FI112356B - Kohtalaisen hauras jauhemainen mannitoli ja menetelmä sen valmistamiseksi - Google Patents

Kohtalaisen hauras jauhemainen mannitoli ja menetelmä sen valmistamiseksi Download PDF

Info

Publication number: FI112356B
Authority: FI; Finland
Prior art keywords: mannitol; less; microns; advantageously; powdered
Prior art date: 1993-09-28

Application number

FI944464A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI944464A0 (fi

FI944464A (fi

Inventor

Michel Serpelloni

Jean-Philippe Boonaert

Original Assignee

Roquette Freres

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-28

Filing date

1994-09-27

Publication date

2003-11-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9451298&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI112356(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1994-09-27 Application filed by Roquette Freres filed Critical Roquette Freres

1994-09-27 Publication of FI944464A0 publication Critical patent/FI944464A0/fi

1995-03-29 Publication of FI944464A publication Critical patent/FI944464A/fi

2003-11-28 Application granted granted Critical

2003-11-28 Publication of FI112356B publication Critical patent/FI112356B/fi

Links

FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 title claims abstract description 126
235000010355 mannitol Nutrition 0.000 title claims abstract description 125
229930195725 Mannitol Natural products 0.000 title claims abstract description 122
239000000594 mannitol Substances 0.000 title claims abstract description 122
238000000034 method Methods 0.000 title claims description 34
238000002360 preparation method Methods 0.000 title claims description 10
239000002245 particle Substances 0.000 claims abstract description 74
238000012360 testing method Methods 0.000 claims abstract description 14
235000013305 food Nutrition 0.000 claims abstract description 8
239000000654 additive Substances 0.000 claims abstract description 7
238000009826 distribution Methods 0.000 claims abstract description 5
239000003795 chemical substances by application Substances 0.000 claims abstract description 3
239000000945 filler Substances 0.000 claims description 21
229920005862 polyol Polymers 0.000 claims description 17
150000003077 polyols Chemical class 0.000 claims description 17
235000000346 sugar Nutrition 0.000 claims description 15
239000000725 suspension Substances 0.000 claims description 12
238000004090 dissolution Methods 0.000 claims description 9
239000000203 mixture Substances 0.000 claims description 9
238000005469 granulation Methods 0.000 claims description 5
230000003179 granulation Effects 0.000 claims description 5
230000000996 additive effect Effects 0.000 claims description 2
238000000889 atomisation Methods 0.000 claims description 2
235000003599 food sweetener Nutrition 0.000 abstract description 6
239000003765 sweetening agent Substances 0.000 abstract description 6
239000000546 pharmaceutical excipient Substances 0.000 abstract description 4
230000002829 reductive effect Effects 0.000 abstract description 3
239000003981 vehicle Substances 0.000 abstract 1
239000000843 powder Substances 0.000 description 25
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 21
239000000126 substance Substances 0.000 description 13
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 11
238000004519 manufacturing process Methods 0.000 description 10
238000005507 spraying Methods 0.000 description 10
239000006188 syrup Substances 0.000 description 10
235000020357 syrup Nutrition 0.000 description 10
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 9
239000000600 sorbitol Substances 0.000 description 9
235000010356 sorbitol Nutrition 0.000 description 9
229920002472 Starch Polymers 0.000 description 8
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 8
229930006000 Sucrose Natural products 0.000 description 8
238000002474 experimental method Methods 0.000 description 8
235000019698 starch Nutrition 0.000 description 8
239000005720 sucrose Substances 0.000 description 8
229960004793 sucrose Drugs 0.000 description 8
239000003826 tablet Substances 0.000 description 8
239000011230 binding agent Substances 0.000 description 7
239000013078 crystal Substances 0.000 description 7
238000002425 crystallisation Methods 0.000 description 7
230000008025 crystallization Effects 0.000 description 7
239000000428 dust Substances 0.000 description 7
239000007787 solid Substances 0.000 description 7
