FI117509B - Humanisoituja vasta-aineita leukosyyttitarttumismolekyyliä VLA-4 vastaan - Google Patents

Humanisoituja vasta-aineita leukosyyttitarttumismolekyyliä VLA-4 vastaan Download PDF

Info

Publication number: FI117509B
Authority: FI; Finland
Prior art keywords: humanized; ser; sequence; human; gly
Prior art date: 1994-01-25

Application number

FI962958A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI962958A0 (fi

FI962958L (fi

Inventor

Jose Saldanha

Mary M Bendig

Olivier J Leger

Tarran S Jones

Ted A Yednock

Original Assignee

Elan Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-01-25

Filing date

1996-07-24

Publication date

2006-11-15

1996-07-24 Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc

1996-07-24 Publication of FI962958A0 publication Critical patent/FI962958A0/fi

1996-09-24 Publication of FI962958L publication Critical patent/FI962958L/fi

2006-11-15 Application granted granted Critical

2006-11-15 Publication of FI117509B publication Critical patent/FI117509B/fi

Links

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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Microbiology (AREA)
Mycology (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Diabetes (AREA)
Hematology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

FI962958A 1994-01-25 1996-07-24 Humanisoituja vasta-aineita leukosyyttitarttumismolekyyliä VLA-4 vastaan FI117509B (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US18626994A	1994-01-25	1994-01-25
US18626994		1994-01-25
PCT/US1995/001219 WO1995019790A1 (en)	1994-01-25	1995-01-25	Humanized antibodies against leukocyte adhesion molecule vla-4
US9501219		1995-01-25

Publications (3)

Publication Number	Publication Date
FI962958A0 FI962958A0 (fi)	1996-07-24
FI962958L FI962958L (fi)	1996-09-24
FI117509B true FI117509B (fi)	2006-11-15

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ID=22684288

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Application Number	Title	Priority Date	Filing Date
FI962958A FI117509B (fi)	1994-01-25	1996-07-24	Humanisoituja vasta-aineita leukosyyttitarttumismolekyyliä VLA-4 vastaan

Country Status (21)

