D1 (de) 1998-07-16
JP4099224B2 (ja) 2008-06-11
FI963398L (fi) 1996-08-30
BR1100625A (pt) 1999-12-28
KR100330942B1 (ko) 2002-11-16
PL316080A1 (en) 1996-12-23
NZ282394A (en) 1997-12-19
EP0746317A1 (en) 1996-12-11
CZ284633B6 (cs) 1999-01-13
NO308772B1 (no) 2000-10-30
FI963398A0 (fi) 1996-08-30
NO963639D0 (no) 1996-08-30
ATE167057T1 (de) 1998-06-15
MX9603713A (es) 1997-12-31
DE122010000050I1 (de) 2011-05-05
DE122010000050I2 (de) 2011-07-21
CN1143320A (zh) 1997-02-19
FR10C0056I1 (no) 2011-01-28
DK0746317T3 (da) 1999-03-22
HU225051B1 (en) 2006-05-29
HU9602383D0 (en) 1996-10-28
RU2139051C1 (ru) 1999-10-10
HK1008417A1 (en) 1999-05-07
JP4616810B2 (ja) 2011-01-19
FR10C0056I2 (no) 2011-11-25
EP0746317B1 (en) 1998-06-10
CA2182981C (en) 2006-10-17
CZ254196A3 (en) 1997-10-15
ES2118584T3 (es) 1998-09-16
JPH09509674A (ja) 1997-09-30
JP2006342178A (ja) 2006-12-21

Similar Documents

Publication Publication Date Title
FI117923B (fi) Kielenalainen tai poskensisäinen farmaseuttinen koostumus
HK1008417B (en) Sublingual or buccal pharmaceutical composition
EP1246668B1 (en) An rapid acting freeze dired oral pharmaceutical composition for treating migraine
JP3001264B2 (ja) 凍結乾燥オンダンセトロン組成物
AU2004266731A1 (en) Compositions for delivering 5-HT agonists across the oral mucosa and methods of use thereof
TWI343262B (en) Rapidly disintegrating lyophilized oral formulations of a thrombin receptor antagonist
US20200276114A1 (en) Dipivefrin orally disintegrating tablet formulations
JPH0812575A (ja) 口腔乾燥症治療剤
US20240009130A1 (en) Rapidly infusing compositions for oral mucosal delivery and methods
JP2665357B2 (ja) 心不全治療用医薬組成物
NO336460B1 (no) Fast hurtigdispergerings-doseringsform inneholdende substituerte imidazolderivater
MXPA96003713A (en) Sublingual pharmaceutical composition or bu
US20210052608A1 (en) Methods of treating bacterial infections with minocycline
CA2205600C (en) Freeze-dried ondansetron compositions
Pravin Formulation and evaluation of oral dispersible tablets of antihypertensive drug atenolol

Legal Events

Date Code Title Description
PC Transfer of assignment of patent

Owner name: N.V. ORGANON

Free format text: N.V. ORGANON

FG Patent granted

Ref document number: 117923

Country of ref document: FI

SPCF Supplementary protection certificate application filed

Free format text: SPC C20100028

Spc suppl protection certif: C20100028

PC Transfer of assignment of patent

Owner name: MSD OSS B.V.

Free format text: MSD OSS B.V.

SPCG Supplementary protection certificate granted

Spc suppl protection certif: 368

Extension date: 20200301

PC Transfer of assignment of patent

Owner name: MERCK SHARP & DOHME B.V.

MA Patent expired