239000000243 solution Substances 0.000 description 7
239000008107 starch Substances 0.000 description 7
239000010419 fine particle Substances 0.000 description 6
230000000704 physical effect Effects 0.000 description 6
150000008163 sugars Chemical class 0.000 description 6
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 5
208000002925 dental caries Diseases 0.000 description 5
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
229960001375 lactose Drugs 0.000 description 4
239000008101 lactose Substances 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
239000007921 spray Substances 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 3
230000002411 adverse Effects 0.000 description 3
238000005259 measurement Methods 0.000 description 3
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 3
239000006199 nebulizer Substances 0.000 description 3
239000002904 solvent Substances 0.000 description 3
239000011782 vitamin Substances 0.000 description 3
235000013343 vitamin Nutrition 0.000 description 3
229940088594 vitamin Drugs 0.000 description 3
229930003231 vitamin Natural products 0.000 description 3
239000000811 xylitol Substances 0.000 description 3
235000010447 xylitol Nutrition 0.000 description 3
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 3
229960002675 xylitol Drugs 0.000 description 3
WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
108090000790 Enzymes Proteins 0.000 description 2
102000004190 Enzymes Human genes 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
239000004480 active ingredient Substances 0.000 description 2
150000001413 amino acids Chemical class 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
238000003556 assay Methods 0.000 description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
239000003086 colorant Substances 0.000 description 2
239000008121 dextrose Substances 0.000 description 2
229920001971 elastomer Polymers 0.000 description 2
229940088598 enzyme Drugs 0.000 description 2
235000019441 ethanol Nutrition 0.000 description 2
238000004880 explosion Methods 0.000 description 2
239000000796 flavoring agent Substances 0.000 description 2
235000013355 food flavoring agent Nutrition 0.000 description 2
238000009472 formulation Methods 0.000 description 2
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
229960001021 lactose monohydrate Drugs 0.000 description 2
235000019359 magnesium stearate Nutrition 0.000 description 2
-1 mannitol Chemical class 0.000 description 2
238000002663 nebulization Methods 0.000 description 2
229940124531 pharmaceutical excipient Drugs 0.000 description 2
230000000717 retained effect Effects 0.000 description 2
239000005060 rubber Substances 0.000 description 2
238000000926 separation method Methods 0.000 description 2
238000005550 wet granulation Methods 0.000 description 2
244000215068 Acacia senegal Species 0.000 description 1
241000416162 Astragalus gummifer Species 0.000 description 1
240000002791 Brassica napus Species 0.000 description 1
235000004977 Brassica sinapistrum Nutrition 0.000 description 1
229920003043 Cellulose fiber Polymers 0.000 description 1
229920002245 Dextrose equivalent Polymers 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
239000004386 Erythritol Substances 0.000 description 1
UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
229920000084 Gum arabic Polymers 0.000 description 1
229920001202 Inulin Polymers 0.000 description 1
240000007472 Leucaena leucocephala Species 0.000 description 1
235000010643 Leucaena leucocephala Nutrition 0.000 description 1
239000005913 Maltodextrin Substances 0.000 description 1
229920002774 Maltodextrin Polymers 0.000 description 1
241000124008 Mammalia Species 0.000 description 1
229920005830 Polyurethane Foam Polymers 0.000 description 1
108010009736 Protein Hydrolysates Proteins 0.000 description 1
241000283984 Rodentia Species 0.000 description 1
229910000831 Steel Inorganic materials 0.000 description 1
241000534944 Thia Species 0.000 description 1
229920001615 Tragacanth Polymers 0.000 description 1
239000000205 acacia gum Substances 0.000 description 1
235000010489 acacia gum Nutrition 0.000 description 1
239000002253 acid Substances 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000013543 active substance Substances 0.000 description 1
230000032683 aging Effects 0.000 description 1
WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
230000003444 anaesthetic effect Effects 0.000 description 1