Country	Link
EP (2)	EP0804237B8 (zh)
JP (5)	JP4115517B2 (zh)
KR (1)	KR100367948B1 (zh)
CN (1)	CN1211123C (zh)
AT (1)	ATE333895T1 (zh)
AU (1)	AU703152B2 (zh)
CA (1)	CA2182013C (zh)
DE (2)	DE69535133T2 (zh)
DK (2)	DK1759709T3 (zh)
ES (2)	ES2424292T3 (zh)
FI (1)	FI117509B (zh)
FR (1)	FR06C0024I2 (zh)
HU (1)	HU220799B1 (zh)
LU (1)	LU91271I2 (zh)
MX (1)	MX9602971A (zh)
NL (1)	NL300238I2 (zh)
NO (3)	NO319867B1 (zh)
NZ (1)	NZ279730A (zh)
PL (1)	PL181827B1 (zh)
PT (1)	PT804237E (zh)
WO (1)	WO1995019790A1 (zh)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6307025B1 (en)	1989-04-28	2001-10-23	Biogen, Inc.	VCAM fusion proteins and DNA coding therefor
US5871734A (en) *	1992-01-13	1999-02-16	Biogen, Inc.	Treatment for asthma with VLA-4 blocking agents
US5932214A (en) *	1994-08-11	1999-08-03	Biogen, Inc.	Treatment for inflammatory bowel disease with VLA-4 blockers
AU688751B2 (en)	1993-01-12	1998-03-19	Biogen Idec Ma Inc.	Recombinant anti-VLA4 antibody molecules
DK0682529T4 (da) *	1993-02-09	2006-05-15	Biogen Idec Inc	Antistof til behandling af insulinkrævende diabetes
US5840299A (en) *	1994-01-25	1998-11-24	Athena Neurosciences, Inc.	Humanized antibodies against leukocyte adhesion molecule VLA-4
US7435802B2 (en)	1994-01-25	2008-10-14	Elan Pharaceuticals, Inc.	Humanized anti-VLA4 immunoglobulins
US6551593B1 (en)	1995-02-10	2003-04-22	Millennium Pharmaceuticals, Inc.	Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam
US7750137B2 (en)	1995-09-01	2010-07-06	Millennium Pharmaceuticals, Inc.	Mucosal vascular addressins
US7803904B2 (en)	1995-09-01	2010-09-28	Millennium Pharmaceuticals, Inc.	Mucosal vascular addressing and uses thereof
US7147851B1 (en) *	1996-08-15	2006-12-12	Millennium Pharmaceuticals, Inc.	Humanized immunoglobulin reactive with α4β7 integrin
WO1998051345A2 (en) *	1997-05-09	1998-11-19	The John P. Robarts Research Institute	Method for dislodging infiltrated leukocytes from a tissue
DE19741235A1 (de)	1997-09-18	1999-03-25	Hoechst Marion Roussel De Gmbh	Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) *	1997-09-23	1999-03-25	Hoechst Marion Roussel De Gmbh	Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de)	1997-11-19	1999-05-20	Hoechst Marion Roussel De Gmbh	Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de)	1998-05-14	1999-11-18	Hoechst Marion Roussel De Gmbh	Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US7618630B2 (en)	1998-09-14	2009-11-17	Board Of Regents, The University Of Texas System	Methods of treating multiple myeloma and myeloma-induced bone resorption using integrin antagonists
DK1113810T3 (da) *	1998-09-14	2009-04-06	Univ Texas	Fremgangsmåder til behandling af multipelt myelom og myelom-induceret knogleresorption under anvendelse af antagonister af integrin/receptor-binding
SK287328B6 (sk) *	1999-04-22	2010-07-07	Biogen Idec Ma Inc.	Použitie kompozície obsahujúcej homológ protilátky, ktorý je antagonistom interakcie medzi integrínom nesúcim podjednotku alfa4 a ligandom pre integrín nesúci podjednotku alfa4
DE19922462A1 (de)	1999-05-17	2000-11-23	Aventis Pharma Gmbh	Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate
WO2000072881A1 (en)	1999-06-01	2000-12-07	Biogen, Inc.	A blocking monoclonal antibody to vla-1 and its use for the treatment of inflammatory disorders
US6949245B1 (en)	1999-06-25	2005-09-27	Genentech, Inc.	Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
EP2140881B1 (en) *	1999-12-16	2013-04-17	Biogen Idec MA Inc.	Methods of treating central nervous system ischemic or hemorrhagic injury using anti alpha4 integrin antagonists
DE10111877A1 (de)	2001-03-10	2002-09-12	Aventis Pharma Gmbh	Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
EE200300509A (et)	2001-04-13	2004-08-16	Biogen, Inc.	Antikehad VLA-1 vastu
DE10137595A1 (de)	2001-08-01	2003-02-13	Aventis Pharma Gmbh	Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung
PT2336184E (pt) *	2002-02-25	2015-03-09	Biogen Idec Inc	Administração de agentes para o tratamento da inflamação
EP1499352A4 (en) *	2002-04-12	2006-10-11	Medimmune Inc	ANTI-INTERLEUKIN-9 RECOMBINANT ANTIBODIES
GB0210121D0 (en) *	2002-05-02	2002-06-12	Celltech R&D Ltd	Biological products
TWI323265B (en) *	2002-08-06	2010-04-11	Glaxo Group Ltd	Antibodies
ATE471946T1 (de) *	2002-12-17	2010-07-15	Merck Patent Gmbh	Humanisierter antikörper (h14.18) des maus antikörpers 14.18, der gd2 bindet und seine fusion mit il-2
CU23403A1 (es) *	2003-04-23	2009-08-04	Centro Inmunologia Molecular	Anticuerpos recombinantes y fragmentos que reconocen el gangliósido n-glicolil gm3 y su uso para diagnóstico y tratamiento de tumores
RU2390520C2 (ru)	2003-12-22	2010-05-27	Адзиномото Ко., Инк.	Новые производные фенилаланина
CA2587597A1 (en) *	2004-11-19	2006-05-26	Biogen Idec Ma Inc.	Treatment for multiple sclerosis
WO2007061679A1 (en) *	2005-11-17	2007-05-31	Millennium Pharmaceuticals, Inc.	HUMANIZED IMMUNOGLOBULIN REACTIVE WITH α4β7 INTEGRIN
DK2034830T3 (da)	2006-05-25	2014-10-27	Biogen Idec Inc	Anti-vla-1-antistof til behandling af slagtilfælde
EP2124996A4 (en)	2007-02-20	2010-03-24	Merrimack Pharmaceuticals Inc	METHODS OF TREATING MULTIPLE SCLEROSIS BY ADMINISTERING ALPHA-FETOPROTEIN COMBINED WITH INTEGRIN ANTAGONIST
AR067011A1 (es) *	2007-06-14	2009-09-30	Biogen Idec Inc	Formulaciones de anticuerpos
WO2009075388A1 (ja)	2007-12-13	2009-06-18	Tokuyama Corporation	フォトクロミック硬化性組成物
ES2525065T3 (es)	2008-04-11	2014-12-17	Merrimack Pharmaceuticals, Inc.	Ligadores de seroalbúmina humana y sus conjugados
TWI466681B (zh)	2009-03-20	2015-01-01	Amgen Inc	α４β７雜二聚體專一性拮抗抗體
WO2011020874A1 (en)	2009-08-20	2011-02-24	Inserm (Institut National De La Sante Et De La Recherche Medicale)	Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
MX340683B (es)	2010-04-16	2016-07-21	Biogen Ma Inc	Anticuerpos anti-vla-4.
UA116189C2 (uk)	2011-05-02	2018-02-26	Мілленніум Фармасьютікалз, Інк.	КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА
PH12018502221B1 (en)	2011-05-02	2023-05-10	Millennium Pharm Inc	FORMULATION FOR ANTI-a4Ã7 ANTIBODY
ES2732243T3 (es)	2012-02-16	2019-11-21	Santarus Inc	Composiciones farmacéuticas de anticuerpos ANTI-VLA1 (CD49A)
US20190225694A1 (en)	2016-06-28	2019-07-25	Zaklady Farmaceutyczne Polpharma Sa	Recombinant production of monoclonal antibodies
US20190374639A1 (en)	2016-11-21	2019-12-12	Polpharma Biologics S.A.	Aqueous pharmaceutical formulations
CN110997714B (zh) *	2017-02-17	2024-05-03	赛诺菲	对肌营养不良蛋白聚糖和层粘连蛋白-2具有特异性的多特异性结合分子
US12043845B2 (en)	2017-06-08	2024-07-23	Polpharma Biologics S.A.	Methods of cell culture
JP7457661B2 (ja)	2018-06-04	2024-03-28	バイオジェン・エムエイ・インコーポレイテッド	低減したエフェクター機能を有する抗ｖｌａ－４抗体
US20240301512A1 (en)	2021-01-29	2024-09-12	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods of assessing the risk of developing progressive multifocal leukoencephalopathy in patients treated with vla-4 antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5225539A (en) *	1986-03-27	1993-07-06	Medical Research Council	Recombinant altered antibodies and methods of making altered antibodies
IL162181A (en) *	1988-12-28	2006-04-10	Pdl Biopharma Inc	A method of producing humanized immunoglubulin, and polynucleotides encoding the same
IL113261A (en) *	1989-09-01	1996-10-16	Hutchinson Fred Cancer Res	Inhibition by peptides of lymphocyte adherence to vascular endothelium utilizing an extracellular matrix receptor-ligand interaction and pharmaceutical compositions containing said peptides
ATE151642T1 (de) *	1992-02-12	1997-05-15	Biogen Inc	Behandlung für entzündungserkrankung des darmes
AU688751B2 (en) *	1993-01-12	1998-03-19	Biogen Idec Ma Inc.	Recombinant anti-VLA4 antibody molecules
AUPP647298A0 (en)	1998-10-13	1998-11-05	Keystone Retaining Wall Systems, Inc.	Retaining wall block

