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FI115166B - Diagnostiska förfaranden - Google Patents

Diagnostiska förfaranden Download PDF

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Publication number
FI115166B
FI115166B FI20012603A FI20012603A FI115166B FI 115166 B FI115166 B FI 115166B FI 20012603 A FI20012603 A FI 20012603A FI 20012603 A FI20012603 A FI 20012603A FI 115166 B FI115166 B FI 115166B
Authority
FI
Finland
Prior art keywords
pylori
antigen
antibodies
binding fragments
biosensor
Prior art date
Application number
FI20012603A
Other languages
English (en)
Finnish (fi)
Other versions
FI20012603A0 (sv
FI20012603A (sv
Inventor
Vesa Kleimola
Erkki Eerola
Markku Viander
Original Assignee
Biofons Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biofons Oy filed Critical Biofons Oy
Publication of FI20012603A0 publication Critical patent/FI20012603A0/sv
Priority to FI20012603A priority Critical patent/FI115166B/sv
Priority to US10/164,555 priority patent/US7544504B2/en
Priority to PCT/FI2002/000762 priority patent/WO2003056338A1/en
Priority to BR0215416-1A priority patent/BR0215416A/pt
Priority to RU2004123636/15A priority patent/RU2309408C2/ru
Priority to AU2002327860A priority patent/AU2002327860A1/en
Priority to JP2003556810A priority patent/JP4323318B2/ja
Priority to EP02762478A priority patent/EP1468292A1/en
Priority to CA002472230A priority patent/CA2472230A1/en
Priority to CNB028284186A priority patent/CN100480703C/zh
Publication of FI20012603A publication Critical patent/FI20012603A/sv
Application granted granted Critical
Publication of FI115166B publication Critical patent/FI115166B/sv

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56922—Campylobacter
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Claims (8)