229960004977 anhydrous lactose Drugs 0.000 description 1
230000002528 anti-freeze Effects 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000007910 chewable tablet Substances 0.000 description 1
229940112822 chewing gum Drugs 0.000 description 1
235000015218 chewing gum Nutrition 0.000 description 1
239000011362 coarse particle Substances 0.000 description 1
238000011109 contamination Methods 0.000 description 1
230000007423 decrease Effects 0.000 description 1
238000001739 density measurement Methods 0.000 description 1
235000011850 desserts Nutrition 0.000 description 1
230000001627 detrimental effect Effects 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000037213 diet Effects 0.000 description 1
229940079919 digestives enzyme preparation Drugs 0.000 description 1
IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 description 1
238000007907 direct compression Methods 0.000 description 1
150000002016 disaccharides Chemical class 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
230000035622 drinking Effects 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
230000005611 electricity Effects 0.000 description 1
UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
235000019414 erythritol Nutrition 0.000 description 1
229940009714 erythritol Drugs 0.000 description 1
NYPJDWWKZLNGGM-RPWUZVMVSA-N esfenvalerate Chemical compound C=1C([C@@H](C#N)OC(=O)[C@@H](C(C)C)C=2C=CC(Cl)=CC=2)=CC=CC=1OC1=CC=CC=C1 NYPJDWWKZLNGGM-RPWUZVMVSA-N 0.000 description 1
239000002360 explosive Substances 0.000 description 1
235000012438 extruded product Nutrition 0.000 description 1
238000001125 extrusion Methods 0.000 description 1
239000003925 fat Substances 0.000 description 1
235000019197 fats Nutrition 0.000 description 1
239000003337 fertilizer Substances 0.000 description 1
239000012634 fragment Substances 0.000 description 1
229930182830 galactose Natural products 0.000 description 1
229960003082 galactose Drugs 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
229920000591 gum Polymers 0.000 description 1
239000008172 hydrogenated vegetable oil Substances 0.000 description 1
239000003262 industrial enzyme Substances 0.000 description 1
JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
229940029339 inulin Drugs 0.000 description 1
230000002147 killing effect Effects 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
239000000845 maltitol Substances 0.000 description 1
235000010449 maltitol Nutrition 0.000 description 1
VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical class OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
229940035436 maltitol Drugs 0.000 description 1
229940035034 maltodextrin Drugs 0.000 description 1
239000012803 melt mixture Substances 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
239000011859 microparticle Substances 0.000 description 1
238000000386 microscopy Methods 0.000 description 1
238000003801 milling Methods 0.000 description 1
238000002156 mixing Methods 0.000 description 1
150000002772 monosaccharides Chemical class 0.000 description 1
235000013615 non-nutritive sweetener Nutrition 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
238000005457 optimization Methods 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
239000003973 paint Substances 0.000 description 1
239000000123 paper Substances 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
239000002304 perfume Substances 0.000 description 1
239000000575 pesticide Substances 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
239000011496 polyurethane foam Substances 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
239000011819 refractory material Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
239000011347 resin Substances 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000012216 screening Methods 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
239000012798 spherical particle Substances 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
230000003068 static effect Effects 0.000 description 1
239000010959 steel Substances 0.000 description 1
150000005846 sugar alcohols Chemical class 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
238000012546 transfer Methods 0.000 description 1
230000000007 visual effect Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/34—Sugar alcohols
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C31/18—Polyhydroxylic acyclic alcohols
- C07C31/26—Hexahydroxylic alcohols