1995
- 1995-01-25 ES ES06013916T patent/ES2424292T3/es not_active Expired - Lifetime
- 1995-01-25 WO PCT/US1995/001219 patent/WO1995019790A1/en active IP Right Grant
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- 1995-01-25 DE DE1995635133 patent/DE122006000043I1/de active Pending
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- 1995-01-25 HU HU9602019A patent/HU220799B1/hu active Protection Beyond IP Right Term
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1996
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2005
- 2005-08-05 JP JP2005228930A patent/JP2006045237A/ja not_active Withdrawn
2006
- 2006-07-27 FR FR06C0024C patent/FR06C0024I2/fr active Active
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Also Published As

Publication number	Publication date
FI962958A0 (fi)	1996-07-24
PT804237E (pt)	2006-10-31
PL181827B1 (pl)	2001-09-28
ATE333895T1 (de)	2006-08-15
NO2017040I1 (no)	2017-08-01
DK0804237T3 (da)	2006-10-16
NO2006008I2 (no)	2009-06-15
MX9602971A (es)	1998-01-31
JP5487382B2 (ja)	2014-05-07
EP1759709A1 (en)	2007-03-07
CA2182013A1 (en)	1995-07-27
CN1140413A (zh)	1997-01-15
EP1759709B1 (en)	2013-02-27
JPH09508272A (ja)	1997-08-26
KR970700513A (ko)	1997-02-12
JP2013165718A (ja)	2013-08-29
JP2006045237A (ja)	2006-02-16
JP4115517B2 (ja)	2008-07-09
FI962958L (fi)	1996-09-24
KR100367948B1 (ko)	2003-07-12
NO319867B1 (no)	2005-09-26
NO2006008I1 (no)	2006-08-07
JP2009235078A (ja)	2009-10-15
CA2182013C (en)	2007-07-17
AU1696095A (en)	1995-08-08
HUT75129A (en)	1997-04-28
DE122006000043I1 (de)	2007-02-15
LU91271I2 (fr)	2006-10-02
NO963097D0 (no)	1996-07-24
EP0804237A1 (en)	1997-11-05
AU703152B2 (en)	1999-03-18
HU9602019D0 (en)	1996-09-30
NO2017040I2 (no)	2018-08-28
DE69535133D1 (de)	2006-09-07
NO963097L (no)	1996-09-24
EP0804237B1 (en)	2006-07-26
NZ279730A (en)	1998-04-27
PL315634A1 (en)	1996-11-25
ES2270425T3 (es)	2007-04-01
FR06C0024I1 (zh)	2006-10-13
HU220799B1 (hu)	2002-05-28
WO1995019790A1 (en)	1995-07-27
FR06C0024I2 (fr)	2009-01-02
NL300238I1 (zh)	2006-10-02
ES2424292T3 (es)	2013-09-30
EP0804237B8 (en)	2006-11-08
DK1759709T3 (da)	2013-06-10
EP0804237A4 (en)	2003-04-16
JP2013173738A (ja)	2013-09-05
NL300238I2 (nl)	2007-05-01
CN1211123C (zh)	2005-07-20
DE69535133T2 (de)	2008-08-21

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FI117509B (fi)	2006-11-15	Humanisoituja vasta-aineita leukosyyttitarttumismolekyyliä VLA-4 vastaan
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CN101134779B (zh)	2013-03-13	人cd22特异性抗体及其治疗和诊断应用
AU4032299A (en)	1999-11-23	Fap alpha-specific antibody with improved producibility
HUE029824T2 (en)	2017-04-28	Novel antagonist antibodies and their fab fragments against gpvi and uses thereof
US20240301047A1 (en)	2024-09-12	Methods and compositions for imaging amyloid deposits

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