1. Icke-invasivt förfarande för detektering av när- eller franvaron av ett Helicobacter py/or/-antigen eller en metabolit producerad av Helicobacter 5 py/or/-bakterium i ett biologiskt prov, kännetecknat avatt ett biologiskt prov som erhällits fran en patient som lider eller som misstänks att Iida av H. pylori-infektion, bringas i kontakt med en biosensor, som omfattar ett bärarsubstrat, pa vilket man har direkt kovalentiskt fästat anti-kroppar mot H. pylori eller antigen-bindande fragment därav tillsammans med 10 biomolekyler-utstötande hydrofila molekyler, vilka belägger ytan mellan immo-biliserade antikroppar eller antigen-bindande fragment därav, och en signal, som härleder sig fran bildandet av ett antikropp-antigen-komplex, detekteras.
2. Förfarande enligt patentkrav 1, kännetecknat av att de 15 biomolekyler-utstötande hydrofila molekylerna är neutrala hydrofila monomerer eller polymerer.
3. Förfarande enligt patentkrav 2, kännetecknat av att de biomolekyler-utstötande hydrofila molekylerna är polyakrylamid, poly-N,N-dimetylakrylamid, polyvinylalkohol, etylen-vinylalkoholkopolymer, poly(hydroxi- 20 etylmetakrylat), poly(etylenoxid) och poly(etylenglykol) och polyetylenftalat, : polytetrafluoretylen, polyuretan eller en likadan biologiskt kompatibel polymer.
:,.,: 4. Förfarande enligt patentkrav 2 eller 3, kännetecknat av att : de biomolekyler-utstötande molekylerna är polyakrylamid och poly-N,N- : ·,· dimetylakrylamid, företrädesvis N-[tris(hydroximetyl)metyl]akrylamid. 25
5. Förfarande enligt nagot av patentkraven 1 - 4, känne- ··. t e c k n a t av att den fasta ytan av bärarsubstratet är en film av ett med yt- plasmonresonans (SPR) kompatibelt material, sasom guld, silver, koppar, , ^ aluminium, palladium eller en annan lämplig metall, företrädesvis guld.
6. Förfarande enligt nagot av patentkraven 1-5, känneteck-‘ 30 n at av att detekteringen utförs genom ett ytplasmonresonans (SPR) - ···: förfarande.
: 7. Användning av en biosensor, vilken omfattar ett bärarsubstrat, pa vilket man har direkt kovalentiskt fästat specifika antikroppar mot H. pylori eller · antigen-bindande fragment därav tillsammans med biomolekyler-utstötande ‘ · » ' 35 hydrofila molekyler, vilka belägger ytan mellan immobiliserade antikroppar eller antigen-bindande fragment därav, för detektering av när- eller franvaron av ett 115166 Helicobacter pylori-antigen eller en metabolit producerad av H. pylori i ett bio-logiskt prov.
8. Testkit för detektering av när- eller fränvaron av ett Helicobacter pylori-antigen eller en metabolit producerad av H. pylori i ett biologiskt prov, 5 kännetecknat avatt den omfattar en biosensor, som omfattar ett bärarsubstrat, pä vilket man har di-rekt kovalentiskt fästat specifika antikroppar mot H. pylori eller antigen-bindande fragment därav tillsammans med biomolekyler utstötande hydrofila molekyler, vilka belägger ytan mellan immobiliserade antikroppar eller antigen-1 o bindande fragment därav, reagenser, som behövs i kalibrering och kvalitetskontroll, och hjälpreagenser, säsom tvättlösningar och utspädningsbuffertar. • ϊ · • · • · • » · * « · * · • * * tl - M > ·
FI20012603A 2001-12-31 2001-12-31 Diagnostiska förfaranden FI115166B (sv)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FI20012603A FI115166B (sv) 2001-12-31 2001-12-31 Diagnostiska förfaranden
US10/164,555 US7544504B2 (en) 2001-12-31 2002-06-10 Diagnostic methods
RU2004123636/15A RU2309408C2 (ru) 2001-12-31 2002-09-24 Способы диагностики
BR0215416-1A BR0215416A (pt) 2001-12-31 2002-09-24 Métodos de diagnóstico
PCT/FI2002/000762 WO2003056338A1 (en) 2001-12-31 2002-09-24 Diagnostic methods
AU2002327860A AU2002327860A1 (en) 2001-12-31 2002-09-24 Diagnostic methods
JP2003556810A JP4323318B2 (ja) 2001-12-31 2002-09-24 ヘリコバクターピロリを検出するための非侵襲的方法
EP02762478A EP1468292A1 (en) 2001-12-31 2002-09-24 Diagnostic methods
CA002472230A CA2472230A1 (en) 2001-12-31 2002-09-24 Diagnosis of helicobacter pylori with surface plasmon resonance
CNB028284186A CN100480703C (zh) 2001-12-31 2002-09-24 幽门螺旋杆菌抗体及其抗原结合片段在传感器制备中的应用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20012603 2001-12-31
FI20012603A FI115166B (sv) 2001-12-31 2001-12-31 Diagnostiska förfaranden

Publications (3)

Publication Number Publication Date
FI20012603A0 FI20012603A0 (sv) 2001-12-31
FI20012603A FI20012603A (sv) 2003-07-01
FI115166B true FI115166B (sv) 2005-03-15

Family

ID=8562607

Family Applications (1)

Application Number Title Priority Date Filing Date
FI20012603A FI115166B (sv) 2001-12-31 2001-12-31 Diagnostiska förfaranden

Country Status (10)

Country Link
US (1) US7544504B2 (sv)
EP (1) EP1468292A1 (sv)
JP (1) JP4323318B2 (sv)
CN (1) CN100480703C (sv)
AU (1) AU2002327860A1 (sv)
BR (1) BR0215416A (sv)
CA (1) CA2472230A1 (sv)
FI (1) FI115166B (sv)
RU (1) RU2309408C2 (sv)
WO (1) WO2003056338A1 (sv)

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Also Published As

Publication number Publication date
JP4323318B2 (ja) 2009-09-02
EP1468292A1 (en) 2004-10-20
FI20012603A0 (sv) 2001-12-31
BR0215416A (pt) 2004-11-09
FI20012603A (sv) 2003-07-01
WO2003056338A1 (en) 2003-07-10
AU2002327860A1 (en) 2003-07-15
CN1623092A (zh) 2005-06-01
US20030124632A1 (en) 2003-07-03
RU2309408C2 (ru) 2007-10-27
RU2004123636A (ru) 2005-04-20
CN100480703C (zh) 2009-04-22
US7544504B2 (en) 2009-06-09
JP2005513504A (ja) 2005-05-12
CA2472230A1 (en) 2003-07-10

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