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Nutrition Science (AREA)
Engineering & Computer Science (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Seasonings (AREA)
General Preparation And Processing Of Foods (AREA)
Peptides Or Proteins (AREA)

FI944464A 1993-09-28 1994-09-27 Kohtalaisen hauras jauhemainen mannitoli ja menetelmä sen valmistamiseksi FI112356B (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9311513A FR2710637B1 (fr)	1993-09-28	1993-09-28	Mannitol pulvérulent de friabilité modérée et son procédé de préparation.
FR9311513		1993-09-28

Publications (3)

Publication Number	Publication Date
FI944464A0 FI944464A0 (fi)	1994-09-27
FI944464A FI944464A (fi)	1995-03-29
FI112356B true FI112356B (fi)	2003-11-28

Family

ID=9451298

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI944464A FI112356B (fi)	1993-09-28	1994-09-27	Kohtalaisen hauras jauhemainen mannitoli ja menetelmä sen valmistamiseksi

Country Status (16)

Country	Link
US (1)	US5573777A (zh)
EP (1)	EP0645096B1 (zh)
JP (1)	JP3492428B2 (zh)
KR (1)	KR100353433B1 (zh)
CN (1)	CN1046622C (zh)
AT (1)	ATE160676T1 (zh)
AU (1)	AU675732B2 (zh)
CA (1)	CA2133012C (zh)
DE (1)	DE69407123T2 (zh)
DK (1)	DK0645096T3 (zh)
ES (1)	ES2109635T3 (zh)
FI (1)	FI112356B (zh)
FR (1)	FR2710637B1 (zh)
GR (1)	GR3025720T3 (zh)
HU (1)	HU217453B (zh)
NO (1)	NO302356B1 (zh)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
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1993
- 1993-09-28 FR FR9311513A patent/FR2710637B1/fr not_active Expired - Fee Related
1994
- 1994-09-26 US US08/311,791 patent/US5573777A/en not_active Expired - Lifetime
- 1994-09-26 DE DE69407123T patent/DE69407123T2/de not_active Expired - Lifetime
- 1994-09-26 DK DK94402134.4T patent/DK0645096T3/da active
- 1994-09-26 EP EP94402134A patent/EP0645096B1/fr not_active Expired - Lifetime
- 1994-09-26 AT AT94402134T patent/ATE160676T1/de active
- 1994-09-26 ES ES94402134T patent/ES2109635T3/es not_active Expired - Lifetime
- 1994-09-26 AU AU74239/94A patent/AU675732B2/en not_active Expired
- 1994-09-27 CN CN94117872A patent/CN1046622C/zh not_active Expired - Lifetime
- 1994-09-27 HU HU9402773A patent/HU217453B/hu unknown
- 1994-09-27 NO NO943586A patent/NO302356B1/no not_active IP Right Cessation
- 1994-09-27 FI FI944464A patent/FI112356B/fi not_active IP Right Cessation
- 1994-09-27 KR KR1019940024331A patent/KR100353433B1/ko not_active IP Right Cessation
- 1994-09-27 CA CA002133012A patent/CA2133012C/en not_active Expired - Lifetime
- 1994-09-28 JP JP23359994A patent/JP3492428B2/ja not_active Expired - Lifetime
1997
- 1997-12-19 GR GR970403367T patent/GR3025720T3/el unknown

Also Published As

Publication number	Publication date
FI944464A0 (fi)	1994-09-27
DE69407123D1 (de)	1998-01-15
JPH07184590A (ja)	1995-07-25
NO302356B1 (no)	1998-02-23
DE69407123T2 (de)	1998-04-23
ES2109635T3 (es)	1998-01-16
HUT70804A (en)	1995-11-28
FR2710637A1 (fr)	1995-04-07
AU7423994A (en)	1995-04-13
ATE160676T1 (de)	1997-12-15
AU675732B2 (en)	1997-02-13
KR950008457A (ko)	1995-04-17
FR2710637B1 (fr)	1995-12-08
EP0645096B1 (fr)	1997-12-03
CA2133012A1 (en)	1995-03-29
JP3492428B2 (ja)	2004-02-03
KR100353433B1 (ko)	2002-12-11
NO943586D0 (no)	1994-09-27
EP0645096A1 (fr)	1995-03-29
DK0645096T3 (da)	1998-05-04
CN1107516A (zh)	1995-08-30
FI944464A (fi)	1995-03-29
HU9402773D0 (en)	1994-12-28
HU217453B (hu)	2000-01-28
NO943586L (no)	1995-03-29
US5573777A (en)	1996-11-12
CN1046622C (zh)	1999-11-24
CA2133012C (en)	2006-01-31
GR3025720T3 (en)	1998-03-31

Publication	Publication Date	Title
FI112356B (fi)	2003-11-28	Kohtalaisen hauras jauhemainen mannitoli ja menetelmä sen valmistamiseksi
US6180157B1 (en)	2001-01-30	Process for preparing an N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester agglomerate
US7662799B2 (en)	2010-02-16	Powder of amino acids and method for producing the same
JPH0386839A (ja)	1991-04-11	ソルビトール結晶小球
SK132094A3 (en)	1995-07-11	Pharmaceutical dosage form
US4973486A (en)	1990-11-27	Formulation of lactitol-containing food
CA2521253A1 (en)	2004-10-14	Pharmaceutical compositions having reduced bitter taste
US9636307B2 (en)	2017-05-02	Oral pharmaceutical composition comprising taste-masked N-acetylcysteine
EP0735042B1 (fr)	2000-05-24	Composition de maltitol et son procédé de préparation
KR101409302B1 (ko)	2014-06-20	인도메타신 및／또는 아세메타신을 포함하는 약학적 조성물
US5114726A (en)	1992-05-19	Process for preparing aspartame coated organic acid
MXPA96001193A (en)	1998-04-01	Composition of maltitol and process for supreparac
FR2732343A1 (fr)	1996-10-04	Composition de maltitol et son procede de preparation
US5989352A (en)	1999-11-23	Lactitol composition and process for the preparation thereof
JP3435109B2 (ja)	2003-08-11	瞬溶性顆粒及びその製法
US20220370368A1 (en)	2022-11-24	Oral pharmaceutical composition comprising a melt-agglomerated active ingredient core
JPH10276715A (ja)	1998-10-20	支持物質上のアスパルテーム

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2014-11-03	MA	Patent expired